Meta-analysis of brain activation in depressive patients with emotional perception disorders

OBJECTIVE：To elucidate the distribution of abnormally activated brain regions in depressive patients during emotional perception processing using activation likelihood estimation,a quantitative meta-analytic technique.DATA SOURCES：Computer-based online retrieval was conducted using the PscyINFO,Pubmed and CNKI databases,searching literature from the establishment of each database until June 2010.STUDY SELECTION：Inclusion criteria：（1） studies examined emotion perception tasks using func-tional magnetic resonance imaging; （2） studies indicated regional brain activation abnormalities in depressive patients compared with controls in standard Talairach or MNI coordinates.Any analyzed coordinates based on the MNI system were converted to Talairach space with icbm2tal software.The map of activation likelihood estimation was finally created through the Gaussian smooth （full-width half-maximum=8 mm）,permutation test and corrected for multiple comparisons using the false discovery rate method （q=0.05） with Ginger-ALE 2.0 software.MAIN OUTCOME MEASURES：Activation of brain regions in patients.RESULTS：Seventeen studies were identified,involving a total of 261 patients,273 healthy controls and 201 foci.Meta-analysis revealed a dysfunctional emotion regulation loop in depressive patients,comprised of the prefrontal cortex,the basal ganglia and the limbic lobe,in which the amygdala was a key component.During emotion processing,the left prefrontal cortex and basal ganglia were hy-poactive among depressive patients,whereas the opposite change was found in the limbic lobe.CONCLUSION：Abnormal connections among the prefrontal cortex,basal ganglia and limbic lobe may be involved in the pathophysiology of depressive disorder.

Abnormal activation of the occipital lobes during emotion picture processing in major depressive disorder patients

A large number of studies have demonstrated that depression patients have cognitive dysfunction. With recently developed brain functional imaging, studies have focused on changes in brain function to investigate cognitive changes. However, there is still controversy regarding abnormalities in brain functions or correlation between cognitive impairment and brain function changes. Thus, it is important to design an emotion-related task for research into brain function changes. We selected positive, neutral, and negative pictures from the International Affective Picture System. Patients with major depressive disorder were asked to judge emotion pictures. In addition, functional MRI was performed to synchronously record behavior data and imaging data. Results showed that the total correct rate for recognizing pictures was lower in patients compared with normal controls. Moreover, the consistency for recognizing pictures for depressed patients was worse than normal controls, and they frequently recognized positive pictures as negative pictures. The consistency for recognizing pictures was negatively correlated with the Hamilton Depression Rating Scale. Functional MRI suggested that the activation of some areas in the frontal lobe, temporal lobe, parietal lobe, limbic lobe, and cerebellum was enhanced, but that the activation of some areas in the frontal lobe, parietal lobe and occipital lobe was weakened while the patients were watching positive and neutral pictures compared with normal controls. The activation of some areas in the frontal lobe temporal lobe, parietal lobe, and limbic lobe was enhanced, but the activation of some areas in the occipital lobe were weakened while the patients were watching the negative pictures compared with normal controls. These findings indicate that patients with major depressive disorder have negative cognitive disorder and extensive brain dysfunction. Thus, reduced activation of the occipital lobe may be an initiating factor for cognitive disorder in depressed patients.

Navigating emotional challenges:A journey with patients undergoing chemotherapy

A recent article reported that cancer patients with subthreshold depression are more likely to develop major depression within a year.Multivariate regression analysis revealed that regular exercise was a protective factor against cancerrelated fatigue,whereas advanced age,radiotherapy,pain,and low hemoglobin were risk factors for cancer-related fatigue.A limitation of this study was the lack of methodological details about leukemia patients receiving depressive treatment at a specific hospital.Professional assessment,behavioral modification plans,communication,destressing techniques,and educational plans may help chemotherapy patients manage emotional issues and reduce anxiety.Furthermore,these strategies can inspire patients to create,facilitate their treatment,and help them to remain healthy.

Effects of mindfulness-based interventions on depressive symptoms in patients with substance use disorders:a systematic review and meta-analysis

Objective:We examined the effects of mindfulness-based interventions(MBIs)on depressive symptoms in patients with substance use disorders(SUDs)and explored the moderating effects of participant,method,and intervention characteristics.Methods:We systematically searched 8 databases from their inception till November 2021.The inclusion criteria were primary studies evaluating MBIs in patients with SUDs with depression measured as an outcome,those including a control group,and those written in English.We used a random-effects model to compute effect sizes(ESs)using Hedges’g,a forest plot,and Q and I2 statistics as measures of heterogeneity;we also examined moderator analyses.Results:Nineteen studies included 1352 participants(age:38.6±7.0 years).Overall,MBIs showed significantly improved depression(g=0.67,95%confidence interval[CI]:0.29,1.05,I2=89%)compared to controls.With regard to moderators,providing MBIs as an individual plus group intervention had a greater effect(g=2.13)on reducing depressive symptoms than providing MBIs as a group intervention(g=0.64)or an individual intervention only(g=0.33,P=0.034).Using concealed allocation tended to reduce depressive symptoms(g=1.22)as compared to not using concealed allocation(g=0.48,P=0.086).No other quality indicators were demonstrated to have a moderating influence on the value of the ES.Conclusions:MBIs improved depressive symptoms in patients with SUDs.MBIs might be used as an adjunctive or alternative to conventional treatment for depressed patients with SUDs.

Chronic pelvic pain,psychiatric disorders and early emotional traumas:Results of a cross sectional case-control study

AIM To compare the prevalence of psychiatric disorders and early emotional traumas between women with chronic pelvic pain(CPP) and healthy women.METHODS One hundred women in reproductive age,50 of them had CPP(according to the criteria set by the International Association for Study of Pain),and 50 were considered healthy after the gynecological evaluation.The eligibility criteria were defined as follows:chronic or persistent pain perceived in the pelvis-related structures(digestive,urinary,genital,myofascial or neurological systems).Only women in reproductive age with acyclic pain for 6 mo,or more,were included in the present study.Menopause was the exclusion criterion.The participants were grouped according to age,school level and socioeconomic status and were individually assessed through DSM-IV Structured Clinical Interview(SCID-I) and Early Trauma Inventory Self-report-short form(ETISR-SF Brazilian version).Descriptive statistics,group comparison tests and multivariate logistics regression were used in the data analysis.RESULTS The early emotional traumas are highly prevalent,but their prevalence did not differ between the two groups.The current Major Depressive Disorder was more prevalent in women with CPP.The CPP was associatedwith endometriosis in 48% of the women.There was no difference in the prevalence of disorders when endometriosis was taken into account(endometriosis vs other diseases:P > 0.29).The current Major Depressive Disorder and the Bipolar Disorder had greater occurrence likelihood in the group of women with CPP(ODDS = 5.25 and 9.0).CONCLUSION The data reinforce the link between mood disorders and CPP.The preview evidences about the association between CPP and early traumas tended not to be significant after a stronger methodological control was implemented.

Behavioural and emotional disorders in childhood: A brief overview for paediatricians

Mental health problems in children and adolescents include several types of emotional and behavioural disorders, including disruptive, depression, anxiety and pervasive developmental(autism) disorders, characterized as either internalizing or externalizing problems. Disruptive behavioural problems such as temper tantrums, attention deficit hyperactivity disorder, oppositional, defiant or conduct disorders are the commonest behavioural problems in preschool and school age children. The routine Paediatric clinic or Family Medicine/General Practitioner surgery presents with several desirable characteristics that make them ideal for providing effective mental health services to children and adolescents. DSM-5 and ICD-10 are the universally accepted standard criteria for the classification of mental and behaviour disorders in childhood and adults. The age and gender prevalence estimation of various childhood behavioural disorders are variable and difficult to compare worldwide. A review of relevant published literature was conducted, including published metaanalyses and national guidelines. We searched for articles indexed by Ovid, Pub Med, Pub Med Medical Central, CINAHL, EMBASE, Database of Abstracts and Reviews, and the Cochrane Database of Systematic reviews and other online sources. The searches were conducted using a combination of search expressions including "childhood", "behaviour", "disorders" or "problems". Childhood behaviour and emotional problems with their related disorders have significant negative impacts on the individual, the family and the society. They are commonly associated with poor academic, occupational, and psychosocial functioning. It is important for all healthcare professionals, especially the Paediatricians to be aware of the range of presentation, prevention and management of the common mental health problems in children and adolescents.

Frequency of Depression and Anxiety among Tuberculosis Patients

Objective: The aim of present study was to determine the frequency of depression and anxiety among tuberculosis patients. Methods: It was a descriptive study that had investigated the co-morbidity of depression and anxiety among tuberculosis patients with reference to gender. This study was conducted in Jinnah Post Graduate Medical Centre—Chest ward (TB clinic) from July 2014 to September 2014. Hundred diagnosed patients of tuberculosis (50 males and 50 females) were randomly selected. Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Questionnaire (GAD-7) were used to assess the level of anxiety and depression. Results: Findings indicated that 56% tuberculosis (TB) patients had moderate to severe level of depression, whereas 65% TB patients had moderate to severe level of anxiety. Female patients had significantly high prevalence of depression as compared to males (t = –2.173, P –3.468, P Conclusion: Likelihood of depression and anxiety was frequent in tuberculosis patients. However, better management of these psychiatric morbidities may improve treatment adherence, illness perception and patient coping skills.

Significance of music therapy in treating depression and anxiety disorders among people with cancer

Globally,cancer cases and mortality have recently escalated and have attracted global concern.The clinical diagnosis and manifestation of cancer can result in significant mental health issues like depression and anxiety disorders.The tendency of people with cancer to suffer from psychological disorders such as anxiety and depression is usually high.A significant number of deaths related to cancer may likely not be from the killer disease but from psychological disorders associated with the illness.The utilization of music as a remedial approach to healing mental disorders cannot be overstated.Thus,identifying the impacts of music therapy in dealing with depression and anxiety disorders among people with cancer is relevant,as the majority of methods used in treating cancer have some side effects which may trigger psychological disorders in cancer patients.Ultimately,this study explored the significance of music therapy in treating depression and anxiety disorders among people with cancer.To achieve the aim of this study,the authors employed a narrative literature review to investigate the significance of music therapy in addressing depression and anxiety disorders among people with cancer.The type of literature review employed in this study is to provide an understanding of the selected research papers.The review found that music therapy significantly reduces depression and anxiety disorders among breast cancer,lung cancer,prostate cancer,and colorectal cancer patients.It is needful for healthcare providers to incorporate music therapy interventions while treating people with cancer.This will help reduce cancer deaths resulting from psychological disorders rather than the killer disease,cancer.However,the standardized procedures and evaluation criteria for applying music-based intervention strategies in oncology medicine still need to be further established and improved.

Application of rational emotive behavior therapy in patients with colorectal cancer undergoing adjuvant chemotherapy

Objective:This study aimed to explore the effects of our rational emotive behavior therapy(REBT)program on symptoms,anxiety,depression,and sleep state in patients with colorectal cancer(CRC)undergoing chemotherapy.Methods:From October 2020 to May 2021,fifty-six patients with CRC in a hospital in the Hunan Province were randomly divided into an intervention group(n=28)and a control group(n=28).The patients in the intervention group completed a 6-week REBT program based on routine nursing care,including four courses:1)establish a relationship and formulate health files;2)group communications and study symptom management;3)continuously provide health knowledge and strengthen healthy behavior;and 4)review the treatment and summary.The control group maintained routine nursing care.The simplified Chinese version of the Memorial Symptom Assessment Scale Short Form(MSASeSFeSC),the Hospital Anxiety and Depression Scale(HADS),and the Pittsburgh Sleep Quality Index(PSQI)scale were used to investigate and compare the intervention effects of the two groups at baseline(T1,before the intervention),four weeks(T2),and six weeks(T3)after the intervention.Results:The intervention group was significantly improved in symptoms,anxiety,depression,and sleep state,compared with the control group.At T2,MSASeSFeSC(24.43±4.26 vs.28.07±3.91),symptom distress(17.29±4.04 vs.19.39±3.59),symptom frequency(7.14±1.51 vs.8.68±1.42),HADS(13.68±3.38 vs.15.86±3.79),anxiety(3.89±1.85 vs.5.18±2.18),and depression(9.79±2.06 vs.10.68±2.23),showed that the difference between the two groups was statistically significant(P<0.05).At T3,MSASeSFeSC(23.89±3.54 vs.30.14±3.94),symptom distress(17.61±3.52 vs.21.32±3.57),symptom frequency(6.29±1.49 vs.8.82±1.47),HADS(11.82±2.57 vs.16.29±3.13),anxiety(3.21±1.64 vs.5.61±1.77),and depression(8.61±1.52 vs.10.68±1.81),showed that the difference between the two groups was statistically significant(P<0.05).The sleep state of the intervention group was better than the control group at T3,with decreased score of PSQI[4.00(3.00,8.00)vs.9.00(7.00,12.50),Z=-3.706,P<0.001].Conclusion:The 6-week REBT program can effectively improve the symptom,anxiety,depression,and sleep state of patients with CRC undergoing chemotherapy,which could as a care plan for patients with CRC who are repeatedly admitted to the hospital for chemotherapy.

The relationship between child maltreatment and axis I mental disorders: A summary of the published literature from 2006 to 2010

Research has indicated that child maltreatment is associated with an increased likelihood of mental disorders and suicidal ideation and attempts that continues into adulthood. The purpose of this paper is to provide a synopsis of the recent published research from 2006 to 2010 on the association between child maltreatment and Axis I mental disorders and suicidal ideation and attempts. The databases MEDLINE and PsycINFO were searched for relevant and high quality citations up to October 2010. The results indicated that all types of child maltreatment examined are linked to reduced mental health. A general noted trend in the literature is that earlier age of onset of child maltreatment is associated with poorer mental health outcomes. Sex differences do exist with some disorders being more likely among males (e.g., anti-social behaviour) and other more likely among females (e.g., depression, PTSD, substance use disorders) following child maltreatment.

Illness Experience in a Very Low Income/Poor District of Rio de Janeiro, Brazil: Tuberculosis, Medication Adherence and Common Mental Disorders

Introduction: Tuberculosis is a global health problem. Improving medication adherence is an important attribute concerning the outcome of tuberculosis treatment. This study investigates illness experience of patients belonging to a low-income district within Manguinhos catchment area. Narrative studies are able to unfold features concerning patient adherence and co-occurrence of depressive symptoms. Methods: Twenty-three patients under treatment were interviewed using McGill Illness Narrative Interview (MINI-McGILL), besides depression screening with “Self-Report Questionnaire-20” (SRQ-20) and “Beck Depression Inventory” (BDI). Results: Explanatory models disregarded airborne microorganism contagion, known but not considered relevant while bohemian or deviant lifestyle was rather perceived as a causal model. Patients mentioned contiguous events suggesting pneumonia or influenza misdiagnosis before final tuberculosis diagnosis (testing or suspicion). Therapeutic pathways were erratic, suggesting low literacy level and postponed or inadequate diagnosis accuracy. Emergency units or private services usually stood for primary care units considered first choice by planners. Expressions such as “dreadful/shameful disease” or “very heavy illness” acknowledged stigma. Research data detected the importance of social network role, highlighting the family through financial and affective support. Hopelessness and depression were closely related to illness suffering and adversities. The percentage of patients for positive common mental disorder and depression approaches 30%. Conclusion: Tuberculosis remains a stigmatizing disease. Building effective health services networks, comprising treatment facilities, community and family resources are very important to improve medication adherence. Effective tuberculosis management through health teams training seems necessary. Incorporating simple screening instruments for depression assessment might promote well-being and patient adherence.

Reduced default mode network functional connectivity in patients with recurrent major depressive disorder

Recently,in collaboration with a total of 25major depressive disorder(MDD)research groups from 17distinct institutes,Yan ChaoGan’s(严超赣)lab published a scientific paper in PNAS(2019,116(18):9078—9083).MDD,often referred to as depression,is a psychiatric disorder with high recurrence rate,high suicide and disability rate,which causes an extremely heavy social and economic burden each year.

Generalized Anxiety and Major Depressive Symptoms of General Public in South Korea during the Early COVID-19 Pandemic

The extent of viral spread and strategies in dealing with the COVID-19 pandemic have been different in each country.There are overall increased mental health concerns in many countries but it is unclear what the general public individuals who do not have heighten vulnerability to stressors for existing mental diseases or significant physical illnesses were experiencing during the pandemic.We evaluated the stressors and mental health of general public in South Korea that has a relatively low confirmed cases and deaths.Responses on the on-line survey questions were used to assess the mental and physical symptoms in association with individuals’reported stressors.Individuals with the symptoms of the generalized anxiety disorder(GAD)were reported in 58.9%,and major depression(MD)in 23.2%,mostly in minimal to mild degrees,cut-off scores of 5 and 10,respectively by the validated screening tools,GAD-7 and PHQ-9.Both GAD and MD symptoms were in 21.5%of the respondents.The total number of stress had significant association with the scores of GAD-7,PHQ-9,physical symptoms,sleep difficulties and resilience(p<0.01).GAD scores were also associated with sleep difficulties(p<0.01)and raising young children(p<0.05).MD scores were associated with sleep difficulties,job-dissatisfaction,and educational level(p<0.05).The limitations of the study include small sample size,usage of smartphone or email,potential under-reporting by stigma in the socio-cultural context and evolving nature of pandemic.We conclude that keeping careful watch for mental symptoms,stressors,sleep difficulties and other physical symptoms are important even for the individuals without previous mental illnesses during the pandemic era.

抑郁障碍青少年对情绪信息的注意偏向的眼动特征及其与反刍思维相关性

目的 分析抑郁障碍青少年对情绪信息的注意偏向的眼动行为特点,及其与反刍思维的相关性。方法 采用注意偏向的眼动测验、反刍思维问卷分别对35例抑郁障碍青少年和45名正常大学生进行测定。结果 抑郁障碍青少年和正常大学生间,注意偏向潜伏期、刺激类别效应、交叉效应分数的差异均有统计学意义(F=8.31、9.39、13.64,均P<0.05)。简单效应分析显示,两组对正性图片的注视潜伏期存在显著差异(F=15.45,P<0.001);注意偏向首视点注视时差异分数上的组间主效应、刺激类别主效应、组间和刺激类别的交叉效应,注意偏向总注视时差异分数的组间主效应、刺激类别效应、组间和刺激类别的交叉效应,差异均无统计学意义(P>0.05)。正性首视点潜伏期分和享受快乐分、积极应对呈显著负相关(r=-0.392、-0.166,均P<0.05),负性首视点潜伏期分和享受快乐分呈显著正相关(r=0.289,P<0.05)。正性首视点注视时间分和享受快乐、积极应对(r=0.309、0.268)呈正相关(均P<0.05),负性首视点注视时间分和消极归因呈正相关(r=0.194,P<0.05)。结论 抑郁障碍青少年缺乏对积极情绪信息的初始注意,反刍思维和抑郁青少年对情绪信息的注意定向加速、注意维持时间有关。

认知行为治疗联合积极心理干预对酒精使用障碍伴抑郁患者的效果

目的探究认知行为治疗(CBT)联合积极心理干预对酒精使用障碍(AUD)伴抑郁患者酒精戒断反应、负性情绪以及复饮情况的影响。方法将184例AUD伴抑郁患者按照随机数字表法分为对照组和研究组,各92例。对照组患者给予常规药物治疗,研究组患者在对照组基础上给予CBT联合积极心理干预。比较治疗前后两组患者修订版临床酒精戒断症状评定量表(CIWAAr)、宾夕法尼亚酒精渴求量表(PACS)、汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)、药物成瘾者生存质量测定量表(QOL-DA)评分,并随访半年统计两组患者的复饮情况。结果对照组脱落2例,研究组脱落0例,最终对照组纳入90例,研究组纳入92例。治疗后,两组患者CIWA-Ar、PACS、HAMA、HAMD评分均低于治疗前,且研究组低于对照组(P<0.01)。治疗后,两组患者QOL-DA各维度评分均高于治疗前,且研究组高于对照组(P<0.01)。随访8周、16周、24周,研究组患者复饮率均低于对照组(P<0.05)。结论对AUD伴抑郁患者在常规药物治疗的基础上给予CBT联合积极心理干预,可有效帮助患者戒断酒精依赖,减轻其负性情绪,降低复饮率,改善生存质量。

心血管疾病与心理疾病流行病学及相关机制研究新进展

根据WHO公布的最新统计数据显示,心血管疾病是全球的头号死因——每年死于心血管疾病的人数多于任何其他疾病,因此心血管疾病研究是世界公共卫生需要攻克的重要难题。与此同时,根据2022年WHO发布的数据统计,中国心理疾病患病率高达17%,近20年,中国人抑郁症发病率增长了120倍,且研究发现心血管疾病和心理疾病之间有着显著的相关性并存在一定的内在机制。本文旨在阐述心血管疾病和心理疾病之间的相关关系及其内在机制最新研究进展,从而发现焦虑症和抑郁症是心血管疾病的重要驱动因素,其可以通过自主神经系统和下丘脑-垂体-肾上腺轴对心脏造成损伤,而缺血性心肌病和心肌梗死可以通过介导脑部缺血性损伤和炎症反应来诱发不良情绪以及认知障碍。本文能够为心血管疾病高风险患者提供更多预防思路,也为心理疾病患者的诊断治疗提供新的研究方向,并为双心学科的交融提供参考。

情绪任务在情感障碍中的近红外脑功能成像研究进展

情绪任务(emotional task)是研究情感障碍(affective disorder)注意偏向和情感功能中的主要手段之一。基于情绪任务下功能性近红外光谱成像(functional near-infrared spectroscopy,fNIRS)的相关研究表明,面部情绪识别任务、情绪stroop任务以及情绪诱导任务结合fNIRS技术在情感障碍诊断、治疗中具有临床价值,情感障碍患者注意功能和情绪处理存在的缺陷与左侧前额叶皮质异常激活有关,特别是脑激活模式的差异与抑郁障碍患者抑郁症状有关。使用fNIRS研究情绪任务的未来方向重点在联合多种神经影像学手段进行大样本纵向队列研究以获得更加客观的诊疗依据,以及对比不同情绪刺激材料所激活区域的差异。

抑郁症情绪失调的动态特征:情绪动力学的视角

抑郁症在DSM-5中界定的核心特征是持久的情绪紊乱,如过度悲伤和急剧减少的愉悦情绪体验。近年来,情绪动力学强调:抑郁症临床人群的情绪失调不局限于较高的消极情绪平均强度和较低的积极情绪平均强度,还表现为异常的情绪动态模式。本综述系统地纳入18篇采用生态瞬时评估探究日常生活中抑郁症临床人群的情绪动态特征的文献,结果表明:1)相比于健康对照组,抑郁症患者消极情绪波动幅度更大,表现为更大的消极情绪变异性和消极情绪不稳定性。2)抑郁症患者的情绪系统僵化且缺乏灵活性,表现为更大的消极情绪惯性和更密集的情绪网络。3)抑郁症患者情绪反应性存在异常,表现为经历积极事件后的心境点亮效应,经历消极事件后更大的消极情绪反应性。4)患者情绪系统的复杂度下降,表现为更低的情绪分化水平。处于抑郁症缓解期的个体也表现出一定程度的情绪失调。本综述首次从情绪动力学的视角总结了抑郁症情绪失调的特征,这些情绪动态特征为抑郁症的个体化医疗和复发预防提供了潜在的、具有高生态效度的干预靶点。

广泛性焦虑症的中医研究进展

广泛性焦虑症中是临床中最常见的焦虑障碍之一,严重威胁患者的身心健康和生活质量。“郁证”是广泛性焦虑症研究较多且较为公认的病名,根据其病因病机、临床表现等,古代文献记载的“心悸”“百合病”“脏躁”等均与之密切相关。本病常因素体正虚,复为七情所伤所致,病位在脑,涉及肝、心、脾,基本病机为肝气不疏,气机郁滞,郁而化火,耗伤阴血,血不养心,心神不宁。肝郁化火、痰火上扰、心脾两虚、心胆气虚、心肾不交等是其常见证型,中医治疗注重辨证论治,多采用经典方、经验方等中药治疗,结合针刺、推拿、八段锦等非药物疗法形神并调,能明显改善焦虑情绪,特别是增效减毒,提升患者生活质量。

生活技能训练联合情感技能训练预防青少年抑郁障碍非自杀性自伤行为及改善手机社交媒体依赖的价值

目的:探讨生活技能训练(living skill training,LST)联合情感技能训练(emotional skill training,EST)预防青少年抑郁障碍非自杀性自伤(non-suicidal self-injury,NSSI)行为及改善手机社交媒体依赖的价值。方法:纳入2020年1月至2022年12月就诊于本院的青少年抑郁障碍患者143例,按照护理方案分为观察组(n=57)和对照组(n=86),观察组予LST联合EST护理,对照组予LST护理,对比护理前后自我伤害行为量表评分、手机社交媒体依赖评分及纽卡斯尔护理满意度量表评分并分析。结果:护理后,两组忧郁孤独、攻击违纪、自残、退缩与自我批评评分及总分均下降,且观察组忧郁孤独、攻击违纪、自残、退缩与自我批评评分及总分均低于对照组,差异均有统计学意义(P均<0.05);两组突显性、社交增益、强迫性、冲突性及戒断性评分均下降,且观察组突显性、社交增益、强迫性及戒断性评分均低于对照组,差异均有统计学意义(P均<0.05);两组关心与爱护、技术与责任、指导与支持评分及总分上升,且观察组关心与爱护、技术与责任、指导与支持评分及总分均高于对照组,差异均有统计学意义(P均<0.05)。结论:LST联合EST可改善青少年抑郁障碍状和手机社交媒体依赖情况,预防NSSI行为。