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Commentary:Indirect action pattern:A remote and cross-organ pharmacological mechanism for drug innovation 被引量:5
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作者 Yuan Gao Jia-bo Wang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2022年第8期3448-3450,共3页
The development of molecular medicine has greatly promoted the research and development (R&D) of innovative drugs. However,drug design and development for those novel targets remains a big challenge with low succe... The development of molecular medicine has greatly promoted the research and development (R&D) of innovative drugs. However,drug design and development for those novel targets remains a big challenge with low success rates and high attrition of drug candidates1. The current methodology of new drug R&D is deeply influenced by the idea of allopathic medicine, which directly inhibits biological targets. 展开更多
关键词 Cross-organ Indirect action pattern Phosphatidic acid Liver toxicity IL-6 epididymal white adipose tissue
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