In 2003,two newguidelines for hyperten—sive prevention andmanagement have beenprovided by AmericanJNC7 and European So-ciety of Hypertension.They advocated that thephysician should choosedrugs following individ—uali...In 2003,two newguidelines for hyperten—sive prevention andmanagement have beenprovided by AmericanJNC7 and European So-ciety of Hypertension.They advocated that thephysician should choosedrugs following individ—ualized treatment,展开更多
The particle characterization from the influent and effluent of a chemical-biological flocculation （CBF） process was studied with a laser diffraction device. Water samples from a chemically enhanced primary treatme...The particle characterization from the influent and effluent of a chemical-biological flocculation （CBF） process was studied with a laser diffraction device. Water samples from a chemically enhanced primary treatment （CEPT） process and a primary sediment tank process were also analyzed for comparison. The results showed that CBF process was not only effective for both the big size particles and small size particles removal, but also the best particle removal process in the three processes. The results also indicated that CBF process was superior to CEPT process in the heavy metals removal. The high and non-selective removal for heavy metals might be closely related to its strong ability to eliminate small particles. Samples from different locations in CBF reactors showed that small particles were easier to aggregate into big ones and those disrupted flocs could properly flocculate again along CBF reactor because of the biological flocculation.展开更多
Tumor hypoxia is one of the hostile tumor micro-environment characteristics occurring in solid tumors.This feature is closely related to tumor progression and can negatively impair the effec-tiveness of cancer therape...Tumor hypoxia is one of the hostile tumor micro-environment characteristics occurring in solid tumors.This feature is closely related to tumor progression and can negatively impair the effec-tiveness of cancer therapeutics.Recently,various strategies have been developed that enable effi-cient tumor oxygenation,not only enhancing tre-atment outcome of oxygen-consuming cancer therapeutics such as radiotherapy and photody-namic therapy,but also reversing the immunosup-pressive tumor microenvironment to promote cancer immunotherapy.This review focuses on the latest progress in design and fabrication of inno-vative tumor-targeted oxygen nanoshuttles that attenuate tumor hypoxia and enhance cancer therapy.Future perspectives for clinical translation of tumor-targeted oxygen nanoshuttles will be fur-ther discussed.展开更多
文摘In 2003,two newguidelines for hyperten—sive prevention andmanagement have beenprovided by AmericanJNC7 and European So-ciety of Hypertension.They advocated that thephysician should choosedrugs following individ—ualized treatment,
基金Project supported by the Hi-Tech Research and Development Program (863) of China (No. 2002AA601320) the Shandong Environment Protection Bureau Program (No. 2006032, 2006043)the Ph.D Fund of Shandong Jianzhu University (No. 624006, 2006043).
文摘The particle characterization from the influent and effluent of a chemical-biological flocculation （CBF） process was studied with a laser diffraction device. Water samples from a chemically enhanced primary treatment （CEPT） process and a primary sediment tank process were also analyzed for comparison. The results showed that CBF process was not only effective for both the big size particles and small size particles removal, but also the best particle removal process in the three processes. The results also indicated that CBF process was superior to CEPT process in the heavy metals removal. The high and non-selective removal for heavy metals might be closely related to its strong ability to eliminate small particles. Samples from different locations in CBF reactors showed that small particles were easier to aggregate into big ones and those disrupted flocs could properly flocculate again along CBF reactor because of the biological flocculation.
基金This work was partially supported by the National Re-search Programs from Ministry of Science and Technol-ogy(MOST)of China(2016YFA0201200)the National Natural Science Foundation of China(51525203,51761145041,and 51802209)+3 种基金the Natural Science Foun-dation of Jiangsu Province(BK20180848)the China Postdoctoral Science Foundation(2017M610348 and 2018T110545)Collaborative Innovation Center of Suz-hou Nano Science and Technology,the 111 Program from the Ministry of Education of China,a project funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,the Joint NSFC-ISF Research Grant no.2533/17by the council for higher education postdoctoral fellowship for outstanding wom-an in Science for Oshra Betzer,and the industry-academy postdoctoral scholarship(3-15677)from the Ministry of Science,Technology&Space Israel for Oshra Betzer.
文摘Tumor hypoxia is one of the hostile tumor micro-environment characteristics occurring in solid tumors.This feature is closely related to tumor progression and can negatively impair the effec-tiveness of cancer therapeutics.Recently,various strategies have been developed that enable effi-cient tumor oxygenation,not only enhancing tre-atment outcome of oxygen-consuming cancer therapeutics such as radiotherapy and photody-namic therapy,but also reversing the immunosup-pressive tumor microenvironment to promote cancer immunotherapy.This review focuses on the latest progress in design and fabrication of inno-vative tumor-targeted oxygen nanoshuttles that attenuate tumor hypoxia and enhance cancer therapy.Future perspectives for clinical translation of tumor-targeted oxygen nanoshuttles will be fur-ther discussed.
