Objective:To investigate the clinical diagnostic significance of peripheral blood T-cell test(T-spot test)for tuberculosis(TB)infection combined with erythrocyte sedimentation rate(ESR)in pulmonary TB.Methods:41 patie...Objective:To investigate the clinical diagnostic significance of peripheral blood T-cell test(T-spot test)for tuberculosis(TB)infection combined with erythrocyte sedimentation rate(ESR)in pulmonary TB.Methods:41 patients with a clinical diagnosis of TB during hospitalization from January 2020 to April 2023 in our hospital were selected as the experimental group,and 45 patients without TB(bronchopneumonia patients)were selected as the control group.The diagnostic specificity,sensitivity,and accuracy of the T-spot TB test,ESR test,and the combined test of the two were calculated respectively.Results:The sensitivity,specificity,and accuracy of the T-spot TB test combined with ESR for the diagnosis of TB in the experimental group were significantly higher than the individual results of the T-spot TB test and ESR test alone(P<0.05).Conclusion:The T-spot TB test combined with the ESR test for TB diagnosis has greater clinical value than carrying out the tests individually.展开更多
Background: ESR and CRP measurements reflect different aspects of systemic inflammation. Generally, they are either elevated or depressed at the same time. This study was aimed at evaluating the clinical ability of th...Background: ESR and CRP measurements reflect different aspects of systemic inflammation. Generally, they are either elevated or depressed at the same time. This study was aimed at evaluating the clinical ability of these markers in the early diagnosis of pulmonary tuberculosis. Materials and Methods: A total of 50 (male 39, female 21) patients who tested positive to Acid Alcohol Fast Bacilli (AAFB) were studied. ESR and CRP values were estimated using standard procedures. Results: The mean ESR value among the AAFB positive patients was 53.16 ± 4.92 mm/hr while the CRP value was 0.273 ± 0.035 mg/L. Gender and age were not found to have any influence on the ESR and CRP values. No relationship was found to exist between ESR and CRP (r = 0.17;p = 0.235) and age (r = 0.125;p = 0.388). Conclusion: A moderately elevated ESR and low CRP values exist at the early diagnosis of tuberculosis. There is no correlation between ESR and CRP at the onset of tuberculosis;hence CRP cannot be used as a screening tool for early diagnosis of tuberculosis.展开更多
In order to provide a scientific basis for laying out a unified standard of the reference value (Wintrobe) of Chinese people's erythrocyte sedimentation rate (ESR). this paper studies the relationship between the ...In order to provide a scientific basis for laying out a unified standard of the reference value (Wintrobe) of Chinese people's erythrocyte sedimentation rate (ESR). this paper studies the relationship between the reference values (Wintrobe) of Chinese healthy people's ESR, and the test is done according to the Wintrobe Laws and five geographical factors. It is found that the altitude is the modt important factor affecting the reference value (Wintrobe) of Chinese people's ESR. As altitude increases gradually, the reference value (Wintrobe) of people's ESR decreases accordingly, the correlation is quite obvious. By using the method of regression analysis, two multivariate regression equations and ten univariate regression equations are deduced If the geographical index values in a particular area are known, the reference value (Wintrobe) of Chinese people's ESR of this region can be established by means of the regression equations. Furthermore, according to the dependent relationship of the reference value (Wintrobe) of Chinese people's ESR on geographical factors.China can be divided into sin districts: Qinghai-Tibet, Southwest. Northwest. Southeast, North and Northeast China.展开更多
Reference values of erythrocyte sedimentation rate(ESR)are the key to interpret ESR blood test in clinic.The common local reference ESR values are more accuracy in blood test that are established with natural geograph...Reference values of erythrocyte sedimentation rate(ESR)are the key to interpret ESR blood test in clinic.The common local reference ESR values are more accuracy in blood test that are established with natural geographical factors by using the multiple linear regression(MLR)model and the artificial neural network(ANN).These knowledge-based methods have limitations since the knowledge domains of ESR and natural geographical factors are limited.This paper presents a new cases-depended model to establish reference ESR values with natural geographical factors and location using case-based reasoning(CBR)since knowledge domain of ESR and geographical factors is weak.Overall 224 local normal ESR values of China that calculated from 13623 samples were obtained,and the corresponding natural geographical factors and location that include altitude,sunshine hours,relative humidity,temperature,precipitation,annual temperature range and annual average wind speed were obtained from the National Geomatics Center of China.CBR was used to predict the unseen local reference ESR values with cases.The average absolute deviation(AAD),mean square error(MSE),prediction accuracy(PA),and Pearson correlation coefficient(r)between the observed and estimated data of proposed model is 33.07%,9.02,66.93% and 0.78,which are better than those of ANN and MLR model.The results show that the proposed model provides higher prediction accuracy than those of the artificial neural network and multiple linear regression models.The predicted values are very close to the observed values.Model results show significant agreement of cases data.Consequently,the model is used to predict the unseen local reference ESR with natural geographical factors and location.In spatial,the highest ESR reference areas are distributed in the southern-western district of China that includes Sichuan,Chongqing,Guangxi and Guizhou provinces,and the reference ESR values are greater than 23 mm/60 min.The higher ESR reference values are distributed in the middle part and northern-eastern of China which include Hubei,Henan,Shaanxi,Shanxi,Jilin and Heilongjiang provinces,and the reference ESR values are greater than 18 mm/60min.The lowest ESR reference values are distributed in the northern-western of China that includes Tibet and Xinjiang,and the reference ESR values are lower than 5 mm/60min.展开更多
BACKGROUND A disease caused by a novel coronavirus virus,named coronavirus disease 2019(COVID-19),broke out in Wuhan,China in December 2019,and spread around the word.As of March 4,2020,93090 confirmed cases and 2984 ...BACKGROUND A disease caused by a novel coronavirus virus,named coronavirus disease 2019(COVID-19),broke out in Wuhan,China in December 2019,and spread around the word.As of March 4,2020,93090 confirmed cases and 2984 deaths have been reported in more than 80 countries and territories.It has triggered global public health security.However,the features and prognosis of COVID-19 are incompletely understood.CASE SUMMARY We here report that the erythrocyte sedimentation rate(ESR)increased in a confirmed COVID patient.The high level of ESR sustained for a long time even after the patient recovered from COVID-19,while all results related to tumor,tuberculosis,rheumatic diseases,anemia,etc.cannot explain the abnormal elevation of ESR presented in this case.CONCLUSION Although the increased ESR cannot be explained by all existing evidence,it possibly links the abnormal pathologic change in some COVID-19 patients and negative prognosis,and provides the clue to dissect the mechanism of illness progressing in COVID-19 and its prognosis.展开更多
Objective: To analyze the clinical value of blood sedimentation rate, C-reactive protein (CRP) and D-dimer (D-D) expression levels in elderly patients before hip replacement for judging the prognosis after operation. ...Objective: To analyze the clinical value of blood sedimentation rate, C-reactive protein (CRP) and D-dimer (D-D) expression levels in elderly patients before hip replacement for judging the prognosis after operation. Methods 88 patients who needed hip replacement in orthopaedic surgery of our hospital from January 2014 to December 2017 were selected as the research object. According to the prognosis of patients, they were divided into two groups. 42 patients with good prognosis were treated as observation group and 46 patients with poor prognosis were treated as control group. The ESR and CRP of the two groups were recorded and analyzed before and after operation. The expression level of D-D, perioperative changes, and the prognostic value of the area under the curve (AUC) were compared by drawing the patient's working characteristic curve (ROC curve). Results The expression levels of ESR, CRP and D-D in the observation group were significantly higher than those in the control group (P < 0.05). The expression levels of CRP in the observation group were significantly higher than those in the control group (P < 0.05). The expression levels of ESR and CRP in the observation group before discharge were significantly higher than those in the control group (P < 0.05). There was significant difference between the two groups (P < 0.05);the level of ESR expression before and 2 days after operation was significantly lower than that before discharge (P < 0.05);the level of ESR expression before operation was significantly lower than that 2 days after operation (P < 0.05);and the CRP and D-D table before operation were compared between the two groups (P < 0.05). The level of CRP and D-D expression in two groups was significantly higher than that before discharge (P < 0.05). In this study, two groups of patients were infected. The incidence of thrombosis in the observation group was higher than that in the control group, but the difference was not statistically significant (P > 0.05). The Harris score of the observation group was significantly higher than that of the control group (P < 0.05). Conclusion There are abnormal levels of ESR, CRP and D-D expression in elderly patients with hip replacement before operation, and they have certain clinical value in evaluating the prognosis of elderly patients after hip replacement.展开更多
Objective To analyze the rate of erythrocyte iron incorporation and provided guidance for the iron nutrition for prepubertal children.Methods Fifty-seven prepubertal children of Beijing were involved in this study and...Objective To analyze the rate of erythrocyte iron incorporation and provided guidance for the iron nutrition for prepubertal children.Methods Fifty-seven prepubertal children of Beijing were involved in this study and each subject was orally administered 3 mg of 57 Fe twice daily to obtain a total of 30 mg 57 Fe after a 5-d period. The stable isotope ratios in RBCs were determined in 14 th day, 28 th day, 60 th day, and 90 th day. The erythrocyte incorporation rate in children was calculated using the stable isotope ratios, blood volume and body iron mass.Results The percentage of erythrocyte 57 Fe incorporation increased starting 14 th day, reached a peak at 60 d(boys: 19.67% ± 0.56%, girls: 21.33% ± 0.59%) and then decreased. The erythrocyte incorporation rates of 57 Fe obtained for girls in 60 th day was significantly higher than those obtained for boys(P < 0.0001).Conclusions The oral administration of 57 Fe to children can be used to obtain erythrocyte iron incorporation within 90 d. Prepubertal girls should begin to increase the intake of iron and further studies should pay more attention to the iron status in prepubertal children.展开更多
文摘Objective:To investigate the clinical diagnostic significance of peripheral blood T-cell test(T-spot test)for tuberculosis(TB)infection combined with erythrocyte sedimentation rate(ESR)in pulmonary TB.Methods:41 patients with a clinical diagnosis of TB during hospitalization from January 2020 to April 2023 in our hospital were selected as the experimental group,and 45 patients without TB(bronchopneumonia patients)were selected as the control group.The diagnostic specificity,sensitivity,and accuracy of the T-spot TB test,ESR test,and the combined test of the two were calculated respectively.Results:The sensitivity,specificity,and accuracy of the T-spot TB test combined with ESR for the diagnosis of TB in the experimental group were significantly higher than the individual results of the T-spot TB test and ESR test alone(P<0.05).Conclusion:The T-spot TB test combined with the ESR test for TB diagnosis has greater clinical value than carrying out the tests individually.
文摘Background: ESR and CRP measurements reflect different aspects of systemic inflammation. Generally, they are either elevated or depressed at the same time. This study was aimed at evaluating the clinical ability of these markers in the early diagnosis of pulmonary tuberculosis. Materials and Methods: A total of 50 (male 39, female 21) patients who tested positive to Acid Alcohol Fast Bacilli (AAFB) were studied. ESR and CRP values were estimated using standard procedures. Results: The mean ESR value among the AAFB positive patients was 53.16 ± 4.92 mm/hr while the CRP value was 0.273 ± 0.035 mg/L. Gender and age were not found to have any influence on the ESR and CRP values. No relationship was found to exist between ESR and CRP (r = 0.17;p = 0.235) and age (r = 0.125;p = 0.388). Conclusion: A moderately elevated ESR and low CRP values exist at the early diagnosis of tuberculosis. There is no correlation between ESR and CRP at the onset of tuberculosis;hence CRP cannot be used as a screening tool for early diagnosis of tuberculosis.
文摘In order to provide a scientific basis for laying out a unified standard of the reference value (Wintrobe) of Chinese people's erythrocyte sedimentation rate (ESR). this paper studies the relationship between the reference values (Wintrobe) of Chinese healthy people's ESR, and the test is done according to the Wintrobe Laws and five geographical factors. It is found that the altitude is the modt important factor affecting the reference value (Wintrobe) of Chinese people's ESR. As altitude increases gradually, the reference value (Wintrobe) of people's ESR decreases accordingly, the correlation is quite obvious. By using the method of regression analysis, two multivariate regression equations and ten univariate regression equations are deduced If the geographical index values in a particular area are known, the reference value (Wintrobe) of Chinese people's ESR of this region can be established by means of the regression equations. Furthermore, according to the dependent relationship of the reference value (Wintrobe) of Chinese people's ESR on geographical factors.China can be divided into sin districts: Qinghai-Tibet, Southwest. Northwest. Southeast, North and Northeast China.
基金Under the auspices of National Natural Science Foundation of China(No.40971060)
文摘Reference values of erythrocyte sedimentation rate(ESR)are the key to interpret ESR blood test in clinic.The common local reference ESR values are more accuracy in blood test that are established with natural geographical factors by using the multiple linear regression(MLR)model and the artificial neural network(ANN).These knowledge-based methods have limitations since the knowledge domains of ESR and natural geographical factors are limited.This paper presents a new cases-depended model to establish reference ESR values with natural geographical factors and location using case-based reasoning(CBR)since knowledge domain of ESR and geographical factors is weak.Overall 224 local normal ESR values of China that calculated from 13623 samples were obtained,and the corresponding natural geographical factors and location that include altitude,sunshine hours,relative humidity,temperature,precipitation,annual temperature range and annual average wind speed were obtained from the National Geomatics Center of China.CBR was used to predict the unseen local reference ESR values with cases.The average absolute deviation(AAD),mean square error(MSE),prediction accuracy(PA),and Pearson correlation coefficient(r)between the observed and estimated data of proposed model is 33.07%,9.02,66.93% and 0.78,which are better than those of ANN and MLR model.The results show that the proposed model provides higher prediction accuracy than those of the artificial neural network and multiple linear regression models.The predicted values are very close to the observed values.Model results show significant agreement of cases data.Consequently,the model is used to predict the unseen local reference ESR with natural geographical factors and location.In spatial,the highest ESR reference areas are distributed in the southern-western district of China that includes Sichuan,Chongqing,Guangxi and Guizhou provinces,and the reference ESR values are greater than 23 mm/60 min.The higher ESR reference values are distributed in the middle part and northern-eastern of China which include Hubei,Henan,Shaanxi,Shanxi,Jilin and Heilongjiang provinces,and the reference ESR values are greater than 18 mm/60min.The lowest ESR reference values are distributed in the northern-western of China that includes Tibet and Xinjiang,and the reference ESR values are lower than 5 mm/60min.
基金Supported by the Central Publicinterest Scientific Institution Basal Research Fund,Chinese Academy of Medical Sciences,No.2019PT320003Science and Technology Support Plan Fund of Zunyi City,No.NS(2020)1and Science Plan Fund of Zunyi City,No.HZ(2020)4.
文摘BACKGROUND A disease caused by a novel coronavirus virus,named coronavirus disease 2019(COVID-19),broke out in Wuhan,China in December 2019,and spread around the word.As of March 4,2020,93090 confirmed cases and 2984 deaths have been reported in more than 80 countries and territories.It has triggered global public health security.However,the features and prognosis of COVID-19 are incompletely understood.CASE SUMMARY We here report that the erythrocyte sedimentation rate(ESR)increased in a confirmed COVID patient.The high level of ESR sustained for a long time even after the patient recovered from COVID-19,while all results related to tumor,tuberculosis,rheumatic diseases,anemia,etc.cannot explain the abnormal elevation of ESR presented in this case.CONCLUSION Although the increased ESR cannot be explained by all existing evidence,it possibly links the abnormal pathologic change in some COVID-19 patients and negative prognosis,and provides the clue to dissect the mechanism of illness progressing in COVID-19 and its prognosis.
文摘Objective: To analyze the clinical value of blood sedimentation rate, C-reactive protein (CRP) and D-dimer (D-D) expression levels in elderly patients before hip replacement for judging the prognosis after operation. Methods 88 patients who needed hip replacement in orthopaedic surgery of our hospital from January 2014 to December 2017 were selected as the research object. According to the prognosis of patients, they were divided into two groups. 42 patients with good prognosis were treated as observation group and 46 patients with poor prognosis were treated as control group. The ESR and CRP of the two groups were recorded and analyzed before and after operation. The expression level of D-D, perioperative changes, and the prognostic value of the area under the curve (AUC) were compared by drawing the patient's working characteristic curve (ROC curve). Results The expression levels of ESR, CRP and D-D in the observation group were significantly higher than those in the control group (P < 0.05). The expression levels of CRP in the observation group were significantly higher than those in the control group (P < 0.05). The expression levels of ESR and CRP in the observation group before discharge were significantly higher than those in the control group (P < 0.05). There was significant difference between the two groups (P < 0.05);the level of ESR expression before and 2 days after operation was significantly lower than that before discharge (P < 0.05);the level of ESR expression before operation was significantly lower than that 2 days after operation (P < 0.05);and the CRP and D-D table before operation were compared between the two groups (P < 0.05). The level of CRP and D-D expression in two groups was significantly higher than that before discharge (P < 0.05). In this study, two groups of patients were infected. The incidence of thrombosis in the observation group was higher than that in the control group, but the difference was not statistically significant (P > 0.05). The Harris score of the observation group was significantly higher than that of the control group (P < 0.05). Conclusion There are abnormal levels of ESR, CRP and D-D expression in elderly patients with hip replacement before operation, and they have certain clinical value in evaluating the prognosis of elderly patients after hip replacement.
基金supported by the National Natural Science Foundation of China grant number 81330066。
文摘Objective To analyze the rate of erythrocyte iron incorporation and provided guidance for the iron nutrition for prepubertal children.Methods Fifty-seven prepubertal children of Beijing were involved in this study and each subject was orally administered 3 mg of 57 Fe twice daily to obtain a total of 30 mg 57 Fe after a 5-d period. The stable isotope ratios in RBCs were determined in 14 th day, 28 th day, 60 th day, and 90 th day. The erythrocyte incorporation rate in children was calculated using the stable isotope ratios, blood volume and body iron mass.Results The percentage of erythrocyte 57 Fe incorporation increased starting 14 th day, reached a peak at 60 d(boys: 19.67% ± 0.56%, girls: 21.33% ± 0.59%) and then decreased. The erythrocyte incorporation rates of 57 Fe obtained for girls in 60 th day was significantly higher than those obtained for boys(P < 0.0001).Conclusions The oral administration of 57 Fe to children can be used to obtain erythrocyte iron incorporation within 90 d. Prepubertal girls should begin to increase the intake of iron and further studies should pay more attention to the iron status in prepubertal children.
