One new cleistanthane-type diterpene named engleromycenolic acid A(1),one new rosane-type diterpene named engleromycenolic acid B(2)and one new natural rosane-type diterpene,engleromycenol(3),along with three known ro...One new cleistanthane-type diterpene named engleromycenolic acid A(1),one new rosane-type diterpene named engleromycenolic acid B(2)and one new natural rosane-type diterpene,engleromycenol(3),along with three known rosanetype diterpenes,rosololactone(4),rosenonolactone(5)and 7-deoxyrosenonolactone(6)were isolated from cultures of the fungus Engleromyces goetzii,where it naturally grows on Alpine bamboo culms.The new compounds were elucidated based on their spectroscopic data.In addition,compounds 1–6 were evaluated for their cholesterol ester transfer protein(CETP)inhibition activity.This paper reports the isolation,structural elucidation,and CETP inhibition activity of these compounds.展开更多
基金the National Science&Technology Pillar Program of China(2012BAD23B0305 and 2013BAI11B02)the National Natural Sciences Foundation of China(U1132607,21302194).
文摘One new cleistanthane-type diterpene named engleromycenolic acid A(1),one new rosane-type diterpene named engleromycenolic acid B(2)and one new natural rosane-type diterpene,engleromycenol(3),along with three known rosanetype diterpenes,rosololactone(4),rosenonolactone(5)and 7-deoxyrosenonolactone(6)were isolated from cultures of the fungus Engleromyces goetzii,where it naturally grows on Alpine bamboo culms.The new compounds were elucidated based on their spectroscopic data.In addition,compounds 1–6 were evaluated for their cholesterol ester transfer protein(CETP)inhibition activity.This paper reports the isolation,structural elucidation,and CETP inhibition activity of these compounds.
