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Toward understanding the role of genomic repeat elements in neurodegenerative diseases
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作者 Zhengyu An Aidi Jiang Jingqi Chen 《Neural Regeneration Research》 SCIE CAS 2025年第3期646-659,共14页
Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage se... Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements. 展开更多
关键词 Alzheimer's disease ATAXIA deep learning long-read sequencing NEURODEGENERATION neurodegenerative diseases Parkinson's disease repeat element structural variant
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Pig H3K4me3,H3K27ac,and gene expression profiles reveal reproductive tissue-specific activity of transposable elements 被引量:1
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作者 Tao Jiang Zhi-Min Zhou +6 位作者 Zi-Qi Ling Qing Zhang Zhong-Zi Wu Jia-Wen Yang Si-Yu Yang Bin Yang Lu-Sheng Huang 《Zoological Research》 SCIE CSCD 2024年第1期138-151,共14页
Regulatory sequences and transposable elements(TEs)account for a large proportion of the genomic sequences of species;however,their roles in gene transcription,especially tissue-specific expression,remain largely unkn... Regulatory sequences and transposable elements(TEs)account for a large proportion of the genomic sequences of species;however,their roles in gene transcription,especially tissue-specific expression,remain largely unknown.Pigs serve as an excellent animal model for studying genomic sequence biology due to the extensive diversity among their wild and domesticated populations.Here,we conducted an integrated analysis using H3K27ac ChIP-seq,H3K4me3 ChIP-seq,and RNA-seq data from 10 different tissues of seven fetuses and eight closely related adult pigs.We aimed to annotate the regulatory elements and TEs to elucidate their associations with histone modifications and mRNA expression across different tissues and developmental stages.Based on correlation analysis between mRNA expression and H3K27ac and H3K4me3 peak activity,results indicated that H3K27ac exhibited stronger associations with gene expression than H3K4me3.Furthermore,1.45%of TEs overlapped with either the H3K27ac or H3K4me3 peaks,with the majority displaying tissue-specific activity.Notably,a TE subfamily(LTR4C_SS),containing binding motifs for SIX1 and SIX4,showed specific enrichment in the H3K27ac peaks of the adult and fetal ovaries.RNA-seq analysis also revealed widespread expression of TEs in the exons or promoters of genes,including 4688 TE-containing transcripts with distinct development stage-specific and tissue-specific expression.Of note,1967 TE-containing transcripts were enriched in the testes.We identified a long terminal repeat(LTR),MLT1F1,acting as a testis-specific alternative promoter in SRPK2(a cell cycle-related protein kinase)in our pig dataset.This element was also conserved in humans and mice,suggesting either an ancient integration of TEs in genes specifically expressed in the testes or parallel evolutionary patterns.Collectively,our findings demonstrate that TEs are deeply embedded in the genome and exhibit important tissue-specific biological functions,particularly in the reproductive organs. 展开更多
关键词 Transposable elements PORCINE Histone modification Alternative promoter TE-containing transcript
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Research on Developing an Assessment Scale for Tourism Experience Elements of Ancient Shu Road Heritage Trail 被引量:1
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作者 Wang Yuan Wang Bo Zhou Jiang 《Contemporary Social Sciences》 2024年第5期118-142,共25页
Cultural ancient roads,known in Chinese as gudao,serve as heritage trails that carry historical exchanges across various regions in China.Due to their extensive preservation,wide geographical distribution,diverse them... Cultural ancient roads,known in Chinese as gudao,serve as heritage trails that carry historical exchanges across various regions in China.Due to their extensive preservation,wide geographical distribution,diverse thematic variations,and considerable tourist appeal,these paths have emerged as representative heritage trails,increasingly transforming into a novel tourism product experience that is highly favored by tourists and recognized by government authorities.However,research on ancient roads for tourism in China currently lacks a systematic theoretical framework,as well as relevant policies,regulations,and standards to guide their practical development.Therefore,there is a pressing need to draw upon international best practices and conduct foundational research to develop an experience element system that aligns with the perceptions,behaviors,and consumption characteristics of Chinese tourists,thereby advancing theoretical exploration in this field.This study focuses on the representative Ancient Shu Road as a case study and employs a mixed-method approach that integrates qualitative and quantitative research.It aims to construct a tourist-centric scale for the experience elements of ancient road tourism while analyzing the interactive relationship between these experience elements and tourist needs.This study addresses a significant gap in the development of indicator systems for domestic studies of ancient road tourism experiences.Ultimately,the study establishes a comprehensive scale that encompasses three core categories—trail resources and environment,facilities and services,and modes of tourism activities—along with eight primary dimensions:core resources,surrounding cultural environment,surrounding natural environment,tourism reception facilities and services,infrastructure and support services,information facilities and information services,and outdoor and recreational activities.This scale consists of thirty-two specific items,providing a robust reference for future research endeavors.Additionally,the study proposes specific development strategies related to key mechanisms,spatial configuration,and facility construction to enhance the overall development of ancient road tourism. 展开更多
关键词 ancient roads heritage trails tourism experience elements scale development
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Repressor elements provide insights into tissue development and phenotypes in pigs
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作者 Yue-Dong Zhang Chao Guo +9 位作者 Hang Liu Yun Gao Yongjun Tan Longjian Niu Ligang Wang Lixian Wang David MIrwin Chunhui Hou Zhong-Yin Zhou Ya-Ping Zhang 《Zoological Research》 SCIE CSCD 2024年第6期1313-1326,共14页
Repressor elements significantly influence economically relevant phenotypes in pigs;however,their precise roles and characteristics are inadequately understood.In the present study,we employed H3K27me3 profiling,assay... Repressor elements significantly influence economically relevant phenotypes in pigs;however,their precise roles and characteristics are inadequately understood.In the present study,we employed H3K27me3 profiling,assay for transposase-accessible chromatin with highthroughput sequencing(ATAC-seq),and RNA sequencing(RNA-seq)data across six tissues derived from three embryonic layers to identify and map 2034 super repressor elements(SREs) and 22223 typical repressor elements(TREs) in the pig genome.Notably,many repressor elements were conserved across mesodermal and ectodermal tissues.SREs exhibited tight regulation of their target genes,affecting a limited number of genes within a specific genomic region with pronounced effects,while TREs exerted broader but weaker regulation over a wider range of target genes.Furthermore,in neuronal tissues,genes regulated by repressor elements started to be repressed during the differentiation of stem cells into progenitor cells.Notably,analysis showed that many repressor elements exhibited cooperative and additive effects on the modulation of KLF4 expression.This research provides the first comprehensive map of pig repressor elements,serving as an essential reference for future studies on repressor elements. 展开更多
关键词 Repressor elements Super repressor elements SILENCER Regulatory model Tissue development KLF4 Pig
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Mobility of Major and Trace Elements during the Bauxitization Processes in Ngaoundal Area (Adamawa Cameroon): Implication on Mining Perspectives
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作者 André Sini Harouna Boukari +4 位作者 Ondoa Augustin Désiré Balla Djetenbe Beral Salomon Wangmené Awé Simon Djakba Basga Jean Pierre Nguetnkam 《Open Journal of Geology》 CAS 2024年第1期81-100,共20页
This study was focused to assess major and trace elements in bauxitic duricrusts from Ngaoundal and its surroundings in order to establish their mining interest. To this end, fieldworks, mineralogical and geochemical ... This study was focused to assess major and trace elements in bauxitic duricrusts from Ngaoundal and its surroundings in order to establish their mining interest. To this end, fieldworks, mineralogical and geochemical analyses were carried out. Four facies of duricrust were identified and characterized from the summit to the top of the slope of the Ngaoundal mountain: scoriaceous, pisolitic, nodular and massive. Mineralogical and geochemical analyses performed on 16 samples, revealed a significant concentration of Al<sub>2</sub>O<sub>3</sub> mainly in the scoriaceous facies (over 45% in grade), moderate in Fe<sub>2</sub>O<sub>3</sub> (averaging 23.69%) and SiO<sub>2</sub> (averaging 21.7%). Trace elements were generally low, excluding Cr (421 ppm on average), Zr (327 ppm on average and V (213 ppm on average). In addition, the limited quantities of alkalis (Na<sub>2</sub>O, K<sub>2</sub>O) and alkaline earths metals (MgO, CaO) coupled with the very high values of Chemical Index of Alteration (CIA) and Mineralogical Index of Alteration (MIA), (more than 99%) attest to the intense weathering of the studied materials. Allitization and monosiallitization constituted the crystallochemical phenomena that have led to the development of bauxitic minerals. More than 90% of gibbsite in scoriaceous facies, 52.21% - 76.01% of kaolinite in pisolitic facies and more than 40% of hematite in nodular facies were quantified. The relationships between the constitutive components indicated their interdependency during the bauxitization phenomenon. The mineralogical and geochemical properties highlighted the mining interest of the studied duricrusts to be valorized. 展开更多
关键词 Duricrust Bauxitization Phenomenon Mineralogical and Geochemical Characterization Major and Trace elements Mining Potential
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Effective Elimination of Hazardous Chromium (VI) Using Periodic Elements and Contemporary Adsorption Methods by Using Magnesium Ferrite Nanoparticle: A Review
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作者 Nazmun Nahar Mahabub Hossain Swaron +1 位作者 Md. Aliuzzaman Sheik Md. Jamal Uddin 《Journal of Environmental Protection》 2024年第5期596-619,共24页
A well-known hazardous metal and top contaminant in wastewater is hexavalent chromium. The two forms of most commonly found chromium are chromate ( CrO 4 2− ) and dichromate ( Cr 2 O 7 2− ). Leather tanning, cooling t... A well-known hazardous metal and top contaminant in wastewater is hexavalent chromium. The two forms of most commonly found chromium are chromate ( CrO 4 2− ) and dichromate ( Cr 2 O 7 2− ). Leather tanning, cooling tower blow-down, plating, electroplating, rinse water sources, anodizing baths etc. are the main sources of Cr (VI) contamination. The Cr (VI) is not only non-biodegradable in the environment but also carcinogenic to living population. It is still difficult to treat Cr contaminated waste water effectively, safely, eco-friendly, and economically. As a result, many techniques have been used to treat Cr (VI)-polluted wastewater, including adsorption, chemical precipitation, coagulation, ion-exchange, and filtration. Among these practices, the most practical method is adsorption for the removal of Cr (VI) from aqueous solutions, which has gained widespread acceptance due to the ease of use and affordability of the equipment and adsorbent. It has been revealed that Fe-based adsorbents’ oxides and hydroxides have high adsorptive potential to lower Cr (VI) content below the advised threshold. Fe-based adsorbents were also discovered to be relatively cheap and toxic-free in Cr (VI) treatment. Fe-based adsorbents are commonly utilized in industry. It has been discovered that nanoparticles of Fe-, Ti-, and Cu-based adsorbents have a better capacity to remove Cr (VI). Cr (VI) was effectively removed from contaminated water using mixed element-based adsorbents (Fe-Mn, Fe-Ti, Fe-Cu, Fe-Zr, Fe-Cu-Y, Fe-Mg, etc.). Initial findings suggest that Cr (VI) removal from wastewater may be accomplished by using magnesium ferrite nanomaterials as an efficient adsorbent. 展开更多
关键词 Chromium (VI) periodic elements Adsorption ELIMINATION Magnesium Ferrite
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Weathering and accumulation of trace elements in the soils of the Porali Plain, Balochistan: repercussions in agriculture
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作者 Maria Kaleem Erum Bashir +2 位作者 Shahid Naseem Tahir Rafique Bushra Shahab 《Acta Geochimica》 EI CAS CSCD 2024年第2期214-234,共21页
This study is thefirst attempt to assess the nature of the soil,especially on the western side of the Porali Plain in Balochistan;a new emerging agriculture hub,using weathering and pollution indices supplemented by mu... This study is thefirst attempt to assess the nature of the soil,especially on the western side of the Porali Plain in Balochistan;a new emerging agriculture hub,using weathering and pollution indices supplemented by multi-variate analysis based on geochemical data.The outcomes of this study are expected to help farmers in soil manage-ment and selecting suitable crops for the region.Twenty-five soil samples were collected,mainly from the arable land of the Porali Plain.After drying and coning-quarter-ing,soil samples were analyzed for major and trace ele-ments using the XRF technique;sieving and hydrometric methods were employed for granulometric analysis.Esti-mated data were analyzed using Excel,SPSS,and Surfer software to calculate various indices,correlation matrix,and spatial distribution.The granulometric analysis showed that 76%of the samples belonged to loam types of soil,12%to sand type,and 8%to silt type.Weathering indices:CIA,CIW,PIA,PWI,WIP,CIX,and ICV were calculated to infer the level of alteration.These indices reflect mod-erate to intense weathering;supported by K_(2)O/AI_(2)O_(3),Rb/K_(2)O,Rb/Ti,and Rb/Sr ratios.Assessment of the geo-ac-cumulation and Nemerow Pollution indices pinpoint rela-tively high concentrations of Pb,Ni,and Cr concentration in the soils.The correlation matrix and Principal Compo-nent Analysis show that the soil in this study area is mainly derived from the weathering of igneous rocks of Bela Ophiolite(Cretaceous age)and Jurassic sedimentary rocks of Mor Range having SEDEX/MVT type mineralization.Weathering may result in the undesirable accumulation of certain trace elements which adversely affects crops. 展开更多
关键词 Weathering indices Pollution indices ACCUMULATION Repercussions Trace elements Multivariate analyses Porali Plain BALOCHISTAN
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Ore-forming mechanism of Huxu Au-dominated polymetallic deposit in the Dongxiang Basin,South China:Constraints from in-situ trace elements and S-Pb isotopes of pyrite
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作者 Hongze Gao Jiajie Chen +3 位作者 Chengbiao Leng Yuhui Hu Huidan Xie Zenghua Li 《Acta Geochimica》 EI CAS CSCD 2024年第6期1223-1240,共18页
The Huxu Au-dominated polymetallic deposit is a hydrothermal deposit located in the Dongxiang volcanic basin in the middle section of the Gan-Hang tectonic belt in South China.The orebodies primarily occur within the ... The Huxu Au-dominated polymetallic deposit is a hydrothermal deposit located in the Dongxiang volcanic basin in the middle section of the Gan-Hang tectonic belt in South China.The orebodies primarily occur within the Jurassic-Cretaceous quartz diorite porphyry,while the genesis of this deposit is unclear.This study focused on geological and mineralogical characteristics,in-situ trace elements and S-Pb isotopes of three generations of pyrite of the Huxu deposit to clarify the distribution of trace elements in pyrite,ore-forming fluid and material sources,and genetic types of the deposit.The mineralization stage of the deposit can be divided into quartz-pyrite stage(S1),quartz-pyrite-hematite stage(S2),quartz-polymetallic sulfide stage(S3)and quartz-hematite stage(S4),with the corresponding pyrite being divided into three generations(Py1-Py3).in-situ trace element data of pyrite show that Au in pyrite mainly exists in the form of solid solution(Au^(+)),and the content is relatively low at all stages(0.18 ppm for Py1,0.32 ppm for Py2,0.68 ppm for Py3),while Pb and Zn mainly exist as sulfide inclusions in the pyrite.S-Pb isotopes show that the sulfur and ore-forming material of this deposit are mainly sourced from magma.The mineral association,mineral textures and trace elements in different stages of pyrite indicate that fluid boiling and fluid mixing are the key factors of native gold precipitation in S2 and S4,respectively,while water-rock interaction controlled the precipitation of Pb-Zn sulfides.These integrating with geological characteristics suggests that the deposit should be an intermediate sulfidation epithermal deposit. 展开更多
关键词 Au-dominated Polymetallic deposit Intermediate sulfidation Epithermal deposit PYRITE Trace element S-Pb isotope Tectonic belt
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Evaluation of Trace Elements in the Soil of Typical Peach Orchards in Zunyi City
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作者 Wenzhao LI Xiong YAN +5 位作者 Jun CHENG Xingyong WANG Changling SUI Xiangchun ZHANG Zhuang ZHAO Peng ZHOU 《Agricultural Biotechnology》 2024年第1期17-19,共3页
[Objectives]This study was conducted to clarify the enrichment and paucity of trace elements in the soil environment of peach orchards in Zunyi City,and to provide reference for supplementary application of microeleme... [Objectives]This study was conducted to clarify the enrichment and paucity of trace elements in the soil environment of peach orchards in Zunyi City,and to provide reference for supplementary application of microelement fertilizers and high-quality peach production in peach orchards.[Methods]Taking the soil of three typical peach orchards(Taoli Renjia peach orchard,Pengrui peach orchard and Taohuadao peach orchard)in Shenxi Town,Honghuagang District,Zunyi City as the research object,the contents of trace elements in soil were analyzed through field sampling and indoor determination of trace elements.[Results]The effective contents of trace elements in the soil of peach orchard bases in the study area were at a medium level,and the soil of the peach orchards was rich in available Fe and Se.The contents of available Cu,Mo and Mn were relatively rich.The contents of available B were not high overall.The contents of available Zn were at a moderate to low level overall.The soil of Taoli Renjia peach orchard was relatively rich in trace elements.[Conclusions]The research results can provide a scientific basis for the production of high-quality crispy peaches in peach orchards. 展开更多
关键词 Zunyi Soil in peach orchard Trace elements EVALUATION
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Preliminary Study of Chemical Elements Distribution in Petroleum Source Rocks Donga and Yogou Formations of the Termit Sedimentary Basin (Est-Niger)
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作者 Alassane Ibrahim Maman Bachir Abdoulaye Dan Makaou Oumarou +2 位作者 Baraou Idi Souley Kouakou Alponse Yaou Abdoulwahid Sani 《Journal of Minerals and Materials Characterization and Engineering》 2024年第1期49-62,共14页
XRF and EDX analyses were carried out on 18 batches of representative raw samples to determine the distribution of major chemical elements in the petroleum source rocks of Donga and Yogou formations of Termit sediment... XRF and EDX analyses were carried out on 18 batches of representative raw samples to determine the distribution of major chemical elements in the petroleum source rocks of Donga and Yogou formations of Termit sedimentary basin. The chemical composition of these formations is dominated by silicon (Si), aluminum (Al) and iron (Fe). This is consistent with the oxide composition, which is also dominated by silicon oxide (SiO2), aluminum oxide (Al<sub>2</sub>O<sub>3</sub>) and iron monoxide (FeO). No less important chemical elements are calcium (Ca), potassium (K), sulfur (S), titanium (Ti), magnesium (Mg), manganese (Mn) and barium (Ba), as well as some of their oxides. All these major chemical elements are carried by silicate detrital minerals associated with pyrite and goethite and/or clay minerals such as kaolinite and interstratified illite, smectite and chlorite. This trend is illustrated by the values of the Si/Al and SiO<sub>2</sub>/Al<sub>2</sub>O<sub>3</sub> ratios. 展开更多
关键词 DISTRIBUTION Major elements Source Rocks Donga Formation Yogou Formation Termit Basin
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磁记忆PE全包覆抽油杆SVM应力预测研究
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作者 周先军 彭煜轩 +3 位作者 刘瑾 刘延峰 杨勇 王瑞琦 《兵器材料科学与工程》 北大核心 2025年第1期108-113,共6页
为探测PE全包覆防腐层抽油杆的应力区域,解决抽油杆状态评估中的技术难点。采集预制点腐蚀、面腐蚀和沟槽腐蚀的PE全包覆防腐层抽油杆的磁记忆信号,并用支持向量机(SVM)研究信号特征值与缺陷应力值,以及应力状态之间的关系,建立应力状... 为探测PE全包覆防腐层抽油杆的应力区域,解决抽油杆状态评估中的技术难点。采集预制点腐蚀、面腐蚀和沟槽腐蚀的PE全包覆防腐层抽油杆的磁记忆信号,并用支持向量机(SVM)研究信号特征值与缺陷应力值,以及应力状态之间的关系,建立应力状态预测模型,引入粒子群优化算法优化SVM模型参数。通过优化,用该模型预测抽油杆应力状态的平均误差仅为3.638%。结果表明:基于粒子群优化算法和7种磁记忆信号特征量建立的支持向量机模型准确率较高,适用于PE全包覆防腐层抽油杆的应力状态预测。 展开更多
关键词 pe全包覆防腐层抽油杆 支持向量机 金属磁记忆 信号特征量 粒子群优化
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Teaching Research and Effect Observation on the Integration of Clinical Medicine Integrated Course and Ideological and Political Elements from the Perspective of“Sanquan Education”
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作者 Wensi Liu Chunyan Zhao +4 位作者 Xiangying Kong Zhiwu Ji Cuicui Yu Fuxiang Song Jincai Shang 《Journal of Contemporary Educational Research》 2024年第4期270-275,共6页
Purpose:To analyze the application path of the integration of clinical medicine integrated courses with the elements of ideology and politics under the theory of“Sanquan Education,”and to provide references for the ... Purpose:To analyze the application path of the integration of clinical medicine integrated courses with the elements of ideology and politics under the theory of“Sanquan Education,”and to provide references for the promotion of educational reform in medical schools.Methods:60 clinical medicine undergraduates at Jiamusi University in 2018 and 2019 were randomly selected as research subjects.On the basis of the analysis of students’characteristics and pre-study content,the students were divided into the integration group and the traditional group,each with 30 students.Students in the integration group carried out clinical medicine integrated class with the integration of ideological and political elements.Students in the traditional group carried out the traditional clinical medicine integrated class.Classroom evaluation scales,anonymous questionnaires,and interviews were used to conduct research,collect data,and compare and observe the application effects.Results:After carrying out different modes of clinical medicine integrated courses,the undergraduates of the Excellent Physician Class in the integration group were higher than those in the traditional group in terms of teaching satisfaction,comprehensive quality,basic knowledge test,and case analysis scores through questionnaire analysis(P<0.05).In the evaluation of the effect of ideological education,the undergraduates of the Excellent Physician Class of the integration group were higher than the traditional group in terms of the acceptance of doctor-patient communication,the correct rate of mastering the history of the discipline,and the correct rate of mastering the frontiers and policies(P<0.05).Conclusion:Through the integration of clinical medicine integrated course and ideological and political elements,we can help students establish correct values while teaching them professional knowledge,improve the implementation of moral education in medical schools,cultivate excellent medical workers with high morality and firm beliefs for the society,and realize the fundamental educational task of establishing morality and educating people in medical schools in the context of“Sanquan Education.” 展开更多
关键词 Sanquan Education Clinical medicine integrated course Ideological and political elements TEACHING
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Sc-doped strontium iron molybdenum cathode for high-efficiency CO_(2)electrolysis in solid oxide electrolysis cell
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作者 LIU Zhen ZHANG Lihong +4 位作者 XU Chunming WANG Zhenhua QIAO Jinshuo SUN Wang SUN Kening 《燃料化学学报(中英文)》 北大核心 2025年第2期272-281,共10页
Solid oxide electrolysis cells(SOECs)can effectively convert CO_(2)into high value-added CO fuel.In this paper,Sc-doped Sr_(2)Fe_(1.5)Mo_(0.3)Sc_(0.2)O_(6−δ)(SFMSc)perovskite oxide material is synthesized via solid-p... Solid oxide electrolysis cells(SOECs)can effectively convert CO_(2)into high value-added CO fuel.In this paper,Sc-doped Sr_(2)Fe_(1.5)Mo_(0.3)Sc_(0.2)O_(6−δ)(SFMSc)perovskite oxide material is synthesized via solid-phase method as the cathode for CO_(2)electrolysis by SOECs.XRD confirms that SFMSc exhibits a stable cubic phase crystal structure.The experimental results of TPD,TG,EPR,CO_(2)-TPD further demonstrate that Sc-doping increases the concentration of oxygen vacancy in the material and the chemical adsorption capacity of CO_(2)molecules.Electrochemical tests reveal that SFMSc single cell achieves a current density of 2.26 A/cm^(2) and a lower polarization impedance of 0.32Ω·cm^(2) at 800°C under the applied voltage of 1.8 V.And no significant performance attenuation or carbon deposition is observed after 80 h continuous long-term stability test.This study provides a favorable support for the development of SOEC cathode materials with good electro-catalytic performance and stability. 展开更多
关键词 solid oxide electrolysis cells CATHODE peROVSKITE ELECTRO-CATALYSIS element doping
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焊接参数和环境温度对聚乙烯(PE)燃气管电熔焊温度场的影响
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作者 刘剑 郑建豹 +4 位作者 张海 张文洲 易际研 缪海波 蔡智会 《电焊机》 2025年第1期87-94,共8页
电熔焊是连接聚乙烯(PE)燃气管的常用方法。采用SYSWELD软件建立PE100圆管电熔焊的1/4轴对称有限元模型,考虑了电热丝产生的电阻热作为体积热源,并通过空气对流和散热面散热的方式模拟焊接过程中的热交换。通过DSC+TG联用测试PE100材料... 电熔焊是连接聚乙烯(PE)燃气管的常用方法。采用SYSWELD软件建立PE100圆管电熔焊的1/4轴对称有限元模型,考虑了电热丝产生的电阻热作为体积热源,并通过空气对流和散热面散热的方式模拟焊接过程中的热交换。通过DSC+TG联用测试PE100材料的熔化温度和分解温度,获得特征温度数据。试验测得PE100材料的熔化起始温度和峰值温度分别为118℃和138℃,分解起始温度为272℃,5%质量损失标定的分解温度为350℃。熔化区宽度的预测值与测量值吻合较好,误差在5%以内,验证了所采用的计算方法的有效性和准确性。模拟结果表明,焊接电压对熔化区宽度有显著影响,较大的焊接电压产生足够的热输入,进而扩大了熔化区宽度。但过高的热输入会导致塑料的过热分解,形成孔洞,降低有效连接面积,可能会影响到接头的力学性能。环境温度通过改变焊接结构的初始温度和对流散热强度,显著影响熔化区的形成过程和最终宽度。实际生产时,有必要依据具体的环境因素对电熔套筒的预设参数进行优化和调整,以保证电熔焊的质量。 展开更多
关键词 pe100 电熔焊 数值仿真 温度场 焊接参数
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Identifying the Impact of Preconstruction Elements on Project Time Variances
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作者 Sogol Salary Matthew Reyes 《Journal of Civil Engineering and Architecture》 2025年第1期9-21,共13页
Working toward an efficient duration and timeline for the preconstruction phase should be one of the main objectives for project owners.Failing to plan for and coordinate preconstruction decisions in order to control ... Working toward an efficient duration and timeline for the preconstruction phase should be one of the main objectives for project owners.Failing to plan for and coordinate preconstruction decisions in order to control preconstruction duration and manage time variances can lead to financial insecurities,incomplete contract documents,permitting issues,and unrealistic schedules and resource allocation during this phase.To minimize time variances and ensure a productive decision-making process,project owners should be familiar with critical elements in a project that cause variances in the preconstruction phase timeline.In this study,the impacts of eleven critical preconstruction elements on time variances were analyzed.These eleven preconstruction elements are considered critical in how they impact time variances during the preconstruction phase.They were determined to be critical based either on significantly impacting time variance during the preconstruction phase or believed to be critical from findings from previous studies,however,the findings from this study showed no significant impact on the time variances.In most previous studies focusing on the elements impacting project schedules,data were collected by surveying construction professionals.In this study,objective and quantitative data related to project preconstruction elements were used as opposed to self-reported data.Using the results of this study,project owners and stakeholders will be able to evaluate the critical preconstruction elements impacting the timing of their projects and prioritize decisions related to the critical elements early on during the preconstruction phase. 展开更多
关键词 Preconstruction time variances critical preconstruction elements objective data.
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Biomechanical Study of Different Scaffold Designs for Reconstructing a Traumatic Distal Femur Defect Using Patient-Specific Computational Modeling
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作者 Hsien-Tsung Lu Ching-Chi Hsu +1 位作者 Qi-Quan Jian Wei-Ting Chen 《Computer Modeling in Engineering & Sciences》 2025年第2期1883-1898,共16页
Reconstruction of a traumatic distal femur defect remains a therapeutic challenge.Bone defect implants have been proposed to substitute the bone defect,and their biomechanical performances can be analyzed via a numeri... Reconstruction of a traumatic distal femur defect remains a therapeutic challenge.Bone defect implants have been proposed to substitute the bone defect,and their biomechanical performances can be analyzed via a numerical approach.However,the material assumptions for past computational human femur simulations were mainly homogeneous.Thus,this study aimed to design and analyze scaffolds for reconstructing the distal femur defect using a patient-specific finite element modeling technique.A three-dimensional finite element model of the human femur with accurate geometry and material distribution was developed using the finite element method and material mapping technique.An intact femur and a distal femur defect model treated with nine microstructure scaffolds and two solid scaffolds were investigated and compared under a single-leg stance loading.The results showed that the metal solid scaffold design could provide the most stable fixation for reconstructing the distal femur defect.However,the fixation stability was affected by various microstructure designs and pillar diameters.A microstructure scaffold can be designed to satisfy all the biomechanical indexes,opening up future possibilities for more stable reconstructions.A three-dimensional finite element model of the femur with real bone geometry and bone material distribution can be developed,and this patient-specific femur model can be used for studying other femoral fractures or injuries,paving the way for more comprehensive research in the field.Besides,this patient-specific finite element modeling technique can also be applied to developing other human or animal bone models,expanding the scope of biomechanical research. 展开更多
关键词 Patient-specific modeling distal femur bone defect microstructure design finite element analysis
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Effects of spatial heterogeneity on pseudo-static stability of coal mine overburden dump slope,using random limit equilibrium and random finite element methods:A comparative study
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作者 Madhumita Mohanty Rajib Sarkar Sarat Kumar Das 《Earthquake Engineering and Engineering Vibration》 2025年第1期83-99,共17页
Sudden and unforeseen seismic failures of coal mine overburden(OB)dump slopes interrupt mining operations,cause loss of lives and delay the production of coal.Consideration of the spatial heterogeneity of OB dump mate... Sudden and unforeseen seismic failures of coal mine overburden(OB)dump slopes interrupt mining operations,cause loss of lives and delay the production of coal.Consideration of the spatial heterogeneity of OB dump materials is imperative for an adequate evaluation of the seismic stability of OB dump slopes.In this study,pseudo-static seismic stability analyses are carried out for an OB dump slope by considering the material parameters obtained from an insitu field investigation.Spatial heterogeneity is simulated through use of the random finite element method(RFEM)and the random limit equilibrium method(RLEM)and a comparative study is presented.Combinations of horizontal and vertical spatial correlation lengths were considered for simulating isotropic and anisotropic random fields within the OB dump slope.Seismic performances of the slope have been reported through the probability of failure and reliability index.It was observed that the RLEM approach overestimates failure probability(P_(f))by considering seismic stability with spatial heterogeneity.The P_(f)was observed to increase with an increase in the coefficient of variation of friction angle of the dump materials.Further,it was inferred that the RLEM approach may not be adequately applicable for assessing the seismic stability of an OB dump slope for a horizontal seismic coefficient that is more than or equal to 0.1. 展开更多
关键词 coal mine overburden dump slope random limit equilibrium method random finite element method seismic slope stability spatial heterogeneity
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冲击载荷下PEMFC力-电耦合建模及电学响应研究
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作者 任立海 陈黎黎 +4 位作者 杨振华 蒋成约 赵清江 刘西 胡远志 《汽车工程》 北大核心 2025年第1期96-106,共11页
为探究冲击载荷作用下质子交换膜燃料电池(PEMFC)电堆电学响应,揭示PEMFC电堆内部力-电耦合机制,对冲击载荷下PEMFC电堆力-电耦合建模方法进行了研究。基于建立的PEMFC电堆力-电耦合模型,系统研究了冲击速度和方向对PEMFC电堆电学响应... 为探究冲击载荷作用下质子交换膜燃料电池(PEMFC)电堆电学响应,揭示PEMFC电堆内部力-电耦合机制,对冲击载荷下PEMFC电堆力-电耦合建模方法进行了研究。基于建立的PEMFC电堆力-电耦合模型,系统研究了冲击速度和方向对PEMFC电堆电学响应影响。结果表明,所提出的PEMFC电堆力-电耦合建模方法可以准确模拟出电池内部的力-电耦合特性;PEMFC电堆内部单电池欧姆损耗会随着冲击载荷的增大而增大;同时,冲击载荷会导致气体扩散层(GDL)与双极板肋部产生额外电接触,引起GDL表面电流密度平均值下降以及分布均匀性变差。本研究工作对冲击载荷下PEMFC力-电耦合建模及电学响应研究具有一定的指导意义。 展开更多
关键词 质子交换膜燃料电池 有限元方法 冲击 力-电耦合 电学响应
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Dynamics of Essential Metal Elements Contents in Winter Oilseed Rape during Cold Acclimation 被引量:4
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作者 张树杰 王琼 +1 位作者 李光明 张春雷 《Agricultural Science & Technology》 CAS 2011年第8期1156-1160,1165,共6页
[Objective]The paper was to investigate the dynamics of essential metal elements(Ca,Mg,Fe,Mn,Zn and Cu)contents in winter oilseed rape(Brassica napus L.)during cold acclimation,and to reveal the effects and mechan... [Objective]The paper was to investigate the dynamics of essential metal elements(Ca,Mg,Fe,Mn,Zn and Cu)contents in winter oilseed rape(Brassica napus L.)during cold acclimation,and to reveal the effects and mechanisms of essential elements in cold resistance of oilseed rape.[Method]Three varieties with different cold resistance including Zhongshuang No.11(ZS,freezing sensitive variety),Ganyouza No.1(GY)and Jinyuyou No.1(JYY,freezing tolerant varieties)were used in the study,and the changes of necessary metal elements in these oilseed rapes during cold acclimation were studied.[Result]The concentration of metal elements in oilseed rape had significant changes during cold acclimation,and the difference between varieties was significant.In plant roots,the concentrations of Ca,Mg,Fe,Mn,Zn and Cu were significantly increased,this might because that low temperature made the transpiration decreased,thus blocking the upward transport of elements.In plant shoots,the concentrations of Ca,Mg and Zn were significantly decreased,while the concentrations of Fe and Mn were significantly increased;the change extent of various elements in ZS variety was the largest.[Conclusion]Maintaining the stability of Ca,Mg and Zn concentrations and increasing Fe,Mn and Cu concentrations in plant shoots might be benefit for increasing the cold tolerance of winter oilseed rape. 展开更多
关键词 Cold acclimation Cold resistance Essential elements Winter oilseed rape
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Influence of canopy on precipitation and its nutrient elements in broadleaved/Korean pine forest on the northern slope of Changbai Mountain 被引量:3
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作者 肖以华 代力民 +3 位作者 牛德奎 佟富春 陈高 邓红兵 《Journal of Forestry Research》 SCIE CAS CSCD 2002年第3期201-204,251,共4页
The precipitation distribution quantity of canopy in broadleaved/Korean pine forest was measured during the growing season (Jun.–Sept.) in 2001 in the Changbai Mountain, Jilin Province, P. R. China. Results indicated... The precipitation distribution quantity of canopy in broadleaved/Korean pine forest was measured during the growing season (Jun.–Sept.) in 2001 in the Changbai Mountain, Jilin Province, P. R. China. Results indicated that the amounts of stemflow, throughfall, and interception were 37.39, 322.12 and 109.69 mm, accounting for 7.97%, 68.65% and 23.38% of the total rainfall, respectively. The rate of stemflow was higher in Jul. and Aug. than other months. The rate of throughfall dropped off from Jun. to Sept., however, rate of interception changed contrarily from 19.43% to 31.02% during the growing season. According to our analysis, the concentration of nutrient elements were arranged as Ca>Mg>N>K>Fe>P>Cu>Mn for rainfall, K>N>Mg>Ca>P>Fe>Mn>Cu for throughfall, and Mn>P>K>Cu>Fe>N>Mg>Ca for being leached through canopy. Nutrients concentration in stewflow and throughfall changed significantly when rainfall passed canopy, and concentration of all elements increased except for Ca and Mg. 展开更多
关键词 Broadleaved/Korean pine forest Precipitation distribution Concentration Nutrient elements CANOPY STEMFLOW THROUGHFALL INTERCEPTION
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