AIM: To investigate the endoscopic findings and patholo- gic characteristics of gastric eosinophilic granuloma (GEG). METHODS: A retrospective study of 18 cases of gastric eosinophilic granulomas was conducted. Gastro...AIM: To investigate the endoscopic findings and patholo- gic characteristics of gastric eosinophilic granuloma (GEG). METHODS: A retrospective study of 18 cases of gastric eosinophilic granulomas was conducted. Gastroscopy was performed and all specimens of biopsies were stained by H&E and observed under light microscopy. RESULTS: Ulcer was the most frequent endoscopic appearance. The others included deformed pylorus and/or duodenal bulb, esophagitis, mucous hyperemia and/or mucosal erosion. Eosinophilic cell infiltration and generous hyperplasia of arterioles, venules and lymph vessels were found in the lesions of the patients. Interstitium had massive eosinophilic infiltrates and was made up of collagen fibers and fibroblasts. Lymphoid follicles were revealed in some sections of biopsies. CONCLUSION: GEG is lack of specific symptoms and physical signs. It can be misdiagnosed as gastric ulcer in most cases before biopsies. Endoscopy and endoscopic multiple deep biopsies in suspected areas are indispensable for correct diagnosis of GEG.展开更多
Dear Editor,I am Dr.Jungyul Park from the Department of Ophthalmology,Pusan National University Hospital,Busan,Korea.I am writing to present a case of eosinophilic granulomatosis with polyangiitis(EGPA)with central re...Dear Editor,I am Dr.Jungyul Park from the Department of Ophthalmology,Pusan National University Hospital,Busan,Korea.I am writing to present a case of eosinophilic granulomatosis with polyangiitis(EGPA)with central retinal artery occlusion(CRAO).It provides important information about the relationship between ANCA and CRAO in a patient who was diagnosed with EGPA who had ophthalmic symptoms.We believe that our study makes a significant contribution to the literature because to our knowledge,the literature of EGPA with CRAO are rare worldwide and this is even the first case of EGPA with CRAO in Republic of Korea.展开更多
Introduction: Osseous eosinophilic granulomas commonly occur in the skull, pelvis, vertebrae, mandible, and ribs. However, the eosinophilic granuloma in the sacrum is rare. Case presentation: We present the case of a ...Introduction: Osseous eosinophilic granulomas commonly occur in the skull, pelvis, vertebrae, mandible, and ribs. However, the eosinophilic granuloma in the sacrum is rare. Case presentation: We present the case of a 13-year-old Japanese boy, who presented with left low-back pain, and was diagnosed with eosinophilic granuloma arising in the sacrum. Computed tomography (CT) and magnetic resonance imaging demonstrated an osteolytic lesion with interruption of the cortex, and signal intensity changes at the left sacral body and wing. Histologic examination indicated an eosinophilic granuloma. Two years after CT-guided biopsy, the tumor had spontaneously healed completely, with no residual pain.Conclusion: The present case was eosiophilic granuloma arising from the rare site of sacrum. The tumor was completely remodeled two years after biopsy.展开更多
BACKGROUND Eosinophilic granuloma(EG)is a proliferative condition that affects the cells of bone tissue.There are no specific clinical signs or imaging manifestations in the early stages of the disease,making it simpl...BACKGROUND Eosinophilic granuloma(EG)is a proliferative condition that affects the cells of bone tissue.There are no specific clinical signs or imaging manifestations in the early stages of the disease,making it simple to overlook and misdiagnose.Because of the disease's rarity,there is presently no standardized treatment principle.There are few accounts of such occurrences affecting the axis among children.We discovered a case of a child whose EG resulted in atlantoaxial joint dislocation and destruction of the axial bone.CASE SUMMARY After having pharyngeal discomfort for more than six months without a clear explanation,a 6-year-old boy was brought to our hospital.Following a careful evaluation,the pathology indicated a strong likelihood of an axial EG.Ultimately,we decided to treat the boy with posterior pedicle screw fixation and local steroid injections.CONCLUSION EGs of the upper cervical spine are quite uncommon in children,and they are exceedingly easy to overlook or misdiagnose.Posterior pedicle screw fixation and local steroid injections are effective treatments for patients with axial EGs affecting the atlantoaxial junction.展开更多
A young man with a previous history of episodes of mild solid food dysphagia was admitted with a total dysphagia. The esophagogastroduodenoscopy (EGDS) showed an extensive disruption of mucosal layer with a cul-de-sac...A young man with a previous history of episodes of mild solid food dysphagia was admitted with a total dysphagia. The esophagogastroduodenoscopy (EGDS) showed an extensive disruption of mucosal layer with a cul-de-sac in the lower part of the esophagus. Soon after the procedure, the patient suffered from an acute chest pain and subsequent CT scan demonstrated an intramural circumferential dissection of thoracic esophagus, and a mediastinal emphysema. An emergency right thoracotomy was performed, followed by a total esophagectomy with esophagogastroplasty and jejunostomy. The histopathology confirmed that mucosal and submucosal layers were circumferentially detached from muscular wall and showed an eosinophilic infiltration of the whole organ with necrosis and erosions of mucosal, submucosal and muscular layers. The diagnosis was esophageal perforation in eosinophilic esophagitis.展开更多
An 1-year-old male Basset Hound dog was evaluated for chronic intermittent vomiting, hematemesis, and melena which had been ongoing for several months. The histopathologic examination revealed that all layers of the s...An 1-year-old male Basset Hound dog was evaluated for chronic intermittent vomiting, hematemesis, and melena which had been ongoing for several months. The histopathologic examination revealed that all layers of the small intestine were thicker than normal. The lamina propria of the mucosa, including the villi, exhibited a prominent cellular infiltrate which consisted of numerous eosinophils and an increased numbers of plasma cells in addition to the normal lymphocytic component. The muscularis mucosa was invaded, and in some places disrupted, by eosinophils, which also infiltrated into the submucosa and muscularis propria. This report describes the pathological findings of a case of eosinophilic gastroenteritis (EG) in a dog.展开更多
Primary Hodgkin disease （HD） of bone is rare. The recognition on it is relatively confined. Bothcases arising-in male adults were suspected to be Potts disease （spinal tuberculosis） on imaging, and pathologic misd...Primary Hodgkin disease （HD） of bone is rare. The recognition on it is relatively confined. Bothcases arising-in male adults were suspected to be Potts disease （spinal tuberculosis） on imaging, and pathologic misdiagnosed initially. The clinical situations rapidly aggravated. The pathomorphology was remarkable malignant changed. They shared similar process in clinical, radiological and diagnostic process and could be representative. We retrospectively analyzed correlative results of them and review points of distinction from other disease entities that might be confused with it.展开更多
文摘AIM: To investigate the endoscopic findings and patholo- gic characteristics of gastric eosinophilic granuloma (GEG). METHODS: A retrospective study of 18 cases of gastric eosinophilic granulomas was conducted. Gastroscopy was performed and all specimens of biopsies were stained by H&E and observed under light microscopy. RESULTS: Ulcer was the most frequent endoscopic appearance. The others included deformed pylorus and/or duodenal bulb, esophagitis, mucous hyperemia and/or mucosal erosion. Eosinophilic cell infiltration and generous hyperplasia of arterioles, venules and lymph vessels were found in the lesions of the patients. Interstitium had massive eosinophilic infiltrates and was made up of collagen fibers and fibroblasts. Lymphoid follicles were revealed in some sections of biopsies. CONCLUSION: GEG is lack of specific symptoms and physical signs. It can be misdiagnosed as gastric ulcer in most cases before biopsies. Endoscopy and endoscopic multiple deep biopsies in suspected areas are indispensable for correct diagnosis of GEG.
文摘Dear Editor,I am Dr.Jungyul Park from the Department of Ophthalmology,Pusan National University Hospital,Busan,Korea.I am writing to present a case of eosinophilic granulomatosis with polyangiitis(EGPA)with central retinal artery occlusion(CRAO).It provides important information about the relationship between ANCA and CRAO in a patient who was diagnosed with EGPA who had ophthalmic symptoms.We believe that our study makes a significant contribution to the literature because to our knowledge,the literature of EGPA with CRAO are rare worldwide and this is even the first case of EGPA with CRAO in Republic of Korea.
文摘Introduction: Osseous eosinophilic granulomas commonly occur in the skull, pelvis, vertebrae, mandible, and ribs. However, the eosinophilic granuloma in the sacrum is rare. Case presentation: We present the case of a 13-year-old Japanese boy, who presented with left low-back pain, and was diagnosed with eosinophilic granuloma arising in the sacrum. Computed tomography (CT) and magnetic resonance imaging demonstrated an osteolytic lesion with interruption of the cortex, and signal intensity changes at the left sacral body and wing. Histologic examination indicated an eosinophilic granuloma. Two years after CT-guided biopsy, the tumor had spontaneously healed completely, with no residual pain.Conclusion: The present case was eosiophilic granuloma arising from the rare site of sacrum. The tumor was completely remodeled two years after biopsy.
基金Supported by the Natural Science Foundation of Fujian Province,No.2021J01546the Innovation and Entrepreneurship Star Fund Project of Zhangzhou,No.ZCZZ[2019]17.
文摘BACKGROUND Eosinophilic granuloma(EG)is a proliferative condition that affects the cells of bone tissue.There are no specific clinical signs or imaging manifestations in the early stages of the disease,making it simple to overlook and misdiagnose.Because of the disease's rarity,there is presently no standardized treatment principle.There are few accounts of such occurrences affecting the axis among children.We discovered a case of a child whose EG resulted in atlantoaxial joint dislocation and destruction of the axial bone.CASE SUMMARY After having pharyngeal discomfort for more than six months without a clear explanation,a 6-year-old boy was brought to our hospital.Following a careful evaluation,the pathology indicated a strong likelihood of an axial EG.Ultimately,we decided to treat the boy with posterior pedicle screw fixation and local steroid injections.CONCLUSION EGs of the upper cervical spine are quite uncommon in children,and they are exceedingly easy to overlook or misdiagnose.Posterior pedicle screw fixation and local steroid injections are effective treatments for patients with axial EGs affecting the atlantoaxial junction.
文摘A young man with a previous history of episodes of mild solid food dysphagia was admitted with a total dysphagia. The esophagogastroduodenoscopy (EGDS) showed an extensive disruption of mucosal layer with a cul-de-sac in the lower part of the esophagus. Soon after the procedure, the patient suffered from an acute chest pain and subsequent CT scan demonstrated an intramural circumferential dissection of thoracic esophagus, and a mediastinal emphysema. An emergency right thoracotomy was performed, followed by a total esophagectomy with esophagogastroplasty and jejunostomy. The histopathology confirmed that mucosal and submucosal layers were circumferentially detached from muscular wall and showed an eosinophilic infiltration of the whole organ with necrosis and erosions of mucosal, submucosal and muscular layers. The diagnosis was esophageal perforation in eosinophilic esophagitis.
文摘An 1-year-old male Basset Hound dog was evaluated for chronic intermittent vomiting, hematemesis, and melena which had been ongoing for several months. The histopathologic examination revealed that all layers of the small intestine were thicker than normal. The lamina propria of the mucosa, including the villi, exhibited a prominent cellular infiltrate which consisted of numerous eosinophils and an increased numbers of plasma cells in addition to the normal lymphocytic component. The muscularis mucosa was invaded, and in some places disrupted, by eosinophils, which also infiltrated into the submucosa and muscularis propria. This report describes the pathological findings of a case of eosinophilic gastroenteritis (EG) in a dog.
文摘Primary Hodgkin disease （HD） of bone is rare. The recognition on it is relatively confined. Bothcases arising-in male adults were suspected to be Potts disease （spinal tuberculosis） on imaging, and pathologic misdiagnosed initially. The clinical situations rapidly aggravated. The pathomorphology was remarkable malignant changed. They shared similar process in clinical, radiological and diagnostic process and could be representative. We retrospectively analyzed correlative results of them and review points of distinction from other disease entities that might be confused with it.
