EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine tar...EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine targeting CTLA-4 and murine targeting PD-1) were tested on C57Bl/6 mice implanted subcutaneously with the GL261 murine tumor cell line. A signal composed of concatenated recordings of siRNA molecules targeting the murine CTLA-4 and PD-1 receptors (labeled A2) was used in immune competent C57Bl/6 mice. The mice were flank implanted with the murine glioblastoma cell line GL261. Mice were exposed to the signal continuously (24 hours a day) until tumor volumes reached the designated volume limit. Tumors were excised and analyzed via PAGE/Western blot for the expression of CTLA-4, PD-1, Ki67, Caspase 3, CD4 and CD8. Terminal blood draws were used for CBCs. We report the down regulation of the checkpoint inhibitors CTLA-4 in the exposed mice. Significant tumor volume reduction was observed in mice exposed to the siRNA signal compared to control mice;no adverse events were recorded. Cell blood counts (CBC) and protein expression patterns were observed to correlate with the expected function of protein expression inhibition of the targets.展开更多
Blockchain,like any other complex technology,needs a strong testing methodology to support its evolution in both research and development contexts.Setting up meaningful tests for permissionless blockchain technology i...Blockchain,like any other complex technology,needs a strong testing methodology to support its evolution in both research and development contexts.Setting up meaningful tests for permissionless blockchain technology is a notoriously complex task for several reasons:software is complex,a large number of nodes are involved,the network is non-ideal,etc.Developers usually adopt small virtual laboratories or costly real devnets based on real software.Researchers usually prefer simulations of a large number of nodes based on simplified models.In this paper,we aim to obtain the advantages of both approaches,i.e.,performing large,realistic,inexpensive,and flexible experiments,using real blockchain software within a virtual environment.To do that,we address the challenge of running large blockchain networks in a single physical machine,leveraging Linux and Docker.We analyze a number of problems that arise when large blockchain networks are emulated,and we provide technical solutions for all of them.Finally,we describe two experiences of emulating fairly large blockchain networks on a single machine:adopting both research-oriented and production-oriented software and involving more than 3000 containers.展开更多
As a promising solution to efficiently achieving fiber to the home （FTTH）, Ethernet passive optical network （EPON） is currently improved to provide intercommunication among customers, together with normal traffic ...As a promising solution to efficiently achieving fiber to the home （FTTH）, Ethernet passive optical network （EPON） is currently improved to provide intercommunication among customers, together with normal traffic delivery, via optical local area network emulation. It is a new research direction and expected to enhance the normal EPON performances. The purpose of this article is to review the state-of -the-art solutions to emulating optical local area networks （OLANs） over EPON. We discuss the major problems involved, e.g., network architecture, control mechanisms, and other potential enhancements. We also outline areas for future researches.展开更多
Based on the research on the solidification of twin-roll continuous casting aluminum thin strip, the analytical model of heterogeneous nucleation, the growth kinetics of tip （KGT） and columnar dendrite transformatio...Based on the research on the solidification of twin-roll continuous casting aluminum thin strip, the analytical model of heterogeneous nucleation, the growth kinetics of tip （KGT） and columnar dendrite transformation to equiaxed dendrite （CET） of twin-roll continuous casting aluminum thin strip solidification was established by means of the principle of metal solidification and modem computer emulational technology. Meantime, based on the cellular automaton, the emulational model of twin-roll continuous casting aluminum thin strip, solidification was established. The foundation for the emulational simulation of twin-roll casting thin strip solidification structure was laid. Meanwhile, the mathematical simulation feasibility was confirmed by using the solidification process of twin-roll continuous casting aluminum thin strip.展开更多
eMule是建立在点对点(peer to peer)技术上,以eDonkey协议为基础的文件共享软件。eMule的集中程度是混合性的,并非是完全无中心服务器。文章从协议的角度论述了eMule是如何实现文件共享,分析了客户端到服务器端、客户端到客户端之间的TC...eMule是建立在点对点(peer to peer)技术上,以eDonkey协议为基础的文件共享软件。eMule的集中程度是混合性的,并非是完全无中心服务器。文章从协议的角度论述了eMule是如何实现文件共享,分析了客户端到服务器端、客户端到客户端之间的TCP通讯、UDP通讯的原理及相关的信息序列图。展开更多
Based on the theory of random process and the characteristic of the functioning of a system component subject to a certain specific probability distribution, emulated the whole process of system production on Iongwall...Based on the theory of random process and the characteristic of the functioning of a system component subject to a certain specific probability distribution, emulated the whole process of system production on Iongwall face was emulated, in which the methods of time pace and computer random emulation were adopted. The paper provides an objective basis for the analysis of a mining Iongwall face and the varied lines of effectiveness, machine stoppage rate and coal flow of components and system, and output etc.lt also offers some theories to improve productivity by discussing the application of the transformation plan and optimization of reasonable coal stock capacity, as well as selection of system equipment and matching optimization.展开更多
A dynamic marine propeller simulation system was developed, which is utilized for meeting the experimental requirement of theory research and engineering design of marine electric propulsion system. By applying an act...A dynamic marine propeller simulation system was developed, which is utilized for meeting the experimental requirement of theory research and engineering design of marine electric propulsion system. By applying an actual ship parameter and its accurate propeller J＇ -KT＇ and J＇ - Kp＇ curve data, functional experiments based on the simulation system were carried out. The experiment results showed that the system can correctly emulate the propeller characteristics, produce the dynamic and steady performances of the propeller under different navigation modes, and present actual load torque for electric propulsion motor.展开更多
文摘EMulate Therapeutics has developed a system for emulating the effects of solvated molecules via their magnetic field recordings. Recordings of magnetic field emissions of select small inhibitor RNAs (siRNAs;murine targeting CTLA-4 and murine targeting PD-1) were tested on C57Bl/6 mice implanted subcutaneously with the GL261 murine tumor cell line. A signal composed of concatenated recordings of siRNA molecules targeting the murine CTLA-4 and PD-1 receptors (labeled A2) was used in immune competent C57Bl/6 mice. The mice were flank implanted with the murine glioblastoma cell line GL261. Mice were exposed to the signal continuously (24 hours a day) until tumor volumes reached the designated volume limit. Tumors were excised and analyzed via PAGE/Western blot for the expression of CTLA-4, PD-1, Ki67, Caspase 3, CD4 and CD8. Terminal blood draws were used for CBCs. We report the down regulation of the checkpoint inhibitors CTLA-4 in the exposed mice. Significant tumor volume reduction was observed in mice exposed to the siRNA signal compared to control mice;no adverse events were recorded. Cell blood counts (CBC) and protein expression patterns were observed to correlate with the expected function of protein expression inhibition of the targets.
基金supported by project SERICS(PE00000014)under the MUR National Recovery and Resilience Plan funded by the European Union-NextGenerationEU.
文摘Blockchain,like any other complex technology,needs a strong testing methodology to support its evolution in both research and development contexts.Setting up meaningful tests for permissionless blockchain technology is a notoriously complex task for several reasons:software is complex,a large number of nodes are involved,the network is non-ideal,etc.Developers usually adopt small virtual laboratories or costly real devnets based on real software.Researchers usually prefer simulations of a large number of nodes based on simplified models.In this paper,we aim to obtain the advantages of both approaches,i.e.,performing large,realistic,inexpensive,and flexible experiments,using real blockchain software within a virtual environment.To do that,we address the challenge of running large blockchain networks in a single physical machine,leveraging Linux and Docker.We analyze a number of problems that arise when large blockchain networks are emulated,and we provide technical solutions for all of them.Finally,we describe two experiences of emulating fairly large blockchain networks on a single machine:adopting both research-oriented and production-oriented software and involving more than 3000 containers.
基金the National Science Fund for Distinguished Young Scholars(Grant No.60725104)the National Basic Research Program of China(Grant No.2007CB310706)+2 种基金the National High Technology Research and Development Program of China(Grant Nos.2007AA01Z246 and 2007AA01Z227)the National Natural Science Foundation of China(Grant No.60672045)the Research Fund for the Doctoral Program of Higher Education(Grant No.20060614018)
文摘As a promising solution to efficiently achieving fiber to the home （FTTH）, Ethernet passive optical network （EPON） is currently improved to provide intercommunication among customers, together with normal traffic delivery, via optical local area network emulation. It is a new research direction and expected to enhance the normal EPON performances. The purpose of this article is to review the state-of -the-art solutions to emulating optical local area networks （OLANs） over EPON. We discuss the major problems involved, e.g., network architecture, control mechanisms, and other potential enhancements. We also outline areas for future researches.
基金Project (u0837601) supported by the New Joint Fund of National Natural Science Foundation of ChinaProject (50874054) supported by the National Natural Science Foundation of China
文摘Based on the research on the solidification of twin-roll continuous casting aluminum thin strip, the analytical model of heterogeneous nucleation, the growth kinetics of tip （KGT） and columnar dendrite transformation to equiaxed dendrite （CET） of twin-roll continuous casting aluminum thin strip solidification was established by means of the principle of metal solidification and modem computer emulational technology. Meantime, based on the cellular automaton, the emulational model of twin-roll continuous casting aluminum thin strip, solidification was established. The foundation for the emulational simulation of twin-roll casting thin strip solidification structure was laid. Meanwhile, the mathematical simulation feasibility was confirmed by using the solidification process of twin-roll continuous casting aluminum thin strip.
文摘eMule是建立在点对点(peer to peer)技术上,以eDonkey协议为基础的文件共享软件。eMule的集中程度是混合性的,并非是完全无中心服务器。文章从协议的角度论述了eMule是如何实现文件共享,分析了客户端到服务器端、客户端到客户端之间的TCP通讯、UDP通讯的原理及相关的信息序列图。
基金Supported by the Special Topics of Major Scientific and Technological Research Projects Shanxi Province (2006031099-01)Youth Science Funds of Shanxi Province (2006021024)Science and Technology Project of Taiyuan City (07010728)
文摘Based on the theory of random process and the characteristic of the functioning of a system component subject to a certain specific probability distribution, emulated the whole process of system production on Iongwall face was emulated, in which the methods of time pace and computer random emulation were adopted. The paper provides an objective basis for the analysis of a mining Iongwall face and the varied lines of effectiveness, machine stoppage rate and coal flow of components and system, and output etc.lt also offers some theories to improve productivity by discussing the application of the transformation plan and optimization of reasonable coal stock capacity, as well as selection of system equipment and matching optimization.
基金supported by the Fund of Shanghai Committee of Science and Technology(Grant No.11170501700)the International Cooperation and Exchange Projects of the Ministry of Science and Technology(Grant No.2012DFG71850)
文摘A dynamic marine propeller simulation system was developed, which is utilized for meeting the experimental requirement of theory research and engineering design of marine electric propulsion system. By applying an actual ship parameter and its accurate propeller J＇ -KT＇ and J＇ - Kp＇ curve data, functional experiments based on the simulation system were carried out. The experiment results showed that the system can correctly emulate the propeller characteristics, produce the dynamic and steady performances of the propeller under different navigation modes, and present actual load torque for electric propulsion motor.
