"Five steps four quadrants" modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in laparoscopic pancreaticoduodenectomy

BACKGROUND Although en bloc dissection of hepatic hilum lymph nodes has many advantages in radical tumor treatment,the feasibility and safety of this approach for laparo-scopic pancreaticoduodenectomy(LPD)require further clinical evaluation and investigation.AIM To explore the application value of the"five steps four quadrants"modularized en bloc dissection technique for accessing hepatic hilum lymph nodes in LPD patients.METHODS A total of 52 patients who underwent LPD via the"five steps four quadrants"modularized en bloc dissection technique for hepatic hilum lymph nodes from April 2021 to July 2023 in our department were analyzed retrospectively.The patients'body mass index(BMI),preoperative laboratory indices,intraoperative variables and postoperative complications were recorded.The relationships between preoperative data and intraoperative lymph node dissection time and blood loss were also analyzed.RESULTS Among the 52 patients,36 were males and 16 were females,and the average age was 62.2±11.0 years.There were 26 patients with pancreatic head cancer,16 patients with periampullary cancer,and 10 patients with distal bile duct cancer.The BMI was 22.3±3.3 kg/m²,and the median total bilirubin(TBIL)concentration was 57.7(16.0-155.7)µmol/L.All patients successfully underwent the"five steps four quadrants"modularized en bloc dissection technique without lymph node clearance-related complications such as postoperative bleeding or lymphatic leakage.Correlation analysis revealed significant associations between preoperative BMI(r=0.3581,P=0.0091),TBIL level(r=0.2988,P=0.0341),prothrombin time(r=0.3018,P=0.0297)and lymph node dissection time.Moreover,dissection time was significantly correlated with intraoperative blood loss(r=0.7744,P<0.0001).Further stratified analysis demonstrated that patients with a preoperative BMI≥21.9 kg/m²and a TIBL concentration≥57.7μmol/L had significantly longer lymph node dissection times(both P<0.05).CONCLUSION The"five steps four quadrants"modularized en bloc dissection technique for accessing the hepatic hilum lymph node is safe and feasible for LPD.This technique is expected to improve the efficiency of hepatic hilum lymph node dissection and shorten the learning curve;thus,it is worthy of further clinical promotion and application.

Stoichiometry and Stability Constant Values for Copper (II) Chelates with Ethylene Diamine in Deep Eutectic Solvents (DES) (Ethaline) Solutions

In this study we used the deep eutectic solvents (ionic liquids) to investigate the reaction between copper (II) with ethylene diamine (en). Two of the existing methods for analyzing spectrophotometric measurements have been applied for establishing, the stoichiometry and whenever possible, the stability constants of the chelates formed. The method of continuous variations was necessary to determine first whether, the metal ion and the ligand ethylene diamine form one or more than one chelate, when more than one chelate formed, the results obtained depend on the wavelength and for meaningful conclusions the wavelengths were carefully selected. The empirical formulae of the chelates were further substantiated by the molar ratio method. The effect of time and temperature on the formation and stability of these chelates in solution is also studied. The stability constants, K1 and K2 for the copper (II) chelates were calculated, though reliable, and are comparable to literature values.

Prolene线在胆总管空肠Roux-en-Y吻合术的临床研究

目的:比较Prolene线连续全层缝合与丝线间断全层外翻缝合两种手术方式在胆总管空肠Roux-en-Y吻合术中的优缺点。方法:65例需行胆总管空肠Roux-En-Y吻合术的患者随机分为两组。观察组:30例,行Prolene线连续全层缝合;对照组:35例,行丝线间断全层外翻缝合。比较两组间吻合时间、术后感染发生率、吻合口狭窄发生率、胆漏发生率、吻合口出血发生率。结果:观察组的吻合时间、术后感染发生率、吻合口狭窄发生率、胆漏发生率、吻合口出血发生率均著低于对照组(P<O.05)。结论:Prolene线在胆总管空肠Roux-en-Y吻合术中连续全层缝合,操作简单易行,手术时间短,效果良好,且安全可靠,是一种理想的缝合材料和缝合方法。

Integration and development of energy and information network in the Pan-Arctic region

The Global Energy Interconnection is an important strategic approach used to achieve efficient worldwide energy allocation.The idea of developing integrated power,information,and transportation networks provides increased power interconnection functionality and meaning,helps condense forces,and accelerates the integration of global infrastructure.Correspondingly,it is envisaged that it will become the trend of industrial technological development in the future.In consideration of the current trend of integrated development,this study evaluates a possible plan of coordinated development of fiber-optic and power networks in the Pan-Arctic region.Firstly,the backbone network architecture of Global Energy Interconnection is introduced and the importance of the Arctic energy backbone network is confirmed.The energy consumption and developmental trend of global data centers are then analyzed.Subsequently,the global network traffic is predicted and analyzed by means of a polynomial regression model.Finally,in combination with the current construction of fiber-optic networks in the Pan-Arctic region,the advantages of the integration of the fiber-optic and power networks in this region are clarified in justification of the decision for the development of a Global Energy Interconnection scheme.

烯烃与单重态氧的“ene”反应

本文以数学研究为基础，系统研究综述有机物光氧化反应的重要基础理论─烯烃与单重态氧（１△ｇ态１Ｏ２）的“ｅｎｅ”反应，论述它的典型反应、反应特性、反应机理及其在有机合成上的应用。

铜络合物手性催化羰基ene反应的密度泛函研究

应用密度泛函理论在M06/6-31G(d,p)(对铜应用LANL2DZ(f)基组)水平下细研究了手性噁唑啉铜(Ⅱ)催化二酮酯与烯烃的不对称羰基ene反应。该反应有四条可能反应通道,主要经历了噁唑啉铜(Ⅱ)与二酮酯配位生成络合物m1,络合物m2a1、m2a2、m2b1、m2b2,噁唑啉铜-α-羟基-β-酮酯络合物m3a、m3b。烯烃进攻噁唑啉铜-二酮酯络合物m1是手性噁唑啉铜(Ⅱ)催化二酮酯与烯烃的不对称羰基ene反应的速率决定步骤,也是该反应的手性决定步骤。因此该反应的主要反应通道为:m1→TS_(m1-m2a1)→m2a1→TS_(m2a1-m3a)→m3a,主要产物为(S)-α-羟基-β-酮酯,这与M.P.Doyle课题组的实验研究一致。

MODIFICATION OF WOLINSKY'S ENE-CHLORINATION

Ene-chtorination of the otefins bearing isopropenyl moieties has been achieved in good yieid by using catcium hypochiorite and sodium biphosphate. An efficient synthesis of San Jose ScaLe's sex pheromone is described.

Lewis酸催化Glyoxylate-Ene反应合成α-羟基酯的研究

研究比较了几种Lewis酸对α-甲基苯乙烯和乙醛酸乙酯反应合成α-羟基-4-苯基-4-戊烯酸乙酯(EHPP)的催化性能,其中SnCl4的催化活性最高。在n(α-甲基苯乙烯)∶n(乙醛酸乙酯)∶n(SnCl4)=1∶1∶0.03,反应温度20℃,反应时间90 min的条件下,α-甲基苯乙烯的转化率为98.6%,EHPP的选择性和收率分别达到95.6%和94.3%。同时研究了其他烯烃和乙醛酸酯合成α-羟基酯的反应,结果表明SnCl4也具有较高的催化活性。

Distribution of Welding Residual Stress of Mixed Steel U-Rib-Stiffened Plates

To analyze the effects of width and thickness of each composition element of mixed steel U-rib-stiffened plates on the welding residual stress distribution, the distribution of the U-rib and the plate residual stress was calculated using a simplified calculation method. The method involved welding the mixed steel U-rib-stiffened plates for a structure with different sizes and different strength ratios of U-rib to plate. Based on a welding residual stress numerical simulation method validated by the blind hole method test, the distribution law of the mixed steel U-rib stiffened plate was studied. The results showed that the change of plate width has little impact on the welding residual stress and that the ratio of the thicknesses of the plate to U-rib stiffeners, the thickness of the plate, and the thickness of the U-rib has a great influence on the distribution of the welding residual stress. The thickness of plate and steel strength also greatly influenced the distribution width of the residual tensile stress. While analyzing the compression capacity of U-rib-stiffened plates, the simplified distribution of welding residual stress was used.

Temperature-Dependent Far-Infrared Absorption in Cyclotrimethylene Trinitramine Single Crystals Using Broadband Time-Domain Terahertz Spectroscopy

We investigate the absorption properties of cyclotrimethylene trinitramine(RDX) single crystals from ~15 to150 cm^(-1) using the terahertz time-domain spectroscopy. We observe that all the absorption modes exhibit strong anisotropic behavior in terms of the crystal orientations. We demonstrate that the anharmonic phonon model can well describe the temperature-dependent behaviors of these absorption modes. These results indicate that the intermolecular interaction plays a major role in the collective motion of large number of RDX molecules. Our findings provide important information for understanding and controlling the dynamic properties in the explosive materials.

Synergistic Catalytic Action of Cobalt(Ⅱ) Hydroxamates and N-Hydroxyphthalimide in the Aerobic Oxidation of p-Xylene

The catalytic performance of a series of cobalt(Ⅱ) hydroxamates (CoL2) and the synergistic catalytic action of the cobalt complexes combined with N-hydroxyphthalimide (NHPI) in the aerobic oxidation of p-xylene to p-toluic acid (PTA) were investigated. The results showed that the existing synergistic action in the catalytic oxidation can shorten the induction period of the radical reaction and improve the yield of PTA.

DeviceNet标准与CANopen标准的比较

我国于2002年10月份正式发布了《低压开关设备和控制设备控制器－设备接口（CDI）第三部分DeviceNet》（GB／T 18858．3）作为国家标准，并于2003年4月正式实施。此DeviceNet协议为我国CAN总线领域唯一的国家标准，在工业生产和科技创新方面发挥了重要作用。但是近年来另一种流行的CAN总线协议－CANopen（EN 50325—4）也在国内的实践应用中被广泛采用。

Thermodynamics of solubility of Cu_2(OH)_2CO_3 in ammonia-ammonium chloride-ethylenediamine(En)-water system

In order to decrease the evaporating rate of ammonia and increase the solubility of copper in the solution,ethylenediamine was added into the ammonia-ammonium chloride system to leach the copper-containing oxide ores.The thermodynamic model was constructed and the solubility of malachite Cu2(OH)2CO3 in the ammonia-ammonium chloride-ethylenediamine(En)-water system was calculated using the exponential computation method based on both mass balance and charge balance.It is found that the solubility of copper can be increased and the free ammonia concentration can be decreased by submitting partial ammonia with ethylenediamine.The lower free ammonia concentration in the solution is a guarantee to the lower evaporating rate of ammonia.The conditions of malachite Cu2(OH)2CO3 converting to atacamite Cu(OH)1.5Cl0.5 were also studied.A group of experiments were designed to validate the veracity of the results of the thermodynamic calculation.It is found that the thermodynamic model is reliable and it can guide the leaching process.

A FRACTAL MODEL AND ENERGY DISSIPATION FOR EN ECHELON FRACTURES

observations from the field and the taboratory show that en echelon fractures withinfracture zones have a foede1 within Ricdel structure’ The tensile fallure mecbanism of en echelonfractures can be described by the pile-ups of sbear crack-dislocations. A fractal model can be used tosimulate the Riedel within Xiedel geometry, allowing the direct rneasarement of tbe ftactal dimen sions of en echelon fractare systems. The energy dissipation of tbe en ccbe1on fracture system canbe deduced using a fracil damage evo1ution model which exptalns tbe evo1ution process of en eche lon fracture svstems. The fractal nature of the fractures can be used to dcrive an accurate estimateof total energy dissipation.

The Synthesis and Structure of Adduct of a New Schiff Base Macrocycle with Two THF: THIONE_2B_4[36]ENE-O_6N_8·2THF

New Schiff base Macrocyclic compound of 2,3: 11, 12:20, 21:29, 30-tetrabenzo-1,13,16,19,31,34-hexaoxa-5,6,8,9,23,24,26,27-octaaza-7,25-dithione-2,3:4,5:9,10:11,12:22, 23:27,28:29,30 cyclo-[36]ene (thione2B4[36] ene-O6N8) containing THF has been prepared. It crystallizes in the monoclinic, space group P21/n. with parameters a=9.829(5) b=24.23(1), c=10.181(9), β=92.93(5)°, Z=2, V=2422(3)3, Dc=1.25gcm-3. Data collection: Rigaku AFC-5R diffractometer,(MoKα, λ=0.71069), ω /2θ scans. θmax=25°, empirical absorption correction, 4658 measured reflections, 4387 independent, 1743 observed reflections [I≥3σ(I)]. The final R=0.056. RW=0.069,S=1 .54, (Δ/σ)max=0.01,Δρmax=0.36e-3.

手性双氮氧－镍络合物催化的高效高选择性不对称carbonyl-ene反应

具有光学活性的高烯丙醇是天然产物和药物合成中的重要有机中间体．催化不对称carbonyl-ene反应作为合成该类化合物重要方法之一，多年来一直被有机化学家们关注和研究．四川大学化学学院冯小明等基于其课题组特色的手性双氮氧化合物，将其与过渡金属镍形成络合物催化剂后，用于催化不对称carbonyl-ene反应．

LEWIS ACID PROMOTFED ASYMMETRIC ENE－REACTION OF（－）－MENTHYL GLYOXYLATE WITH HOMOALLYL SILYL ETHER

The reaction of (-)-menthyl gloxylate 2 with homoallyl silyl ether 3 under I ewis acid conditions gave optically active one-reaction product 4 with de in a range of 20-45°and 4-chloro-2-hydroxy carboxylate 5 The effect of suloxy group and Lewis acid on the regio- and stereochemistry and distribution of 4 and 5 in the mixture of the product product was examined.

Synergic effect of sex pheromone(7R,8S)-cis-7,8-epoxy-2-methyloctadec-17-ene on(+)-disparlure of the Asian gypsy moth,Lymantria dispar, in Korea

field attraction test of (7R,8S)-cis-7,8-epoxy-2- methyloctadec-17-ene (= 7R,8S-epo-2me-17ene-18Hy), a trace component of the sex pheromone gland of the Asian gypsy moth,(Lymantria dispar), traps that were baited with the trace component attracted more L. dispar than traps baited with (7S,8R)-cis-7,8-epoxy-2-methyloctadec-17-ene (= 7S,8R-epo-2me-17ene-18Hy) and unbaited traps. However, traps baited with 7R,8S-epo-2me-17ene-18Hy were less attractive than traps baited with (+)-disparlure [=(7R,8S)-cis-7,8-epoxy-2-methyloctadecane], the sex pheromone of L. dispar. Combination tests with (?)-disparlure, 7R,8S-epo-2me-17ene-18Hy, and 7S,8R-epo-2me- 17ene-18Hy revealed that 7R,8S-epo-2me-17ene-18Hy acted synergistically with (?)-disparlure.

Dual loop(Roux en Y) reconstruction with isolated gastric limb reduces delayed gastric emptying after pancreatico-duodenectomy

BACKGROUND Single loop reconstruction(SLR) was routine in our institution for patients undergoing pancreatico-duodenectomy(PD). Roux-en Y reconstruction with an isolated gastric limb(RIGL) recently became the reconstruction of choice.AIM To evaluate the impact of RIGL on incidence and severity of delayed gastric emptying(DGE).METHODS This is a single institution, retrospective analysis of patients undergoing PD. All patients undergoing PD from July 2010 through December 2016 were included in the study. Outcome of RIGL were compared to SLR. Primary measure of outcome included incidence and severity of DGE. Secondary measures of outcome were overall complications and postoperative mortality.RESULTS One hundred and seventy-nine patients were included in the study. Fifty-two had RIGL, 127 had SLR. Overall complication rate was 40.2%, patients in the RIGL group experienced lower rates of DGE(15.4% vs 59.1%, P = 0.001). Other patient related outcomes were also significantly reduced: day of nasogastric tube removal(3 vs 5, P < 0.001), regain of normal diet(8 vs 9, P < 0.001). On multivariate analysis RIGL was associated independently with reduced rates of DGE(P < 0.001, OR 0.14)CONCLUSION The current study shows that RIGL reduces the rate of DGE after PD. Further prospective randomized controlled trials are required to affirm the current data.

Construction of Controllable Expression Vector of Mus musculus Growth Hormone (GH) shRNA and Its Gene Si- lencing Efficiency Detection

Growth hormone （GH） is a polypeptide hormone secreted by the pituitary, which promotes animal growth, muscle development, metabolism regulation and other important physiological functions. In this study, a pair of mGH short hairpin RNA （shRNA） was designed according to mouse （ Mus musculus） GH mRNA sequence; pSingle-tTS-mGH shRNA-RFP, an integrated controllable expression vector of mGH shRNA, was constructed successfully. The recombinant vector was transfected into mouse pituitary tumor cell line AtT-20. After addition of doxycyelin （ DOX）, the expression of red fluorescent protein （RFP） was observed un- der a fluorescent microscope. The expression level of mGH in cells was detected by quantitative Realtime PCR （qRT-PCR） and Western blot. After DOX induction, the relative expression level of GH mRNA in cells transfected with GH shRNA was reduced by about 70% compared with that in DOX-free group and other control groups, exhibiting extremely significant differences （P 〈 0.01 ） ; moreover, the relative expression level of GH protein was reduced by about 90% ; the expression level of GH mRNA and GH protein exhibited no significant difference among other groups （P 〉 0.05）. In this study, a controllable expression vector of GH shRNA with high gene silencing efficiency was constructed successfully, which could be used to reveal GH autocfine / paracrine interactions and analyze functions of GH gene in growth, development and disease occurrence of animals by regulating GH expression levels.