Objective -To determine the distribution of endothelin-converting enzyme (ECE) in different parts of the heart of adult normal Chinese and Sprague-Dawley (SD-) rat. Methods-The ECE mRNA was determined by semi-quantita...Objective -To determine the distribution of endothelin-converting enzyme (ECE) in different parts of the heart of adult normal Chinese and Sprague-Dawley (SD-) rat. Methods-The ECE mRNA was determined by semi-quantitative reverse transcription-polymer ase chain reaction. ECE activity was determined by the conversion of exogenously added big endothelin-1 to endothelin-1. Results : The ECE mRNA and activity were detected in different parts of the heart. In human, the ECE expression in atria was significantly higher than those in ventricles. No significant difference was observed between left and right atrium, and among the left ventricle, right ventricle and interventricular septum. The distribution of ECE activity was consistent with that of mRNA expression. The rat had a similar pattern of distribution of either ECE mRNA expression or activity with that of human. Conclusion :ECE exists in all parts of the heart of normal Chinese and SD rat and its distribution is similar in human and rat hearts.展开更多
Since the worldwide outbreak of coronavirus disease 2019,angiotensin-converting enzyme 2(ACE2)has received widespread attention as the cell receptor of the severe acute respiratory syndrome coronavirus 2 virus.At the ...Since the worldwide outbreak of coronavirus disease 2019,angiotensin-converting enzyme 2(ACE2)has received widespread attention as the cell receptor of the severe acute respiratory syndrome coronavirus 2 virus.At the same time,as a key enzyme in the renin-angiotensin-system,ACE2 is considered to be an endogenous negative regulator of vasoconstriction,proliferation,fibrosis,and proinflammation caused by the ACE-angiotensin II-angiotensin type 1 receptor axis.ACE2 is now implicated as being closely connected to diabetes,cardiovascular,kidney,and lung diseases,and so on.This review covers the available information on the host factors regulating ACE2 and discusses its role in a variety of pathophysiological conditions in animal models and humans.展开更多
The coronavirus disease 2019(COVID-19), which is caused by SARS-CoV-2, has become a worldwide public health crisis. Published clinical data from China and other countries have shown a much higher risk of developing CO...The coronavirus disease 2019(COVID-19), which is caused by SARS-CoV-2, has become a worldwide public health crisis. Published clinical data from China and other countries have shown a much higher risk of developing COVID-19 and dying from the disease among the elderly, especially among those who had preexisting hypertension, cardiovascular diseases(CVD) and diabetes mellitus[1].展开更多
The current coronavirus disease 2019(COVID-19) pandemic has had devastating impact on populations around the world.The high mortality rates in patients with COVID-19 has been attributed to the influence of severe acut...The current coronavirus disease 2019(COVID-19) pandemic has had devastating impact on populations around the world.The high mortality rates in patients with COVID-19 has been attributed to the influence of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),its causative viral agent,on several physiological systems in human body,including the respiratory,cardiovascular,and neurological systems.There is emerging evidence on propensity of this virus to attack cardiovascular system.However,various pathophysiological mechanisms by which SARS-CoV-2 interacts with cardiovascular system and leads to high morbidity and mortality,including cardiovascular complications,are poorly understood.This mini review aims to provide an update on the current knowledge and perspectives on areas of future research.展开更多
This paper examines the bidirectional relationship between heart failure (HF) and cognitive impairment, underscoring the need for integrated intervention strategies to address these interconnected conditions effective...This paper examines the bidirectional relationship between heart failure (HF) and cognitive impairment, underscoring the need for integrated intervention strategies to address these interconnected conditions effectively. Cognitive deficits often hinder the effective management of HF, leading to poorer treatment adherence and health outcomes, while the physiological stress of HF can further impair cognitive function, creating a complex interplay that complicates patient care. This study highlights the effectiveness of angiotensin-converting enzyme (ACE) inhibitors and cardiac resynchronization therapy (CRT) in improving both cardiac and cognitive functions. By targeting the underlying physiological and neurobiological mechanisms of HF, these therapies enhance patient outcomes, leading to better adherence to treatment regimens and overall quality of life. Furthermore, the findings suggest that regular cognitive assessments should be integrated into HF management protocols, enabling early identification of cognitive impairment and timely intervention. Incorporating ACE inhibitors and CRT into standard care practices not only addresses the complexities of managing HF and cognitive decline but also fosters a holistic approach to patient health. Ultimately, this multifaceted strategy has the potential to significantly improve health outcomes, enhance the quality of care, and support sustainable management of patients with heart failure and cognitive impairment.展开更多
基金Supported by grant from the National Science Foundation of Jiangsu Province(BK 99141-2)
文摘Objective -To determine the distribution of endothelin-converting enzyme (ECE) in different parts of the heart of adult normal Chinese and Sprague-Dawley (SD-) rat. Methods-The ECE mRNA was determined by semi-quantitative reverse transcription-polymer ase chain reaction. ECE activity was determined by the conversion of exogenously added big endothelin-1 to endothelin-1. Results : The ECE mRNA and activity were detected in different parts of the heart. In human, the ECE expression in atria was significantly higher than those in ventricles. No significant difference was observed between left and right atrium, and among the left ventricle, right ventricle and interventricular septum. The distribution of ECE activity was consistent with that of mRNA expression. The rat had a similar pattern of distribution of either ECE mRNA expression or activity with that of human. Conclusion :ECE exists in all parts of the heart of normal Chinese and SD rat and its distribution is similar in human and rat hearts.
基金National Natural Science Foundation of China,No.81873861and Key Grant of Research and Development in Hunan Province,No.2020DK2002.
文摘Since the worldwide outbreak of coronavirus disease 2019,angiotensin-converting enzyme 2(ACE2)has received widespread attention as the cell receptor of the severe acute respiratory syndrome coronavirus 2 virus.At the same time,as a key enzyme in the renin-angiotensin-system,ACE2 is considered to be an endogenous negative regulator of vasoconstriction,proliferation,fibrosis,and proinflammation caused by the ACE-angiotensin II-angiotensin type 1 receptor axis.ACE2 is now implicated as being closely connected to diabetes,cardiovascular,kidney,and lung diseases,and so on.This review covers the available information on the host factors regulating ACE2 and discusses its role in a variety of pathophysiological conditions in animal models and humans.
文摘The coronavirus disease 2019(COVID-19), which is caused by SARS-CoV-2, has become a worldwide public health crisis. Published clinical data from China and other countries have shown a much higher risk of developing COVID-19 and dying from the disease among the elderly, especially among those who had preexisting hypertension, cardiovascular diseases(CVD) and diabetes mellitus[1].
文摘The current coronavirus disease 2019(COVID-19) pandemic has had devastating impact on populations around the world.The high mortality rates in patients with COVID-19 has been attributed to the influence of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),its causative viral agent,on several physiological systems in human body,including the respiratory,cardiovascular,and neurological systems.There is emerging evidence on propensity of this virus to attack cardiovascular system.However,various pathophysiological mechanisms by which SARS-CoV-2 interacts with cardiovascular system and leads to high morbidity and mortality,including cardiovascular complications,are poorly understood.This mini review aims to provide an update on the current knowledge and perspectives on areas of future research.
文摘This paper examines the bidirectional relationship between heart failure (HF) and cognitive impairment, underscoring the need for integrated intervention strategies to address these interconnected conditions effectively. Cognitive deficits often hinder the effective management of HF, leading to poorer treatment adherence and health outcomes, while the physiological stress of HF can further impair cognitive function, creating a complex interplay that complicates patient care. This study highlights the effectiveness of angiotensin-converting enzyme (ACE) inhibitors and cardiac resynchronization therapy (CRT) in improving both cardiac and cognitive functions. By targeting the underlying physiological and neurobiological mechanisms of HF, these therapies enhance patient outcomes, leading to better adherence to treatment regimens and overall quality of life. Furthermore, the findings suggest that regular cognitive assessments should be integrated into HF management protocols, enabling early identification of cognitive impairment and timely intervention. Incorporating ACE inhibitors and CRT into standard care practices not only addresses the complexities of managing HF and cognitive decline but also fosters a holistic approach to patient health. Ultimately, this multifaceted strategy has the potential to significantly improve health outcomes, enhance the quality of care, and support sustainable management of patients with heart failure and cognitive impairment.
