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经右心室电刺激致颤建立家兔心脏骤停模型 被引量:1
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作者 肖盐 林兆奋 +2 位作者 管军 刁孟元 张浙 《中国急救医学》 CAS CSCD 北大核心 2014年第10期927-931,I0003,共6页
目的:建立一种简单、有效、稳定的家兔电刺激致颤心脏骤停( CA)后脑复苏模型。方法选用20只新西兰雄性家兔,采用体表胸壁及心内膜下交流电诱发室颤的方法制作CA模型,CA 4 min后开始心肺复苏(CPR)。记录手术操作时间(TOP)、自... 目的:建立一种简单、有效、稳定的家兔电刺激致颤心脏骤停( CA)后脑复苏模型。方法选用20只新西兰雄性家兔,采用体表胸壁及心内膜下交流电诱发室颤的方法制作CA模型,CA 4 min后开始心肺复苏(CPR)。记录手术操作时间(TOP)、自主循环恢复时间(TROSC)、恢复率,除颤、肾上腺素次数,24 h、72 h存活率以及进行72 h大脑皮质凋亡细胞检测。另取10只兔为对照组,只进行致颤前手术操作。结果①20只家兔全部诱发CA成功,室颤发生率为100%。自主循环恢复率为80%;24 h、72 h存活率为50%、30%;除颤和肾上腺素次数为1.20±0.89、1.60±0.75;TOP和TROSC分别为(79±25)min、(268±33)s。②血浆神经元特异性烯醇化酶(NSE)水平显著升高,ROSC 72 h略有回降,但仍高于造模前(P<0.05)。③与对照组比较,ROSC后72 h大脑皮质区出现了较多神经细胞的凋亡(P<0.05)。④神经功能评分(NDS)在复苏后3 h时最低,以后渐趋好转。结论该模型操作简单、结果稳定、复苏成功率高,是一个较为理想的心肺脑复苏研究模型。 展开更多
关键词 心脏骤停( CA) 心肺脑复苏 动物模型 神经元特异性烯醇化酶( NSE) 神经功能评分( NDS) Cardiac ARREST ( CA) Specificity ENOLIZATION of neurons ( NSE) Neural deficit scores ( NDS)
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儿童热性惊厥NSE与视频脑电图检测的临床研究 被引量:1
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作者 李温慈 《浙江临床医学》 2009年第11期1142-1143,共2页
目的探讨血清NSE(神经元特异性烯醇化酶)和视频脑电图在热性惊厥儿童中的诊断价值。方法通过对40例单纯性热性惊厥患儿和30例复杂性热性惊厥患儿在发作以后的第1天和第7天用酶联免疫法(ELISA)对NSE进行检测。同时对所有患儿在发作第... 目的探讨血清NSE(神经元特异性烯醇化酶)和视频脑电图在热性惊厥儿童中的诊断价值。方法通过对40例单纯性热性惊厥患儿和30例复杂性热性惊厥患儿在发作以后的第1天和第7天用酶联免疫法(ELISA)对NSE进行检测。同时对所有患儿在发作第1天、第7天和1个月进行视频脑电图检查。结果在惊厥后24h和7d NSE水平差异有统计学意义(P〈0.01);NSE浓度在单纯性惊厥和复杂性惊厥中差异亦有统计学意义(P〈0.01)。NSE恢复的越慢,脑电图的异常率越高。结论患儿NSE在发作以后24h内明显增高,尤其是复杂性惊厥患儿。视频脑电图的异常率和NSE浓度变化有相关。 展开更多
关键词 NSE 视频脑电图 热性惊厥
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CO_2气腹对缺氧缺血性脑损伤大鼠脑组织S-100﹑NSE mRNA表达的影响
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作者 徐辉 郭永章 +1 位作者 陈训如 崔明 《昆明医学院学报》 2008年第1期77-80,共4页
目的研究在不同CO2气腹压及不同时段下正常及缺氧缺血性脑损伤大鼠脑组织S-100mRNA(S-100)、神经元特异性烯醇化酶(NSE)mRNA表达的变化,并进而探讨CO2气腹对中枢神经系统的影响.方法采用健康成年Wistar大鼠建立缺氧缺血性脑损伤模型和... 目的研究在不同CO2气腹压及不同时段下正常及缺氧缺血性脑损伤大鼠脑组织S-100mRNA(S-100)、神经元特异性烯醇化酶(NSE)mRNA表达的变化,并进而探讨CO2气腹对中枢神经系统的影响.方法采用健康成年Wistar大鼠建立缺氧缺血性脑损伤模型和气腹模型,用RT-PCR技术检测脑组织中S-100、NSEmRNA表达的变化.结果(1)CO2气腹后,S-100mRNA表达在A5-1组(64.215±10.404)和A10-2组(67.020±13.339),NSE分别为(8.976±2.379)和(9.183±3.365),对照组S-100、NSEmRNA分别为(59.340±11.378)和(8.500±2.940),S-100、NSEmRNA表达在CO2气腹后逐渐增加,但与对照组比较,差异无统计学意义(P>0.05);(2)S-100、NSEmRNA表达在B组较对照组明显升高(P<0.05),在B10-2组与B组比较有统计学意义(P<0.05).结论在10mmHg、2h范围,CO2气腹对正常大鼠脑组织S-100、NSEmRNA表达无明显影响;对缺氧缺血性脑损伤大鼠有显著性影响,应尽可能缩短气腹时间及采取相应的调控措施. 展开更多
关键词 S-100蛋白 神经元特异性烯醇化酶 大鼠 CO2 气腹 缺氧缺血性脑损伤
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Highly selective catalysts for the hydrogenation of alkynols:A review 被引量:5
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作者 Xiao Chen Chuang Shi Changhai Liang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2021年第12期2105-2121,共17页
The semi-hydrogenation of alkynols to enols is a crucial process in the production of pharmaceuticals,agrochemicals,fragrances,and flavors that involves a complex set of parallel and consecutive isomerization and hydr... The semi-hydrogenation of alkynols to enols is a crucial process in the production of pharmaceuticals,agrochemicals,fragrances,and flavors that involves a complex set of parallel and consecutive isomerization and hydrogenation reactions and proceeds via several key intermediates.In view of the industrial importance of large-scale enol production through alkynol hydrogenation,various noble and non-noble metal(e.g.,Ni and Pd)-based catalysts promoting this transformation have been developed.This paper reviews the design of highly selective catalysts for the semi-hydrogenation of alkynols,focusing on the role of additives,second metals,catalyst supports,and reaction conditions and combining catalytic reaction kinetics with theoretical calculations to establish the reaction mechanism and the decisive factors for boosting selectivity.Finally,a strategy for designing highly efficient and selective catalysts based on the characteristics of aqueous-phase alkynol hydrogenation is proposed. 展开更多
关键词 ALKYNOL ENOL Selective hydrogenation Metal-based catalyst Catalyst design
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Effect of SO_2 on the performance of Ag-Pd/Al_2O_3 for the selective catalytic reduction of NOx with C_2H_5OH 被引量:4
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作者 XIE Shu-xia YU Yun-bo WANG Jin HE Hong 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2006年第5期973-978,共6页
The influence of SO2 on the performance of Ag-Pd/Al2O3 for the selective catalytic reduction (SCR) of NOx with C2H5OH was investigated experimentally. The activity test results suggest that Ag-Pd/Al2O3 shows a small... The influence of SO2 on the performance of Ag-Pd/Al2O3 for the selective catalytic reduction (SCR) of NOx with C2H5OH was investigated experimentally. The activity test results suggest that Ag-Pd/Al2O3 shows a small activity loss in the presence of SO2 when using C2H5OH as a reductant. In situ DRIFTS spectra show that the activity loss originates from the formation of surface sulphate species on the Ag-Pd/Al2O3. The surface sulphate species formation inhibits the formation of nitrate, whereas hardly changes the partial oxidation of C2H5OH. Compared with the NOx reduction by C3H6, an obvious suppression of the surface sulphate species formation was observed by DRIFTS experiment when using C2H5OH as a reductant. This phenomenon reveals the better catalytic performance and strong SO2 tolerance of Ag-Pd/Al2O3-C2H50H system. 展开更多
关键词 sulphate SCR NITRATE enolic species ISOCYANATE reaction mechanism
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In-situ generated ionic liquid catalyzed aldol condensation of trioxane with ester in mild homogeneous system 被引量:5
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作者 Gang Wang Zengxi Li +1 位作者 Chunshan Li Suojiang Zhang 《Green Energy & Environment》 SCIE CSCD 2019年第3期293-299,共7页
α, β-unsaturated esters were often synthesized from aldehydes and esters in the presence of strong organic base that was very sensitive to air and moisture via aldol reaction. Trioxane was very useful C1 resource, h... α, β-unsaturated esters were often synthesized from aldehydes and esters in the presence of strong organic base that was very sensitive to air and moisture via aldol reaction. Trioxane was very useful C1 resource, however, the decomposition of it was always the challenging problem that facing researchers. Herein, a novel synthetic methodology for α, β-unsaturated ester preparation from trioxane and ester with mild catalysis of generated ammonium trifluoromethanesulfonate ionic liquid. The enolization of ester as well as the decomposition of trioxane could proceed easily in the presence of boryl trifluoromethanesulfonate and amine at 20–25℃. Then the enolate and decomposed formaldehyde occurs aldol reaction to form α, β-unsaturated ester. With this strategy, the yield and selectivity of product from various substrates including aliphatic esters,lactones and thioester could reach up to 85.2% and 90.1%. 展开更多
关键词 α β-unsaturated ESTER TRIOXANE Ionic liquid ALDOL reaction ENOLIZATION
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ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment 被引量:2
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作者 Huizhi Sun Jing Mo +10 位作者 Runfen Cheng Fan Li Yue Li Yuhong Guo Yanlei Li Yanhui Zhang Xiaoyu Bai Yalei Wang Xueyi Dong Danfang Zhang Jihui Hao 《Cancer Biology & Medicine》 SCIE CAS CSCD 2022年第11期1598-1616,共19页
Objective: Hypoxia is an important feature of pancreatic ductal adenocarcinoma(PDAC). Previously, we found that hypoxia promotes ENO1 expression and PDAC invasion. However, the underlying molecular mechanism was remai... Objective: Hypoxia is an important feature of pancreatic ductal adenocarcinoma(PDAC). Previously, we found that hypoxia promotes ENO1 expression and PDAC invasion. However, the underlying molecular mechanism was remains unclear.Methods: The relationship between ENO1 expression and clinicopathological characteristics was analyzed in 84 patients with PADC. The effects of CoCl2-induced hypoxia and ENO1 downregulation on the apoptosis, invasion, and proliferation of PDAC cells were evaluated in vitro and in vivo. Hypoxia-and ENO1-induced gene expression was analyzed by transcriptomic sequencing.Results: The prognosis of PDAC with high ENO1 expression was poor(P < 0.05). High ENO1 expression was closely associated with histological differentiation and tumor invasion in 84 PDAC cases(P < 0.05). Hypoxia increased ENO1 expression in PDAC and promoted its migration and invasion. Apoptotic cells and the apoptosis marker caspase-3 in the CoCl_(2)-treated ENO1-sh group were significantly elevated(P < 0.05). Transcriptomic sequencing indicated that CoCl_(2)-induced PDAC cells initiated MAPK signaling. Under hypoxic conditions, PDAC cells upregulated ENO1 expression, thereby accelerating ERK phosphorylation and inhibiting apoptosis(P < 0.05). Consistent results were also observed in a PDAC-bearing mouse hindlimb ischemia model.Conclusions: Hypoxia-induced ENO1 expression promotes ERK phosphorylation and inhibits apoptosis, thus leading to PDAC survival and invasion. These results suggest that ENO1 is a potential therapeutic target for PDAC. 展开更多
关键词 Pancreatic cancer HYPOXIA ENOL APOPTOSIS Erk phosphorylation
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Zirconyl Chloride Promoted Highly Efficient Domino Synthesis of New 1, 2, 3, 4-Tetrahydroquinoline Derivatives in Water 被引量:1
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作者 Rahul R.NAGAWADE Devanand B.SHINDE 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第9期1137-1140,共4页
The tetrahydroquinoline moiety is a structural feature of many natural products. By using a domino reaction of aromatic amines and cyclic enol ethers catalyzed by zirconyl chloride in water, various tetrahydroquinolin... The tetrahydroquinoline moiety is a structural feature of many natural products. By using a domino reaction of aromatic amines and cyclic enol ethers catalyzed by zirconyl chloride in water, various tetrahydroquinoline derivatives were synthesized efficiently. Most cyclized products showed cis selectivity. The cis selectivity was tentatively rationalized due to chelation control in water. 展开更多
关键词 ANILINES cyclic enol ether domino reaction TETRAHYDROQUINOLINE zirconyl chloride
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PMA-SiO_2 catalyzed synthesis of β-keto enol ethers 被引量:1
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作者 P.Srihari S.S.Mandal +2 位作者 J.S.S.Reddy R.Srinivasa Rao J.S.Yadav 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第7期767-770,共4页
An efficient conversion of β-diketones into corresponding β-keto enol ethers with catalytic amount of PMA-SiO2 has been achieved.
关键词 β-Keto enol ethers β-Diketones
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A Novel Oscillating Chemical Reaction Using Ninhydrin as Single Organic Substrate
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作者 Fu Wei YANG Jin Zhang GAO Wu YANG Kan Jun SUN 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第1期77-80,共4页
A novel oscillating chemical reaction using ninhydrin as a single organic substrate was represented in this paper. It distinguished from the classically catalyzed BZ oscillating chemical reaction due to there was no a... A novel oscillating chemical reaction using ninhydrin as a single organic substrate was represented in this paper. It distinguished from the classically catalyzed BZ oscillating chemical reaction due to there was no active methene (CH2=) and/or enol structure in the ninhydrin molecule, which served as single organic substrate. This suggested that the substrates used in catalyzed BZ reaction were not always the organic compounds containing active methene (CH2=) and/or enol structure and bromination process in this kind of catalyzed chemical oscillating reaction was not also necessary. 展开更多
关键词 Single organic substrate active methene enol structure oscillating chemical reaction.
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Regioselective 1,2-Addition of Ti(IV)-enolate to α, β–Unsaturated Compounds
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作者 GuiShengDENG MingYiLIAO XueTIAN JianBoWANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第5期589-592,共4页
The nucleophilic addition of Ti(IV) enolate derived from methyl aryl ketones to α, β–unsaturated compounds was found to be highly selective to give 1, 2 addition products.
关键词 Ti(IV) enolates nucleophilic addition regioselectivity ENONES Lewis acid.
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Synthesis and Crystal Structure of Arylbiscyclohexeneylmethane Derivatives
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作者 屠树江 王苏惠 +1 位作者 路再生 史达清 《International Journal of Mining Science and Technology》 SCIE EI 1998年第2期198-201,共4页
The title compound (p-methylphenylbis(4, 4-dimethyl-6-hydroxycyclohexene-1-one-2-yl)methane) has been synthesized by the reaction of 4-methylbenzaldehyde and 5, 5-dimethyl-1, 3-cyclohexanedione in N,N-dimethylformamid... The title compound (p-methylphenylbis(4, 4-dimethyl-6-hydroxycyclohexene-1-one-2-yl)methane) has been synthesized by the reaction of 4-methylbenzaldehyde and 5, 5-dimethyl-1, 3-cyclohexanedione in N,N-dimethylformamide. Its structure was determined by single crystal X-ray diffraction. The Crystal is monoclinic, space group P21/a, a=0. 9304 (2)nm, b=1. 1754 (2)nm, c=2. 0134 (4)nm, β=102. 40(2)°, Mr= 382. 50, V=2. 1505 (7)nm3, Dc = 1. 181g/cm3, Z=4, μ(MoKα) = 0. 79cm-1, F(000) = 856.The structure was solved by direct methods, and refined by full-matris least-Squares method to a final R =0. 042 and Rw = 0. 045. The crystal structure shows that there are two conjugated enol form in the molecule. 展开更多
关键词 p-methylphenylbis (4 4-dimethyl-6-hydroxycyclohexene-1-one-2-yl)methane ENOL form synthesis crystal structure
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Synthesis of 14-Bromo and 14-Hydroxy Baccatin III Derviatives
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作者 Wei Shuo FANG Qi Cheng FANG Xiao Tian LIANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2001年第8期675-678,共4页
Several 14 alpha- and 14 beta -bromo baccatin III derivatives were synthesized by direct bromination and from silyl enol ether of 13-oxo-7-TES-baccatin III. 14 beta -Hyroxy baccatin III derivative was also obtained fr... Several 14 alpha- and 14 beta -bromo baccatin III derivatives were synthesized by direct bromination and from silyl enol ether of 13-oxo-7-TES-baccatin III. 14 beta -Hyroxy baccatin III derivative was also obtained from the same silyl enol ether. 展开更多
关键词 Bromo baccatin III 14-hydroxy baccatin III PACLITAXEL silyl enol ether
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Regioselective Addition of Silyl Enolates to α, β-Unsaturated Aldehyde and its Acetal Catalyzed by MgI2 Etherate
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作者 Xing Xian ZHANG Wei Dong ZL.I 《Chinese Chemical Letters》 SCIE CAS CSCD 2003年第8期800-803,共4页
Regioselective addition reactions of silyl enolates to a, b-unsaturated aldehyde and its acetal catalyzed by MgI2 etherate give aldol adducts (1, 2-addition) preferentially over Michael adducts (1, 4-addition). This ... Regioselective addition reactions of silyl enolates to a, b-unsaturated aldehyde and its acetal catalyzed by MgI2 etherate give aldol adducts (1, 2-addition) preferentially over Michael adducts (1, 4-addition). This unique regioselectivity is distinctly different with other Lewis acidic promoters and may be attributed to the high oxyphilicity of IMg+. 展开更多
关键词 MgI_2 etherate silyl enolate addition regioselective.
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Two-water-assisted racemization of the succinimide intermediate formed in proteins. A computational model study
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作者 Ohgi Takahashi 《Health》 2013年第12期2018-2021,共4页
Racemization of aspartic acid (Asp) residues in proteins plays an important role in the molecular biology of aging. In the widely accepted mechanism of the Asp racemization, a succinimide (SI) intermediate is the spec... Racemization of aspartic acid (Asp) residues in proteins plays an important role in the molecular biology of aging. In the widely accepted mechanism of the Asp racemization, a succinimide (SI) intermediate is the species which actually undergo the direct racemization. In the present study, a two-water-assisted mechanism of the SI racemization was computationally investigated using a model compound in which an aminosuccinyl (Asu) residue is capped with acetyl and NMe groups on the N-and C-termini, respectively. The two water molecules catalyze the enolization of the Hα-Cα-C=O portion in the Asu residue by mediating proton relay from the α-carbon atom to the carboxyl oxygen atom. After the enolization, migration of the water molecules and conformational change lead to the mirror image of the initially formed enol two-water complex, and the racemization is completed by the following ketonization. The overall activation barrier (28.2 kcal·mol-1) corresponds to the enolization and ketonization steps, and falls within the available experimental activation energies (21.4-29.0 kcal·mol-1). Therefore, the two-water-assisted mechanism investigated here is plausible for the in vivo and in vitro racemization reactions of the SI intermediates formed in peptides and proteins. 展开更多
关键词 Aspartic Acid Residue RACEMIZATION NONENZYMATIC Reaction SUCCINIMIDE WATER Catalysis ENOLIZATION COMPUTATIONAL Chemistry Density Functional Theory
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Reactions of fluoroalkanesulfonyl azides with trimethylsilyl enol ethers
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《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 1999年第S1期233-233,共1页
关键词 Reactions of fluoroalkanesulfonyl azides with trimethylsilyl enol ethers
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A Novel Example of Hetero Diels-Alder Reaction
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作者 Yan ZHANG Yun Zhen JIANG Xiao Tian LIANG (Institute. of Chemistry, The Chinese Academy of Sciences, Beijing 100080)(Institute. of Materia Medica, Peking Union Medical College,The Chinese Academy of Medical Sciences, Beijing 100050) 《Chinese Chemical Letters》 SCIE CAS CSCD 1998年第8期705-706,共2页
2, 3, 3a, 4, 5, 9b-hexahydro-8-(N-methylsulfamylmethyl)-4-phenylfuro[3, 2-c]quinoline was obtained when the alkylation of compound 1 was carried out with THF as solvent. The structure of the product was determined and... 2, 3, 3a, 4, 5, 9b-hexahydro-8-(N-methylsulfamylmethyl)-4-phenylfuro[3, 2-c]quinoline was obtained when the alkylation of compound 1 was carried out with THF as solvent. The structure of the product was determined and the mechanism of the reaction was studied and proved by the imitation reaction. 展开更多
关键词 hetero Diels-Alder reaction Schiff base enol ether THF
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Rhodium(Ⅲ)-catalyzed diastereo-and enantioselective hydrosilylation/cyclization reaction of cyclohexadienone-tetheredα,β-unsaturated aldehydes
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作者 Yi-Fan Wang Hao-Yun Yu +5 位作者 Hao Xu Ya-Jie Wang Xiaodi Yang Yu-Hui Wang Ping Tian Guo-Qiang Lin 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第9期160-164,共5页
A rhodium(Ⅲ)-catalyzed hydrosilylation/cyclization reaction of cyclohexadienone-tetheredα,β-unsaturated aldehydes(1,6-dienes)with triethylsilane is described,providing a series of cishydrobenzofurans,cis-hydroindol... A rhodium(Ⅲ)-catalyzed hydrosilylation/cyclization reaction of cyclohexadienone-tetheredα,β-unsaturated aldehydes(1,6-dienes)with triethylsilane is described,providing a series of cishydrobenzofurans,cis-hydroindoles,and cishydroindenes bearing silyl enol ether in good to excellent yields and excellent stereoselectivities.Additionally,the versatility of this method was demonstrated through a gram-scale experiment and various downstream transformations,highlighting its utility. 展开更多
关键词 Rhodium(Ⅲ)catalysis Hydrosilylation/cyclization 1 6-Dienes Silyl enol ether Diastereo-and enantioselectivity
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Co-Catalyzed Dehydrogenation Claisen Condensation of Secondary Alcohols with Esters
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作者 Shuo Gao Wentao Hao +3 位作者 Yuqi Ji Xiulin Li Chunyan Zhang Guoying Zhang 《Chinese Journal of Chemistry》 SCIE CAS 2024年第22期2818-2824,共7页
Comprehensive Summary Catalytic dehydrogenation,with its exceptional atom economy and chemoselectivity,offers a highly desirable yet challenging approach for converting multiple environmentally friendly alcohols into ... Comprehensive Summary Catalytic dehydrogenation,with its exceptional atom economy and chemoselectivity,offers a highly desirable yet challenging approach for converting multiple environmentally friendly alcohols into crucial molecules.Furthermore,the utilization of catalysts based on abundant elements found on Earth for alcohol dehydrogenation to produce acryl ketone holds significant promise as a versatile strategy in synthesizing key building blocks for numerous pharmaceutical applications.The present study describes a practical Co-catalyzed cascade dehydrogenative Claisen condensation of secondary alcohols with esters,facilitating the synthesis of a wide range of 3-hydroxy-prop-2-en-1-ones.We introduce a catalytic system based on novel and scalable indazole NNP-ligands coordinated to cobalt for efficient dehydrogenations of secondary alcohols,and propose a plausible reaction mechanism supported by control experiments and labeling studies.Notably,it allows for the streamlined synthesis of multiple pharmaceuticals in one-pot. 展开更多
关键词 Cobalt Pincer Ligand Dehydrogenation Claisen Condensation 3-Hydroxy-prop-2-en-1-one Alcohols 3d transition metals enols Enones
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Construction of Angularly Fused Tricyclic Compounds via Photo-induced Radical Cascade Cyclization
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作者 Mengqin Hu Wei Cao +6 位作者 Zhen Wang Yan Hao Ganxing Huang Yuqiao Zhou Song Qin Shaomin Fu Bo Liu 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2023年第19期2502-2506,共5页
Photo-induced electron transfer (PET) of silyl enol ethers has been employed to synthesize several fused ring systems. However, the method has limited applicability due to its narrow substrate scope, low product yield... Photo-induced electron transfer (PET) of silyl enol ethers has been employed to synthesize several fused ring systems. However, the method has limited applicability due to its narrow substrate scope, low product yields, unsatisfactory stereo- and regioselectivity. Herein, we report a PET-triggered cascade reaction of silyl enolates that leads to the formation of angularly fused tricyclic scaffolds. The reaction exhibits broad substrate scope and excellent stereoselectivity. The regio- and stereoselectivity of this cascade reaction is elucidated via DFT calculation and conformational analysis. 展开更多
关键词 CYCLIZATION RADICAL Tricyclic compounds PHOTOCATALYSIS enols Fused-ring systems Domino reactions Regioselectivity
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