OBJECTIVE： To investigate the effects and mecha- nisms of Erbanxiao solution in inhibiting tumor an- giogenesis. METHODS： We observed the effects and mecha- nisms of Chinese medicines on inhibiting tumor an- giogene...OBJECTIVE： To investigate the effects and mecha- nisms of Erbanxiao solution in inhibiting tumor an- giogenesis. METHODS： We observed the effects and mecha- nisms of Chinese medicines on inhibiting tumor an- giogenesis and studied the theories and results of treatment. Sixty patients with lung cancer were ran- domized into two groups （n=30）. Patients in the control group were given compound Kushen injec- tion, and patients in the treatment group were giv- en Erbanxiao solution. The effect of Erbanxiao solu- tion on vascular endothelium growth factor （VEGF）, basic fibroblast growth factor （bFGF）, and tumor ne- crosis factor-α （TNF-α） was observed. RESULTS： The effective rate of the treatment group was 60% while the control group was 36%. There was a significant difference between the twogroups （P〈0.05）. VEGF, bFGF, and TNF-a levels of the two groups were significantly different before and after treatment （P〈0.01）. These Traditional Chi- nese Medicines significantly inhibited tumor angio- genesis, possibly by changing levels of VEGF, bFGF, and TNF-α. CONCLUSION： It is necessary to further explore the potential of Traditional Chinese Medicine in the treatment of angiogenesis in tumor patients.展开更多
基金Supported by 5451 project of Health Science and Technology of Henan Province(No.201108)
文摘OBJECTIVE： To investigate the effects and mecha- nisms of Erbanxiao solution in inhibiting tumor an- giogenesis. METHODS： We observed the effects and mecha- nisms of Chinese medicines on inhibiting tumor an- giogenesis and studied the theories and results of treatment. Sixty patients with lung cancer were ran- domized into two groups （n=30）. Patients in the control group were given compound Kushen injec- tion, and patients in the treatment group were giv- en Erbanxiao solution. The effect of Erbanxiao solu- tion on vascular endothelium growth factor （VEGF）, basic fibroblast growth factor （bFGF）, and tumor ne- crosis factor-α （TNF-α） was observed. RESULTS： The effective rate of the treatment group was 60% while the control group was 36%. There was a significant difference between the twogroups （P〈0.05）. VEGF, bFGF, and TNF-a levels of the two groups were significantly different before and after treatment （P〈0.01）. These Traditional Chi- nese Medicines significantly inhibited tumor angio- genesis, possibly by changing levels of VEGF, bFGF, and TNF-α. CONCLUSION： It is necessary to further explore the potential of Traditional Chinese Medicine in the treatment of angiogenesis in tumor patients.
