Eosinophilic pancreatitis(EP)is an extremely rare disease caused by purely eosinophilic infiltration of the pancreas.EP is prone to being misdiagnosed as pancreatic cancer,causing unnecessary economic and physical har...Eosinophilic pancreatitis(EP)is an extremely rare disease caused by purely eosinophilic infiltration of the pancreas.EP is prone to being misdiagnosed as pancreatic cancer,causing unnecessary economic and physical harm to the patient.We report three cases of EP that were cured by steroids without relapse from 2017 to now.The clinical data of the three patients,including clinical manifestations,serological manifestations,imaging(ultrasound,computed tomography,and MRI),pathological diagnosis and treatment,and telephone follow-up of all patients,were retrospectively analysed.In addition,a literature search was conducted on the Web of Science and PubMed databases using key terms related to EP,considering case reports with no restrictions on the date of publication or language.In conclusion,we analysed 19 cases and determined the diagnostic criteria for EP.The diagnostic algorithm for EP can be used to diagnose EP easily.We hope that our standards and algorithm can reduce the rate of misdiagnosis and contribute to clinical diagnosis and treatment.In addition,we expect to evaluate more EP cases to test our diagnostic criteria and design a systematic diagnostic flow chart.展开更多
Eosinophilic gastroenteritis (EG) is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, and is usually associated with dyspepsia, diarrhea and peripheral eos...Eosinophilic gastroenteritis (EG) is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, and is usually associated with dyspepsia, diarrhea and peripheral eosinophilia. Diffuse gastrointestinal tract and colonic involvement are uncommon. The endoscopic appearance may vary from normal to mucosal nodularity and ulceration. Gastrointestinal obstruction is unusual and is associated with predominantly muscular disease. We present five unusual cases of EG associated with gastric outlet and duodenal obstruction. Two cases presented with acute pancreatitis and one had a history of pancreatitis. Four cases responded well to medical therapy and one had recurrent gastric outlet obstruction that required surgery. Four out of the five cases had endoscopic and histological evidence of esophagitis and two had colitis. Two patients had ascites. These cases reaffirm that EG is a disorder with protean manifestations and may involve the entire gastrointestinal tract. Gastric outlet and/or small bowel obstruction is an important though uncommon presentation of EG. It may also present as esophagitis, gastritis with polypoid lesions, ulcers or erosions, colitis and pancreatitis and may mimic malignancy.展开更多
基金Support Program for Young and Middle-Aged Science and Technology Innovation Talents of Shenyang [No.RC170446].
文摘Eosinophilic pancreatitis(EP)is an extremely rare disease caused by purely eosinophilic infiltration of the pancreas.EP is prone to being misdiagnosed as pancreatic cancer,causing unnecessary economic and physical harm to the patient.We report three cases of EP that were cured by steroids without relapse from 2017 to now.The clinical data of the three patients,including clinical manifestations,serological manifestations,imaging(ultrasound,computed tomography,and MRI),pathological diagnosis and treatment,and telephone follow-up of all patients,were retrospectively analysed.In addition,a literature search was conducted on the Web of Science and PubMed databases using key terms related to EP,considering case reports with no restrictions on the date of publication or language.In conclusion,we analysed 19 cases and determined the diagnostic criteria for EP.The diagnostic algorithm for EP can be used to diagnose EP easily.We hope that our standards and algorithm can reduce the rate of misdiagnosis and contribute to clinical diagnosis and treatment.In addition,we expect to evaluate more EP cases to test our diagnostic criteria and design a systematic diagnostic flow chart.
文摘Eosinophilic gastroenteritis (EG) is an uncommon disease characterized by focal or diffuse eosinophilic infiltration of the gastrointestinal tract, and is usually associated with dyspepsia, diarrhea and peripheral eosinophilia. Diffuse gastrointestinal tract and colonic involvement are uncommon. The endoscopic appearance may vary from normal to mucosal nodularity and ulceration. Gastrointestinal obstruction is unusual and is associated with predominantly muscular disease. We present five unusual cases of EG associated with gastric outlet and duodenal obstruction. Two cases presented with acute pancreatitis and one had a history of pancreatitis. Four cases responded well to medical therapy and one had recurrent gastric outlet obstruction that required surgery. Four out of the five cases had endoscopic and histological evidence of esophagitis and two had colitis. Two patients had ascites. These cases reaffirm that EG is a disorder with protean manifestations and may involve the entire gastrointestinal tract. Gastric outlet and/or small bowel obstruction is an important though uncommon presentation of EG. It may also present as esophagitis, gastritis with polypoid lesions, ulcers or erosions, colitis and pancreatitis and may mimic malignancy.
