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假刺藤醇提物对佐剂性关节炎大鼠踝关节及脾脏组织病理学的影响
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作者 梁方旭 戴卫波 +3 位作者 梅全喜 吴凤荣 董鹏鹏 曾聪彦 《中医药导报》 2017年第22期17-22,共6页
目的:观察假刺藤醇提物对弗氏完全佐剂(CFA)诱导的佐剂性关节炎(AA)大鼠踝关节及脾脏组织病理学的影响。方法:采用CFA诱导大鼠AA模型,给予不同剂量假刺藤醇提物干预,测定关节肿胀个数和全身炎症状态评分以及足爪肿胀度,并观察各组大鼠... 目的:观察假刺藤醇提物对弗氏完全佐剂(CFA)诱导的佐剂性关节炎(AA)大鼠踝关节及脾脏组织病理学的影响。方法:采用CFA诱导大鼠AA模型,给予不同剂量假刺藤醇提物干预,测定关节肿胀个数和全身炎症状态评分以及足爪肿胀度,并观察各组大鼠踝关节滑膜、软骨、关节腔、周围软组织炎症反应及脾脏等组织病理改变情况,进行综合评分。结果:与模型组比较,假刺藤醇提物能显著减少AA大鼠关节肿胀个数,降低AA大鼠全身炎症评分,显著降低AA大鼠致炎侧和继发侧足肿胀度(P<0.05或P<0.01);踝关节组织病理结果显示,假刺藤醇提物能显著抑制炎症细胞的浸润和滑膜增生以及血管翳的形成,减轻软骨及骨质损伤程度(P<0.05或P<0.01);降低AA大鼠脾脏病理组织动脉周围淋巴鞘(PALS)的细胞密度、红髓及边缘区评分(P<0.05或P<0.01)。结论:假刺藤醇提物可显著改善AA模型大鼠炎症状态、踝关节及脾脏组织病变。 展开更多
关键词 假刺藤 佐剂性关节炎 组织病理学 大鼠
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A Pharmacognostical Study on Ardisia gigantifolia and Its Adulterants 被引量:1
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作者 Weibo DAI Pengpeng DONG +1 位作者 Suying TIAN Quanxi MEI 《Medicinal Plant》 CAS 2018年第4期35-40,共6页
[Objectives]The research aimed to study the characteristics of Ardisia gigantifolia and its adulterants Embelia scandens and Mappianthus iodoides for identification. [Methods] Through the trait identification method,p... [Objectives]The research aimed to study the characteristics of Ardisia gigantifolia and its adulterants Embelia scandens and Mappianthus iodoides for identification. [Methods] Through the trait identification method,powder microscopic identification method,TLC,inclusions detection and content determination,A. gigantifolia and its adulterants were contrasted. [Results]The morphological and histological characteristics of A. gigantifolia,E. scandens and M. iodoides were different from each other. Containing water,total ash,acid insoluble ash and other inclusions also had difference; the total triterpenoid saponins were respectively 122. 90 mg/g of A. gigantifolia,147. 052 mg/g of E. scandens,and 63. 06 mg/g of M. iodoides. [Conclusions] These methods are accurate and reliable,which could be used for the identification of A. gigantifolia and its adulterants. 展开更多
关键词 Ardisia gigantifolia stapf. embelia scandens(lour.) mez Mappianthus iodoides Hand.-Mazz. ADULTERANT IDENTIFICATION
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