Surgical Treatment of Carcinoma of Esophagus and Gastric Cardia—A 34—year Investigation

Objective To understand the progress in surgical treatment of 12 970 patients with carcinoma of esophagus and gastric cardiac during 1965-1998.Methods The patients were divided into A, B and C groups: 3 155 patients (group A) were treated surgically in the first 14 years, 5952 patients (group B) in the next 10 years, and 3 863 patients (group C) in the last 10 years. The early stage lesions (Tis, Tl) were assigned as a separate group. The results of these groups were compared.Results The resectability for esophageal and gastric cardiac carcinoma was 94.0% and 84.4% respectively, and the overall resectability was 91.3% . The resectabih'ty for groups A, B, C and the early stage group was 82.1% , 85.1% , 90.2% and 100% , respectively. The overall operative mortality was 1.8%, it was 4.4% for group A, 1.6% for group B, and 0.5% for group C. The overall 5-year survival was 31.6% . The 5-year survival for groups A, B, C and the early stage group was 27.0% , 29.1%, 32.0% and 92.6%, respectively . Among the 3 temporal groups, differences were observed in terms of lesion stage, location and size, surgery with or without combined therapy and postoperative complications.Conclusion Best results were achieved in the early cases, with a resectability of 100% and a 5-year survival of 92.6% . The indications for surgical treatment were extended with increased resectability and decreased mortality. Subtotal esophagectomy combined with cervical esophagogastrostomy was advocated as the procedure of first choice for esophageal carcinoma in attempt to diminish the chance of recurrence, and to achieve better outcomes by using combined therapy for patients with e" stage b! lesion.

Transesophageal ultrasonography in assessment of operability for advanced esophageal carcinoma

Sixty-one intermediate and advanced esophageal carcinoma patients were examined by transesophageal ultrasonography(TEUS),including 53 squamous carcinomas and 8 adenocarcinomas. The ultrasonic images showed that there were clearly demarcated spaces between the tumours and the important adjacent structures in 42 out of 48 patients having undergone esophagectomy,while in 10 non-resectable patients,the ultrasonic images displayed an unclear demarcation between the tumours and thoracic aorta,pulmonary vein and pericardium. The study discovered that the regional echo of thoracic aortic wall was interrupted and replaced by tumour hypoecho, and the aorta pressed,indicating carcinoma's serious invasion of the aorta. The non-resectability of carcinoma of this kind was later confirmed in operation. On 3 cases,operations couldn't be performed due to metastasis of liver.Six cases failed to be accurately assessed owing to the impassability for probe caused by esophageal stenosis or other factors. Accuracy of assessment was 85. 2%. So we believe TEUS is a useful,simple,reliable and secure method for assessing operability of esophageal carcinoma.

Analysis on relative factors of lymph node metastasis and pattern of postoperative locoreginal relapse of esophageal carcinoma

Objective: We aimed to study the relative factors of lymph node metastasis of esophageal carcinoma, and to analyze the distribution rule of lymph node metastasis of post esophagectomy patients for guiding the radiotherapy. Methods: To collect the patients' data (102 cases) in our hospital from 2001 to 2009, who were found lymph node metastasis confirmed by pathologic in a certain period of time after esophageal cancer surgery. The factors affected the lymph node metastasis in esophageal cancer were analysed by single logistic regression and Logistic Regression Method. To analyze the rule of post-operative lymph node metastasis in different regions, according to the lymph node partition, in accordance with paragraphs of esophageal cancer in different groups. Results: Of the 102 patients after esophageal cancer surgery, who were confirmed by pathological examination, 50 cases had positive lymph node metastasis and 52 cases had negative, the lymph node metastasis rate was 49.0%. Lymph node metastasis rates of different depth, length and paragraph of tumor invasion had statistical difference (P < 0.05). The impact on lymph node metastasis rates of the different age and degree of differentiation had no statistical difference (P > 0.05). Multivariate analysis showed that the lesion length, depth of invasion and paragraph of tumor were meaningful factors affecting the lymph node metastasis. Of the 102 patients, 132 sites node metastasis were found by imaging study and histopathology with lower neck and supraclavicular node 59 (44.70%), upper mediastinum node 51 (38.64%), A-P windows node 1 (0.76%), anterior mediastinum node 1 (0.76%), Subcarinal node 5 (3.79%), paraesopha- geal node 3 (2.27%), hilar node 3 (2.27%), abdominal node 9 (6.82%). Conclusion: The length and depth of invasion, and paragraph of esophageal cancer are meaningful factors that affect the lymph node metastasis. The longer of lesion, deeper of infiltration and lower of paragraph, the easier to get independently lymph node metastasis. The postoperative lymph node metastasis was mainly distributed in the lower neck and supraclavicular region and upper mediastinal region, which is the focus of postoperative radiotherapy.

Surgical treatment effects in cancer of the cardia and esophagogastric junction

Objective： To evaluate the treatment effects of total gastrectomy （TG） and proximal gastrectomy （PG） for cancer of the cardia and esophagogastric junction. Methods： forty-five patients with cancer of the cardia and esophagogastric junction underwent surgical resection. Of them, 29 were treated using proximal gastrectomy and 16 total gastrectomy. The 3-year and 5-year survival rate and the postoperative complication rate and mortality rate were followed up and compared between the two groups. Results： The 3-year and 5-year survival rates of group PG were 44.8% and 20.7%, of group TG were 37.5% and 18.8%, respectively, and the differences were not statistically significant （X^2= 3.84, P 〉 0.05; X^2= 3.89, P 〉 0.05）. The postoperative complication and mortality rate of group PG were 13.7% and 6.8%, of group TG was all 6%, respectively. Conclusion： Proximal and total gastrectomy treatment effects can not significantly influence the prognosis of patients in progressive stage of cancer of cardia and esophagogastric junction.

Recent advances in the surgical treatment of pancreatic cancer

INTRODUCTIONPancreatic cancer remains the fourth commonest cause of cancer related death in the western world[1]. The prognosis remains dismal due partly to late presentation, with associated low resectability rates, and the aggressive biological nature of these tumors. The median survival time from diagnosis in unresectable tumors remains only 4 6 months.For those patients amenable to surgical resection over the last 20 years have seen marked improvements in postoperative mortality and morbidity, especially in specialist pancreatic centres 23. Despite these changes long-term survival remains low. with a total 5-year survival rate remaining less than 5%.Patients with ampullary cancer have a better 5-year survival of 40°%-60°%.

Covered nitinol stents for the treatment of esophageal strictures and leaks

AIM:To compare 2 different types of covered esophageal nitinol stents(Ultraflex and Choostent) in terms of efficacy,complications,and long-term outcome.METHODS:A retrospective review of a consecutive series of 65 patients who underwent endoscopic placement of an Ultraflex stent(n = 33) or a Choostent(n = 32) from June 2001 to October 2009 was conducted.RESULTS:Stent placement was successful in all patients without hospital mortality.No significant differences in patient discomfort and complications were observed between the Ultraflex stent and Choostent groups.The median follow-up time was 6 mo(interquartile range 3-16 mo).Endoscopic reintervention was required in 9 patients(14%) because of stent migration or food obstruction.No significant difference in the rate of reintervention between the 2 groups was observed(P = 0.8).The mean dysphagia score 1 mo after stent placement was 1.9 ± 0.3 for the Ultraflex stent and 2.1 ± 0.4 for the Choostent(P = 0.6).At 1-mo follow-up endoscopy,the cover membrane of the stent appeared to be damaged more frequently in the Choostent group(P = 0.34).Removal of the Choostent was possible up to 8 wk without difficulty.CONCLUSION:Ultraflex and Choostent proved to be equally reliable for palliation of dysphagia and leaks.Removal of the Choostent was easy and safe under mild sedation.

Intensify standardized therapy for esophageal and stomach cancer in tumor hospitals

INTRODUCTIONCancer treatment situation in tumor hospitals inChina has its own unique characteristics which arenot found in other parts of the world. Because ofthe huge population and high incidence rates ofesophageal and stomach cancer[1-5], the number ofcancer patients waiting for admission isinconceivably large.

Radiotherapy combined with surgical treatment for gastric cancer:a meta-analysis

Objective:We carried out a meta-analysis to assess the effectiveness and safety of radiotherapy combined with surgery for gastric cancer.Methods:Randomized Clinical Trials (RCTs) in which radiotherapy (preoperative,intraoperative and postoperative),was compared with surgery alone in resectable gastric cancer were identified by searching Cochrane Library (Issue 2,2009),PubMed (Jan 1966-Jun 2009),EMBASE (Jan 1974-Jun 2009),Chinese Biomedical Literature Database (Jan 1978-Jun 2009),Chinese Science and Technology Periodicals Database (Jan 1989-Jun 2009),China National Knowledge Infrastructure (Jan 1994-Jun 2009) and Wanfang database (Jan 1997-Jun 2009) in English and Chinese languang.Two researchers assessed the quality of included randomized controlled trials (RCT) extracted data independently.The RevMan 5.0 software was used for meta-analysis.Our researchers assessed the quality of included randomized controlled trials (RCT) extracted data independently.The RevMan 5.0 software was used for meta-analysis.Results:Nine randomized controlled trials of 1 548 patients were selected for meta-analysis.Five randomized controlled trials were related with comparison of preoperative radiotherapy plus surgery with single surgery.Two randomized controlled trials were the comparative studies between surgery plus postoperative and single surgery.The meta-analysis results showed that:(1) compared with surgery alone,preoperative radiotherapy combined with surgery can increase 3 years (OR=1.78;95% CI 1.14-2.78,P=0.01),5 years (OR=1.67;95% CI 1.22-2.29,P=0.001),10 years (OR=1.64;95% CI 1.03-2.60,P=0.04) survival rate and resection rate (OR=2.15;95% CI 1.31-3.54,P=0.003);reduce the of tumor recurrence rate (OR=0.59;95% CI 0.37-0.92,P=0.02) and metastasis rate (OR=0.44;95% CI 0.27-0.73,P=0.001);(2) The tumor recurrent rates (OR=0.19,95% CI 0.03-1.14,P=0.07) and tumor metastasis rate (OR=0.09;95% CI 0.00-1.77,P=0.11) had no difference between single surgery group and peri-operative radiotherapy plus surgery group;(3) Postoperative radiotherapy compared with surgery alone had no significant effects on 1 year (OR=0.83;95% CI 0.60-1.15,P=0.26) and 3 years (OR=0.75;95% CI 0.51-1.11,P=0.15) survival rate compared with single surgery,but the 5-year survival rates (OR=0.57;95% CI 0.34-0.95,P=0.03) of the patients who received surgery alone was higher than those who received combined therapy.No difference of the tumor recurrence rate (OR=0.59;95% CI 0.33-1.05,P=0.07),tumor metestasis rate (OR=0.90;95% CI 0.51-1.59,P=0.71) and anastomotic leak (OR=0.98;95% CI 0.25-3.65,P=0.98) were observed between the two groups.Conclusion:Preoperative radiotherapy combined surgery is more rational and effective than surgery alone of gastric cancer.However,in terms of the clinical effects of perioperarive or postoperative radoiotherapy combined with surgery,much multicenter,largescale,high-quality,double-blind and rigorously designed studies would be needed than currently available in the future.

Application of mastoscopic in modified radical operation for preserving nipple-areolar complex

Objective: To probe the effect of mastoscopic in modified radical mastectomy operation for preserving nipple-areolar complex in the treatment of breast cancer. Methods: Thirty patients, with breast cancer of a diameter≤3 cm and a distance≥3 cm from the mammary areola were treated by mastoscopic from November 2003 to August 2006. After the lipoly- sis and suction of axillary fat, mastoscopic axillary lymph node dissection was performed. Results: The average operation time was 128.9 min (120–156 min), the intraoperative blood loss was 56 mL (30–100 mL). The mean lymph nodes harvested by endoscopy were 16 (6–34). Excellent cosmetic outcomes were obtained with symmetrical breast development and all the patients were satisfied with the treatment. Postoperative follow-up for 2–29 months (mean, 16.6 months) found no local recur-rence. Conclusion:This model of operation can protect the upper limb function and has value of aesthetics of the brisket. What’s more, improve the quality of survive of the patients.

pN_(0)期食管鳞癌患者胸腹两野术后2年内复发的因素分析

目的:探讨胸腹两野术后pN_(0)期食管鳞癌患者2年内复发的因素及其特点。方法:收集自2013年01月至2018年12月在我院接受手术治疗且符合入组条件的食管癌术后患者共467例,分析其生存情况、2年内复发的影响因素和复发模式等,应用SPSS 25.0统计软件进行统计分析。结果:全组患者1、3、5年总生存率分别为88.4%、71.9%和62.9%;55例患者2年内出现复发,其1、3、5年总生存率显著性低于其他患者(χ^(2)=103.258,P=0.000)。2年内复发患者的复发时间为1.2~24.0个月,中位9.0个月。单因素分析结果显示胸上段食管癌患者在2年内复发的比率为21.3%,显著性高于胸中/下段癌患者(χ^(2)=7.045,P=0.030);术中粘连程度越高则复发率越高(χ^(2)=6.653,P=0.036);pT分期越晚的患者其复发的风险也显著性增加(χ^(2)=15.975,P=0.001)。多因素分析结果显示食管病变部位和T分期为影响本组患者2年内复发的独立性因素(P=0.011、0.000)。单纯纵隔内淋巴结复发26例(47.3%),为本组2年内复发患者的主要复发部位。结论:pN_(0)期胸段食管鳞癌患者其2年内有较高的局部复发率,且复发模式主要以纵隔淋巴结复发为主,病理T分期和病变部位为影响其2年内复发的独立性影响因素,临床医师应对胸上段食管癌和pT分期较晚的患者进行积极随访观察和必要的辅助治疗。

神经内分泌肿瘤肝转移的外科干预策略

神经内分泌肿瘤是一组较罕见的肿瘤性疾病,可发生于身体多种脏器,具有高度肿瘤异质性,常形成以肝脏为最主要受累器官的继发性肿瘤并伴发类癌综合征。肝转移是造成神经内分泌肿瘤患者治疗失败的重要临床事件,通过及时、合理的外科干预有效控制病情发展、争取达到肿瘤无病状态或根治目标,有效延长患者总体生存,是近年来临床医师和研究者聚焦的重要课题。本文综合近年来国内外神经内分泌肿瘤肝转移的外科治疗策略和我国最新诊治指南,并结合笔者实际临床工作经验进行综述和讨论。

Is surgical treatment of cancer of the gastric cardia or esophagus associated with a concurrent major pulmonary operation feasible？One center＇s experience

Background Pulmonary complications are a major cause of mortality after operation for cancer of the gastric cardia or esophagus.Although the risk involved in gastric cardiectomy or esophagectomy associated with a concurrent major pulmonary operation is expected to be much higher,it has seldom been evaluated on the basis of clinical experience.The aim of this study was to investigate the possibility and feasibility of the gastric cardiectomy or esophagectomy associated with a major pulmonary operation.Methods From August 2003 to January 2011,14 patients underwent concurrent gastric cardiectomy or esophagectomy and a major pulmonary operation in our hospital.This included eight for pulmonary invasion of esophageal carcinoma,and six for synchronous lung tumor.All patients underwent systematic lymph node dissection for cardiac or esophageal cancer.To prevent postoperative complications,the operative approach and dissection procedures for cardiac or esophageal carcinoma were modified according to the associated pulmonary operation and the extent of cancer invasion.All thoracotomies for cardiectomy or esophagectomy were performed on the same side as the major pulmonary operation.Results All patients underwent a curative operation.There were no deaths or postoperative complications in the six synchronous lung tumor patients.In the eight pulmonary invasion patients,one patient died of respiratory failure 11 days after operation,and postoperative complications developed in four of them,but none was fatal.Six patients were still alive.Conclusions Curative gastric cardiectomy or esophagectomy associated with concurrent major pulmonary operation is not contraindicated in patients in good condition.In selected patients,when the operative procedures for cardiectomy or esophagectomy are appropriately modified to minimize the effect of the associated pulmonary operation,the treatment is associated with a low operative morbidity and mortality with an acceptable long-term survival.

90例儿童颅内残留或复发性室管膜瘤的手术疗效分析

目的探讨儿童颅内残留或复发性室管膜瘤的手术治疗效果。方法回顾性分析2014年3月至2023年8月北京大学第一医院小儿外科收治的90例行外科手术治疗颅内残留或复发性室管膜瘤患儿的临床资料,其中32例为首次手术后肿瘤残留,58例为肿瘤复发;肿瘤位于后颅窝60例,小脑幕上23例,后颅窝肿瘤转移至侧脑室7例。术后通过门诊或电话方式进行随访,末次随访时间为2023年10月,获知患儿生存及后续治疗情况,通过头颅MRI检查评估患儿肿瘤是否再次复发或转移。结果90例患儿手术均顺利完成,其中肿瘤扩大全切除10例,全切除71例,近全切除9例。术后78例(86.7%)患儿出现并发症,其中发热70例,皮下积液39例,出现声音嘶哑、吞咽困难等后组脑神经损伤症状16例,面瘫13例;术后13例(14.4%)患儿因继发性脑积水行脑室-腹腔分流术,其中2例分别出现消化道大出血、心力衰竭于术后24h死亡;1例因术后并发肺炎出院后死亡。术后经病理学证实,69例患儿的肿瘤病理学诊断与首次诊断相同,其中世界卫生组织(WHO)2级5例,3级62例,2~3级2例;21例肿瘤病理学诊断与首次诊断不同,其中7例由WHO2级转为3级,1例由1级转为2级,9例由2~3级转为3级,4例由3级转为2级。87例患儿均获得临床随访,随访时间[M(范围)]为16个月(3~116个月)。49例患儿术后行首次或二次放疗,3例行单纯化疗3例行放疗和化疗。末次随访显示,27例患儿死于肿瘤复发或转移;存活的60例患儿中,局部再复发5例,脊髓转移2例。结论儿童颅内残留或复发性室管膜瘤的治疗效果欠佳,目前仍以手术切除辅助术后放疗为主要治疗手段。

浅表食管癌内镜黏膜下剥离术与外科手术疗效对比的研究进展

浅表食管癌(SEC)的传统治疗以内镜治疗和外科手术治疗为主。外科手术是食管肿瘤治疗的标准方法,但其围手术期并发症发生率和病死率均较高。近年来,内镜黏膜下剥离术已取得较大进展,为SEC患者提供了有效的诊断和治疗方法。本文就SEC内镜黏膜下剥离术与外科手术的疗效对比和超出内镜黏膜下剥离术适应证的SEC的治疗策略作一综述,以期提高临床医师对SEC治疗的认知。

海信CAS辅助下高强度聚焦超声消融治疗晚期胰腺癌效果

目的探讨海信计算机辅助系统(CAS)辅助下高强度聚焦超声(HIFU)治疗胰腺癌的效果。方法选取2020年1月-2021年5月于我院拟行HIFU治疗的22例胰腺癌患者。术前采用海信CAS将二维CT图像进行三维重建,明确胰腺肿瘤与周围肠道、脏器的毗邻关系,通过实体瘤疗效评价标准评价局部消融疗效,并记录患者术后并发症发生情况。结果海信CAS数字化三维重建结果可清晰显示胰腺肿瘤与周围肠道、脏器的毗邻关系,协助实现精准消融。22例胰腺癌患者中完全缓解率为9.1%,部分缓解率为68.2%,疾病稳定率为13.6%,疾病进展率为9.1%。所有患者在HIFU术后均未出现胃肠道穿孔、急性胰腺炎、胰瘘及消化道出血等严重并发症,仅1例患者出现浅Ⅱ度皮肤灼伤。结论海信CAS辅助下HIFU治疗晚期胰腺癌效果较好,值得在临床推广。

不同免充气腔镜术式治疗甲状腺癌的效果比较

目的比较免充气经口腔前庭入路与免充气经腋窝入路对腔镜治疗甲状腺癌效果的影响。方法回顾性分析2019年1月至2023年6月中国科学技术大学附属第一医院西区(安徽省肿瘤医院)收治的95例单侧甲状腺癌患者的临床资料,其中45例患者选自同期行经腋窝入路腔镜手术患者,50例选自同期行经口腔前庭腔入路腔镜手术患者。比较2种手术方式的疗效。结果2组患者在手术时间、术中出血量、住院时间、术后3 d引流量、术后并发症及美容满意度方面比较,差异无统计学意义(P>0.05);经口腔前庭组中央区淋巴结清扫数目多于经腋窝组(P<0.05)。结论经口腔前庭入路腔镜甲状腺手术体表无瘢痕较经腋窝入路腔镜手术在中央区淋巴结清扫上更有优势。

Clinical Experience of Primary Retroperitoneal Tumor: Report of 600 Cases

Objective： To summarize the experience of management for primary retroperitoneal tumor （PRPT） and to analyze the factors influencing the outcome after operation. Methods： The data of 600 cases of PRPT in General Hospital of PLA were reviewed retrospectively. Results： Of 600 cases of PRPT, 546 were surgically treated. Among theme 369 were malignant and 177 benign. 366 cases were followed up for 1 month to 15 years. The 1-years 3-year, and 5-year survival rate in the patients subject to complete resection was 90.5%, 73.2% and 53.6%, respectively, and that in incomplete resection patients was 70.6%, 32.0%, 5.7% respectively （P〈0.01）. The Cox multi-various regression analysis revealed showed completeness of tumor resection, sex and histologic type were associated closely with local recurrence. Conclusion： Sufficient preoperative preparation and complete tumor resection play important roles for reducing recurrence and improving survival.

MR多模态成像在直肠癌TN分期及手术方式选择中的应用

目的探讨MR多模态成像在直肠癌TN分期及手术方式选择中的应用价值。方法回顾性分析我院2020年1月—2022年5月396例直肠癌患者的MR征象,以此进行术前TN分期并模拟制定手术方式,分析手术前后TN分期的准确性,并比较拟定手术方式与实际手术方式的一致性。结果MR多模态成像辅助术前拟定直肠癌T分期的符合率为90.15%,与术后病理结果的一致性较高(K=0.82,P<0.01),且对于T2~T4分期的诊断准确率较高;N分期的符合率为71.46%,与术后病理结果的一致性适中(K=0.53,P<0.01)。MR多模态成像辅助拟定手术方式的符合率为89.14%,与实际术式一致性较高(K=0.79,P<0.01),且对于直肠癌各种术式拟定的准确率均较高。结论MR多模态成像对直肠癌的术前TN分期以及手术方式的制定有较高的临床价值。

长段型食管闭锁磁力吻合治疗现状及展望

长段型食管闭锁(long-gap esophageal atresia,LGEA)是小儿外科治疗难题之一,需分期手术。实现微创化治疗、缩短治疗周期并改善预后是临床医师和患儿家属的共同目标。近年来,通过磁吻合完成消化道无缝线吻合技术取得了长足进展,并在复杂消化道梗阻疾病中获得了理想的治疗效果。国内外均有利用磁吻合技术成功救治LGEA的病例报道。磁吻合实现空腔器官腔内吻合的特点为LGEA患儿重建食管结构提供了一种全新、微创、有效的治疗方法。随着对磁吻合技术的不断改良,尤其是电磁吻合(electromagnetic anastomosis,EA)技术的开发,有望突破传统磁吻合技术重建食管盲端距离≥3 cm的复杂LGEA。

原发性腹膜后平滑肌肉瘤初次术后影响生存期的因素分析

目的分析初次手术后对原发性腹膜后平滑肌肉瘤患者生存期的影响因素,并了解其临床特征。方法搜集2018年1月—2023年1月67例原发性腹膜后平滑肌肉瘤患者的临床资料进行回顾性分析。根据患者的手术情况、年龄、性别、病理类型及其他相关因素,对其生存期进行统计和分析。符合正态分布的计量资料以xˉ±s表示、采用t检验;计数资料以%表示、采用χ2检验。对影响患者预后因素的分析采用单因素分析,其中差异有统计学意义的因素采用多因素Logistic回归分析。结果67例患者的平均生存期为(18.25±2.41)个月,病理证实肿瘤类型均为平滑肌肉瘤。生存分析显示,年龄>60岁、肿瘤最大径>10 cm、肿瘤分期Ⅲ~Ⅳ期、肿瘤分化程度低~差、肿瘤累及其他脏器均是影响患者术后生存期的危险因素(P均<0.05);性别、体质量指数、吸烟史、饮酒史、手术方式对患者的生存期无明显影响(P均>0.05)。经多因素Logistic回归分析,表明年龄≥60岁、显微镜下切缘看到肿瘤细胞(R1切除)、肿瘤最大径≥10 cm、肿瘤分期Ⅲ~Ⅳ期、肿瘤低~差分化、肿瘤累及其他脏器均是影响原发性腹膜后平滑肌肉瘤初次手术后生存率的独立危险因素。结论患者年龄、肿瘤最大径、肿瘤分期等是影响患者预后的主要因素,准确评估这些影响因素有助于指导临床决策,进一步改善患者的预后结果。