BACKGROUND Primary ciliary dyskinesia(PCD)is an inherited autosomal-recessive disorder of impaired mucociliary clearance characterized by chronic respiratory diseases,otolaryngological diseases,central nervous system ...BACKGROUND Primary ciliary dyskinesia(PCD)is an inherited autosomal-recessive disorder of impaired mucociliary clearance characterized by chronic respiratory diseases,otolaryngological diseases,central nervous system abnormalities,reproductive system abnormalities,and cardiac function abnormalities.General anesthesia in these patients is associated with a higher incidence of respiratory complications than in patients without the disease.CASE SUMMARY A 16-year-old male patient was referred to the emergency room complaining of right ankle pain due to distal tibiofibular fracture.Three years prior,he had been diagnosed with PCD.At that time,he had experienced several episodes of pneumonia,sinusitis,and chronic middle ear infections,for which he underwent surgical interventions.At the current admission,he presented with cough and sputum but no other respiratory symptoms.A chest computed tomography scan revealed centrilobular ground-glass opacities in both lower lobes and a calcified nodule in the left lower lobe.For the surgical procedure and postoperative pain management,combined spinal-epidural anesthesia was employed.The patient’s postoperative pain score was measured by the numerical rating scale(NRS).On the day of surgery,his NRS was 5 points.By the second postoperative day,the NRS score had decreased to 2–3 points.The epidural catheter was removed on the fourth day following the operation.The patient was subsequently discharged no respiratory complications.CONCLUSION We performed combined spinal-epidural anesthesia in a patient with PCD.The patient experienced no additional respiratory complications and was discharged with a low NRS score for pain.展开更多
Pain is the predominant symptom troubling patients.Pain management is one of the most important aspects in the management of surgical patients leading to early recovery from surgical procedures or in patients with chr...Pain is the predominant symptom troubling patients.Pain management is one of the most important aspects in the management of surgical patients leading to early recovery from surgical procedures or in patients with chronic diseases or malignancy.Various groups of drugs are used for dealing with this;however,they have their own implications in the form of adverse effects and dependence.In this article,we review the concerns of different pain-relieving medicines used postoperatively in gastrointestinal surgery and for malignant and chronic diseases.展开更多
Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconi...Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22. 5 mg of bupivacaine, was used for the observed group, and lappaconitine 12 mg, bupivacaine 22. 5 mg and morphine 2 mg for the control group respectively, All were given by epidural injection with single blind method during post-operative pain of incision operation. Results: It was showed that the initiating of analgesia was earlier in LB and bupivacaine group than that in group B and D, and the efficacy was morphine group > LB > bupivacaine > lappaconitine.There was significant difference between group A and B in the above two parameters, P < 0. 01 and P < 0. 05. The analgesia maintenance time of a single injection was morphine > LB > lappaconitine > bupivacaine, that of group D was significantly longer than that of group A (P < 0. 01 ). Conclusions: It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia. Besides, it had no side-effect and safer than morphine.展开更多
This paper studied the effect and side-effect of epidural injected Lappaconitine (LC) for post-operative analgesia. 50 patients who were operated in the upper abdomen with epidural anesthesia, wererandomly divided int...This paper studied the effect and side-effect of epidural injected Lappaconitine (LC) for post-operative analgesia. 50 patients who were operated in the upper abdomen with epidural anesthesia, wererandomly divided into 5 groups. The general condition of each group was similar. Group A, B , C was given LC4mg, 8mg, 12mg respectively for observation. Group D, E was given 0.9% NS 6ml and morphine 2mg indi-vidually as control. When the operation was finished, LC was injected into the epidural space with singleblind method. The result showed the analgesia of LC and its effective time was: group E >C > B >A > D . Theanalgesic effect of group C was satistactory. The efficacy and the maintenance time of A, B, C groups weresignificantly different from that of group D ( P < 0. 05 , P < 0 . 01 ) . Although the effect ot group C was less po-tent than that of group E ( morphine injection) , there was no side-effect like that of morphine. It suggestedthat epidural injected LC for post-operative analgesia is effective and safe.展开更多
文摘BACKGROUND Primary ciliary dyskinesia(PCD)is an inherited autosomal-recessive disorder of impaired mucociliary clearance characterized by chronic respiratory diseases,otolaryngological diseases,central nervous system abnormalities,reproductive system abnormalities,and cardiac function abnormalities.General anesthesia in these patients is associated with a higher incidence of respiratory complications than in patients without the disease.CASE SUMMARY A 16-year-old male patient was referred to the emergency room complaining of right ankle pain due to distal tibiofibular fracture.Three years prior,he had been diagnosed with PCD.At that time,he had experienced several episodes of pneumonia,sinusitis,and chronic middle ear infections,for which he underwent surgical interventions.At the current admission,he presented with cough and sputum but no other respiratory symptoms.A chest computed tomography scan revealed centrilobular ground-glass opacities in both lower lobes and a calcified nodule in the left lower lobe.For the surgical procedure and postoperative pain management,combined spinal-epidural anesthesia was employed.The patient’s postoperative pain score was measured by the numerical rating scale(NRS).On the day of surgery,his NRS was 5 points.By the second postoperative day,the NRS score had decreased to 2–3 points.The epidural catheter was removed on the fourth day following the operation.The patient was subsequently discharged no respiratory complications.CONCLUSION We performed combined spinal-epidural anesthesia in a patient with PCD.The patient experienced no additional respiratory complications and was discharged with a low NRS score for pain.
文摘Pain is the predominant symptom troubling patients.Pain management is one of the most important aspects in the management of surgical patients leading to early recovery from surgical procedures or in patients with chronic diseases or malignancy.Various groups of drugs are used for dealing with this;however,they have their own implications in the form of adverse effects and dependence.In this article,we review the concerns of different pain-relieving medicines used postoperatively in gastrointestinal surgery and for malignant and chronic diseases.
文摘Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22. 5 mg of bupivacaine, was used for the observed group, and lappaconitine 12 mg, bupivacaine 22. 5 mg and morphine 2 mg for the control group respectively, All were given by epidural injection with single blind method during post-operative pain of incision operation. Results: It was showed that the initiating of analgesia was earlier in LB and bupivacaine group than that in group B and D, and the efficacy was morphine group > LB > bupivacaine > lappaconitine.There was significant difference between group A and B in the above two parameters, P < 0. 01 and P < 0. 05. The analgesia maintenance time of a single injection was morphine > LB > lappaconitine > bupivacaine, that of group D was significantly longer than that of group A (P < 0. 01 ). Conclusions: It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia. Besides, it had no side-effect and safer than morphine.
文摘This paper studied the effect and side-effect of epidural injected Lappaconitine (LC) for post-operative analgesia. 50 patients who were operated in the upper abdomen with epidural anesthesia, wererandomly divided into 5 groups. The general condition of each group was similar. Group A, B , C was given LC4mg, 8mg, 12mg respectively for observation. Group D, E was given 0.9% NS 6ml and morphine 2mg indi-vidually as control. When the operation was finished, LC was injected into the epidural space with singleblind method. The result showed the analgesia of LC and its effective time was: group E >C > B >A > D . Theanalgesic effect of group C was satistactory. The efficacy and the maintenance time of A, B, C groups weresignificantly different from that of group D ( P < 0. 05 , P < 0 . 01 ) . Although the effect ot group C was less po-tent than that of group E ( morphine injection) , there was no side-effect like that of morphine. It suggestedthat epidural injected LC for post-operative analgesia is effective and safe.
