Myelodysplastic syndrome(MDS)is a malignant clonal disease of human hematopoietic stem cells.In this paper,a case of MDS with fever and rash as the first symptom was reported in our hospital,and the related literature...Myelodysplastic syndrome(MDS)is a malignant clonal disease of human hematopoietic stem cells.In this paper,a case of MDS with fever and rash as the first symptom was reported in our hospital,and the related literature was reviewed and summarized to provide ideas for the diagnosis of MDS.Case summary:The patient,male,62 years old,with systemic rash and fever as the initial symptoms,early multiple bone marrow examination showed no typical abnormalities.With the progress of the disease,bone marrow cytology,flow cytometry,molecular karyotype,chromosomal karyotype,skin biopsy and pathological diagnosis were performed,and the diagnosis was MDS.展开更多
目的探讨和分析氯吡格雷致皮肤不良反应的发生规律及特点,为临床安全用药提供参考。方法通过检索国内外期刊文献,包括Cochrane、PubMed、Web of science、Springer link、Embase、Scopus、中国知网、万方期刊论文数据库、维普期刊数据...目的探讨和分析氯吡格雷致皮肤不良反应的发生规律及特点,为临床安全用药提供参考。方法通过检索国内外期刊文献,包括Cochrane、PubMed、Web of science、Springer link、Embase、Scopus、中国知网、万方期刊论文数据库、维普期刊数据库、中国生物医学文献数据库等,对氯吡格雷致皮肤不良反应的相关文献进行统计和分析。结果收集到氯吡格雷致皮肤不良反应病例15例,年龄60岁以上11例(73.3%);不良反应发生时间最短于用药后30 min,最长于用药后约310 d;临床表现为不同程度的皮肤瘙痒,其中1例伴有低热,1例伴有高热;患者停用氯吡格雷或服用其他治疗药物后不良反应均有所减轻直至消失。结论临床使用氯吡格雷时应加强对患者进行药学监护,警惕皮肤不良反应的发生,同时应慎重评估再次给药后的治疗风险。展开更多
文摘Myelodysplastic syndrome(MDS)is a malignant clonal disease of human hematopoietic stem cells.In this paper,a case of MDS with fever and rash as the first symptom was reported in our hospital,and the related literature was reviewed and summarized to provide ideas for the diagnosis of MDS.Case summary:The patient,male,62 years old,with systemic rash and fever as the initial symptoms,early multiple bone marrow examination showed no typical abnormalities.With the progress of the disease,bone marrow cytology,flow cytometry,molecular karyotype,chromosomal karyotype,skin biopsy and pathological diagnosis were performed,and the diagnosis was MDS.
