The effect of Epimedium extract (EE) on erythrocytes was investigated by atomic force microscopy (AFM). The images of the surface structures showed clear concave and progressive increase of surface roughness of er...The effect of Epimedium extract (EE) on erythrocytes was investigated by atomic force microscopy (AFM). The images of the surface structures showed clear concave and progressive increase of surface roughness of erythrocyte after incubation with EE at concentration of 0.2 or 0.05 g/L, far below its critical hemolytic levels. The AFM results also indicated that the granules of the fine surface structure increased, which caused by aggregation of membrane protein. Further study showed that the change in surface topography of erythrocyte membrane might be connected with the increase of intracellular free Ca^2+ induced by EE.展开更多
Event Extraction(EE)is a key task in information extraction,which requires high-quality annotated data that are often costly to obtain.Traditional classification-based methods suffer from low-resource scenarios due to...Event Extraction(EE)is a key task in information extraction,which requires high-quality annotated data that are often costly to obtain.Traditional classification-based methods suffer from low-resource scenarios due to the lack of label semantics and fine-grained annotations.While recent approaches have endeavored to address EE through a more data-efficient generative process,they often overlook event keywords,which are vital for EE.To tackle these challenges,we introduce KeyEE,a multi-prompt learning strategy that improves low-resource event extraction by Event Keywords Extraction(EKE).We suggest employing an auxiliary EKE sub-prompt and concurrently training both EE and EKE with a shared pre-trained language model.With the auxiliary sub-prompt,KeyEE learns event keywords knowledge implicitly,thereby reducing the dependence on annotated data.Furthermore,we investigate and analyze various EKE sub-prompt strategies to encourage further research in this area.Our experiments on benchmark datasets ACE2005 and ERE show that KeyEE achieves significant improvement in low-resource settings and sets new state-of-the-art results.展开更多
针对现有流水线式事件抽取方法依靠大量训练数据、在低资源情况下难以快速迁移运用等问题,利用提示调优技术,提出适用于低资源场景下的流水线式事件抽取方法(low-resource event extraction method using the multi-information fusion ...针对现有流水线式事件抽取方法依靠大量训练数据、在低资源情况下难以快速迁移运用等问题,利用提示调优技术,提出适用于低资源场景下的流水线式事件抽取方法(low-resource event extraction method using the multi-information fusion with prompt tuning,IFPT)。该方法通过构造语义映射和提示模板充分利用事件类型描述、实体类型等多种信息,能够高效使用有限训练数据,流水线式地完成事件检测和论元抽取。实验结果表明,在低资源情况下,IFPT方法论元抽取性能超过了所有基准模型,采取流水线方式能够达到与SOTA模型相媲美的性能。展开更多
目的探讨全蝎醇提物(Ethanol Extracts of Scorpion,EES)对大鼠癫痫持续状态(SE)后海马神经元凋亡的影响。方法建立氯化锂-匹罗卡品癫痫持续状态(Lithium-Pilocarpine induced status epilepticus,Li-Pilo SE)模型。使用TUNEL技术观察...目的探讨全蝎醇提物(Ethanol Extracts of Scorpion,EES)对大鼠癫痫持续状态(SE)后海马神经元凋亡的影响。方法建立氯化锂-匹罗卡品癫痫持续状态(Lithium-Pilocarpine induced status epilepticus,Li-Pilo SE)模型。使用TUNEL技术观察正常对照组、Li-Pilo SE模型组、丙戊酸钠组(VPA)和EES低(L)、中(M)、高(H)剂量组大鼠SE后6h、24h、48h、72h和7d海马CA1区和CA3区TUNEL阳性细胞的动态变化,并进行组间比较。结果正常对照组未见TUNEL阳性细胞。造模各组大鼠SE后6h海马可见部分TUNEL阳性细胞,主要分布在CA1、CA3区,其中模型组和EES(L)组72h达高峰,而VPA、EES(M)和EES(H)组高峰提前到SE后48h,以后各组逐渐下降。VPA、EES(M)和EES(H)组SE后各观察时间点TUNEL阳性细胞数较模型组极显著减少(P<0.01),而EES(L)组除个别时间点外,与模型组比较无统计学差异(P>0.05),其中VPA和EES(H)组各时间点TUNEL阳性细胞数减少较EES(M)组(P<0.01,和P<0.05)及EES(L)组(P<0.01,和P<0.05)更显著,EES(M)组各时间点减少又较EES(L)组更显著(P<0.01),而VPA与EES(H)组TUNEL阳性细胞数在各时间点无统计学差异(P>0.05)。结论EES能防止Li-Pilo SE大鼠海马神经元凋亡,并呈明显的量-效关系,高剂量EES抗凋亡作用与VPA相近。展开更多
文摘The effect of Epimedium extract (EE) on erythrocytes was investigated by atomic force microscopy (AFM). The images of the surface structures showed clear concave and progressive increase of surface roughness of erythrocyte after incubation with EE at concentration of 0.2 or 0.05 g/L, far below its critical hemolytic levels. The AFM results also indicated that the granules of the fine surface structure increased, which caused by aggregation of membrane protein. Further study showed that the change in surface topography of erythrocyte membrane might be connected with the increase of intracellular free Ca^2+ induced by EE.
基金supported by the National Key Research and Development Program of China(No.2021YFF1201200)the Science and Technology Major Project of Changsha(No.kh2202004)the Natural Science Foundation of China(No.62006251)。
文摘Event Extraction(EE)is a key task in information extraction,which requires high-quality annotated data that are often costly to obtain.Traditional classification-based methods suffer from low-resource scenarios due to the lack of label semantics and fine-grained annotations.While recent approaches have endeavored to address EE through a more data-efficient generative process,they often overlook event keywords,which are vital for EE.To tackle these challenges,we introduce KeyEE,a multi-prompt learning strategy that improves low-resource event extraction by Event Keywords Extraction(EKE).We suggest employing an auxiliary EKE sub-prompt and concurrently training both EE and EKE with a shared pre-trained language model.With the auxiliary sub-prompt,KeyEE learns event keywords knowledge implicitly,thereby reducing the dependence on annotated data.Furthermore,we investigate and analyze various EKE sub-prompt strategies to encourage further research in this area.Our experiments on benchmark datasets ACE2005 and ERE show that KeyEE achieves significant improvement in low-resource settings and sets new state-of-the-art results.
文摘针对现有流水线式事件抽取方法依靠大量训练数据、在低资源情况下难以快速迁移运用等问题,利用提示调优技术,提出适用于低资源场景下的流水线式事件抽取方法(low-resource event extraction method using the multi-information fusion with prompt tuning,IFPT)。该方法通过构造语义映射和提示模板充分利用事件类型描述、实体类型等多种信息,能够高效使用有限训练数据,流水线式地完成事件检测和论元抽取。实验结果表明,在低资源情况下,IFPT方法论元抽取性能超过了所有基准模型,采取流水线方式能够达到与SOTA模型相媲美的性能。
文摘目的探讨全蝎醇提物(Ethanol Extracts of Scorpion,EES)对大鼠癫痫持续状态(SE)后海马神经元凋亡的影响。方法建立氯化锂-匹罗卡品癫痫持续状态(Lithium-Pilocarpine induced status epilepticus,Li-Pilo SE)模型。使用TUNEL技术观察正常对照组、Li-Pilo SE模型组、丙戊酸钠组(VPA)和EES低(L)、中(M)、高(H)剂量组大鼠SE后6h、24h、48h、72h和7d海马CA1区和CA3区TUNEL阳性细胞的动态变化,并进行组间比较。结果正常对照组未见TUNEL阳性细胞。造模各组大鼠SE后6h海马可见部分TUNEL阳性细胞,主要分布在CA1、CA3区,其中模型组和EES(L)组72h达高峰,而VPA、EES(M)和EES(H)组高峰提前到SE后48h,以后各组逐渐下降。VPA、EES(M)和EES(H)组SE后各观察时间点TUNEL阳性细胞数较模型组极显著减少(P<0.01),而EES(L)组除个别时间点外,与模型组比较无统计学差异(P>0.05),其中VPA和EES(H)组各时间点TUNEL阳性细胞数减少较EES(M)组(P<0.01,和P<0.05)及EES(L)组(P<0.01,和P<0.05)更显著,EES(M)组各时间点减少又较EES(L)组更显著(P<0.01),而VPA与EES(H)组TUNEL阳性细胞数在各时间点无统计学差异(P>0.05)。结论EES能防止Li-Pilo SE大鼠海马神经元凋亡,并呈明显的量-效关系,高剂量EES抗凋亡作用与VPA相近。