Human longevity has increased dramatically during the past century.More than 20%of the 9 billion population of the world will exceed the age of 60 in 2050.Since the last three decades,some interventions and many precl...Human longevity has increased dramatically during the past century.More than 20%of the 9 billion population of the world will exceed the age of 60 in 2050.Since the last three decades,some interventions and many preclinical studies have been found to show slowing aging and increasing the healthy lifespan of organisms from yeast,flies,rodents to nonhuman primates.The interventions are classified into two groups:lifestyle modifications and pharmacological/genetic manipulations.Some genetic pathways have been characterized to have a specific role in controlling aging and lifespan.Thus,all genes in the pathways are potential antiaging targets.Currently,many antiaging compounds target the calorie-restriction mimetic,autophagy induction,and putative enhancement of cell regeneration,epige-netic modulation of gene activity such as inhibition of histone deacetylases and DNA methyltransferases,are under development.It appears evident that the exploration of new targets for these antiaging agents based on biogeron-tological research provides an incredible opportunity for the healthcare and pharmaceutical industries.The present review focus on the properties of slow aging and healthy life span extension of natural products from various biologi-cal resources,endogenous substances,drugs,and synthetic compounds,as well as the mechanisms of targets for antiaging evaluation.These bioactive compounds that could benefit healthy aging and the potential role of life span extension are discussed.展开更多
There are increasing evidences for the presence of an endogenous digitalis-like substance (EDLS) which interacts with the digitalis receptor and acts against the digoxin serum response in human body. The plasma EDLS l...There are increasing evidences for the presence of an endogenous digitalis-like substance (EDLS) which interacts with the digitalis receptor and acts against the digoxin serum response in human body. The plasma EDLS level increases in response to fluid or salt loading. EDLS may play a role in salt and blood pressure regulation. Being considered as a volume-expanding state, pregnancy may cause an increase in maternal EDLS. However, further studies to identify the origin of EDLS in normal pregnancy are needed.展开更多
基金funding from the National Natural Science Foundation of China (Grant numbers 21961142008,22177138).
文摘Human longevity has increased dramatically during the past century.More than 20%of the 9 billion population of the world will exceed the age of 60 in 2050.Since the last three decades,some interventions and many preclinical studies have been found to show slowing aging and increasing the healthy lifespan of organisms from yeast,flies,rodents to nonhuman primates.The interventions are classified into two groups:lifestyle modifications and pharmacological/genetic manipulations.Some genetic pathways have been characterized to have a specific role in controlling aging and lifespan.Thus,all genes in the pathways are potential antiaging targets.Currently,many antiaging compounds target the calorie-restriction mimetic,autophagy induction,and putative enhancement of cell regeneration,epige-netic modulation of gene activity such as inhibition of histone deacetylases and DNA methyltransferases,are under development.It appears evident that the exploration of new targets for these antiaging agents based on biogeron-tological research provides an incredible opportunity for the healthcare and pharmaceutical industries.The present review focus on the properties of slow aging and healthy life span extension of natural products from various biologi-cal resources,endogenous substances,drugs,and synthetic compounds,as well as the mechanisms of targets for antiaging evaluation.These bioactive compounds that could benefit healthy aging and the potential role of life span extension are discussed.
文摘There are increasing evidences for the presence of an endogenous digitalis-like substance (EDLS) which interacts with the digitalis receptor and acts against the digoxin serum response in human body. The plasma EDLS level increases in response to fluid or salt loading. EDLS may play a role in salt and blood pressure regulation. Being considered as a volume-expanding state, pregnancy may cause an increase in maternal EDLS. However, further studies to identify the origin of EDLS in normal pregnancy are needed.
