Objective:To describe the situation of measles in Sri Lanka from May to November,2023 and to define the role of virology laboratory towards case confirmation and epidemiological and genetic characterization of the out...Objective:To describe the situation of measles in Sri Lanka from May to November,2023 and to define the role of virology laboratory towards case confirmation and epidemiological and genetic characterization of the outbreak.Methods:This retrospective study analyzed all samples tested for measles from 1st of May to 30th of November,2023 at National Measles Rubella Laboratory,Sri Lanka.According to the World Health Organization(WHO)algorithm,serum and oropharyngeal/nasopharyngeal swabs were tested with WHO recommended kits for anti-measles IgM and measles virus specific RNA,respectively.Selected RNA positive samples were sequenced at reference laboratory,India.Analysis of sequencing data and construction of phylogenetic tree were carried out at National Measles Rubella Laboratory.Data was analyzed using descriptive statistics.Results:Of the total 1132 serum samples and 497 oropharyngeal/nasopharyngeal swabs from 1326 patients,657(49.5%)patients were confirmed as measles by anti-measles IgM,measles virus specific RNA or both.Males(55.6%,n=365)and the age group from>20 to≤30 years(33.0%,n=217)predominated positive patients.All provinces reported measles positive cases.All samples sequenced(100%,n=42)were genotype D8 with 95.2%(n=40)bearing Victoria.Australia origin.Conclusions:We described resurgence of measles in an eliminated country,confirming the genotype to be D8,one of the two genotypes currently circulating globally.Further,the study strongly convinced the importance of a strengthened virological surveillance system in an eliminated country,despite its eliminated status.展开更多
This is an erratum to our published paper entitled“Can physical activity eliminate the mortality risk associated with poor sleep?A 15-year follow-up of 341,248 MJ Cohort participants”.In the paper mentioned above,th...This is an erratum to our published paper entitled“Can physical activity eliminate the mortality risk associated with poor sleep?A 15-year follow-up of 341,248 MJ Cohort participants”.In the paper mentioned above,there are some errors that we want to clear in this erratum.On page 601,2 reference lines(i.e.,HR=1)in(A)and(B)of Fig.1 were not labeled.The details are as follows.展开更多
Objective:To investigate the therapeutic effect of osteopathic osteopathy on hormonal osteonecrosis in rabbits by regulating the Wnt/PI3K-AKT signaling pathway.Methods:Thirty clean-grade New Zealand rabbits were rando...Objective:To investigate the therapeutic effect of osteopathic osteopathy on hormonal osteonecrosis in rabbits by regulating the Wnt/PI3K-AKT signaling pathway.Methods:Thirty clean-grade New Zealand rabbits were randomly divided into control group,model group and experimental group,and all except for the control group,allogeneic serum combined with glucocorticoids were used to establish animal models of simulated hormonal osteonecrosis of the femoral head.After successful modeling,the experimental group was given the model group and the control group the same amount of normal saline,and the experimental group was given bone palsy granule concentrate according to the equivalent dose of humans and rabbits,once a day for 8 weeks,and after intraperitoneal anesthesia,blood was collected from the extracorporeal heart and the serum ALP and TGF-β1 levels were detected by immunoenzyme-linked adsorption.The experimental animals were sacrificed,,and the bilateral femoral heads of rabbits were removed for hematoxylin-eosin staining,and the apoptosis of cells in the femoral head area was observed by TUNEL staining.RT-qPCR analyzed the expression of Bax and Bcl-2 genes,and Western blot detected the expression levels of pathway proteins Wnt,β-catenin,GSK-3β,AKT and p-AKT.Results:Compared with the control group,the expression levels of ALP and TGF-β1 in rabbit bone tissue in the model group decreased significantly(P<0.05),the bone trabeculae were sparse and thinned,the number of hollow bone fosses and the number of apoptosis-positive cells increased significantly(P<0.05),the expression of pro-apoptotic gene Bax was increased,and the expression of anti-apoptotic gene Bcl-2 was inhibited(P<0.05).After the intervention and treatment of bone palsy granules,the hollow bone depression and apoptosis of rabbit bone tissue in the experimental group were effectively improved(P<0.05).In addition,compared with the model group,the osteopathic elimination particles could upregulate the expression of ALP and TGF-β1(P<0.05),promote the expression of pathway proteins Wnt andβ-catenin,increase the phosphorylation level of AKT,and downregulate the expression of GSK-3β(P<0.05).Conclusion:Under glucocorticoids,osteoblast development dysfunction and apoptosis increase.Bone palsy granules can regulate the two signaling pathways of Wnt/PI3K-AKT,promote osteoblast development and inhibit apoptosis,effectively maintain bone metabolic balance,prolong the collapse time of the femoral head,and further treat osteonecrosis of the femoral head.展开更多
The "expectations gap" signifies the differences between what the public expects from an audit and what the auditing profession prefers the audit objectives to be.Although the gap exists,it seems that the pr...The "expectations gap" signifies the differences between what the public expects from an audit and what the auditing profession prefers the audit objectives to be.Although the gap exists,it seems that the professions trust that it could be eliminated.In this paper,further evidence was provided to deny the above point by exploring the inevitability nature and the structure of the audit expectation gap.In addition,the author concludes that expectations gap cannot be eliminated;instead,the only thing can be done is to narrow down the gap.展开更多
Nowadays, distributing network-connected photovoltaic (PV) systems are expanded by merging a PV system and a Direct Current (DC)/Alternating Current (AC) energy converter. DC/AC conversion of PV energy is in great dem...Nowadays, distributing network-connected photovoltaic (PV) systems are expanded by merging a PV system and a Direct Current (DC)/Alternating Current (AC) energy converter. DC/AC conversion of PV energy is in great demand for AC applications. The supply of electrical machines and transfer energy to the distribution network is a typical case. In this work, we study and design a DC/AC energy converter using harmonic selective eliminated (HSE) method. To this end, we have combined two power stages connected in derivation. Each power stage is constituted of transistors and transformers. The connection by switching of the two rectangular waves, delivered by each of the stages, makes it possible to create a quasi-sinusoidal output voltage of the inverter. Mathematical equations based on the current-voltage characteristics of the inverter have been developed. The simulation model was validated using experimental data from a 25.2 kWp grid-coupled (PV) system, connected to Gridfit type inverters. The data were exported and implemented in programming software. A good agreement was observed and this shows all the robustness and the technical performances of the energy converter device. It emerges from this analysis that the inverter output voltage and the phase angle thus simulated are very important to control in order to orientate the transfer of the power flow from the continuous cell to cell to the alternating part. Simulated and field-testing results also show that increases in the value of the modulation factor (m) for low power output are highly significant. This study is an important tool for DC/AC inverter designers during initial planning stages. A short presentation of the design model of the inverter has been proposed in this article.展开更多
Dengue is a febrile disease caused by a member of the Flaviviridae family called dengue virus(DENV).DENV is primarily transmitted to humans by blood ingestion of Aedes(Ae.)aegypti[1,2].Space spraying is a vector contr...Dengue is a febrile disease caused by a member of the Flaviviridae family called dengue virus(DENV).DENV is primarily transmitted to humans by blood ingestion of Aedes(Ae.)aegypti[1,2].Space spraying is a vector control measure recommended by the World Health Organization(WHO)for eliminating vector mosquitos and preventing further infections in an epidemic setting[3].展开更多
According to the notice of the Office of Planned, Safe and Effective Use of Electricity (short as OPSEUE), all non-industrial consumers, such as hotels, shopping centers, are asked to use energy saving lamps instead o...According to the notice of the Office of Planned, Safe and Effective Use of Electricity (short as OPSEUE), all non-industrial consumers, such as hotels, shopping centers, are asked to use energy saving lamps instead of incandescent lamp and to eliminate inductive ballasts within the coming 3 years.展开更多
The novel coronavirus continues to rage around the world.Cooperation on vaccine research and development is key to a global response.On May 21,Chinese President Xi Jinping attended the Global Health Summit via video a...The novel coronavirus continues to rage around the world.Cooperation on vaccine research and development is key to a global response.On May 21,Chinese President Xi Jinping attended the Global Health Summit via video and delivered an important speech announcing new measures that China will take to promote global solidarity in the fight against the virus:China will provide an additional US$3 billion in international aid over the next three years to support COVID-19 response and economic and social recovery in other developing countries.It will continue sharing vaccines with the world after having supplied 300 million doses.China will support the transfer of vaccine technologies to other developing countries and carry out joint production on them.展开更多
Structural redundancy elimination in case resource pools (CRP) is critical for avoiding performance bottlenecks and maintaining robust decision capabilities in cloud computing services. For these purposes, this pape...Structural redundancy elimination in case resource pools (CRP) is critical for avoiding performance bottlenecks and maintaining robust decision capabilities in cloud computing services. For these purposes, this paper proposes a novel approach to ensure redundancy elimination of a reasoning system in CRP. By using α entropy and mutual information, functional measures to eliminate redundancy of a system are developed with respect to a set of outputs. These measures help to distinguish both the optimal feature and the relations among the nodes in reasoning networks from the redundant ones with the elimination criterion. Based on the optimal feature and its harmonic weight, a model for knowledge reasoning in CRP (CRPKR) is built to complete the task of query matching, and the missing values are estimated with Bayesian networks. Moreover, the robustness of decisions is verified through parameter analyses. This approach is validated by the simulation with benchmark data sets using cloud SQL. Compared with several state-of-the-art techniques, the results show that the proposed approach has a good performance and boosts the robustness of decisions.展开更多
Removal of spiral waves in cardiac muscle is necessary because of their threat to life.Common methods for this removal are to apply a local disturbance to the media,such as a periodic forcing.However,most of these met...Removal of spiral waves in cardiac muscle is necessary because of their threat to life.Common methods for this removal are to apply a local disturbance to the media,such as a periodic forcing.However,most of these methods accelerate the beating of the cardiac muscle,resulting in the aggravation of the ventricular tachycardia,which directly threatens life.In the present study,in order to clear off spiral waves,a global pulse-disturbance is applied to the media based on three models of cardiac muscle.It is found that the spiral waves are eliminated and the frequency of the cardiac muscle is decreased in a short time,and finally,the state of the medium reaches the normal oscillation,which supports a target waves.Our method sheds light on the removal of spiral waves in cardiac muscle and can prevent the ventricular tachycardia as well as the ventricular fibrillation.展开更多
Establishing a pre-metastatic niche(PMN)in secondary organs is a prerequisite for cancer metastases.Despite advances in cancer therapy,the efficient inhibition of PMN formation remains a clinical challenge.Recent adva...Establishing a pre-metastatic niche(PMN)in secondary organs is a prerequisite for cancer metastases.Despite advances in cancer therapy,the efficient inhibition of PMN formation remains a clinical challenge.Recent advances in understanding the specific characteristics of PMN and advances in nanotechnology have provided hope for manipulating their microenvironments.A series of nanostrategies have been designed to eliminate the PMN,including the removal of pro-metastatic exosomes from the bloodstream for excretion via the intestines,the targeting and scavenging of myeloid-derived suppressor cells,fibroblasts,and critical extracellular matrix components,and the elimination of circulating tumor cells prior to colonization in distant organs.This review summarizes the underlying mechanisms of PMN formation,highlights the anti-PMN efficacy of currently reported nanostrategies,and underlines the unresolved questions.展开更多
Models and simulations are particularly useful for exploring ideas and concepts in the biological sciences that are expe rimentally impracticable.in silico methods are also gaining acceptance with regulatory authoriti...Models and simulations are particularly useful for exploring ideas and concepts in the biological sciences that are expe rimentally impracticable.in silico methods are also gaining acceptance with regulatory authorities as an alternative to animal testing.For example,the Environmental Protection Agency aims to eliminate animal testi ng by 2035.展开更多
High-rate Gamma Spectrometry Using a LaBr_(3)(Ce)Scintillator with a Fast Pulse Shaping.Tianyi Ren1,2,Soo Hyun Byun1,2(1.Department of Physics and Astronomy,McMaster University,Hamilton,ON,L8S 4K1,Canada;2.Radiation S...High-rate Gamma Spectrometry Using a LaBr_(3)(Ce)Scintillator with a Fast Pulse Shaping.Tianyi Ren1,2,Soo Hyun Byun1,2(1.Department of Physics and Astronomy,McMaster University,Hamilton,ON,L8S 4K1,Canada;2.Radiation Sciences Graduate Program,McMaster University,Hamilton,ON,L8S 4K1,Canada)Abstract:The performance of a LaBr_(3)(Ce)gamma spectrometer at high count rates was investigated up to an input count rate of 1.3 Mcps.In order to make its pulse processing faster,a preamplifier provided by the detector manufacturer was eliminated,and the signal from the photomultiplier tubewas fed directly to a digital pulse processing system.展开更多
Lithium-ion batteries(LIBs)featuring a Ni-rich cathode exhibit increased specific capacity,but the establishment of a stable interphase through the implementation of a functional electrolyte strategy remains challengi...Lithium-ion batteries(LIBs)featuring a Ni-rich cathode exhibit increased specific capacity,but the establishment of a stable interphase through the implementation of a functional electrolyte strategy remains challenging.Especially when the battery is operated under high temperature,the trace water present in the electrolyte will accelerate the hydrolysis of the electrolyte and the resulting HF will further erode the interphase.In order to enhance the long-term cycling performance of graphite/LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)LIBs,herein,Tolylene-2,4-diisocyanate(TDI)additive containing lone-pair electrons is employed to formulate a novel bifunctional electrolyte aimed at eliminating H_(2)O/HF generated at elevated temperature.After 1000 cycles at 25℃,the battery incorporating the TDI-containing electrolyte exhibits an impressive capacity retention of 94%at 1 C.In contrast,the battery utilizing the blank electrolyte has a lower capacity retention of only 78%.Furthermore,after undergoing 550 cycles at 1 C under45℃,the inclusion of TDI results in a notable enhancement of capacity,increasing it from 68%to 80%.This indicates TDI has a favorable influence on the cycling performance of LIBs,especially at elevated temperatures.The analysis of the film formation mechanism suggests that the lone pair of electrons of the isocyanate group in TDI play a crucial role in inhibiting the generation of H_(2)O and HF,which leads to the formation of a thin and dense interphase.The existence of this interphase is thought to substantially enhance the cycling performance of the LIBs.This work not only improves the performance of graphite/NCM811 batteries at room temperature and high temperature by eliminating H_(2)O/HF but also presents a novel strategy for advancing functional electrolyte development.展开更多
The new DynaPel^(TM) zipper uses GTT EMPEL® technology to eliminate the need for a PU film Atlanta,GA (Dec 13,2023)-The ISPO Textrends judges have selected YKK’s DynaPel^(TM) water-repellent zipper as the Best P...The new DynaPel^(TM) zipper uses GTT EMPEL® technology to eliminate the need for a PU film Atlanta,GA (Dec 13,2023)-The ISPO Textrends judges have selected YKK’s DynaPel^(TM) water-repellent zipper as the Best Product in the accessories category.The competition,held twice a year in conjunction with the ISPO trade show,recognizes the most innovative performance textiles,components,and apparel.展开更多
Crisis of antibiotic resistant has become a global threat to public health in recent decades[1–4].Carbapenem antibiotics are a class of atypicalβ-lactam antibiotics with the broadest antibacterial spectrum and the s...Crisis of antibiotic resistant has become a global threat to public health in recent decades[1–4].Carbapenem antibiotics are a class of atypicalβ-lactam antibiotics with the broadest antibacterial spectrum and the strongest antibacterial activity.However,carbapenem-resistant Acinetobacter baumannii(CRAB)is stilly emerging,which is a gram-negative bacterium with lipopolysaccharide(LPS),which makes it resistant to several antibiotics and thus difficult to eliminate[5,6].As the number one pathogen of nosocomial infection,CRAB can cause severe pneumonia and bloodstream infection,etc.The mortality rate of patients infected with invasive CRAB can be as high as 40%to 60%,and it has been listed as the key pathogen of Class 1 by the World Health Organization.Due to the lack of feasible antibiotic strategies,phage combination therapy has been used in some patients,while the efficacy is limited[7].Therefore,new discovery and development of antibiotic that targeting CRAB is urgently demand.Fortunately,Kenneth A.展开更多
Migdal Haemek,Israel,April 2,2024.NILIT,the global market leader,and a producer of high quality Nylon 6.6 for apparel and owner of the SENSIL?brand,introduces SENSIL?Flow,a new approach to Nylon 6.6 circularity that e...Migdal Haemek,Israel,April 2,2024.NILIT,the global market leader,and a producer of high quality Nylon 6.6 for apparel and owner of the SENSIL?brand,introduces SENSIL?Flow,a new approach to Nylon 6.6 circularity that enables yarn,fabric,and,ultimately,apparel recycling to eliminate waste and further reduce apparel’s environmental impact.SENSIL?Flow is more than just a sustainable performance product.It is an innovative approach that engages the entire supply chain to truly attain circularity through product design and partnership.展开更多
The effect of terrain shadow, including the self and cast shadows, is one ofthe main obstacles for accurate retrieval of vegetation parameters byremote sensing in rugged terrains. A shadow- eliminated vegetation index...The effect of terrain shadow, including the self and cast shadows, is one ofthe main obstacles for accurate retrieval of vegetation parameters byremote sensing in rugged terrains. A shadow- eliminated vegetation index(SEVI) was developed, which was computed from only red and nearinfrared top-of-atmosphere reflectance without other heterogeneous dataand topographic correction. After introduction of the conceptual modeland feature analysis of conventional wavebands, the SEVI was constructedby ratio vegetation index (RVI), shadow vegetation index (SVI) andadjustment factor (f (Δ)). Then three methods were used to validate theSEVI accuracy in elimination of terrain shadow effects, including relativeerror analysis, correlation analysis between the cosine of solar incidenceangle (cosi) and vegetation indices, and comparison analysis between SEVIand conventional vegetation indices with topographic correction. Thevalidation results based on 532 samples showed that the SEVI relativeerrors for self and cast shadows were 4.32% and 1.51% respectively. Thecoefficient of determination between cosi and SEVI was only 0.032 and thecoefficient of variation (std/mean) for SEVI was 12.59%. The results indicatethat the proposed SEVI effectively eliminated the effect of terrain shadowsand achieved similar or better results than conventional vegetation indiceswith topographic correction.展开更多
文摘Objective:To describe the situation of measles in Sri Lanka from May to November,2023 and to define the role of virology laboratory towards case confirmation and epidemiological and genetic characterization of the outbreak.Methods:This retrospective study analyzed all samples tested for measles from 1st of May to 30th of November,2023 at National Measles Rubella Laboratory,Sri Lanka.According to the World Health Organization(WHO)algorithm,serum and oropharyngeal/nasopharyngeal swabs were tested with WHO recommended kits for anti-measles IgM and measles virus specific RNA,respectively.Selected RNA positive samples were sequenced at reference laboratory,India.Analysis of sequencing data and construction of phylogenetic tree were carried out at National Measles Rubella Laboratory.Data was analyzed using descriptive statistics.Results:Of the total 1132 serum samples and 497 oropharyngeal/nasopharyngeal swabs from 1326 patients,657(49.5%)patients were confirmed as measles by anti-measles IgM,measles virus specific RNA or both.Males(55.6%,n=365)and the age group from>20 to≤30 years(33.0%,n=217)predominated positive patients.All provinces reported measles positive cases.All samples sequenced(100%,n=42)were genotype D8 with 95.2%(n=40)bearing Victoria.Australia origin.Conclusions:We described resurgence of measles in an eliminated country,confirming the genotype to be D8,one of the two genotypes currently circulating globally.Further,the study strongly convinced the importance of a strengthened virological surveillance system in an eliminated country,despite its eliminated status.
文摘This is an erratum to our published paper entitled“Can physical activity eliminate the mortality risk associated with poor sleep?A 15-year follow-up of 341,248 MJ Cohort participants”.In the paper mentioned above,there are some errors that we want to clear in this erratum.On page 601,2 reference lines(i.e.,HR=1)in(A)and(B)of Fig.1 were not labeled.The details are as follows.
基金supported by Fund Information:Postgraduate Research Project of Universities in Anhui Province(YJS20210477)Natural Science Foundation of Anhui Province(2008085MH281)Key Project of Natural Science Research in Colleges and Universities in Anhui Province(KJ2020A0403).
文摘Objective:To investigate the therapeutic effect of osteopathic osteopathy on hormonal osteonecrosis in rabbits by regulating the Wnt/PI3K-AKT signaling pathway.Methods:Thirty clean-grade New Zealand rabbits were randomly divided into control group,model group and experimental group,and all except for the control group,allogeneic serum combined with glucocorticoids were used to establish animal models of simulated hormonal osteonecrosis of the femoral head.After successful modeling,the experimental group was given the model group and the control group the same amount of normal saline,and the experimental group was given bone palsy granule concentrate according to the equivalent dose of humans and rabbits,once a day for 8 weeks,and after intraperitoneal anesthesia,blood was collected from the extracorporeal heart and the serum ALP and TGF-β1 levels were detected by immunoenzyme-linked adsorption.The experimental animals were sacrificed,,and the bilateral femoral heads of rabbits were removed for hematoxylin-eosin staining,and the apoptosis of cells in the femoral head area was observed by TUNEL staining.RT-qPCR analyzed the expression of Bax and Bcl-2 genes,and Western blot detected the expression levels of pathway proteins Wnt,β-catenin,GSK-3β,AKT and p-AKT.Results:Compared with the control group,the expression levels of ALP and TGF-β1 in rabbit bone tissue in the model group decreased significantly(P<0.05),the bone trabeculae were sparse and thinned,the number of hollow bone fosses and the number of apoptosis-positive cells increased significantly(P<0.05),the expression of pro-apoptotic gene Bax was increased,and the expression of anti-apoptotic gene Bcl-2 was inhibited(P<0.05).After the intervention and treatment of bone palsy granules,the hollow bone depression and apoptosis of rabbit bone tissue in the experimental group were effectively improved(P<0.05).In addition,compared with the model group,the osteopathic elimination particles could upregulate the expression of ALP and TGF-β1(P<0.05),promote the expression of pathway proteins Wnt andβ-catenin,increase the phosphorylation level of AKT,and downregulate the expression of GSK-3β(P<0.05).Conclusion:Under glucocorticoids,osteoblast development dysfunction and apoptosis increase.Bone palsy granules can regulate the two signaling pathways of Wnt/PI3K-AKT,promote osteoblast development and inhibit apoptosis,effectively maintain bone metabolic balance,prolong the collapse time of the femoral head,and further treat osteonecrosis of the femoral head.
文摘The "expectations gap" signifies the differences between what the public expects from an audit and what the auditing profession prefers the audit objectives to be.Although the gap exists,it seems that the professions trust that it could be eliminated.In this paper,further evidence was provided to deny the above point by exploring the inevitability nature and the structure of the audit expectation gap.In addition,the author concludes that expectations gap cannot be eliminated;instead,the only thing can be done is to narrow down the gap.
文摘Nowadays, distributing network-connected photovoltaic (PV) systems are expanded by merging a PV system and a Direct Current (DC)/Alternating Current (AC) energy converter. DC/AC conversion of PV energy is in great demand for AC applications. The supply of electrical machines and transfer energy to the distribution network is a typical case. In this work, we study and design a DC/AC energy converter using harmonic selective eliminated (HSE) method. To this end, we have combined two power stages connected in derivation. Each power stage is constituted of transistors and transformers. The connection by switching of the two rectangular waves, delivered by each of the stages, makes it possible to create a quasi-sinusoidal output voltage of the inverter. Mathematical equations based on the current-voltage characteristics of the inverter have been developed. The simulation model was validated using experimental data from a 25.2 kWp grid-coupled (PV) system, connected to Gridfit type inverters. The data were exported and implemented in programming software. A good agreement was observed and this shows all the robustness and the technical performances of the energy converter device. It emerges from this analysis that the inverter output voltage and the phase angle thus simulated are very important to control in order to orientate the transfer of the power flow from the continuous cell to cell to the alternating part. Simulated and field-testing results also show that increases in the value of the modulation factor (m) for low power output are highly significant. This study is an important tool for DC/AC inverter designers during initial planning stages. A short presentation of the design model of the inverter has been proposed in this article.
基金supported by the Program Management Unit for Human Resources&Institutional Development,Research and Innovation-CU(grant number B16F630071)TSRI Fund(CU_FRB640001_01_30_1)
文摘Dengue is a febrile disease caused by a member of the Flaviviridae family called dengue virus(DENV).DENV is primarily transmitted to humans by blood ingestion of Aedes(Ae.)aegypti[1,2].Space spraying is a vector control measure recommended by the World Health Organization(WHO)for eliminating vector mosquitos and preventing further infections in an epidemic setting[3].
文摘According to the notice of the Office of Planned, Safe and Effective Use of Electricity (short as OPSEUE), all non-industrial consumers, such as hotels, shopping centers, are asked to use energy saving lamps instead of incandescent lamp and to eliminate inductive ballasts within the coming 3 years.
文摘The novel coronavirus continues to rage around the world.Cooperation on vaccine research and development is key to a global response.On May 21,Chinese President Xi Jinping attended the Global Health Summit via video and delivered an important speech announcing new measures that China will take to promote global solidarity in the fight against the virus:China will provide an additional US$3 billion in international aid over the next three years to support COVID-19 response and economic and social recovery in other developing countries.It will continue sharing vaccines with the world after having supplied 300 million doses.China will support the transfer of vaccine technologies to other developing countries and carry out joint production on them.
基金supported by the National Natural Science Foundation of China (7117114371201087)+1 种基金the Tianjin Municipal Research Program of Application Foundation and Advanced Technology of China (10JCY-BJC07300)the Science and Technology Program of FOXCONN Group (120024001156)
文摘Structural redundancy elimination in case resource pools (CRP) is critical for avoiding performance bottlenecks and maintaining robust decision capabilities in cloud computing services. For these purposes, this paper proposes a novel approach to ensure redundancy elimination of a reasoning system in CRP. By using α entropy and mutual information, functional measures to eliminate redundancy of a system are developed with respect to a set of outputs. These measures help to distinguish both the optimal feature and the relations among the nodes in reasoning networks from the redundant ones with the elimination criterion. Based on the optimal feature and its harmonic weight, a model for knowledge reasoning in CRP (CRPKR) is built to complete the task of query matching, and the missing values are estimated with Bayesian networks. Moreover, the robustness of decisions is verified through parameter analyses. This approach is validated by the simulation with benchmark data sets using cloud SQL. Compared with several state-of-the-art techniques, the results show that the proposed approach has a good performance and boosts the robustness of decisions.
基金the National Natural Science Foundation of China(Grant Nos.11875042 and 11505114)the Shanghai project for construction of top disciplines(Grant No.USST-SYS01)。
文摘Removal of spiral waves in cardiac muscle is necessary because of their threat to life.Common methods for this removal are to apply a local disturbance to the media,such as a periodic forcing.However,most of these methods accelerate the beating of the cardiac muscle,resulting in the aggravation of the ventricular tachycardia,which directly threatens life.In the present study,in order to clear off spiral waves,a global pulse-disturbance is applied to the media based on three models of cardiac muscle.It is found that the spiral waves are eliminated and the frequency of the cardiac muscle is decreased in a short time,and finally,the state of the medium reaches the normal oscillation,which supports a target waves.Our method sheds light on the removal of spiral waves in cardiac muscle and can prevent the ventricular tachycardia as well as the ventricular fibrillation.
基金the National Natural Science Foundation of China(Nos.82325029,U23A20591,U22A20156,52273158,82102845,52173149,and 52022095)the Shandong Province Innovation Platform Projects(No.2021LCZX04)+3 种基金the Academic Promotion Program of Shandong First Medical University(No.2019LJ004)the Shandong Natural Science Foundation Major Basic Research Project(No.ZR2022ZD31)the Shandong Province Traditional Chinese Medicine Science and Technology Program(No.Z-2022075)the Shandong Province Natural Science Foundation(No.ZR2020MH090).
文摘Establishing a pre-metastatic niche(PMN)in secondary organs is a prerequisite for cancer metastases.Despite advances in cancer therapy,the efficient inhibition of PMN formation remains a clinical challenge.Recent advances in understanding the specific characteristics of PMN and advances in nanotechnology have provided hope for manipulating their microenvironments.A series of nanostrategies have been designed to eliminate the PMN,including the removal of pro-metastatic exosomes from the bloodstream for excretion via the intestines,the targeting and scavenging of myeloid-derived suppressor cells,fibroblasts,and critical extracellular matrix components,and the elimination of circulating tumor cells prior to colonization in distant organs.This review summarizes the underlying mechanisms of PMN formation,highlights the anti-PMN efficacy of currently reported nanostrategies,and underlines the unresolved questions.
文摘Models and simulations are particularly useful for exploring ideas and concepts in the biological sciences that are expe rimentally impracticable.in silico methods are also gaining acceptance with regulatory authorities as an alternative to animal testing.For example,the Environmental Protection Agency aims to eliminate animal testi ng by 2035.
文摘High-rate Gamma Spectrometry Using a LaBr_(3)(Ce)Scintillator with a Fast Pulse Shaping.Tianyi Ren1,2,Soo Hyun Byun1,2(1.Department of Physics and Astronomy,McMaster University,Hamilton,ON,L8S 4K1,Canada;2.Radiation Sciences Graduate Program,McMaster University,Hamilton,ON,L8S 4K1,Canada)Abstract:The performance of a LaBr_(3)(Ce)gamma spectrometer at high count rates was investigated up to an input count rate of 1.3 Mcps.In order to make its pulse processing faster,a preamplifier provided by the detector manufacturer was eliminated,and the signal from the photomultiplier tubewas fed directly to a digital pulse processing system.
基金financially supported by the Scientific and Technological Plan Projects of Guangzhou City(202103040001),P.R.Chinathe Project of Science and Technology Department of Henan Province(222102240074)the Key Research Programs of Higher Education Institutions of Henan Province(24B150009)。
文摘Lithium-ion batteries(LIBs)featuring a Ni-rich cathode exhibit increased specific capacity,but the establishment of a stable interphase through the implementation of a functional electrolyte strategy remains challenging.Especially when the battery is operated under high temperature,the trace water present in the electrolyte will accelerate the hydrolysis of the electrolyte and the resulting HF will further erode the interphase.In order to enhance the long-term cycling performance of graphite/LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)LIBs,herein,Tolylene-2,4-diisocyanate(TDI)additive containing lone-pair electrons is employed to formulate a novel bifunctional electrolyte aimed at eliminating H_(2)O/HF generated at elevated temperature.After 1000 cycles at 25℃,the battery incorporating the TDI-containing electrolyte exhibits an impressive capacity retention of 94%at 1 C.In contrast,the battery utilizing the blank electrolyte has a lower capacity retention of only 78%.Furthermore,after undergoing 550 cycles at 1 C under45℃,the inclusion of TDI results in a notable enhancement of capacity,increasing it from 68%to 80%.This indicates TDI has a favorable influence on the cycling performance of LIBs,especially at elevated temperatures.The analysis of the film formation mechanism suggests that the lone pair of electrons of the isocyanate group in TDI play a crucial role in inhibiting the generation of H_(2)O and HF,which leads to the formation of a thin and dense interphase.The existence of this interphase is thought to substantially enhance the cycling performance of the LIBs.This work not only improves the performance of graphite/NCM811 batteries at room temperature and high temperature by eliminating H_(2)O/HF but also presents a novel strategy for advancing functional electrolyte development.
文摘The new DynaPel^(TM) zipper uses GTT EMPEL® technology to eliminate the need for a PU film Atlanta,GA (Dec 13,2023)-The ISPO Textrends judges have selected YKK’s DynaPel^(TM) water-repellent zipper as the Best Product in the accessories category.The competition,held twice a year in conjunction with the ISPO trade show,recognizes the most innovative performance textiles,components,and apparel.
文摘Crisis of antibiotic resistant has become a global threat to public health in recent decades[1–4].Carbapenem antibiotics are a class of atypicalβ-lactam antibiotics with the broadest antibacterial spectrum and the strongest antibacterial activity.However,carbapenem-resistant Acinetobacter baumannii(CRAB)is stilly emerging,which is a gram-negative bacterium with lipopolysaccharide(LPS),which makes it resistant to several antibiotics and thus difficult to eliminate[5,6].As the number one pathogen of nosocomial infection,CRAB can cause severe pneumonia and bloodstream infection,etc.The mortality rate of patients infected with invasive CRAB can be as high as 40%to 60%,and it has been listed as the key pathogen of Class 1 by the World Health Organization.Due to the lack of feasible antibiotic strategies,phage combination therapy has been used in some patients,while the efficacy is limited[7].Therefore,new discovery and development of antibiotic that targeting CRAB is urgently demand.Fortunately,Kenneth A.
文摘Migdal Haemek,Israel,April 2,2024.NILIT,the global market leader,and a producer of high quality Nylon 6.6 for apparel and owner of the SENSIL?brand,introduces SENSIL?Flow,a new approach to Nylon 6.6 circularity that enables yarn,fabric,and,ultimately,apparel recycling to eliminate waste and further reduce apparel’s environmental impact.SENSIL?Flow is more than just a sustainable performance product.It is an innovative approach that engages the entire supply chain to truly attain circularity through product design and partnership.
基金China National Key Research and Development Plan[grant number 2017YFB0504203]China Scholarship Fund[grant number 201706655028]Natural Science Foundation of Fujian Province[grant number 2017J01658].
文摘The effect of terrain shadow, including the self and cast shadows, is one ofthe main obstacles for accurate retrieval of vegetation parameters byremote sensing in rugged terrains. A shadow- eliminated vegetation index(SEVI) was developed, which was computed from only red and nearinfrared top-of-atmosphere reflectance without other heterogeneous dataand topographic correction. After introduction of the conceptual modeland feature analysis of conventional wavebands, the SEVI was constructedby ratio vegetation index (RVI), shadow vegetation index (SVI) andadjustment factor (f (Δ)). Then three methods were used to validate theSEVI accuracy in elimination of terrain shadow effects, including relativeerror analysis, correlation analysis between the cosine of solar incidenceangle (cosi) and vegetation indices, and comparison analysis between SEVIand conventional vegetation indices with topographic correction. Thevalidation results based on 532 samples showed that the SEVI relativeerrors for self and cast shadows were 4.32% and 1.51% respectively. Thecoefficient of determination between cosi and SEVI was only 0.032 and thecoefficient of variation (std/mean) for SEVI was 12.59%. The results indicatethat the proposed SEVI effectively eliminated the effect of terrain shadowsand achieved similar or better results than conventional vegetation indiceswith topographic correction.