A new series of 1,3,2-oxazaborolidine catalysts substituted in position 4 by the (CH3)(3)C(CH2)(n) group (n=2, 3, 4, 5) were synthesized and applied to the borane reduction of prochiral ketones. The relationship betwe...A new series of 1,3,2-oxazaborolidine catalysts substituted in position 4 by the (CH3)(3)C(CH2)(n) group (n=2, 3, 4, 5) were synthesized and applied to the borane reduction of prochiral ketones. The relationship between catalyst structure and enantioselectivity was discussed.展开更多
An asymmetric borane reduction of prochiral ketones catalyzed by simple amino alcohols and corresponding amino acids was examined to give alcohols with e.e. value up to 92% .
基金Project supported by the National Natural Science Foundation of China and the Natural Science Foundation of Jiangsu Education Commission of China
文摘A new series of 1,3,2-oxazaborolidine catalysts substituted in position 4 by the (CH3)(3)C(CH2)(n) group (n=2, 3, 4, 5) were synthesized and applied to the borane reduction of prochiral ketones. The relationship between catalyst structure and enantioselectivity was discussed.
文摘An asymmetric borane reduction of prochiral ketones catalyzed by simple amino alcohols and corresponding amino acids was examined to give alcohols with e.e. value up to 92% .
