Swiss lever escapement is almost always used in all mechanical watches, which is one of the most critical com- ponents in a mechanical watch. However, its dynamics has not been fully studied. This paper presents a met...Swiss lever escapement is almost always used in all mechanical watches, which is one of the most critical com- ponents in a mechanical watch. However, its dynamics has not been fully studied. This paper presents a method for dy- namics analysis and simulation of the Swiss level escapement. First, the Swiss lever escapement mechanism is introduced and its motion in a half-period is divided into four sections. Then the dynamics model is developed using impulsive differ- ential equations and the simulation result is obtained by MATIAB. A watch called Seiko7OO9a is taken as an example. The simulation result shows the dynamic behavior in terms of the relationship among displacement, angle and time. The spring constant and balance wheel inertia that governed the timekeeping accuracy are also discussed.展开更多
A series of silver-doped graphite-like carbon coatings was prepared on the surface of aluminum alloy using the magnetron sputtering method. The spontaneous escape behavior and inhibition mechanism of silver from graph...A series of silver-doped graphite-like carbon coatings was prepared on the surface of aluminum alloy using the magnetron sputtering method. The spontaneous escape behavior and inhibition mechanism of silver from graphite-like carbon coating were studied. The results showed that when the sample prepared with a 0.01-A current on the silver target was placed in an atmospheric environment for 0.5 h, an apparent silver escape phenomenon could be observed. However, the silver escape phenomenon was not observed for samples prepared with a 0.05-A current on the silver target if the sample was retained in a 10^（-1） Pa vacuum environment, even after 48 h. Compared with the sample placed in the atmospheric environment immediately after an ion plating process, the silver escape time lagged for 6 h. Nanometer-thick pure carbon coating coverage could effectively suppress silver escape. When the coating thickness reached700 nm, permanent retention of silver could be achieved in the silver-doped graphite-like carbon coating.As the silver residue content in the graphite-like carbon coating increased from 2.27 at.% to 5.35 at.%, the interfacial contact resistance of the coating decreased from 51mΩcm^2 to 6 mΩcm^2.展开更多
Immune escape mechanisms in non-small cell lung cancer(NSCLC)can disrupt every step of the anti-cancer immune response.In recent years,an increased understanding of the specific mechanisms fueling immune escape has al...Immune escape mechanisms in non-small cell lung cancer(NSCLC)can disrupt every step of the anti-cancer immune response.In recent years,an increased understanding of the specific mechanisms fueling immune escape has allowed for the development of numerous immunotherapeutic treatments that have been introduced into the clinical practice.The advent of immunotherapy has dramatically changed the current treatment landscape of advanced or metastatic NSCLC because of its durable efficacy and manageable toxicity.In this review,we will first present a brief overview of recent evidence on immune escape mechanisms in NSCLC.We will then discuss the current promising immunotherapeutic strategies in advanced or metastatic NSCLC tumors.展开更多
文摘Swiss lever escapement is almost always used in all mechanical watches, which is one of the most critical com- ponents in a mechanical watch. However, its dynamics has not been fully studied. This paper presents a method for dy- namics analysis and simulation of the Swiss level escapement. First, the Swiss lever escapement mechanism is introduced and its motion in a half-period is divided into four sections. Then the dynamics model is developed using impulsive differ- ential equations and the simulation result is obtained by MATIAB. A watch called Seiko7OO9a is taken as an example. The simulation result shows the dynamic behavior in terms of the relationship among displacement, angle and time. The spring constant and balance wheel inertia that governed the timekeeping accuracy are also discussed.
基金financial support of the project from the National Natural Science Foundation of China (Nos. 51571114 and 51401106)the Natural Science Foundation of Jiangsu Province (No. BK20130935)
文摘A series of silver-doped graphite-like carbon coatings was prepared on the surface of aluminum alloy using the magnetron sputtering method. The spontaneous escape behavior and inhibition mechanism of silver from graphite-like carbon coating were studied. The results showed that when the sample prepared with a 0.01-A current on the silver target was placed in an atmospheric environment for 0.5 h, an apparent silver escape phenomenon could be observed. However, the silver escape phenomenon was not observed for samples prepared with a 0.05-A current on the silver target if the sample was retained in a 10^（-1） Pa vacuum environment, even after 48 h. Compared with the sample placed in the atmospheric environment immediately after an ion plating process, the silver escape time lagged for 6 h. Nanometer-thick pure carbon coating coverage could effectively suppress silver escape. When the coating thickness reached700 nm, permanent retention of silver could be achieved in the silver-doped graphite-like carbon coating.As the silver residue content in the graphite-like carbon coating increased from 2.27 at.% to 5.35 at.%, the interfacial contact resistance of the coating decreased from 51mΩcm^2 to 6 mΩcm^2.
基金CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2021-I2M-1-050)Beijing Hospital Project(No.BJ-2019-145)
文摘Immune escape mechanisms in non-small cell lung cancer(NSCLC)can disrupt every step of the anti-cancer immune response.In recent years,an increased understanding of the specific mechanisms fueling immune escape has allowed for the development of numerous immunotherapeutic treatments that have been introduced into the clinical practice.The advent of immunotherapy has dramatically changed the current treatment landscape of advanced or metastatic NSCLC because of its durable efficacy and manageable toxicity.In this review,we will first present a brief overview of recent evidence on immune escape mechanisms in NSCLC.We will then discuss the current promising immunotherapeutic strategies in advanced or metastatic NSCLC tumors.
