Enantiomerically pure syn-4,5-dihydroxy carboxylic acid lactones were prepared by microbial reduction of acyl lactones with resting cell of Aspergillus niger.
The benzophenone-initiated photoaddition of N-methyl ammes 2 to the chiral synthon1 proceeds in a regiospecitlc and highlyr stereocontrolled thshion to give the C-C photoadductscontaining a ne\viy stereogenic center 3...The benzophenone-initiated photoaddition of N-methyl ammes 2 to the chiral synthon1 proceeds in a regiospecitlc and highlyr stereocontrolled thshion to give the C-C photoadductscontaining a ne\viy stereogenic center 3a-3c. The enantiomerically pure N-C photoadducts, aminobutenolides 5a-5c have been obtained from the enantioselective photoaddition of secondary cyclicammes 4 with the chiral synthon 1 under the same conditions.展开更多
A series of novel enantiomerically pure diols were synthesized from D-erythorbic acid in three steps, and the absolute configuration of one of them 4a has been confirmed by X-ray analysis.
In this paper, stereocontrolled tandem Michael addition-elimination reaction of the novel chiral source, S-(ι-menthyloxy)-3,4-dichloro-2(5H)-furanone, with various thiols and amines has been investigated. A series of...In this paper, stereocontrolled tandem Michael addition-elimination reaction of the novel chiral source, S-(ι-menthyloxy)-3,4-dichloro-2(5H)-furanone, with various thiols and amines has been investigated. A series of new enantiomerically pure compounds, 5-(ι-menthyloxy)-4-substituted-3-cnloro-2(5H)-furanones, were obtained in good yields with d. e.(?)98% under mild conditions.展开更多
文摘Enantiomerically pure syn-4,5-dihydroxy carboxylic acid lactones were prepared by microbial reduction of acyl lactones with resting cell of Aspergillus niger.
文摘The benzophenone-initiated photoaddition of N-methyl ammes 2 to the chiral synthon1 proceeds in a regiospecitlc and highlyr stereocontrolled thshion to give the C-C photoadductscontaining a ne\viy stereogenic center 3a-3c. The enantiomerically pure N-C photoadducts, aminobutenolides 5a-5c have been obtained from the enantioselective photoaddition of secondary cyclicammes 4 with the chiral synthon 1 under the same conditions.
基金the National Natural Science Foundation of China for the project support (No. 29972021 )
文摘A series of novel enantiomerically pure diols were synthesized from D-erythorbic acid in three steps, and the absolute configuration of one of them 4a has been confirmed by X-ray analysis.
基金Project (No. 29132036) supported by the National Natural Science Foundation of China
文摘In this paper, stereocontrolled tandem Michael addition-elimination reaction of the novel chiral source, S-(ι-menthyloxy)-3,4-dichloro-2(5H)-furanone, with various thiols and amines has been investigated. A series of new enantiomerically pure compounds, 5-(ι-menthyloxy)-4-substituted-3-cnloro-2(5H)-furanones, were obtained in good yields with d. e.(?)98% under mild conditions.
