Mechanical force between cells relates to many biological processes of cell development.The cellular collective migration comes from cell-cell cooperation,and studying the intercellular mechanical properties helps elu...Mechanical force between cells relates to many biological processes of cell development.The cellular collective migration comes from cell-cell cooperation,and studying the intercellular mechanical properties helps elucidate collective cell migration.Herein,we studied cell-cell junctions,intercellular tensile force and the related cellular energetic costs in confined microchannels.Using the intercellular force sensor,we found that cells adapt to different confinement environments by regulating intercellular force,and thereby the relationship between collective cell migration and cell-cell junction were verified.Through the observation of cell orientation,actomyosin contractility,energetic costs,and glucose uptake,we can make a reasonable explanation of cell-force driven migration in different confined environments.Under highly confined conditions,the intercellular force and energetic costs are greater,and the cell orientation is more orderly.The collective migration behavior in confined spaces is closely related to the intercellular force and energetic costs,which is helpful to understand the collective migration behaviors in various confined spaces.展开更多
A shortcut to the adiabatic process is an effective method for quantum information processing.The fast and robust quantum information transfer can be implemented by this method.The energetic cost is an important measu...A shortcut to the adiabatic process is an effective method for quantum information processing.The fast and robust quantum information transfer can be implemented by this method.The energetic cost is an important measurement for the shortcut.In this paper,we investigate how to inhibit the energetic cost in stimulated Raman shortcut-to-adiabatic passage in a three-level system.The energetic cost can be manipulated by adjusting detuning of the system and the energetic cost takes the minimum with one-photon resonance condition.展开更多
基金supported by the National Natural Science Foundation of China(No.22034003)Excellent Research Program of Nanjing University(No.ZYJH004)+2 种基金Fundamental Research Funds for the Central Universities(No.020514380181)State Key Laboratory of Analytical Chemistry for Life Science(No.5431ZZXM2002)Program B for Outstanding PhD candidate of Nanjing University(No.201702B052)。
文摘Mechanical force between cells relates to many biological processes of cell development.The cellular collective migration comes from cell-cell cooperation,and studying the intercellular mechanical properties helps elucidate collective cell migration.Herein,we studied cell-cell junctions,intercellular tensile force and the related cellular energetic costs in confined microchannels.Using the intercellular force sensor,we found that cells adapt to different confinement environments by regulating intercellular force,and thereby the relationship between collective cell migration and cell-cell junction were verified.Through the observation of cell orientation,actomyosin contractility,energetic costs,and glucose uptake,we can make a reasonable explanation of cell-force driven migration in different confined environments.Under highly confined conditions,the intercellular force and energetic costs are greater,and the cell orientation is more orderly.The collective migration behavior in confined spaces is closely related to the intercellular force and energetic costs,which is helpful to understand the collective migration behaviors in various confined spaces.
基金This work was supported by the National Natural Science Foundation of China under Grant No.11505024the Natural Science Foundation of Liaoning Province under Grant No.20180550944.
文摘A shortcut to the adiabatic process is an effective method for quantum information processing.The fast and robust quantum information transfer can be implemented by this method.The energetic cost is an important measurement for the shortcut.In this paper,we investigate how to inhibit the energetic cost in stimulated Raman shortcut-to-adiabatic passage in a three-level system.The energetic cost can be manipulated by adjusting detuning of the system and the energetic cost takes the minimum with one-photon resonance condition.
