Empty nose syndrome (ENS) is a rare complication that develops after partial orcomplete turbinectomy. The main feature of ENS is paradoxical nasal obstructionfeeling despite objectively wide nasal airway. ENS pathogen...Empty nose syndrome (ENS) is a rare complication that develops after partial orcomplete turbinectomy. The main feature of ENS is paradoxical nasal obstructionfeeling despite objectively wide nasal airway. ENS pathogenesis is multifactorialand includes changes in laminar physiological airflow, disruption of mucosafunctions and deficient neural sensation. This leads to the development of ENSsymptomatology such as dyspnea, nasal dryness, nasal burning, nasalobstruction, feeling of suffocation and even comorbid psychiatric disorders thatsignificantly impairs life quality. Specific effective treatment of ENS does not existup to date. In this review we outline existing biomaterial for surgical reconstitutionof nasal anatomy and discuss the perspective of stem cell-based technologiesin ENS management. The main focus is directed to justification ofrationality application of adult mesenchymal stem cells (MSCs) from differenttissues origin and neural crest-derived stem cells (NCSCs) based on their intrinsicbiological properties. MSCs transplantation may stimulate mucosa tissueregeneration via trophic factors secretion, direct transdifferentiation into epithelialcells and pronounced immunosuppressive effect. From the other hand, NCSCsbased on their high neuroprotective properties may reconstitute nerve structureand functioning leading to normal sensation in ENS patients. We postulate thatapplication of cell-based and tissue-engineered products can help to significantlyimprove ENS symptomatology only as complex approach aimed at reconstitutionof nasal anatomy, recovery the nasal mucosa functionality and neural tissuesensation.展开更多
Background:Empty nose syndrome(ENS)is an iatrogenic disorder that most commonly presents with paradoxical nasal obstruction.Diagnosis of ENS is based mainly on symptomatology and surgical history.Symptomatic or surgic...Background:Empty nose syndrome(ENS)is an iatrogenic disorder that most commonly presents with paradoxical nasal obstruction.Diagnosis of ENS is based mainly on symptomatology and surgical history.Symptomatic or surgical treatment is typically offered to patients.Case presentation:A 17-year-old Chinese male presented with ENS following inferior turbinate resection.His main symptoms were dizziness and nasal congestion.He was diagnosed with a traditional Chinese medicine syndrome pattern of liver yang ascending.Acupuncture treatment involved needling ST 36(Zusanli)GB 20(Fengchi),PC 6(Neiguan),LI 4(Hegu),LR 3(Taichong),LR 2(Xingjian),GB 43(Xiaxi),DU 20(Baihui),EX-HN3(Yintang),ST 2(Sibai),and LI 20(Yingxiang).Near complete resolution of dizziness and nasal congestion were achieved after 2 treatments.Conclusion:Acupuncture may be used to resolve symptoms of ENS.Acupoint selection and needle manipulation should be based on TCM pattern diagnosis.展开更多
文摘Empty nose syndrome (ENS) is a rare complication that develops after partial orcomplete turbinectomy. The main feature of ENS is paradoxical nasal obstructionfeeling despite objectively wide nasal airway. ENS pathogenesis is multifactorialand includes changes in laminar physiological airflow, disruption of mucosafunctions and deficient neural sensation. This leads to the development of ENSsymptomatology such as dyspnea, nasal dryness, nasal burning, nasalobstruction, feeling of suffocation and even comorbid psychiatric disorders thatsignificantly impairs life quality. Specific effective treatment of ENS does not existup to date. In this review we outline existing biomaterial for surgical reconstitutionof nasal anatomy and discuss the perspective of stem cell-based technologiesin ENS management. The main focus is directed to justification ofrationality application of adult mesenchymal stem cells (MSCs) from differenttissues origin and neural crest-derived stem cells (NCSCs) based on their intrinsicbiological properties. MSCs transplantation may stimulate mucosa tissueregeneration via trophic factors secretion, direct transdifferentiation into epithelialcells and pronounced immunosuppressive effect. From the other hand, NCSCsbased on their high neuroprotective properties may reconstitute nerve structureand functioning leading to normal sensation in ENS patients. We postulate thatapplication of cell-based and tissue-engineered products can help to significantlyimprove ENS symptomatology only as complex approach aimed at reconstitutionof nasal anatomy, recovery the nasal mucosa functionality and neural tissuesensation.
文摘Background:Empty nose syndrome(ENS)is an iatrogenic disorder that most commonly presents with paradoxical nasal obstruction.Diagnosis of ENS is based mainly on symptomatology and surgical history.Symptomatic or surgical treatment is typically offered to patients.Case presentation:A 17-year-old Chinese male presented with ENS following inferior turbinate resection.His main symptoms were dizziness and nasal congestion.He was diagnosed with a traditional Chinese medicine syndrome pattern of liver yang ascending.Acupuncture treatment involved needling ST 36(Zusanli)GB 20(Fengchi),PC 6(Neiguan),LI 4(Hegu),LR 3(Taichong),LR 2(Xingjian),GB 43(Xiaxi),DU 20(Baihui),EX-HN3(Yintang),ST 2(Sibai),and LI 20(Yingxiang).Near complete resolution of dizziness and nasal congestion were achieved after 2 treatments.Conclusion:Acupuncture may be used to resolve symptoms of ENS.Acupoint selection and needle manipulation should be based on TCM pattern diagnosis.
