This paper examines audit reports issued to 39 Malaysian listed companies in financial distress categorized as Practice Note 17 （PNI7） companies by Bursa Malaysia. The study finds that for companies which experience...This paper examines audit reports issued to 39 Malaysian listed companies in financial distress categorized as Practice Note 17 （PNI7） companies by Bursa Malaysia. The study finds that for companies which experienced financial distress, the audit reports are not similar, despite all companies are similarly troubled financially. Companies receive either a disclaimer or an emphasis of matter （EOM） report. The study finds that which of the two reports is given is associated with three variables： current-year operating loss, shareholders＇ deficit, and default status, implying that audit reports do convey information that financial distress is not of the same level and severity among PN 17 companies.展开更多
T-box expressed in T cells(T-bet)和Eomesodermin(Eomes)是调控I型效应T细胞的重要转录因子,对CD4I型辅助T细胞(Th1细胞)、NK细胞、CD8+细胞毒T淋巴细胞(CTL)等的分化发育和功能调控有重要作用。机体的抗肿瘤免疫主要依赖T淋巴细胞介...T-box expressed in T cells(T-bet)和Eomesodermin(Eomes)是调控I型效应T细胞的重要转录因子,对CD4I型辅助T细胞(Th1细胞)、NK细胞、CD8+细胞毒T淋巴细胞(CTL)等的分化发育和功能调控有重要作用。机体的抗肿瘤免疫主要依赖T淋巴细胞介导的适应性免疫应答和NK细胞介导的固有免疫应答。T-bet和Eomes通过调控这些免疫细胞影响抗肿瘤免疫应答,对肿瘤的发生、发展及转归有重要意义。展开更多
Objective C/eome rutidosperma （Capparidaceae）, commonly known as ＂Fringed Spider Flower＂, is a medicinal plant found in Southeast Asia. C. rutidosperma is used in folk medicine for diuretic, laxative, analgesic, a...Objective C/eome rutidosperma （Capparidaceae）, commonly known as ＂Fringed Spider Flower＂, is a medicinal plant found in Southeast Asia. C. rutidosperma is used in folk medicine for diuretic, laxative, analgesic, anti-inflammatory, antipyretic, antimicrobial, anti-oxidant, hypoglycemic, and anthelmintic activities. We have evaluated the anti-nociceptive properties of methanol extract from C. rutidosperma （MECR） in vivo. Methods Thermal method （hot plate test and tail flick test） was induced to judge the anti-inflammatory effect and couple of chemical method also used （formalin induced licking test; writhing test carried by acetic acid） to evaluate analgesic effect. Both of these tests were made over animal models, like mice and rats. Two different doses （1 O0 and 200 mg/kg） were used for each case of test, while morphine sulphate （5mg/kg, ip） was used as reference drug. Results MECR demonstrated the significantly anti-nociceptive activity in the analgesic and anti-inflammatory tests by reducing nociception in mice models （P 〈 0.001）. in the hot-plate and tail-flick tests, MECR significantly elongated the time to response to the thermal stimuli （100 and 200 mg/kg with P 〈 0.05, 0.001）. The remarkable increase in the latency was observed at 90 and 120 min. In acetic acid-induced writhing test and formalin induced licking test for anti-inflammatory activity, MECR at 100 and 200 mg/kg doses exhibited significant （P〈 0.001） reduction of writhing and licking response. Conclusion The anti-inflammatory and analgesic effects of C. rutidosperma propose that this effect may be a result of both peripheral and central mechanisms. Further study is required to ensure the proper mechanism of action as well as the active ingredient.展开更多
为了保持电光调制器(EOM)输入光偏振方向始终与其内部可传播模式偏振方向一致,使EOM获得良好的调制效果,提出了一种基于比例-积分-微分(PID)算法的EOM自适应偏振控制方法,理论分析并实验验证了该方法的可行性。实验结果表明,基于该方法...为了保持电光调制器(EOM)输入光偏振方向始终与其内部可传播模式偏振方向一致,使EOM获得良好的调制效果,提出了一种基于比例-积分-微分(PID)算法的EOM自适应偏振控制方法,理论分析并实验验证了该方法的可行性。实验结果表明,基于该方法设计的控制系统不仅能实时监测EOM输出光功率,而且能保持其输出光功率最大;与激光器和EOM输入端直接用保偏光纤连接时相比,PID偏振控制下EOM输出平均功率提高了3.08 d B,PD输出电压标准差由0.121 4降至1.237 5×10-4,稳定控制状态下偏振态矫正时间在ms量级。展开更多
文摘This paper examines audit reports issued to 39 Malaysian listed companies in financial distress categorized as Practice Note 17 （PNI7） companies by Bursa Malaysia. The study finds that for companies which experienced financial distress, the audit reports are not similar, despite all companies are similarly troubled financially. Companies receive either a disclaimer or an emphasis of matter （EOM） report. The study finds that which of the two reports is given is associated with three variables： current-year operating loss, shareholders＇ deficit, and default status, implying that audit reports do convey information that financial distress is not of the same level and severity among PN 17 companies.
文摘T-box expressed in T cells(T-bet)和Eomesodermin(Eomes)是调控I型效应T细胞的重要转录因子,对CD4I型辅助T细胞(Th1细胞)、NK细胞、CD8+细胞毒T淋巴细胞(CTL)等的分化发育和功能调控有重要作用。机体的抗肿瘤免疫主要依赖T淋巴细胞介导的适应性免疫应答和NK细胞介导的固有免疫应答。T-bet和Eomes通过调控这些免疫细胞影响抗肿瘤免疫应答,对肿瘤的发生、发展及转归有重要意义。
文摘Objective C/eome rutidosperma （Capparidaceae）, commonly known as ＂Fringed Spider Flower＂, is a medicinal plant found in Southeast Asia. C. rutidosperma is used in folk medicine for diuretic, laxative, analgesic, anti-inflammatory, antipyretic, antimicrobial, anti-oxidant, hypoglycemic, and anthelmintic activities. We have evaluated the anti-nociceptive properties of methanol extract from C. rutidosperma （MECR） in vivo. Methods Thermal method （hot plate test and tail flick test） was induced to judge the anti-inflammatory effect and couple of chemical method also used （formalin induced licking test; writhing test carried by acetic acid） to evaluate analgesic effect. Both of these tests were made over animal models, like mice and rats. Two different doses （1 O0 and 200 mg/kg） were used for each case of test, while morphine sulphate （5mg/kg, ip） was used as reference drug. Results MECR demonstrated the significantly anti-nociceptive activity in the analgesic and anti-inflammatory tests by reducing nociception in mice models （P 〈 0.001）. in the hot-plate and tail-flick tests, MECR significantly elongated the time to response to the thermal stimuli （100 and 200 mg/kg with P 〈 0.05, 0.001）. The remarkable increase in the latency was observed at 90 and 120 min. In acetic acid-induced writhing test and formalin induced licking test for anti-inflammatory activity, MECR at 100 and 200 mg/kg doses exhibited significant （P〈 0.001） reduction of writhing and licking response. Conclusion The anti-inflammatory and analgesic effects of C. rutidosperma propose that this effect may be a result of both peripheral and central mechanisms. Further study is required to ensure the proper mechanism of action as well as the active ingredient.
文摘为了保持电光调制器(EOM)输入光偏振方向始终与其内部可传播模式偏振方向一致,使EOM获得良好的调制效果,提出了一种基于比例-积分-微分(PID)算法的EOM自适应偏振控制方法,理论分析并实验验证了该方法的可行性。实验结果表明,基于该方法设计的控制系统不仅能实时监测EOM输出光功率,而且能保持其输出光功率最大;与激光器和EOM输入端直接用保偏光纤连接时相比,PID偏振控制下EOM输出平均功率提高了3.08 d B,PD输出电压标准差由0.121 4降至1.237 5×10-4,稳定控制状态下偏振态矫正时间在ms量级。
