Objective: The comparison of the remote and recent therapeutic effects on perennial allergic rhinitis was carried on among single application of acupoint-thread embedding, western medicine (certirizine+flixonase) and ...Objective: The comparison of the remote and recent therapeutic effects on perennial allergic rhinitis was carried on among single application of acupoint-thread embedding, western medicine (certirizine+flixonase) and allied therapy. Method: Ninety cases were randomized into thread-embedding group, western medicine group and embedding+western medicine group (allied-therapy group), 30 cases in each one. In thread embedding group, Yingxiang (迎香 LI 20) and Feishu (肺俞 BL 13) were selected for thread embedding, once a week, totally 4 treatments were required. In western medicine group, certirizine tablet 10 mg in combination with flixonase sprayer was applied once per day, continuously for 30 days in treatment. In allied-therapy group, both of the above methods were adopted continuously for 30 days in treatment. The therapeutic effects were in statistics at the end of treatment and 1 year later. Results: At the end of treatment, in thread-embedding group, 21 cases were remarkably effective, 3 cases effective and 6 cases no effect. In western medicine group, 20 cases were remarkably effective, 3 cases effective and 7 cases no effect. In allied-therapy group, 23 cases were remarkably effective, 2 cases effective and 5 cases no effect. It was shown in statistics that there was no significant difference in therapeutic effects among three groups ( P>0.05 ). But one year after the end of treatment, it was indicated that in thread-embedding group, 3 cases were remarkably effective, 10 cases effective and 17 cases no effect; in western medicine group, 2 cases were remarkably effective, 9 cases effective and 19 cases no effect; in allied-therapy group, 7 cases were remarkably effective, 11 cases effective and 12 cases no effect. The significant difference in the therapeutic effects had not been presented in the comparison between thread-embedding group and western medicine group (P>0.05), but that had been presented between allied-therapy group with either of the groups with single therapy applied (P<0.05). Conclusion: Quite good recent therapeutic effect of either acupoint-thread embedding or western medicine (certirizine+flixonase) was achieved on perennial allergic rhinitis. The remote therapeutic effect of allied therapy was more advantageous than that of single application of either thread embedding or western medicine.展开更多
Poly( glycolic acid-lactic acid)( PGLA) threadembedding material was modified by chitosan coating which could improve the rigidity,hydrophilicity and moisture absorption of the material,and produced better stimulation...Poly( glycolic acid-lactic acid)( PGLA) threadembedding material was modified by chitosan coating which could improve the rigidity,hydrophilicity and moisture absorption of the material,and produced better stimulation effect. Thus,this kind of thread-embedding materials which can be buried into acupuncture points to produce a long-time stimulation is popular in the acupuncture and moxibustion therapies. The variation tendencies of diameter,weight, hydrophilicity, and flexibility of the samples under the change of chitosan coating concentration,coating time and coating times were studied respectively. The results showed that the hydrophilicity,weight,and rigidity after coating rose in a certain range with the increase of coating time,coating times and coating concentration. The coating time had little influence on the diameter of fiber.展开更多
Thread-embedding materials buried into acupuncture points to produce a long-time stimulation is a method which has been widely applied in the acupuncture and moxibustion therapies for diseases treating and they should...Thread-embedding materials buried into acupuncture points to produce a long-time stimulation is a method which has been widely applied in the acupuncture and moxibustion therapies for diseases treating and they should have excellent properties of good biocompatibility,biodegradability and moderate rigidity.Polyactic acid(PLA) as the thread-embedding material had some shortcomings such as poor hydrophilicity and slowly biodegradable speed.In this paper,PLA thread-embedding material was modified by chitosan coating which could improve rigidity,hydrophilicity and moisture absorption and thus produce better stimulation effect.The variation tendency of diameter,mass,hydrophilicity,and initial modulus of the sample under the change of chitosan coating concentration,coating time and coating times were studied respectively.The results showed that the hydrophilicity,mass,and initial modulus after coating rose in a certain range when the coating time,coating times and coating concentration increased,while the changing of coating had little impact on fiber diameter.展开更多
Objective:To explore the clinical effect of embedding thread combined with Jianpi Qushi Huayu ointment in the treatment of bronchiectasis in remission period,and to observe the effect on the level of inflammatory cyto...Objective:To explore the clinical effect of embedding thread combined with Jianpi Qushi Huayu ointment in the treatment of bronchiectasis in remission period,and to observe the effect on the level of inflammatory cytokines.Methods:150 patients with bronchiectasis in remission period were divided into three groups(50 cases in each group),western medicine group(treated with salmeterol fluticasone and low dose erythromycin),combined group(treated with Jianpi Qushi Huayu plaster),observation group(treated with western medicine+Jianpi Qushi Huayu plaster+embedding thread),and the clinical treatment of the three groups were compared.Result:before and after treatment,the improvement of TCM syndrome score,the improvement of pulmonary ventilation index,the improvement of inflammatory cytokines,and the change of adverse reactions.Results:the treatment efficiency of the observation group and the combination group was significantly higher than that of the western medicine group P The peak level of expiratory flow velocity,the maximum expiratory flow,the forced expiratory volume in one second and the ratio of forced expiratory volume in one second to vital capacity in the observation group and the combined group were significantly better than those in the western medicine group and the pre-treatment level(P<0.05),and the improvement in the observation group was better than that in the combined group After treatment,the expression of IL-13,IL-10 and IL-4 in the combined group was significantly better than that in the western medicine group and before treatment(P<0.05),and the improvement in the observation group was better than that in the combined group;there was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:catgut embedding combined with Jianpi Qushi Huayu ointment can significantly alleviate the related clinical symptoms and signs,effectively control the further aggravation of the disease,improve the lung function of patients,regulate the level of inflammatory cytokines to reduce the degree of inflammatory reaction,and do not significantly aggravate the adverse reactions of drugs.展开更多
Information steganography has received more and more attention from scholars nowadays,especially in the area of image steganography,which uses image content to transmit information and makes the existence of secret in...Information steganography has received more and more attention from scholars nowadays,especially in the area of image steganography,which uses image content to transmit information and makes the existence of secret information undetectable.To enhance concealment and security,the Steganography without Embedding(SWE)method has proven effective in avoiding image distortion resulting from cover modification.In this paper,a novel encrypted communication scheme for image SWE is proposed.It reconstructs the image into a multi-linked list structure consisting of numerous nodes,where each pixel is transformed into a single node with data and pointer domains.By employing a special addressing algorithm,the optimal linked list corresponding to the secret information can be identified.The receiver can restore the secretmessage fromthe received image using only the list header position information.The scheme is based on the concept of coverless steganography,eliminating the need for any modifications to the cover image.It boasts high concealment and security,along with a complete message restoration rate,making it resistant to steganalysis.Furthermore,this paper proposes linked-list construction schemeswithin theproposedframework,which caneffectively resist a variety of attacks,includingnoise attacks and image compression,demonstrating a certain degree of robustness.To validate the proposed framework,practical tests and comparisons are conducted using multiple datasets.The results affirm the framework’s commendable performance in terms of message reduction rate,hidden writing capacity,and robustness against diverse attacks.展开更多
A novel image encryption scheme based on parallel compressive sensing and edge detection embedding technology is proposed to improve visual security. Firstly, the plain image is sparsely represented using the discrete...A novel image encryption scheme based on parallel compressive sensing and edge detection embedding technology is proposed to improve visual security. Firstly, the plain image is sparsely represented using the discrete wavelet transform.Then, the coefficient matrix is scrambled and compressed to obtain a size-reduced image using the Fisher–Yates shuffle and parallel compressive sensing. Subsequently, to increase the security of the proposed algorithm, the compressed image is re-encrypted through permutation and diffusion to obtain a noise-like secret image. Finally, an adaptive embedding method based on edge detection for different carrier images is proposed to generate a visually meaningful cipher image. To improve the plaintext sensitivity of the algorithm, the counter mode is combined with the hash function to generate keys for chaotic systems. Additionally, an effective permutation method is designed to scramble the pixels of the compressed image in the re-encryption stage. The simulation results and analyses demonstrate that the proposed algorithm performs well in terms of visual security and decryption quality.展开更多
Identification of underlying partial differential equations(PDEs)for complex systems remains a formidable challenge.In the present study,a robust PDE identification method is proposed,demonstrating the ability to extr...Identification of underlying partial differential equations(PDEs)for complex systems remains a formidable challenge.In the present study,a robust PDE identification method is proposed,demonstrating the ability to extract accurate governing equations under noisy conditions without prior knowledge.Specifically,the proposed method combines gene expression programming,one type of evolutionary algorithm capable of generating unseen terms based solely on basic operators and functional terms,with symbolic regression neural networks.These networks are designed to represent explicit functional expressions and optimize them with data gradients.In particular,the specifically designed neural networks can be easily transformed to physical constraints for the training data,embedding the discovered PDEs to further optimize the metadata used for iterative PDE identification.The proposed method has been tested in four canonical PDE cases,validating its effectiveness without preliminary information and confirming its suitability for practical applications across various noise levels.展开更多
Objective:To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods: We predicted and characterized HQD patt...Objective:To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods: We predicted and characterized HQD pattern genes using the new strategy,TCM-HIN2Vec,which involves heterogeneous network embedding and transcriptomic experiments.First,a heterogeneous network of traditional Chinese medicine(TCM)patterns was constructed using public databases.Next,we predicted HQD pattern genes using a heterogeneous network-embedding algorithm.We then analyzed the functional characteristics of HQD pattern genes using gene enrichment analysis and examined gene expression levels using RNA-seq.Finally,we identified TCM herbs that demonstrated enriched interactions with HQD pattern genes via herbal enrichment analysis.Results: Our TCM-HIN2Vec strategy revealed that candidate genes associated with HQD pattern were significantly enriched in energy metabolism,signal transduction pathways,and immune processes.Moreover,we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency pattern.Furthermore,herbal enrichment analysis identified TCM herbs that demonstrated enriched interactions with the top 10 candidate genes and could potentially serve as drug candidates for treating HQD.Conclusion: Our results suggested that TCM-HIN2Vec is capable of not only accurately identifying HQD pattern genes,but also deciphering the basis of HQD pattern.Furthermore our finding indicated that TCM-HIN2Vec may be further expanded to develop other patterns,leading to a new approach aimed at elucidating general TCM patterns and developing precision medicine.展开更多
In the tobacco industry,insider employee attack is a thorny problem that is difficult to detect.To solve this issue,this paper proposes an insider threat detection method based on heterogeneous graph embedding.First,t...In the tobacco industry,insider employee attack is a thorny problem that is difficult to detect.To solve this issue,this paper proposes an insider threat detection method based on heterogeneous graph embedding.First,the interrelationships between logs are fully considered,and log entries are converted into heterogeneous graphs based on these relationships.Second,the heterogeneous graph embedding is adopted and each log entry is represented as a low-dimensional feature vector.Then,normal logs and malicious logs are classified into different clusters by clustering algorithm to identify malicious logs.Finally,the effectiveness and superiority of the method is verified through experiments on the CERT dataset.The experimental results show that this method has better performance compared to some baseline methods.展开更多
Security during remote transmission has been an important concern for researchers in recent years.In this paper,a hierarchical encryption multi-image encryption scheme for people with different security levels is desi...Security during remote transmission has been an important concern for researchers in recent years.In this paper,a hierarchical encryption multi-image encryption scheme for people with different security levels is designed,and a multiimage encryption(MIE)algorithm with row and column confusion and closed-loop bi-directional diffusion is adopted in the paper.While ensuring secure communication of medical image information,people with different security levels have different levels of decryption keys,and differentiated visual effects can be obtained by using the strong sensitivity of chaotic keys.The highest security level can obtain decrypted images without watermarks,and at the same time,patient information and copyright attribution can be verified by obtaining watermark images.The experimental results show that the scheme is sufficiently secure as an MIE scheme with visualized differences and the encryption and decryption efficiency is significantly improved compared to other works.展开更多
We are developing a speed reducer that can be considered a transformation of a worm gear reducer: the worm is replaced by an inverted roller screw, and the gear is replaced by a threaded chain drive. This configuratio...We are developing a speed reducer that can be considered a transformation of a worm gear reducer: the worm is replaced by an inverted roller screw, and the gear is replaced by a threaded chain drive. This configuration lessens wear, increases load capacity, and improves efficiency. The threaded chain consists of nut-shaped links. This paper presents the results of tests carried out on a prototype with a reduction ratio of 46.展开更多
This paper discusses the feasibility of thin-shell wormholes in spacetimes of embedding class one admitting a one-parameter group of conformal motions. It is shown that the surface energy density σis positive, while ...This paper discusses the feasibility of thin-shell wormholes in spacetimes of embedding class one admitting a one-parameter group of conformal motions. It is shown that the surface energy density σis positive, while the surface pressure is negative, resulting in , thereby signaling a violation of the null energy condition, a necessary condition for holding a wormhole open. For a Morris-Thorne wormhole, matter that violates the null energy condition is referred to as “exotic”. For the thin-shell wormholes in this paper, however, the violation has a physical explanation since it is a direct consequence of the embedding theory in conjunction with the assumption of conformal symmetry. These properties avoid the need to hypothesize the existence of the highly problematical exotic matter.展开更多
针对基于Linux和TCG软件栈(Trusted computing group Software Stack,TSS)的复杂性问题,提出一种轻量级的可信软件栈。分析了TSS的基本结构与TSS在嵌入式系统的局限,总结出基于嵌入式系统的可信软件栈设计需求,设计出软件栈命令调用的...针对基于Linux和TCG软件栈(Trusted computing group Software Stack,TSS)的复杂性问题,提出一种轻量级的可信软件栈。分析了TSS的基本结构与TSS在嵌入式系统的局限,总结出基于嵌入式系统的可信软件栈设计需求,设计出软件栈命令调用的机制和软件栈的结构。此外,分析了TSS密钥管理缓存算法,在flash中定义一块密钥槽空间,方便密钥管理中直接访问,阐述密钥生成的逻辑过程,实现面向嵌入式系统的可信软件系统。经实验验证,该软件栈可以结合RT-Thread实时系统实现基本的可信计算功能。展开更多
Cryptocurrency, as a typical application scene of blockchain, has attracted broad interests from both industrial and academic communities. With its rapid development, the cryptocurrency transaction network embedding(C...Cryptocurrency, as a typical application scene of blockchain, has attracted broad interests from both industrial and academic communities. With its rapid development, the cryptocurrency transaction network embedding(CTNE) has become a hot topic. It embeds transaction nodes into low-dimensional feature space while effectively maintaining a network structure,thereby discovering desired patterns demonstrating involved users' normal and abnormal behaviors. Based on a wide investigation into the state-of-the-art CTNE, this survey has made the following efforts: 1) categorizing recent progress of CTNE methods, 2) summarizing the publicly available cryptocurrency transaction network datasets, 3) evaluating several widely-adopted methods to show their performance in several typical evaluation protocols, and 4) discussing the future trends of CTNE. By doing so, it strives to provide a systematic and comprehensive overview of existing CTNE methods from static to dynamic perspectives,thereby promoting further research into this emerging and important field.展开更多
文摘Objective: The comparison of the remote and recent therapeutic effects on perennial allergic rhinitis was carried on among single application of acupoint-thread embedding, western medicine (certirizine+flixonase) and allied therapy. Method: Ninety cases were randomized into thread-embedding group, western medicine group and embedding+western medicine group (allied-therapy group), 30 cases in each one. In thread embedding group, Yingxiang (迎香 LI 20) and Feishu (肺俞 BL 13) were selected for thread embedding, once a week, totally 4 treatments were required. In western medicine group, certirizine tablet 10 mg in combination with flixonase sprayer was applied once per day, continuously for 30 days in treatment. In allied-therapy group, both of the above methods were adopted continuously for 30 days in treatment. The therapeutic effects were in statistics at the end of treatment and 1 year later. Results: At the end of treatment, in thread-embedding group, 21 cases were remarkably effective, 3 cases effective and 6 cases no effect. In western medicine group, 20 cases were remarkably effective, 3 cases effective and 7 cases no effect. In allied-therapy group, 23 cases were remarkably effective, 2 cases effective and 5 cases no effect. It was shown in statistics that there was no significant difference in therapeutic effects among three groups ( P>0.05 ). But one year after the end of treatment, it was indicated that in thread-embedding group, 3 cases were remarkably effective, 10 cases effective and 17 cases no effect; in western medicine group, 2 cases were remarkably effective, 9 cases effective and 19 cases no effect; in allied-therapy group, 7 cases were remarkably effective, 11 cases effective and 12 cases no effect. The significant difference in the therapeutic effects had not been presented in the comparison between thread-embedding group and western medicine group (P>0.05), but that had been presented between allied-therapy group with either of the groups with single therapy applied (P<0.05). Conclusion: Quite good recent therapeutic effect of either acupoint-thread embedding or western medicine (certirizine+flixonase) was achieved on perennial allergic rhinitis. The remote therapeutic effect of allied therapy was more advantageous than that of single application of either thread embedding or western medicine.
基金Biomedical Textile Materials Science and Technology(111 Project),China(No.B07024)
文摘Poly( glycolic acid-lactic acid)( PGLA) threadembedding material was modified by chitosan coating which could improve the rigidity,hydrophilicity and moisture absorption of the material,and produced better stimulation effect. Thus,this kind of thread-embedding materials which can be buried into acupuncture points to produce a long-time stimulation is popular in the acupuncture and moxibustion therapies. The variation tendencies of diameter,weight, hydrophilicity, and flexibility of the samples under the change of chitosan coating concentration,coating time and coating times were studied respectively. The results showed that the hydrophilicity,weight,and rigidity after coating rose in a certain range with the increase of coating time,coating times and coating concentration. The coating time had little influence on the diameter of fiber.
文摘Thread-embedding materials buried into acupuncture points to produce a long-time stimulation is a method which has been widely applied in the acupuncture and moxibustion therapies for diseases treating and they should have excellent properties of good biocompatibility,biodegradability and moderate rigidity.Polyactic acid(PLA) as the thread-embedding material had some shortcomings such as poor hydrophilicity and slowly biodegradable speed.In this paper,PLA thread-embedding material was modified by chitosan coating which could improve rigidity,hydrophilicity and moisture absorption and thus produce better stimulation effect.The variation tendency of diameter,mass,hydrophilicity,and initial modulus of the sample under the change of chitosan coating concentration,coating time and coating times were studied respectively.The results showed that the hydrophilicity,mass,and initial modulus after coating rose in a certain range when the coating time,coating times and coating concentration increased,while the changing of coating had little impact on fiber diameter.
基金2020 Hebei provincial research project of Chinese medicine(No.2020374)
文摘Objective:To explore the clinical effect of embedding thread combined with Jianpi Qushi Huayu ointment in the treatment of bronchiectasis in remission period,and to observe the effect on the level of inflammatory cytokines.Methods:150 patients with bronchiectasis in remission period were divided into three groups(50 cases in each group),western medicine group(treated with salmeterol fluticasone and low dose erythromycin),combined group(treated with Jianpi Qushi Huayu plaster),observation group(treated with western medicine+Jianpi Qushi Huayu plaster+embedding thread),and the clinical treatment of the three groups were compared.Result:before and after treatment,the improvement of TCM syndrome score,the improvement of pulmonary ventilation index,the improvement of inflammatory cytokines,and the change of adverse reactions.Results:the treatment efficiency of the observation group and the combination group was significantly higher than that of the western medicine group P The peak level of expiratory flow velocity,the maximum expiratory flow,the forced expiratory volume in one second and the ratio of forced expiratory volume in one second to vital capacity in the observation group and the combined group were significantly better than those in the western medicine group and the pre-treatment level(P<0.05),and the improvement in the observation group was better than that in the combined group After treatment,the expression of IL-13,IL-10 and IL-4 in the combined group was significantly better than that in the western medicine group and before treatment(P<0.05),and the improvement in the observation group was better than that in the combined group;there was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:catgut embedding combined with Jianpi Qushi Huayu ointment can significantly alleviate the related clinical symptoms and signs,effectively control the further aggravation of the disease,improve the lung function of patients,regulate the level of inflammatory cytokines to reduce the degree of inflammatory reaction,and do not significantly aggravate the adverse reactions of drugs.
基金supported in part by the National Natural Science Foundation of China(Nos.62372083,62072074,62076054,62027827,62002047)the Sichuan Science and Technology Innovation Platform and Talent Plan(No.2022JDJQ0039)+2 种基金the Sichuan Science and Technology Support Plan(Nos.2024NSFTD0005,2022YFQ0045,2022YFS0220,2023YFS0020,2023YFS0197,2023YFG0148)the CCF-Baidu Open Fund(No.202312)the Medico-Engineering Cooperation Funds from University of Electronic Science and Technology of China(Nos.ZYGX2021YGLH212,ZYGX2022YGRH012).
文摘Information steganography has received more and more attention from scholars nowadays,especially in the area of image steganography,which uses image content to transmit information and makes the existence of secret information undetectable.To enhance concealment and security,the Steganography without Embedding(SWE)method has proven effective in avoiding image distortion resulting from cover modification.In this paper,a novel encrypted communication scheme for image SWE is proposed.It reconstructs the image into a multi-linked list structure consisting of numerous nodes,where each pixel is transformed into a single node with data and pointer domains.By employing a special addressing algorithm,the optimal linked list corresponding to the secret information can be identified.The receiver can restore the secretmessage fromthe received image using only the list header position information.The scheme is based on the concept of coverless steganography,eliminating the need for any modifications to the cover image.It boasts high concealment and security,along with a complete message restoration rate,making it resistant to steganalysis.Furthermore,this paper proposes linked-list construction schemeswithin theproposedframework,which caneffectively resist a variety of attacks,includingnoise attacks and image compression,demonstrating a certain degree of robustness.To validate the proposed framework,practical tests and comparisons are conducted using multiple datasets.The results affirm the framework’s commendable performance in terms of message reduction rate,hidden writing capacity,and robustness against diverse attacks.
基金supported by the Key Area R&D Program of Guangdong Province (Grant No.2022B0701180001)the National Natural Science Foundation of China (Grant No.61801127)+1 种基金the Science Technology Planning Project of Guangdong Province,China (Grant Nos.2019B010140002 and 2020B111110002)the Guangdong-Hong Kong-Macao Joint Innovation Field Project (Grant No.2021A0505080006)。
文摘A novel image encryption scheme based on parallel compressive sensing and edge detection embedding technology is proposed to improve visual security. Firstly, the plain image is sparsely represented using the discrete wavelet transform.Then, the coefficient matrix is scrambled and compressed to obtain a size-reduced image using the Fisher–Yates shuffle and parallel compressive sensing. Subsequently, to increase the security of the proposed algorithm, the compressed image is re-encrypted through permutation and diffusion to obtain a noise-like secret image. Finally, an adaptive embedding method based on edge detection for different carrier images is proposed to generate a visually meaningful cipher image. To improve the plaintext sensitivity of the algorithm, the counter mode is combined with the hash function to generate keys for chaotic systems. Additionally, an effective permutation method is designed to scramble the pixels of the compressed image in the re-encryption stage. The simulation results and analyses demonstrate that the proposed algorithm performs well in terms of visual security and decryption quality.
基金supported by the National Natural Science Foundation of China(Grant Nos.92152102 and 92152202)the Advanced Jet Propulsion Innovation Center/AEAC(Grant No.HKCX2022-01-010)。
文摘Identification of underlying partial differential equations(PDEs)for complex systems remains a formidable challenge.In the present study,a robust PDE identification method is proposed,demonstrating the ability to extract accurate governing equations under noisy conditions without prior knowledge.Specifically,the proposed method combines gene expression programming,one type of evolutionary algorithm capable of generating unseen terms based solely on basic operators and functional terms,with symbolic regression neural networks.These networks are designed to represent explicit functional expressions and optimize them with data gradients.In particular,the specifically designed neural networks can be easily transformed to physical constraints for the training data,embedding the discovered PDEs to further optimize the metadata used for iterative PDE identification.The proposed method has been tested in four canonical PDE cases,validating its effectiveness without preliminary information and confirming its suitability for practical applications across various noise levels.
基金supported by the National Natural Science Foundation of China(32088101)National key Research and Development Program of China(2017YFC1700105,2021YFA1301603).
文摘Objective:To elucidate the biological basis of the heart qi deficiency(HQD)pattern,an in-depth understanding of which is essential for improving clinical herbal therapy.Methods: We predicted and characterized HQD pattern genes using the new strategy,TCM-HIN2Vec,which involves heterogeneous network embedding and transcriptomic experiments.First,a heterogeneous network of traditional Chinese medicine(TCM)patterns was constructed using public databases.Next,we predicted HQD pattern genes using a heterogeneous network-embedding algorithm.We then analyzed the functional characteristics of HQD pattern genes using gene enrichment analysis and examined gene expression levels using RNA-seq.Finally,we identified TCM herbs that demonstrated enriched interactions with HQD pattern genes via herbal enrichment analysis.Results: Our TCM-HIN2Vec strategy revealed that candidate genes associated with HQD pattern were significantly enriched in energy metabolism,signal transduction pathways,and immune processes.Moreover,we found that these candidate genes were significantly differentially expressed in the transcriptional profile of mice model with heart failure with a qi deficiency pattern.Furthermore,herbal enrichment analysis identified TCM herbs that demonstrated enriched interactions with the top 10 candidate genes and could potentially serve as drug candidates for treating HQD.Conclusion: Our results suggested that TCM-HIN2Vec is capable of not only accurately identifying HQD pattern genes,but also deciphering the basis of HQD pattern.Furthermore our finding indicated that TCM-HIN2Vec may be further expanded to develop other patterns,leading to a new approach aimed at elucidating general TCM patterns and developing precision medicine.
基金Supported by the National Natural Science Foundation of China(No.62203390)the Science and Technology Project of China TobaccoZhejiang Industrial Co.,Ltd(No.ZJZY2022E004)。
文摘In the tobacco industry,insider employee attack is a thorny problem that is difficult to detect.To solve this issue,this paper proposes an insider threat detection method based on heterogeneous graph embedding.First,the interrelationships between logs are fully considered,and log entries are converted into heterogeneous graphs based on these relationships.Second,the heterogeneous graph embedding is adopted and each log entry is represented as a low-dimensional feature vector.Then,normal logs and malicious logs are classified into different clusters by clustering algorithm to identify malicious logs.Finally,the effectiveness and superiority of the method is verified through experiments on the CERT dataset.The experimental results show that this method has better performance compared to some baseline methods.
基金Project supported by the National Natural Science Foundation of China(Grant No.62061014)the Natural Science Foundation of Liaoning province of China(Grant No.2020-MS-274).
文摘Security during remote transmission has been an important concern for researchers in recent years.In this paper,a hierarchical encryption multi-image encryption scheme for people with different security levels is designed,and a multiimage encryption(MIE)algorithm with row and column confusion and closed-loop bi-directional diffusion is adopted in the paper.While ensuring secure communication of medical image information,people with different security levels have different levels of decryption keys,and differentiated visual effects can be obtained by using the strong sensitivity of chaotic keys.The highest security level can obtain decrypted images without watermarks,and at the same time,patient information and copyright attribution can be verified by obtaining watermark images.The experimental results show that the scheme is sufficiently secure as an MIE scheme with visualized differences and the encryption and decryption efficiency is significantly improved compared to other works.
文摘We are developing a speed reducer that can be considered a transformation of a worm gear reducer: the worm is replaced by an inverted roller screw, and the gear is replaced by a threaded chain drive. This configuration lessens wear, increases load capacity, and improves efficiency. The threaded chain consists of nut-shaped links. This paper presents the results of tests carried out on a prototype with a reduction ratio of 46.
文摘This paper discusses the feasibility of thin-shell wormholes in spacetimes of embedding class one admitting a one-parameter group of conformal motions. It is shown that the surface energy density σis positive, while the surface pressure is negative, resulting in , thereby signaling a violation of the null energy condition, a necessary condition for holding a wormhole open. For a Morris-Thorne wormhole, matter that violates the null energy condition is referred to as “exotic”. For the thin-shell wormholes in this paper, however, the violation has a physical explanation since it is a direct consequence of the embedding theory in conjunction with the assumption of conformal symmetry. These properties avoid the need to hypothesize the existence of the highly problematical exotic matter.
文摘针对基于Linux和TCG软件栈(Trusted computing group Software Stack,TSS)的复杂性问题,提出一种轻量级的可信软件栈。分析了TSS的基本结构与TSS在嵌入式系统的局限,总结出基于嵌入式系统的可信软件栈设计需求,设计出软件栈命令调用的机制和软件栈的结构。此外,分析了TSS密钥管理缓存算法,在flash中定义一块密钥槽空间,方便密钥管理中直接访问,阐述密钥生成的逻辑过程,实现面向嵌入式系统的可信软件系统。经实验验证,该软件栈可以结合RT-Thread实时系统实现基本的可信计算功能。
基金supported in part by the National Natural Science Foundation of China (62272078)the CAAI-Huawei MindSpore Open Fund (CAAIXSJLJJ-2021-035A)the Doctoral Student Talent Training Program of Chongqing University of Posts and Telecommunications (BYJS202009)。
文摘Cryptocurrency, as a typical application scene of blockchain, has attracted broad interests from both industrial and academic communities. With its rapid development, the cryptocurrency transaction network embedding(CTNE) has become a hot topic. It embeds transaction nodes into low-dimensional feature space while effectively maintaining a network structure,thereby discovering desired patterns demonstrating involved users' normal and abnormal behaviors. Based on a wide investigation into the state-of-the-art CTNE, this survey has made the following efforts: 1) categorizing recent progress of CTNE methods, 2) summarizing the publicly available cryptocurrency transaction network datasets, 3) evaluating several widely-adopted methods to show their performance in several typical evaluation protocols, and 4) discussing the future trends of CTNE. By doing so, it strives to provide a systematic and comprehensive overview of existing CTNE methods from static to dynamic perspectives,thereby promoting further research into this emerging and important field.