This paper investigates the adjacent interactions of three novel solitons for the quintic complex Ginzburg-Landau equation, which are plain pulsating, erupting and creeping solitons. It is found that different perform...This paper investigates the adjacent interactions of three novel solitons for the quintic complex Ginzburg-Landau equation, which are plain pulsating, erupting and creeping solitons. It is found that different performances are presented for different solitons due to isolated regions of the parameter space where they exist. For example, plain pulsating and erupting solitons exhibit mutual annihilation during collisions with the decrease of total energy, but for creeping soliton, the two adjacent pulses present soliton fusion without any loss of energy. Otherwise, the method for restraining the interactions is also found and it can suppress interactions between these two adjacent pulses effectively.展开更多
The Solar Close Observations and Proximity Experiments(SCOPE)mission,which has been proposed by the Yunnan Observatories,Chinese Academy of Sciences,aiming to operate at a distance of 5 to 10 solar radii from the Sun,...The Solar Close Observations and Proximity Experiments(SCOPE)mission,which has been proposed by the Yunnan Observatories,Chinese Academy of Sciences,aiming to operate at a distance of 5 to 10 solar radii from the Sun,plans to complete the in situ detection of the solar eruption process and observation of the magnetic field structure response.The solar flux received by the satellite ranges from 10^(3) to 10^(6) Wm^(-2),which poses challenges for thermal management of the solar arrays.In this work,the solar array cooling system of the Parker Solar Probe is discussed,the developments of the fluid loop technique are reviewed,and a research plan for a next-generation solar array cooling system is proposed.This paper provides a valuable reference for novel thermal control systems in spacecraft for solar observation.展开更多
To explain the recent three-year La Niña event from 2020 to 2022,which has caused catastrophic weather events worldwide,Fasullo et al.(2023)demonstrated that the increase in biomass aerosol resulting from the 201...To explain the recent three-year La Niña event from 2020 to 2022,which has caused catastrophic weather events worldwide,Fasullo et al.(2023)demonstrated that the increase in biomass aerosol resulting from the 2019-20 Australian wildfire season could have triggered this multi-year La Niña.Here,we present compelling evidence from paleo-proxies,utilizing a substantial sample size of 26 volcanic eruptions in the Southern Hemisphere(SH),to support the hypothesis that ocean cooling in the SH can lead to a multi-year La Niña event.This research highlights the importance of focusing on the Southern Ocean,as current climate models struggle to accurately simulate the Pacific response driven by the Southern Ocean.展开更多
1.Objective The Emeishan basalts is located in southwest China and northern Vietnam,covering an area of 2.5×10^(5) km^(2)(Zhong YT et al.,2014),which is the first widely recognized large igneous province(LIP)in C...1.Objective The Emeishan basalts is located in southwest China and northern Vietnam,covering an area of 2.5×10^(5) km^(2)(Zhong YT et al.,2014),which is the first widely recognized large igneous province(LIP)in China(Zhang ZS,2009).The Emeishan LIP has attracted a numbers of scholars for the reason that the LIP may play a significant role in the evolution of environment and climate.Yang JH et al.,(2018)pointed out that the weathering of the Emeishan basalts consumed carbon dioxide and caused a decrease in the climate of the early Wuchiapingian.However,the duration and termination of the Emeishan basalts eruption remain in doubt.This paper reports a new discovery of tuffaceous in the middle part of the Upper Permian Wujiaping Formation from the northern margin of the Sichuan Basin,applying of LA-ICP-MS to obtain zircon U-Pb ages of tuffaceous and to constrain the lasted eruption timing of Emeishan LIP.展开更多
BACKGROUND Xanthomatosis,a metabolic disorder causing yellow growths(xanthomas),poses challenges in lipid metabolism.This case study introduces the first documented instance within China's Yi population,emphasizin...BACKGROUND Xanthomatosis,a metabolic disorder causing yellow growths(xanthomas),poses challenges in lipid metabolism.This case study introduces the first documented instance within China's Yi population,emphasizing the need to explore dietary habits and treatment strategies tailored to this specific community.CASE SUMMARY Xanthomatosis is a metabolic disorder where lipid metabolism goes awry,resulting in the development of yellowish growths called xanthomas.A male patient,47 years of age,from China's Yi population,who is obese,visited our dermatology clinic complaining of widespread,non-painful rashes that have been present for two weeks.The patient works as a chef and has a diet that frequently includes oily and greasy foods.This case represents the initial documentation of xanthomatosis within the Yi population in China,offering a theoretical foundation for understanding dietary patterns and treatment options specific to the Yi community.CONCLUSION The first report of xanthomatosis in the Yi population in China lays a theoretical foundation for understanding Yi dietary patterns and treatment.展开更多
Cutaneous larva migrans (CLM) is a zoonotic hookworm infection of dogs and cats commonly found in low-income countries in the tropical and subtropical regions and travellers to these regions. It is caused by invasion ...Cutaneous larva migrans (CLM) is a zoonotic hookworm infection of dogs and cats commonly found in low-income countries in the tropical and subtropical regions and travellers to these regions. It is caused by invasion of the skin by the parasitic larvae of hookworms which, after entry, move under the skin causing an inflammatory reaction resulting in a single or multiple tracks. Patients commonly present with a progressive, itchy, erythematous serpiginous skin rash, affecting the feet, although it can affect any other parts of the body. The diagnosis is mainly clinical, based on history and physical examination. Treatment of this condition can effectively be achieved with either albendazole or ivermectin. We present a case of a 7-year-old boy who was diagnosed with CLM after presenting to the hospital with a history of a progressive itchy rash with tracks on the left foot. Although CLM is a self-limiting disease, it causes a lot of suffering and, therefore, it is of public concern. There is a need to increase awareness of this disease among health workers, and to implement and promote preventive measures against the disease since the cause is known.展开更多
The understanding of soliton dynamics promotes the development of ultrafast laser technology. High-energy purequartic solitons(PQSs) have gradually become a hotspot in recent years. Herein, we numerically study the in...The understanding of soliton dynamics promotes the development of ultrafast laser technology. High-energy purequartic solitons(PQSs) have gradually become a hotspot in recent years. Herein, we numerically study the influence of the gain bandwidth, saturation power, small-signal gain, and output coupler on PQS dynamics in passively mode-locked fiber lasers. The results show that the above four parameters can affect PQS dynamics. Pulsating PQSs occur as we alter the other three parameters when the gain bandwidth is 50 nm. Meanwhile, PQSs evolve from pulsating to erupting and then to splitting as the other three parameters are altered when the gain bandwidth is 10 nm, which can be attributed to the existence of the spectral filtering effect and intra-cavity fourth-order dispersion. These findings provide new insights into PQS dynamics in passively mode-locked fiber lasers.展开更多
Since the eruption of the Tianchi volcano about 1000 years ago, there have been at least 3 to 5 eruptions of small to moderate size. In addition, hazardous avalanches, rock falls and debris flows have occurred during ...Since the eruption of the Tianchi volcano about 1000 years ago, there have been at least 3 to 5 eruptions of small to moderate size. In addition, hazardous avalanches, rock falls and debris flows have occurred during periods between eruptions. A future eruption of the Tianchi volcano is likely to involve explosive interaction between magma and the caldera lake. The volume of erupted magma is almost in a range of 0.1-0.5 km3. Tephra fallout may damage agriculture in a large area near the volcano. If only 1% of the lake water were ejected during an eruption and then precipitated over an area of 200 km2, the average rainfall would be 100 mm. Moreover, lahars are likely to occur as both tephra and water ejected from the caldera lake fall onto flanks of the volcano. Rocks avalanching into the caldera lake also would bring about grave hazards because seiches would be triggered and lake water with the volume equal to that of the landslide would spill out of the existing breach in the caldera and cause flooding downstream.展开更多
Several clinical trials have demonstrated the potent antiviral efficacy of entecavir (ETV), and this relatively new nucleoside analogue drug has rapidly become a frequently prescribed therapy for chronic hepatitis B (...Several clinical trials have demonstrated the potent antiviral efficacy of entecavir (ETV), and this relatively new nucleoside analogue drug has rapidly become a frequently prescribed therapy for chronic hepatitis B (CHB) worldwide. While the studies have also shown a good overall safety profile for ETV, adverse drug reactions (ADRs) in patients with advanced cirrhosis have been reported and represent a broad spectrum of drug-induced injuries, including lactic acidosis, myalgia, neuropathy, azotemia, hypophosphatemia, muscular weakness, and pancreatitis, as well as immune-mediated responses (i.e., allergic reactions). Cutaneous ADRs associated with ETV are very rare, with only two case reports in the publicly available literature; both of these cases were classified as unspecified hypersensitivity allergic (type I) ADR, but neither were reported as pathologically proven or as evaluated by cytokine release analysis. Here, we report the case of a 45-year-old woman who presented with a generalized maculopapular rash after one week of ETV treatment for lamivudine-resistant CHB. The patient reported having experienced a similar skin eruption during a previous three-month regimen of ETV, for which she had self-discontinued the medication. Histopathological analysis of a skin biopsy showed acanthotic epidermis with focal parakeratosis and a perivascular lymphocytic infiltrate admixed with interstitial eosinophils in the papillary and reticular dermis, consistent with a diagnosis of drug sensitivity. A lymphocyte stimulation test showed significantly enhanced IL-4, indicating a classification of type IVb delayed hypersensitivity. The patient was switched to an adefovir-lamivudine combination regimen and the skin eruption resolved two weeks after the ETV withdrawal. This case represents the first pathologically and immunologically evidenced ETV-induced delayed type hypersensitivity skin reaction reported to date. Physicians should be aware of the potential, although rare, for cutaneous ADRs associated with ETV treatment.展开更多
Based on the transmitting theory of "smoke ring effect", the transient electromagnetism technique was used in coal mines to detect abnormal areas of aquiferous structures in both roofs and floors of coal sea...Based on the transmitting theory of "smoke ring effect", the transient electromagnetism technique was used in coal mines to detect abnormal areas of aquiferous structures in both roofs and floors of coal seams and in front of excavated roadways. Survey devices, working methods and techniques as well as data processing and interpretation are discussed systematically. In addition, the direction of mini-wireframe emission electromagnetic wave of the full space transient electromagnetism technique was verified by an underground borehole for water detection and drainage. The result indicates that this technique can detect both horizontal and vertical development rules of abnormal water bodies to a certain depth below the floor of coal seams and can also detect the abnormal, low resistance water bodies within a certain distance of roofs. Furthermore, it can detect such abnormal bodies in ahead of the excavated roadway front. Limited by the underground environment, the full space transient electromagnetism technique can detect to a depth of only 120 m or so.展开更多
An undersea volcano at Hunga Tonga-Hunga Ha'apai(HTHH)near the South Pacific island nation of Tonga,erupted violently on 15 January 2022.Potential climate impact of the HTHH volcanic eruption is of great concern t...An undersea volcano at Hunga Tonga-Hunga Ha'apai(HTHH)near the South Pacific island nation of Tonga,erupted violently on 15 January 2022.Potential climate impact of the HTHH volcanic eruption is of great concern to the public;here,we intend to size up the impact of the HTHH eruption from a historical perspective.The influence of historical volcanic eruptions on the global climate are firstly reviewed,which are thought to have contributed to decreased surface temperature,increased stratospheric temperature,suppressed global water cycle,weakened monsoon circulation and El Niño-like sea surface temperature.Our understanding of the impacts of past volcanic eruptions on global-scale climate provides potential implication to evaluate the impact of the HTHH eruption.Based on historical simulations,we estimate that the current HTHH eruption with an intensity of 0.4 Tg SO_(2)injection will decrease the global mean surface temperature by only 0.004℃in the first year after eruption,which is within the amplitude of internal variability at the interannual time scale and thus not strong enough to have significant impacts on the global climate.展开更多
With the gradual yet unequivocal phasing out of ozone depleting substances(ODSs), the environmental crisis caused by the discovery of an ozone hole over the Antarctic has lessened in severity and a promising recovery ...With the gradual yet unequivocal phasing out of ozone depleting substances(ODSs), the environmental crisis caused by the discovery of an ozone hole over the Antarctic has lessened in severity and a promising recovery of the ozone layer is predicted in this century. However, strong volcanic activity can also cause ozone depletion that might be severe enough to threaten the existence of life on Earth. In this study, a transport model and a coupled chemistry–climate model were used to simulate the impacts of super volcanoes on ozone depletion. The volcanic eruptions in the experiments were the 1991 Mount Pinatubo eruption and a 100 × Pinatubo size eruption. The results show that the percentage of global mean total column ozone depletion in the 2050 RCP8.5 100 × Pinatubo scenario is approximately 6% compared to two years before the eruption and 6.4% in tropics. An identical simulation, 100 × Pinatubo eruption only with natural source ODSs, produces an ozone depletion of 2.5% compared to two years before the eruption, and with 4.4% loss in the tropics. Based on the model results,the reduced ODSs and stratospheric cooling lighten the ozone depletion after super volcanic eruption.展开更多
The role of third molars in the oral cavity has been extensively studied over the years. Literature includes numerous diagnostic and treatment alternatives regarding the third molars. However, an issue that has not be...The role of third molars in the oral cavity has been extensively studied over the years. Literature includes numerous diagnostic and treatment alternatives regarding the third molars. However, an issue that has not been discussed at the same level is their involvement in orthodontic therapy. The aim of this study is to present a review of the contemporary literature regarding the most broadly discussed aspects of the multifactorial role of third molars in orthodontics and which are of general dental interest too.展开更多
A 600-year integration performed with the Bergen Climate Model and National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis data were used to investigate the impa...A 600-year integration performed with the Bergen Climate Model and National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis data were used to investigate the impact of strong tropical volcanic eruptions on the East Asian summer monsoon (EASM) and EASM rainfall.Both the simulation and NCEP/NCAR reanalysis data show a weakening of the EASM in strong eruption years.The model simulation suggests that North and South China experience droughts and the Yangtze-Huaihe River Valley experiences floods during eruption years.In response to strong tropical volcanic eruptions,the meridional air temperature gradient in the upper troposphere is enhanced,which leads to a southward shift and an increase of the East Asian subtropical westerly jet stream (EASWJ).At the same time,the land-sea thermal contrast between the Asian land mass and Northwest Pacific Ocean is weakened.The southward shift and increase of the EASWJ and reduction of the land-sea thermal contrast all contribute to a weakening of the EASM and EASM rainfall anomaly.展开更多
In the last decade a New Geophysics has been proposed,whereby the crust and uppermost ~400 km of the mantle of the Earth are so pervaded by closely-spaced stress-aligned microcracks(intergranular films of hydrated mel...In the last decade a New Geophysics has been proposed,whereby the crust and uppermost ~400 km of the mantle of the Earth are so pervaded by closely-spaced stress-aligned microcracks(intergranular films of hydrated melt in the mantle) that in situ rocks verge on failure by fracturing,and hence are critical-systems that impose a range of fundamentally-new properties on conventional sub-critical geophysics.Enough of these new properties have been observed to confirm that New Geophysics is a new understanding of fluid/rock deformation with important implications and applications.Evidence supporting New Geophysics has been published in a wide variety of publications.Here,for clarification,we summarise in one document the evidence supporting New Geophysics.展开更多
We present a narrative of the eruptive events culminating in the cataclysmic January 15, 2022 eruption of Hunga Tonga-Hunga Ha’apai Volcano by synthesizing diverse preliminary seismic, volcanological, sound wave, and...We present a narrative of the eruptive events culminating in the cataclysmic January 15, 2022 eruption of Hunga Tonga-Hunga Ha’apai Volcano by synthesizing diverse preliminary seismic, volcanological, sound wave, and lightning data available within the first few weeks after the eruption occurred. The first hour of eruptive activity produced fast-propagating tsunami waves, long-period seismic waves, loud audible sound waves, infrasonic waves, exceptionally intense volcanic lightning and an unsteady volcanic plume that transiently reached-at 58km-the Earth’s mesosphere. Energetic seismic signals were recorded worldwide and the globally stacked seismogram showed episodic seismic events within the most intense periods of phreatoplinian activity, and they correlated well with the infrasound pressure waveform recorded in Fiji. Gravity wave signals were strong enough to be observed over the entire planet in just the first few hours, with some circling the Earth multiple times subsequently. These large-amplitude, long-wavelength atmospheric disturbances come from the Earth’s atmosphere being forced by the magmatic mixture of tephra, melt and gasses emitted by the unsteady but quasicontinuous eruption from 0402±1–1800 UTC on January 15, 2022. Atmospheric forcing lasted much longer than rupturing from large earthquakes recorded on modern instruments, producing a type of shock wave that originated from the interaction between compressed air and ambient(wavy) sea surface. This scenario differs from conventional ideas of earthquake slip, landslides, or caldera collapse-generated tsunami waves because of the enormous(~1000x) volumetric change due to the supercritical nature of volatiles associated with the hot,volatile-rich phreatoplinian plume. The time series of plume altitude can be translated to volumetric discharge and mass flow rate. For an eruption duration of ~12 h, the eruptive volume and mass are estimated at 1.9 km^(3) and~2 900 Tg, respectively, corresponding to a VEI of 5–6 for this event. The high frequency and intensity of lightning was enhanced by the production of fine ash due to magma-seawater interaction with concomitant high charge per unit mass and the high pre-eruptive concentration of dissolved volatiles. Analysis of lightning flash frequencies provides a rapid metric for plume activity and eruption magnitude. Many aspects of this eruption await further investigation by multidisciplinary teams. It represents a unique opportunity for fundamental research regarding the complex, non-linear behavior of high energetic volcanic eruptions and attendant phenomena, with critical implications for hazard mitigation, volcano forecasting, and first-response efforts in future disasters.展开更多
FAM20A has been studied to a very limited extent. Mutations in human FAM20A cause amelogenesis imperfecta, gingival fibromatosis and kidney problems. It would be desirable to systemically analyse the expression of FAM...FAM20A has been studied to a very limited extent. Mutations in human FAM20A cause amelogenesis imperfecta, gingival fibromatosis and kidney problems. It would be desirable to systemically analyse the expression of FAM20A in dental tissues and to assess the pathological changes when this molecule is specifically nullified in individual tissues. Recently, we generated mice with a Fam2OA-floxed allele containing the beta-galactosidase reporter gene. We analysed FAM20A expression in dental tissues using X-Gal staining, immunohistochemistry and in situ hybridization, which showed that the ameloblasts in the mouse mandibular first molar began to express FAM20A at 1 day after birth, and the reduced enamel epithelium in erupting molars expressed a significant level of FAM2OA. By breeding K14-Cre mice with Fam20An^x/fl^x mice, we created K14-Cre;Fam20Af/flox/flox (conditional knock out, cKO) mice, in which Fam20A was inactivated in the epithelium. We analysed the dental tissues of cKO mice using X-ray radiography: histology and immunohistochemistry. The molar enamel matrix in cKO mice was much thinner than normal and was often separated from the dentinoenamel junction. The Fam2OA-deficient ameloblasts were non-polarized and disorganized and were detached from the enamel matrix. The enamel abnormality in cKO mice was consistent with the diagnosis of amelogenesis imperfecta. The levels of enamelin and matrix metalloproteinase 20 were lower in the ameloblasts and enamel of cKO mice than the normal mice, The cKO mice had remarkable delays in the eruption of molars and hyperplasia of the gingival epithelium. The findings emphasize the essential roles of FAM20A in the development of dental and oral tissues.展开更多
A gas field consisting of volcanic reservoir rocks was discovered in the block-T units of the Xihu Sag,East China Sea Basin.The lithology of the volcanic rocks is dominated by tuff and reworked tuff.The lithofacies ar...A gas field consisting of volcanic reservoir rocks was discovered in the block-T units of the Xihu Sag,East China Sea Basin.The lithology of the volcanic rocks is dominated by tuff and reworked tuff.The lithofacies are dominated by base surge deposits of explosive facies.As the architecture model of volcanic facies is still uncertain,it has restricted the exploration and development of mineral resources in this area.Using core and cuttings data,the lithology,lithofacies,geochemistry as well as grain size characteristics of volcanic rocks were analyzed.Based on these analyses,the volcanic rocks in the well section are divided into three eruptive stages.The transport direction of each volcanic eruption is analyzed using crystal fragment size analysis.The facies architecture of the block-T units was established based on the reconstruction results of paleo-geomorphology.The results show that the drilling reveals proximal facies(PF)and distal facies(DF)of the volcanic edifices.However,the crater-near crater facies(CNCF)are not revealed.Compared with the reservoirs of the Songliao Basin,it is shown that the volcanic rocks in the Xihu Sag have good exploration potential;a favorable target area is the CNCF near the contemporaneous fault.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant No 60477026).
文摘This paper investigates the adjacent interactions of three novel solitons for the quintic complex Ginzburg-Landau equation, which are plain pulsating, erupting and creeping solitons. It is found that different performances are presented for different solitons due to isolated regions of the parameter space where they exist. For example, plain pulsating and erupting solitons exhibit mutual annihilation during collisions with the decrease of total energy, but for creeping soliton, the two adjacent pulses present soliton fusion without any loss of energy. Otherwise, the method for restraining the interactions is also found and it can suppress interactions between these two adjacent pulses effectively.
基金This work has been supported by National Key R&D Program of China No.2022YFF0503804.
文摘The Solar Close Observations and Proximity Experiments(SCOPE)mission,which has been proposed by the Yunnan Observatories,Chinese Academy of Sciences,aiming to operate at a distance of 5 to 10 solar radii from the Sun,plans to complete the in situ detection of the solar eruption process and observation of the magnetic field structure response.The solar flux received by the satellite ranges from 10^(3) to 10^(6) Wm^(-2),which poses challenges for thermal management of the solar arrays.In this work,the solar array cooling system of the Parker Solar Probe is discussed,the developments of the fluid loop technique are reviewed,and a research plan for a next-generation solar array cooling system is proposed.This paper provides a valuable reference for novel thermal control systems in spacecraft for solar observation.
基金the National Key Research and Development Program of China(Grant No.2020YFA0608803)the National Natural Science Foundation of China(Grant Nos.41975107,41875092 and 42005020).
文摘To explain the recent three-year La Niña event from 2020 to 2022,which has caused catastrophic weather events worldwide,Fasullo et al.(2023)demonstrated that the increase in biomass aerosol resulting from the 2019-20 Australian wildfire season could have triggered this multi-year La Niña.Here,we present compelling evidence from paleo-proxies,utilizing a substantial sample size of 26 volcanic eruptions in the Southern Hemisphere(SH),to support the hypothesis that ocean cooling in the SH can lead to a multi-year La Niña event.This research highlights the importance of focusing on the Southern Ocean,as current climate models struggle to accurately simulate the Pacific response driven by the Southern Ocean.
基金jointly supported by the Open Fund of State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Developmentthe Natural Science Foundation of Sichuan Province(Grant No.24NSFSC4125)。
文摘1.Objective The Emeishan basalts is located in southwest China and northern Vietnam,covering an area of 2.5×10^(5) km^(2)(Zhong YT et al.,2014),which is the first widely recognized large igneous province(LIP)in China(Zhang ZS,2009).The Emeishan LIP has attracted a numbers of scholars for the reason that the LIP may play a significant role in the evolution of environment and climate.Yang JH et al.,(2018)pointed out that the weathering of the Emeishan basalts consumed carbon dioxide and caused a decrease in the climate of the early Wuchiapingian.However,the duration and termination of the Emeishan basalts eruption remain in doubt.This paper reports a new discovery of tuffaceous in the middle part of the Upper Permian Wujiaping Formation from the northern margin of the Sichuan Basin,applying of LA-ICP-MS to obtain zircon U-Pb ages of tuffaceous and to constrain the lasted eruption timing of Emeishan LIP.
文摘BACKGROUND Xanthomatosis,a metabolic disorder causing yellow growths(xanthomas),poses challenges in lipid metabolism.This case study introduces the first documented instance within China's Yi population,emphasizing the need to explore dietary habits and treatment strategies tailored to this specific community.CASE SUMMARY Xanthomatosis is a metabolic disorder where lipid metabolism goes awry,resulting in the development of yellowish growths called xanthomas.A male patient,47 years of age,from China's Yi population,who is obese,visited our dermatology clinic complaining of widespread,non-painful rashes that have been present for two weeks.The patient works as a chef and has a diet that frequently includes oily and greasy foods.This case represents the initial documentation of xanthomatosis within the Yi population in China,offering a theoretical foundation for understanding dietary patterns and treatment options specific to the Yi community.CONCLUSION The first report of xanthomatosis in the Yi population in China lays a theoretical foundation for understanding Yi dietary patterns and treatment.
文摘Cutaneous larva migrans (CLM) is a zoonotic hookworm infection of dogs and cats commonly found in low-income countries in the tropical and subtropical regions and travellers to these regions. It is caused by invasion of the skin by the parasitic larvae of hookworms which, after entry, move under the skin causing an inflammatory reaction resulting in a single or multiple tracks. Patients commonly present with a progressive, itchy, erythematous serpiginous skin rash, affecting the feet, although it can affect any other parts of the body. The diagnosis is mainly clinical, based on history and physical examination. Treatment of this condition can effectively be achieved with either albendazole or ivermectin. We present a case of a 7-year-old boy who was diagnosed with CLM after presenting to the hospital with a history of a progressive itchy rash with tracks on the left foot. Although CLM is a self-limiting disease, it causes a lot of suffering and, therefore, it is of public concern. There is a need to increase awareness of this disease among health workers, and to implement and promote preventive measures against the disease since the cause is known.
基金the financial support from Science and Technology Project of the Jilin Provincial Department of Education (Grant No. JJKH20231171KJ)。
文摘The understanding of soliton dynamics promotes the development of ultrafast laser technology. High-energy purequartic solitons(PQSs) have gradually become a hotspot in recent years. Herein, we numerically study the influence of the gain bandwidth, saturation power, small-signal gain, and output coupler on PQS dynamics in passively mode-locked fiber lasers. The results show that the above four parameters can affect PQS dynamics. Pulsating PQSs occur as we alter the other three parameters when the gain bandwidth is 50 nm. Meanwhile, PQSs evolve from pulsating to erupting and then to splitting as the other three parameters are altered when the gain bandwidth is 10 nm, which can be attributed to the existence of the spectral filtering effect and intra-cavity fourth-order dispersion. These findings provide new insights into PQS dynamics in passively mode-locked fiber lasers.
基金The research was funded by the Natural Science Foundation of China(40172033)and the state volcano program of the tenth Five-Year Plan period(2001BA601B06-01-4).
文摘Since the eruption of the Tianchi volcano about 1000 years ago, there have been at least 3 to 5 eruptions of small to moderate size. In addition, hazardous avalanches, rock falls and debris flows have occurred during periods between eruptions. A future eruption of the Tianchi volcano is likely to involve explosive interaction between magma and the caldera lake. The volume of erupted magma is almost in a range of 0.1-0.5 km3. Tephra fallout may damage agriculture in a large area near the volcano. If only 1% of the lake water were ejected during an eruption and then precipitated over an area of 200 km2, the average rainfall would be 100 mm. Moreover, lahars are likely to occur as both tephra and water ejected from the caldera lake fall onto flanks of the volcano. Rocks avalanching into the caldera lake also would bring about grave hazards because seiches would be triggered and lake water with the volume equal to that of the landslide would spill out of the existing breach in the caldera and cause flooding downstream.
基金Supported by grant from the Chungbuk National University Hospital(2013)
文摘Several clinical trials have demonstrated the potent antiviral efficacy of entecavir (ETV), and this relatively new nucleoside analogue drug has rapidly become a frequently prescribed therapy for chronic hepatitis B (CHB) worldwide. While the studies have also shown a good overall safety profile for ETV, adverse drug reactions (ADRs) in patients with advanced cirrhosis have been reported and represent a broad spectrum of drug-induced injuries, including lactic acidosis, myalgia, neuropathy, azotemia, hypophosphatemia, muscular weakness, and pancreatitis, as well as immune-mediated responses (i.e., allergic reactions). Cutaneous ADRs associated with ETV are very rare, with only two case reports in the publicly available literature; both of these cases were classified as unspecified hypersensitivity allergic (type I) ADR, but neither were reported as pathologically proven or as evaluated by cytokine release analysis. Here, we report the case of a 45-year-old woman who presented with a generalized maculopapular rash after one week of ETV treatment for lamivudine-resistant CHB. The patient reported having experienced a similar skin eruption during a previous three-month regimen of ETV, for which she had self-discontinued the medication. Histopathological analysis of a skin biopsy showed acanthotic epidermis with focal parakeratosis and a perivascular lymphocytic infiltrate admixed with interstitial eosinophils in the papillary and reticular dermis, consistent with a diagnosis of drug sensitivity. A lymphocyte stimulation test showed significantly enhanced IL-4, indicating a classification of type IVb delayed hypersensitivity. The patient was switched to an adefovir-lamivudine combination regimen and the skin eruption resolved two weeks after the ETV withdrawal. This case represents the first pathologically and immunologically evidenced ETV-induced delayed type hypersensitivity skin reaction reported to date. Physicians should be aware of the potential, although rare, for cutaneous ADRs associated with ETV treatment.
文摘Based on the transmitting theory of "smoke ring effect", the transient electromagnetism technique was used in coal mines to detect abnormal areas of aquiferous structures in both roofs and floors of coal seams and in front of excavated roadways. Survey devices, working methods and techniques as well as data processing and interpretation are discussed systematically. In addition, the direction of mini-wireframe emission electromagnetic wave of the full space transient electromagnetism technique was verified by an underground borehole for water detection and drainage. The result indicates that this technique can detect both horizontal and vertical development rules of abnormal water bodies to a certain depth below the floor of coal seams and can also detect the abnormal, low resistance water bodies within a certain distance of roofs. Furthermore, it can detect such abnormal bodies in ahead of the excavated roadway front. Limited by the underground environment, the full space transient electromagnetism technique can detect to a depth of only 120 m or so.
基金supported by the National Natural Science Foundation of China(Grant Nos.41988101,,42105047).
文摘An undersea volcano at Hunga Tonga-Hunga Ha'apai(HTHH)near the South Pacific island nation of Tonga,erupted violently on 15 January 2022.Potential climate impact of the HTHH volcanic eruption is of great concern to the public;here,we intend to size up the impact of the HTHH eruption from a historical perspective.The influence of historical volcanic eruptions on the global climate are firstly reviewed,which are thought to have contributed to decreased surface temperature,increased stratospheric temperature,suppressed global water cycle,weakened monsoon circulation and El Niño-like sea surface temperature.Our understanding of the impacts of past volcanic eruptions on global-scale climate provides potential implication to evaluate the impact of the HTHH eruption.Based on historical simulations,we estimate that the current HTHH eruption with an intensity of 0.4 Tg SO_(2)injection will decrease the global mean surface temperature by only 0.004℃in the first year after eruption,which is within the amplitude of internal variability at the interannual time scale and thus not strong enough to have significant impacts on the global climate.
基金supported by the National Key Research and Development Project of China (Grant No. 2016YFA0600604)the National Natural Science Foundation of China (Grant No. 41461144001 and No. 41861144016)the Youth Innovation Promotion Association of the Chinese Academy of Sciences (Grant No. 2014064)
文摘With the gradual yet unequivocal phasing out of ozone depleting substances(ODSs), the environmental crisis caused by the discovery of an ozone hole over the Antarctic has lessened in severity and a promising recovery of the ozone layer is predicted in this century. However, strong volcanic activity can also cause ozone depletion that might be severe enough to threaten the existence of life on Earth. In this study, a transport model and a coupled chemistry–climate model were used to simulate the impacts of super volcanoes on ozone depletion. The volcanic eruptions in the experiments were the 1991 Mount Pinatubo eruption and a 100 × Pinatubo size eruption. The results show that the percentage of global mean total column ozone depletion in the 2050 RCP8.5 100 × Pinatubo scenario is approximately 6% compared to two years before the eruption and 6.4% in tropics. An identical simulation, 100 × Pinatubo eruption only with natural source ODSs, produces an ozone depletion of 2.5% compared to two years before the eruption, and with 4.4% loss in the tropics. Based on the model results,the reduced ODSs and stratospheric cooling lighten the ozone depletion after super volcanic eruption.
文摘The role of third molars in the oral cavity has been extensively studied over the years. Literature includes numerous diagnostic and treatment alternatives regarding the third molars. However, an issue that has not been discussed at the same level is their involvement in orthodontic therapy. The aim of this study is to present a review of the contemporary literature regarding the most broadly discussed aspects of the multifactorial role of third molars in orthodontics and which are of general dental interest too.
基金supported by the Strategic Priority Research Program(Grant No.XDA05110203) of the Chinese Academy of Sciencesthe Research Council of Norway through the India-Clim projectthe National Basic Research Program of China(Grant Nos.2012CB955401 and 2010CB951802)
文摘A 600-year integration performed with the Bergen Climate Model and National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis data were used to investigate the impact of strong tropical volcanic eruptions on the East Asian summer monsoon (EASM) and EASM rainfall.Both the simulation and NCEP/NCAR reanalysis data show a weakening of the EASM in strong eruption years.The model simulation suggests that North and South China experience droughts and the Yangtze-Huaihe River Valley experiences floods during eruption years.In response to strong tropical volcanic eruptions,the meridional air temperature gradient in the upper troposphere is enhanced,which leads to a southward shift and an increase of the East Asian subtropical westerly jet stream (EASWJ).At the same time,the land-sea thermal contrast between the Asian land mass and Northwest Pacific Ocean is weakened.The southward shift and increase of the EASWJ and reduction of the land-sea thermal contrast all contribute to a weakening of the EASM and EASM rainfall anomaly.
文摘In the last decade a New Geophysics has been proposed,whereby the crust and uppermost ~400 km of the mantle of the Earth are so pervaded by closely-spaced stress-aligned microcracks(intergranular films of hydrated melt in the mantle) that in situ rocks verge on failure by fracturing,and hence are critical-systems that impose a range of fundamentally-new properties on conventional sub-critical geophysics.Enough of these new properties have been observed to confirm that New Geophysics is a new understanding of fluid/rock deformation with important implications and applications.Evidence supporting New Geophysics has been published in a wide variety of publications.Here,for clarification,we summarise in one document the evidence supporting New Geophysics.
基金partially supported by US Department of Energy Grant DE-SC0019759National Science Foundation (NSF) Grants EAR-1918126, EAR-2027150, EAR-1925965, and OCE-1842989。
文摘We present a narrative of the eruptive events culminating in the cataclysmic January 15, 2022 eruption of Hunga Tonga-Hunga Ha’apai Volcano by synthesizing diverse preliminary seismic, volcanological, sound wave, and lightning data available within the first few weeks after the eruption occurred. The first hour of eruptive activity produced fast-propagating tsunami waves, long-period seismic waves, loud audible sound waves, infrasonic waves, exceptionally intense volcanic lightning and an unsteady volcanic plume that transiently reached-at 58km-the Earth’s mesosphere. Energetic seismic signals were recorded worldwide and the globally stacked seismogram showed episodic seismic events within the most intense periods of phreatoplinian activity, and they correlated well with the infrasound pressure waveform recorded in Fiji. Gravity wave signals were strong enough to be observed over the entire planet in just the first few hours, with some circling the Earth multiple times subsequently. These large-amplitude, long-wavelength atmospheric disturbances come from the Earth’s atmosphere being forced by the magmatic mixture of tephra, melt and gasses emitted by the unsteady but quasicontinuous eruption from 0402±1–1800 UTC on January 15, 2022. Atmospheric forcing lasted much longer than rupturing from large earthquakes recorded on modern instruments, producing a type of shock wave that originated from the interaction between compressed air and ambient(wavy) sea surface. This scenario differs from conventional ideas of earthquake slip, landslides, or caldera collapse-generated tsunami waves because of the enormous(~1000x) volumetric change due to the supercritical nature of volatiles associated with the hot,volatile-rich phreatoplinian plume. The time series of plume altitude can be translated to volumetric discharge and mass flow rate. For an eruption duration of ~12 h, the eruptive volume and mass are estimated at 1.9 km^(3) and~2 900 Tg, respectively, corresponding to a VEI of 5–6 for this event. The high frequency and intensity of lightning was enhanced by the production of fine ash due to magma-seawater interaction with concomitant high charge per unit mass and the high pre-eruptive concentration of dissolved volatiles. Analysis of lightning flash frequencies provides a rapid metric for plume activity and eruption magnitude. Many aspects of this eruption await further investigation by multidisciplinary teams. It represents a unique opportunity for fundamental research regarding the complex, non-linear behavior of high energetic volcanic eruptions and attendant phenomena, with critical implications for hazard mitigation, volcano forecasting, and first-response efforts in future disasters.
基金supported by the National Natural Science Foundation of China (Grant No. 81171744)the Natural Science Foundation of Heilongjiang Province of China (Grant H201418)
文摘FAM20A has been studied to a very limited extent. Mutations in human FAM20A cause amelogenesis imperfecta, gingival fibromatosis and kidney problems. It would be desirable to systemically analyse the expression of FAM20A in dental tissues and to assess the pathological changes when this molecule is specifically nullified in individual tissues. Recently, we generated mice with a Fam2OA-floxed allele containing the beta-galactosidase reporter gene. We analysed FAM20A expression in dental tissues using X-Gal staining, immunohistochemistry and in situ hybridization, which showed that the ameloblasts in the mouse mandibular first molar began to express FAM20A at 1 day after birth, and the reduced enamel epithelium in erupting molars expressed a significant level of FAM2OA. By breeding K14-Cre mice with Fam20An^x/fl^x mice, we created K14-Cre;Fam20Af/flox/flox (conditional knock out, cKO) mice, in which Fam20A was inactivated in the epithelium. We analysed the dental tissues of cKO mice using X-ray radiography: histology and immunohistochemistry. The molar enamel matrix in cKO mice was much thinner than normal and was often separated from the dentinoenamel junction. The Fam2OA-deficient ameloblasts were non-polarized and disorganized and were detached from the enamel matrix. The enamel abnormality in cKO mice was consistent with the diagnosis of amelogenesis imperfecta. The levels of enamelin and matrix metalloproteinase 20 were lower in the ameloblasts and enamel of cKO mice than the normal mice, The cKO mice had remarkable delays in the eruption of molars and hyperplasia of the gingival epithelium. The findings emphasize the essential roles of FAM20A in the development of dental and oral tissues.
基金supported by the National Natural Science Foundation of China(41472304)the MOST(2012CB822002)+1 种基金the National Science and Technology Major Project of the Ministry of Science and Technology of China(2016ZX05026-004-001)the Natural Science Foundation of Jilin Province(20170101001JC)
文摘A gas field consisting of volcanic reservoir rocks was discovered in the block-T units of the Xihu Sag,East China Sea Basin.The lithology of the volcanic rocks is dominated by tuff and reworked tuff.The lithofacies are dominated by base surge deposits of explosive facies.As the architecture model of volcanic facies is still uncertain,it has restricted the exploration and development of mineral resources in this area.Using core and cuttings data,the lithology,lithofacies,geochemistry as well as grain size characteristics of volcanic rocks were analyzed.Based on these analyses,the volcanic rocks in the well section are divided into three eruptive stages.The transport direction of each volcanic eruption is analyzed using crystal fragment size analysis.The facies architecture of the block-T units was established based on the reconstruction results of paleo-geomorphology.The results show that the drilling reveals proximal facies(PF)and distal facies(DF)of the volcanic edifices.However,the crater-near crater facies(CNCF)are not revealed.Compared with the reservoirs of the Songliao Basin,it is shown that the volcanic rocks in the Xihu Sag have good exploration potential;a favorable target area is the CNCF near the contemporaneous fault.