To investigate the interaction between membranes and polypeptides, the structure of the polypeptide must be known first. Enkephalin, a natural ligand for opiate receptors is composed of the pentapeptides H 2N Tyr G...To investigate the interaction between membranes and polypeptides, the structure of the polypeptide must be known first. Enkephalin, a natural ligand for opiate receptors is composed of the pentapeptides H 2N Tyr Gly Gly Phe Met OH and H 2N Tyr Gly Gly Phe Leu OH. Two dimensional 1 H NMR techniques can be used to determine the structure of Leucine Enkephalin in solution and to build a foundation for research on the interaction between Enkephalin and the membrane. Complete proton resonance assignments were obtained using 2 D COSY, TOCSY, and NOESY techniques.展开更多
文摘To investigate the interaction between membranes and polypeptides, the structure of the polypeptide must be known first. Enkephalin, a natural ligand for opiate receptors is composed of the pentapeptides H 2N Tyr Gly Gly Phe Met OH and H 2N Tyr Gly Gly Phe Leu OH. Two dimensional 1 H NMR techniques can be used to determine the structure of Leucine Enkephalin in solution and to build a foundation for research on the interaction between Enkephalin and the membrane. Complete proton resonance assignments were obtained using 2 D COSY, TOCSY, and NOESY techniques.
