BACKGROUND Erythema multiforme(EM)is an extremely rare condition in neonates,and studies suggest its association with certain infections and neonatal vaccinations;however,few specific etiological agents have been iden...BACKGROUND Erythema multiforme(EM)is an extremely rare condition in neonates,and studies suggest its association with certain infections and neonatal vaccinations;however,few specific etiological agents have been identified.Rotavirus,a common pathogenic gastrointestinal virus in the neonatal period that is preventable via vaccination,has not been identified as a possible etiology.We report the case of a neonate who was referred for skin lesions presenting as EM,where a meticulous workup identified rotavirus as the sole causative agent.CASE SUMMARY A 14-day-old male infant was admitted to our hospital with a 1-day history of skin lesions.No medical history or medication intake was recorded.Except for the complaint of skin lesions,the caregivers denied any abnormal symptoms.Multiple tests,including routine laboratory evaluations,were performed to identify the cause of skin lesions.Serological tests for Immunoglobulin M for Toxoplasma,Rubella,Cytomegalovirus,Herpes Simplex Virus,and Epstein-Barr virus viral-capsid antigen were all negative.Multiple polymerase chain reaction(PCR)tests for respiratory viruses and bacterial pathogens were negative(including the severe acute respiratory syndrome coronavirus 2).Multiple PCR tests for gastrointestinal viruses and bacterial pathogens demonstrated evidence of rotavirus infection.No growth was reported in the blood and urine cultures.The patient received intravenous fluids for hydration;meanwhile,no other medications were prescribed.The lesions improved rapidly without specific treatment,and full recovery was achieved within a week.CONCLUSION The possibility of rotavirus,a major cause of pediatric gastrointestinal infections,being a trigger for neonatal EM should be considered.展开更多
Rowell syndrome is a disease diagnosed by three major and three minor criteria. The major criteria include the presence of lupus erythematosus (systemic, discoid, or subacute lupus), EM-like lesions (with or without i...Rowell syndrome is a disease diagnosed by three major and three minor criteria. The major criteria include the presence of lupus erythematosus (systemic, discoid, or subacute lupus), EM-like lesions (with or without involvement of mucous membranes), and a speckled pattern of antinuclear antibodies. The minor criteria include chilblains, anti-Ro and/or anti-La antibodies, and positive RF. In this article, we present a patient whose manifestation indicated RS, because his diagnosis of Systemic lupus erythematosus was definite, and also onset with EM-like lesions and positive antinuclear antibodies. All these above are consistent with the three major criteria. In addition, his RF was positive, which was the complement for the minor criteria.展开更多
目的探讨重症药疹的发生发展规律、治疗、临床特点和预后。方法回顾分析山西医科大学第一医院皮肤科2014年12月至2018年4月间收治的32例重症药疹(Severe Drug Eruption,SDE)病人相关资料。结果重症多形红斑型药疹是最常见重症药疹类型,...目的探讨重症药疹的发生发展规律、治疗、临床特点和预后。方法回顾分析山西医科大学第一医院皮肤科2014年12月至2018年4月间收治的32例重症药疹(Severe Drug Eruption,SDE)病人相关资料。结果重症多形红斑型药疹是最常见重症药疹类型,共20例(62.50%)。潜伏期最长的重症药疹类型是剥脱性皮炎型药疹,为(22.44±13.97)d。最常见致敏药物为抗癫痫药。发热及黏膜损害发生率最高。激素联合静脉滴注丙种球蛋白治疗重症药疹病人在皮损控制时间(6.38±1.71)d、激素的最大用量(1.06±0.37)mg·kg-1·d-1、皮损控制时激素累积剂量(6.62±3.32)mg/kg、激素总累积剂量(8.40±3.39)mg/kg等方面均较单用激素组低(P<0.05)。结论各型重症药疹临床表现各有不同;且易对黏膜、肝肾等造成伤害,威胁到病人生命,临床医师应该谨慎使用易致敏药物,如卡马西平、中药/中成药、青霉素等;首选治疗方案仍然是静脉滴注糖皮质激素,早期联合丙种球蛋白疗效更佳。展开更多
文摘BACKGROUND Erythema multiforme(EM)is an extremely rare condition in neonates,and studies suggest its association with certain infections and neonatal vaccinations;however,few specific etiological agents have been identified.Rotavirus,a common pathogenic gastrointestinal virus in the neonatal period that is preventable via vaccination,has not been identified as a possible etiology.We report the case of a neonate who was referred for skin lesions presenting as EM,where a meticulous workup identified rotavirus as the sole causative agent.CASE SUMMARY A 14-day-old male infant was admitted to our hospital with a 1-day history of skin lesions.No medical history or medication intake was recorded.Except for the complaint of skin lesions,the caregivers denied any abnormal symptoms.Multiple tests,including routine laboratory evaluations,were performed to identify the cause of skin lesions.Serological tests for Immunoglobulin M for Toxoplasma,Rubella,Cytomegalovirus,Herpes Simplex Virus,and Epstein-Barr virus viral-capsid antigen were all negative.Multiple polymerase chain reaction(PCR)tests for respiratory viruses and bacterial pathogens were negative(including the severe acute respiratory syndrome coronavirus 2).Multiple PCR tests for gastrointestinal viruses and bacterial pathogens demonstrated evidence of rotavirus infection.No growth was reported in the blood and urine cultures.The patient received intravenous fluids for hydration;meanwhile,no other medications were prescribed.The lesions improved rapidly without specific treatment,and full recovery was achieved within a week.CONCLUSION The possibility of rotavirus,a major cause of pediatric gastrointestinal infections,being a trigger for neonatal EM should be considered.
文摘Rowell syndrome is a disease diagnosed by three major and three minor criteria. The major criteria include the presence of lupus erythematosus (systemic, discoid, or subacute lupus), EM-like lesions (with or without involvement of mucous membranes), and a speckled pattern of antinuclear antibodies. The minor criteria include chilblains, anti-Ro and/or anti-La antibodies, and positive RF. In this article, we present a patient whose manifestation indicated RS, because his diagnosis of Systemic lupus erythematosus was definite, and also onset with EM-like lesions and positive antinuclear antibodies. All these above are consistent with the three major criteria. In addition, his RF was positive, which was the complement for the minor criteria.
文摘目的探讨重症药疹的发生发展规律、治疗、临床特点和预后。方法回顾分析山西医科大学第一医院皮肤科2014年12月至2018年4月间收治的32例重症药疹(Severe Drug Eruption,SDE)病人相关资料。结果重症多形红斑型药疹是最常见重症药疹类型,共20例(62.50%)。潜伏期最长的重症药疹类型是剥脱性皮炎型药疹,为(22.44±13.97)d。最常见致敏药物为抗癫痫药。发热及黏膜损害发生率最高。激素联合静脉滴注丙种球蛋白治疗重症药疹病人在皮损控制时间(6.38±1.71)d、激素的最大用量(1.06±0.37)mg·kg-1·d-1、皮损控制时激素累积剂量(6.62±3.32)mg/kg、激素总累积剂量(8.40±3.39)mg/kg等方面均较单用激素组低(P<0.05)。结论各型重症药疹临床表现各有不同;且易对黏膜、肝肾等造成伤害,威胁到病人生命,临床医师应该谨慎使用易致敏药物,如卡马西平、中药/中成药、青霉素等;首选治疗方案仍然是静脉滴注糖皮质激素,早期联合丙种球蛋白疗效更佳。
