On September 25 2003, ZTE Corporation, thelargest listed telecom equipment manufacturer inChina, and Microsoft(China)Co. Ltd., the globalleading software supplier, signed a memo forstrategie cooperation in Beijing.The...On September 25 2003, ZTE Corporation, thelargest listed telecom equipment manufacturer inChina, and Microsoft(China)Co. Ltd., the globalleading software supplier, signed a memo forstrategie cooperation in Beijing.The cooperation focuses on setting up a ZTE-Microsoft Software Teehnology Lab at ZTE. It willmake use of advanced technologies and products ofMicrosoft in the software platform field and ZTE’sample communication product lines to conduct co-operation in multiple communication product展开更多
ZTE Corporation announced on April 16, 2009 that it has partnered with Sichuan Telecom to successfully establish the first IMS-based EV-DO Video Telephony (VT) call in China.
The regeneration of Tetracentron sinense Oliv.is poor in the understory and in open areas due to the charac-teristics of natural regeneration of the species on forest edges and in gaps.It is unclear whether different ...The regeneration of Tetracentron sinense Oliv.is poor in the understory and in open areas due to the charac-teristics of natural regeneration of the species on forest edges and in gaps.It is unclear whether different light intensities in various habitats affect eco-physiological characteristics of saplings and their natural regeneration.In this study,the light intensity in T.sinense habitats was simulated by artificial shading(L1:100%NS(natural sunlight)in the open;L2:50%NS in a forest gap or edge;L3:10%NS in understory)to investigate differences in morphology,leaf structure,physiology,and photosynthesis of 2-year-old sap-lings,and to analyze the mechanism of light intensity on sapling establishment.Significant differences were observed in morphology(including leaf area,and specific leaf area)under different light intensities.Compared to L1 and L3,chloroplast structure in L2 was intact.With increasing time,superoxide dismutase(SOD)and catalase(CAT)activities in L2 became gradually higher than under the other light intensities,while malondialdehyde(MDA)content was opposite.Shading decreased osmoregulation substance contents of leaves but increased chlorophyll.The results suggest that light intensities significantly affect the eco-physiological characteristics of T.sinense saplings and they would respond most favorably at intermediate levels of light by optimizing eco-physiological characteristics.Therefore,50%natural sunlight should be created to promote saplings establishment and population recovery of T.sinense during in situ conservation,including sowing mature seeds in forest edges or gaps and providing appropriate shade protection for seedlings and saplings in the open.展开更多
Background Most existing chemical experiment teaching systems lack solid immersive experiences,making it difficult to engage students.To address these challenges,we propose a chemical simulation teaching system based ...Background Most existing chemical experiment teaching systems lack solid immersive experiences,making it difficult to engage students.To address these challenges,we propose a chemical simulation teaching system based on virtual reality and gesture interaction.Methods The parameters of the models were obtained through actual investigation,whereby Blender and 3DS MAX were used to model and import these parameters into a physics engine.By establishing an interface for the physics engine,gesture interaction hardware,and virtual reality(VR)helmet,a highly realistic chemical experiment environment was created.Using code script logic,particle systems,as well as other systems,chemical phenomena were simulated.Furthermore,we created an online teaching platform using streaming media and databases to address the problems of distance teaching.Results The proposed system was evaluated against two mainstream products in the market.In the experiments,the proposed system outperformed the other products in terms of fidelity and practicality.Conclusions The proposed system which offers realistic simulations and practicability,can help improve the high school chemistry experimental education.展开更多
Building the capacity of standardization workers can help implement the strategy to enhance China’s strengths via standardization.The National Standardization Development Outline,issued by the Central Government,puts...Building the capacity of standardization workers can help implement the strategy to enhance China’s strengths via standardization.The National Standardization Development Outline,issued by the Central Government,puts forward strengthening the building of standardization talent teams and establishing a sound vocational ability evaluation and incentive mechanism of standardization talents.展开更多
Since establishing a business in her rural hometown in 2017,Shi Jia,an ethnic Miao entrepreneur,has been committed to exploring ethnic resources to develop local industries.“Compared with other embroidery styles,the ...Since establishing a business in her rural hometown in 2017,Shi Jia,an ethnic Miao entrepreneur,has been committed to exploring ethnic resources to develop local industries.“Compared with other embroidery styles,the Miao embroidery focuses on vivid expression.At the beginning,it was used to record big events in place of writing,and distinguish tribes by different totems.Its color is brighter,and the design is simpler.There are also many auspicious patterns to pray for good luck,”Shi Jia,a deputy to the National People’s Congress(NPC)and president of a Miao clothing company,told China Today.展开更多
This year marks a significant year for establishing guardrails around artificial intelligence(AI),with major regions like the EU,the U.S.,and China converging over a risk-based regulatory approach,albeit with distinct...This year marks a significant year for establishing guardrails around artificial intelligence(AI),with major regions like the EU,the U.S.,and China converging over a risk-based regulatory approach,albeit with distinct differences.This trend reflects a broader trend towards digital sovereignty,with governments seeking increased control over their digital markets and technologies to ensure safety and security,while aiming to boost their AI competitiveness.展开更多
The year 2024 marks the 65th anniversary of democratic reform in Xizang.March 28th of this year is the 15th anniversary of establishing the commemoration day for the emancipation of one million serfs in Xizang.Xizang&...The year 2024 marks the 65th anniversary of democratic reform in Xizang.March 28th of this year is the 15th anniversary of establishing the commemoration day for the emancipation of one million serfs in Xizang.Xizang's democratic reform is the greatest and most profound social transformation in the history of Xizang.Under the leadership of the Communist Party of China(CPC),within just a few decades,these one million former serfs in old Xizang were not only liberated but also transformed into the masters of their nation and society.展开更多
Tsinghua University's Center unveiled its Center for Engineering Education (CEE), a cross-disciplinary research center for engineering education studies, at an inauguration ceremony in the Main Building on January ...Tsinghua University's Center unveiled its Center for Engineering Education (CEE), a cross-disciplinary research center for engineering education studies, at an inauguration ceremony in the Main Building on January 12, 2009.展开更多
Tsinghua University unveiled its Center for Engineering Education (CEE), a cross-disciplinary research center for engineering education studies, at an inauguration ceremony in the Main Building on January 12, 2009.
Kenya Airways,one of the best and most respected airline companies in Africa, recently officially announced its intent to fly to Ouagadougou, capital of Burkina Faso, starting July 15,
HIRING a fitness consultant for one year is as easy as filling in a form and paying 10 yuan to get a membership. You will receive a bulletin entitled Fitness Guide and therefore after the bulletin provides free
Northern Rare Earth and Xiamen Tungsten announced on the evening of November 1 that they have signed a Strategic Cooperation Framework Agreement in Baotou,Inner Mongolia and will cooperate in a number of areas includi...Northern Rare Earth and Xiamen Tungsten announced on the evening of November 1 that they have signed a Strategic Cooperation Framework Agreement in Baotou,Inner Mongolia and will cooperate in a number of areas including guarantee for the supply of rare earth products,hydrogen storage展开更多
IN July, 1993, an international seminar titled "Chinese Women and Development—Status, Health and Employment" was sponsored by the Women’s Studies Center at Tianjin Normal University. More than 100 internat...IN July, 1993, an international seminar titled "Chinese Women and Development—Status, Health and Employment" was sponsored by the Women’s Studies Center at Tianjin Normal University. More than 100 international and domestic specialists and workers who deal with women’s issues attended. At the conference, the Women’s Research Institute of the All-China Women’s Federation disclosed the results of an investigation about the status of women in China, which was launched in the early 1990s on a nationwide scale. The results showed that China’s economic reform has greatly affected women. As a result, many researchers who began their research by considering China’s present economic situation, tried to determine the influences the展开更多
Early bacterial colonization and succession within the gastrointestinal tract have been suggested to be crucial in the development of host immunity.In this study,we have investigated the changes in live weight and con...Early bacterial colonization and succession within the gastrointestinal tract have been suggested to be crucial in the development of host immunity.In this study,we have investigated the changes in live weight and concentrations of selected serum parameters in relation to their fecal bacterial communities as determined by high throughput sequencing of the 16S r RNA gene over the same period in lambs.The results showed that lambs’growth performance,the serum parameters,fecal bacterial community and fecal bacterial functions were all affected(P<0.05)by age of the lambs.Similarity within age groups of fecal microbiota was lower in the preweaning period and increased sharply(P<0.05)after weaning at 60 days.The similarity between the samples collected from birth to 90 days of age and those collected at 120 days of age,increased(P<0.05)sharply after 30 days of age.Some age-associated changes in microbial genera were correlated with the changes in concentrations of immune indicators,including negative(P<0.05)correlations between the relative abundance of Lachnospiraceae UCG-010,Eubacterium coprostanoligenes group,Ruminococcaceae UCG-005,Ruminococcaceae UCG-009,Ruminococcaceae UCG-013,Ruminiclostridium 6,Ruminococcaceae UCG-008,and Oscillibacter with serum concentrations of lipopolysaccharide(LPS),D-lactate dehydrogenase(DLA),immunoglobulin(IgA,IgM,and IgG),and cytokines(interleukin-1β(IL-1β),IL-6,IL-12,and IL-17),tumor necrosis factor-α(TNF-α),and the relative abundance of these genera increased from 45 days of age.In conclusion,these results suggested that the age-related abundances of particular genera were correlated with serum markers of immunity in lambs,and there might be a critical window in the period from birth to 45 days of age which provide an opportunity for potential manipulation of the fecal microbial ecosystems to enhance immune function.展开更多
Unmanned aerial vehicles(UAVs) enable flexible networking functions in emergency scenarios.However,due to the movement characteristic of ground users(GUs),it is challenging to capture the interactions among GUs.Thus,w...Unmanned aerial vehicles(UAVs) enable flexible networking functions in emergency scenarios.However,due to the movement characteristic of ground users(GUs),it is challenging to capture the interactions among GUs.Thus,we propose a learningbased dynamic connectivity maintenance architecture to reduce the delay for the UAV-assisted device-todevice(D2D) multicast communication.In this paper,each UAV transmits information to a selected GU,and then other GUs receive the information in a multi-hop manner.To minimize the total delay while ensuring that all GUs receive the information,we decouple it into three subproblems according to the time division on the topology:For the cluster-head selection,we adopt the Whale Optimization Algorithm(WOA) to imitate the hunting behavior of whales by abstracting the UAVs and cluster-heads into whales and preys,respectively;For the D2D multi-hop link establishment,we make the best of social relationships between GUs,and propose a node mapping algorithm based on the balanced spanning tree(BST) with reconfiguration to minimize the number of hops;For the dynamic connectivity maintenance,Restricted Q-learning(RQL) is utilized to learn the optimal multicast timeslot.Finally,the simulation results show that our proposed algorithms perfor better than other benchmark algorithms in the dynamic scenario.展开更多
BACKGROUND Extrahepatic cholangiocarcinoma sarcoma is extremely rare in clinical practice.These cells consist of both epithelial and mesenchymal cells.Patient-derived cell lines that maintain tumor characteristics are...BACKGROUND Extrahepatic cholangiocarcinoma sarcoma is extremely rare in clinical practice.These cells consist of both epithelial and mesenchymal cells.Patient-derived cell lines that maintain tumor characteristics are valuable tools for studying the molecular mechanisms associated with carcinosarcoma.However,cholangiocarcinoma sarcoma cell lines are not available in cell banks.AIM To establish and characterize a new extrahepatic cholangiocarcinoma sarcoma cell line,namely CBC2T-2.METHODS We conducted a short tandem repeat(STR)test to confirm the identity of the CBC2T-2 cell line.Furthermore,we assessed the migratory and invasive properties of the cells and performed clonogenicity assay to evaluate the ability of individual cells to form colonies.The tumorigenic potential of CBC2T-2 cells was tested in vivo using nonobese diabetic/severe combined immunodeficient(NOD/SCID)mice.The cells were injected subcutaneously and tumor formation was observed.In addition,immunohistochemical analysis was carried out to examine the expression of epithelial marker CK19 and mesenchymal marker vimentin in both CBC2T-2 cells and xenografts.The CBC2T-2 cell line was used to screen the potential therapeutic effects of various clinical agents in patients with cholangiocarcinoma sarcoma.Lastly,whole-exome sequencing was performed to identify genetic alterations and screen for somatic mutations in the CBC2T-2 cell line.RESULTS The STR test showed that there was no cross-contamination and the results were identical to those of the original tissue.The cells showed round or oval-shaped epithelioid cells and mesenchymal cells with spindle-shaped or elongated morphology.The cells exhibited a high proliferation ratio with a doubling time of 47.11 h.This cell line has migratory,invasive,and clonogenic abilities.The chromosomes in the CBC2T-2 cells were polyploidy,with numbers ranging from 69 to 79.The subcutaneous tumorigenic assay confirmed the in vivo tumorigenic ability of CBC2T-2 cells in NOD/SCID mice.CBC2T-2 cells and xenografts were positive for both the epithelial marker,CK19,and the mesenchymal marker,vimentin.These results suggest that CBC2T-2 cells may have both epithelial and mesenchymal characteristics.The cells were also used to screen clinical agents in patients with cholangiocarcinoma sarcoma,and a combination of paclitaxel and gemcitabine was found to be the most effective treatment option.CONCLUSION We established the first human cholangiocarcinoma sarcoma cell line,CBC2T-2,with stable biogenetic traits.This cell line,as a research model,has a high clinical value and would facilitate the understanding of the pathogenesis of cholangiocarcinoma sarcoma.展开更多
Nature-based coastal protection is increasingly recognised as a potentially sustainable and cost-effective solution to reduce coastal flood risk.It uses coastal ecosystems such as mangrove forests to create resilient ...Nature-based coastal protection is increasingly recognised as a potentially sustainable and cost-effective solution to reduce coastal flood risk.It uses coastal ecosystems such as mangrove forests to create resilient designs for coastal flood protection.However,to use mangroves effectively as a nature-based measure for flood risk reduction,we must understand the biophysical processes that govern risk reduction capacity through mangrove ecosystem size and structure.In this perspective,we evaluate the current state of knowledge on local physical drivers and ecological processes that determine mangrove functioning as part of a nature-based flood defence.We show that the forest properties that comprise coastal flood protection are well-known,but models cannot yet pinpoint how spatial heterogeneity of the forest structure affects the capacity for wave or surge attenuation.Overall,there is relatively good understanding of the ecological processes that drive forest structure and size,but there is a lack of knowledge on how daily bed-level dynamics link to long-term biogeomorphic forest dynamics,and on the role of combined stressors influencing forest retreat.Integrating simulation models of forest structure under changing physical(e.g.due to sea-level change)and ecological drivers with hydrodynamic attenuation models will allow for better projections of long-term natural coastal protection.展开更多
Underwater magnetic induction(MI)-assisted acoustic cooperative multiple-input-multipleoutput(MIMO) has been recently proposed as a promising technique for underwater wireless sensor networks(UWSNs).For the more,the e...Underwater magnetic induction(MI)-assisted acoustic cooperative multiple-input-multipleoutput(MIMO) has been recently proposed as a promising technique for underwater wireless sensor networks(UWSNs).For the more,the energy utilization of energy-constrained sensor nodes is one of the key issues in UWSNs,and it relates to the network lifetime.In this paper,we present an energy-efficient data collection for underwater MI-assisted acoustic cooperative MIMO wireless sensor networks(WSNs),including the formation of cooperative MIMO and relay link establishment.Firstly,the cooperative MIMO is formed by considering its expected transmission range and the energy balance of nodes with it.Particularly,from the perspective of the node’s energy consumption,the expected cooperative MIMO size and the selection of master node(MN) are proposed.Sequentially,to improve the coverage of the networks and prolong the network lifetime,relay links are established by relay selection algorithm that using matching theory.Finally,the simulation results show that the proposed data collection improves its efficiency,reduces the energy consumption of the master node,improves the networks’ coverage,and extends the network lifetime.展开更多
文摘On September 25 2003, ZTE Corporation, thelargest listed telecom equipment manufacturer inChina, and Microsoft(China)Co. Ltd., the globalleading software supplier, signed a memo forstrategie cooperation in Beijing.The cooperation focuses on setting up a ZTE-Microsoft Software Teehnology Lab at ZTE. It willmake use of advanced technologies and products ofMicrosoft in the software platform field and ZTE’sample communication product lines to conduct co-operation in multiple communication product
文摘ZTE Corporation announced on April 16, 2009 that it has partnered with Sichuan Telecom to successfully establish the first IMS-based EV-DO Video Telephony (VT) call in China.
基金funded by the National Natural Science Foundation of China (No.32070371)the Innovation Team Funds of China West Normal University (No.KCXTD2022-4)+1 种基金the fund of Sichuan Meigu Dafegnding National Nature Reserve (No.mgdfd2022-13)Sichuan Micang Mountain National Nature Reserve (No.N5108212022000043)。
文摘The regeneration of Tetracentron sinense Oliv.is poor in the understory and in open areas due to the charac-teristics of natural regeneration of the species on forest edges and in gaps.It is unclear whether different light intensities in various habitats affect eco-physiological characteristics of saplings and their natural regeneration.In this study,the light intensity in T.sinense habitats was simulated by artificial shading(L1:100%NS(natural sunlight)in the open;L2:50%NS in a forest gap or edge;L3:10%NS in understory)to investigate differences in morphology,leaf structure,physiology,and photosynthesis of 2-year-old sap-lings,and to analyze the mechanism of light intensity on sapling establishment.Significant differences were observed in morphology(including leaf area,and specific leaf area)under different light intensities.Compared to L1 and L3,chloroplast structure in L2 was intact.With increasing time,superoxide dismutase(SOD)and catalase(CAT)activities in L2 became gradually higher than under the other light intensities,while malondialdehyde(MDA)content was opposite.Shading decreased osmoregulation substance contents of leaves but increased chlorophyll.The results suggest that light intensities significantly affect the eco-physiological characteristics of T.sinense saplings and they would respond most favorably at intermediate levels of light by optimizing eco-physiological characteristics.Therefore,50%natural sunlight should be created to promote saplings establishment and population recovery of T.sinense during in situ conservation,including sowing mature seeds in forest edges or gaps and providing appropriate shade protection for seedlings and saplings in the open.
基金National Innovation and Entrepreneurship Program for College Students(202218213001)Science and Technology Innovation Strategy of Guangdong Province(Science and Technology Innovation Cultivation of University Students 2020329182130C000002).
文摘Background Most existing chemical experiment teaching systems lack solid immersive experiences,making it difficult to engage students.To address these challenges,we propose a chemical simulation teaching system based on virtual reality and gesture interaction.Methods The parameters of the models were obtained through actual investigation,whereby Blender and 3DS MAX were used to model and import these parameters into a physics engine.By establishing an interface for the physics engine,gesture interaction hardware,and virtual reality(VR)helmet,a highly realistic chemical experiment environment was created.Using code script logic,particle systems,as well as other systems,chemical phenomena were simulated.Furthermore,we created an online teaching platform using streaming media and databases to address the problems of distance teaching.Results The proposed system was evaluated against two mainstream products in the market.In the experiments,the proposed system outperformed the other products in terms of fidelity and practicality.Conclusions The proposed system which offers realistic simulations and practicability,can help improve the high school chemistry experimental education.
文摘Building the capacity of standardization workers can help implement the strategy to enhance China’s strengths via standardization.The National Standardization Development Outline,issued by the Central Government,puts forward strengthening the building of standardization talent teams and establishing a sound vocational ability evaluation and incentive mechanism of standardization talents.
文摘Since establishing a business in her rural hometown in 2017,Shi Jia,an ethnic Miao entrepreneur,has been committed to exploring ethnic resources to develop local industries.“Compared with other embroidery styles,the Miao embroidery focuses on vivid expression.At the beginning,it was used to record big events in place of writing,and distinguish tribes by different totems.Its color is brighter,and the design is simpler.There are also many auspicious patterns to pray for good luck,”Shi Jia,a deputy to the National People’s Congress(NPC)and president of a Miao clothing company,told China Today.
文摘This year marks a significant year for establishing guardrails around artificial intelligence(AI),with major regions like the EU,the U.S.,and China converging over a risk-based regulatory approach,albeit with distinct differences.This trend reflects a broader trend towards digital sovereignty,with governments seeking increased control over their digital markets and technologies to ensure safety and security,while aiming to boost their AI competitiveness.
文摘The year 2024 marks the 65th anniversary of democratic reform in Xizang.March 28th of this year is the 15th anniversary of establishing the commemoration day for the emancipation of one million serfs in Xizang.Xizang's democratic reform is the greatest and most profound social transformation in the history of Xizang.Under the leadership of the Communist Party of China(CPC),within just a few decades,these one million former serfs in old Xizang were not only liberated but also transformed into the masters of their nation and society.
文摘Tsinghua University's Center unveiled its Center for Engineering Education (CEE), a cross-disciplinary research center for engineering education studies, at an inauguration ceremony in the Main Building on January 12, 2009.
文摘Tsinghua University unveiled its Center for Engineering Education (CEE), a cross-disciplinary research center for engineering education studies, at an inauguration ceremony in the Main Building on January 12, 2009.
文摘Kenya Airways,one of the best and most respected airline companies in Africa, recently officially announced its intent to fly to Ouagadougou, capital of Burkina Faso, starting July 15,
文摘HIRING a fitness consultant for one year is as easy as filling in a form and paying 10 yuan to get a membership. You will receive a bulletin entitled Fitness Guide and therefore after the bulletin provides free
文摘Northern Rare Earth and Xiamen Tungsten announced on the evening of November 1 that they have signed a Strategic Cooperation Framework Agreement in Baotou,Inner Mongolia and will cooperate in a number of areas including guarantee for the supply of rare earth products,hydrogen storage
文摘IN July, 1993, an international seminar titled "Chinese Women and Development—Status, Health and Employment" was sponsored by the Women’s Studies Center at Tianjin Normal University. More than 100 international and domestic specialists and workers who deal with women’s issues attended. At the conference, the Women’s Research Institute of the All-China Women’s Federation disclosed the results of an investigation about the status of women in China, which was launched in the early 1990s on a nationwide scale. The results showed that China’s economic reform has greatly affected women. As a result, many researchers who began their research by considering China’s present economic situation, tried to determine the influences the
基金supported by the China Agriculture Research System(CARS-38)the National Key Research&Development Program of China(2018YFD0502100)the Scientific Research Foundation of Hebei Agricultural University,China(YJ201825)。
文摘Early bacterial colonization and succession within the gastrointestinal tract have been suggested to be crucial in the development of host immunity.In this study,we have investigated the changes in live weight and concentrations of selected serum parameters in relation to their fecal bacterial communities as determined by high throughput sequencing of the 16S r RNA gene over the same period in lambs.The results showed that lambs’growth performance,the serum parameters,fecal bacterial community and fecal bacterial functions were all affected(P<0.05)by age of the lambs.Similarity within age groups of fecal microbiota was lower in the preweaning period and increased sharply(P<0.05)after weaning at 60 days.The similarity between the samples collected from birth to 90 days of age and those collected at 120 days of age,increased(P<0.05)sharply after 30 days of age.Some age-associated changes in microbial genera were correlated with the changes in concentrations of immune indicators,including negative(P<0.05)correlations between the relative abundance of Lachnospiraceae UCG-010,Eubacterium coprostanoligenes group,Ruminococcaceae UCG-005,Ruminococcaceae UCG-009,Ruminococcaceae UCG-013,Ruminiclostridium 6,Ruminococcaceae UCG-008,and Oscillibacter with serum concentrations of lipopolysaccharide(LPS),D-lactate dehydrogenase(DLA),immunoglobulin(IgA,IgM,and IgG),and cytokines(interleukin-1β(IL-1β),IL-6,IL-12,and IL-17),tumor necrosis factor-α(TNF-α),and the relative abundance of these genera increased from 45 days of age.In conclusion,these results suggested that the age-related abundances of particular genera were correlated with serum markers of immunity in lambs,and there might be a critical window in the period from birth to 45 days of age which provide an opportunity for potential manipulation of the fecal microbial ecosystems to enhance immune function.
基金supported by the Future Scientists Program of China University of Mining and Technology(2020WLKXJ030)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX201993).
文摘Unmanned aerial vehicles(UAVs) enable flexible networking functions in emergency scenarios.However,due to the movement characteristic of ground users(GUs),it is challenging to capture the interactions among GUs.Thus,we propose a learningbased dynamic connectivity maintenance architecture to reduce the delay for the UAV-assisted device-todevice(D2D) multicast communication.In this paper,each UAV transmits information to a selected GU,and then other GUs receive the information in a multi-hop manner.To minimize the total delay while ensuring that all GUs receive the information,we decouple it into three subproblems according to the time division on the topology:For the cluster-head selection,we adopt the Whale Optimization Algorithm(WOA) to imitate the hunting behavior of whales by abstracting the UAVs and cluster-heads into whales and preys,respectively;For the D2D multi-hop link establishment,we make the best of social relationships between GUs,and propose a node mapping algorithm based on the balanced spanning tree(BST) with reconfiguration to minimize the number of hops;For the dynamic connectivity maintenance,Restricted Q-learning(RQL) is utilized to learn the optimal multicast timeslot.Finally,the simulation results show that our proposed algorithms perfor better than other benchmark algorithms in the dynamic scenario.
基金the National Natural Science Foundation of China,No.82060551and Lanzhou Chengguan District Science and Technology Planning Project,No.2019JSCX0092.
文摘BACKGROUND Extrahepatic cholangiocarcinoma sarcoma is extremely rare in clinical practice.These cells consist of both epithelial and mesenchymal cells.Patient-derived cell lines that maintain tumor characteristics are valuable tools for studying the molecular mechanisms associated with carcinosarcoma.However,cholangiocarcinoma sarcoma cell lines are not available in cell banks.AIM To establish and characterize a new extrahepatic cholangiocarcinoma sarcoma cell line,namely CBC2T-2.METHODS We conducted a short tandem repeat(STR)test to confirm the identity of the CBC2T-2 cell line.Furthermore,we assessed the migratory and invasive properties of the cells and performed clonogenicity assay to evaluate the ability of individual cells to form colonies.The tumorigenic potential of CBC2T-2 cells was tested in vivo using nonobese diabetic/severe combined immunodeficient(NOD/SCID)mice.The cells were injected subcutaneously and tumor formation was observed.In addition,immunohistochemical analysis was carried out to examine the expression of epithelial marker CK19 and mesenchymal marker vimentin in both CBC2T-2 cells and xenografts.The CBC2T-2 cell line was used to screen the potential therapeutic effects of various clinical agents in patients with cholangiocarcinoma sarcoma.Lastly,whole-exome sequencing was performed to identify genetic alterations and screen for somatic mutations in the CBC2T-2 cell line.RESULTS The STR test showed that there was no cross-contamination and the results were identical to those of the original tissue.The cells showed round or oval-shaped epithelioid cells and mesenchymal cells with spindle-shaped or elongated morphology.The cells exhibited a high proliferation ratio with a doubling time of 47.11 h.This cell line has migratory,invasive,and clonogenic abilities.The chromosomes in the CBC2T-2 cells were polyploidy,with numbers ranging from 69 to 79.The subcutaneous tumorigenic assay confirmed the in vivo tumorigenic ability of CBC2T-2 cells in NOD/SCID mice.CBC2T-2 cells and xenografts were positive for both the epithelial marker,CK19,and the mesenchymal marker,vimentin.These results suggest that CBC2T-2 cells may have both epithelial and mesenchymal characteristics.The cells were also used to screen clinical agents in patients with cholangiocarcinoma sarcoma,and a combination of paclitaxel and gemcitabine was found to be the most effective treatment option.CONCLUSION We established the first human cholangiocarcinoma sarcoma cell line,CBC2T-2,with stable biogenetic traits.This cell line,as a research model,has a high clinical value and would facilitate the understanding of the pathogenesis of cholangiocarcinoma sarcoma.
基金supported by the Joint Research Project Sustainable Deltas co-funded by the National Natural Science Foundation of China(NSFCGrant No.51761135022)+11 种基金the Dutch Research Council(NWOGrant No.ALWSD.2016.026)the Engineering and Physical Sciences Research Council(EPSRCGrant No.EP/R024537/1)the National Natural Science Foundation of China(Grant No.42176202)the Innovation Group Project of the Southern Marine Science and Engineering Guangdong Laboratory,Zhuhai(Grant No.311021004)the Guangdong Provincial Department of Science and Technology(Grant No.2019ZT08G090)the 111 Project(Grant No.B21018)the ERC H2020 ESTUARIES Project(Grant No.647570)the Horizon 2020 Marie Skłodowska-Curie Actions Individual Fellowship(Grant No.896888)the China Scholarship Council(Grant No.201706710005)the NWO“LIVING DIKES e Realising Resilient and Climate-Proof Coastal Protection”Project(Grant No.NWA.1292.19.257)。
文摘Nature-based coastal protection is increasingly recognised as a potentially sustainable and cost-effective solution to reduce coastal flood risk.It uses coastal ecosystems such as mangrove forests to create resilient designs for coastal flood protection.However,to use mangroves effectively as a nature-based measure for flood risk reduction,we must understand the biophysical processes that govern risk reduction capacity through mangrove ecosystem size and structure.In this perspective,we evaluate the current state of knowledge on local physical drivers and ecological processes that determine mangrove functioning as part of a nature-based flood defence.We show that the forest properties that comprise coastal flood protection are well-known,but models cannot yet pinpoint how spatial heterogeneity of the forest structure affects the capacity for wave or surge attenuation.Overall,there is relatively good understanding of the ecological processes that drive forest structure and size,but there is a lack of knowledge on how daily bed-level dynamics link to long-term biogeomorphic forest dynamics,and on the role of combined stressors influencing forest retreat.Integrating simulation models of forest structure under changing physical(e.g.due to sea-level change)and ecological drivers with hydrodynamic attenuation models will allow for better projections of long-term natural coastal protection.
基金supported in part by the program for "Industrial Io T and Emergency Collaboration" Innovative Research Team in CUMT (No.2020ZY002)in part by the Postgraduate Research&Practice Innovation Program of Jiangsu Province,2021WLKXJ054Postgraduate Research&Practice Innovation Program of China University of Mining and Technology,KYCX21_2242
文摘Underwater magnetic induction(MI)-assisted acoustic cooperative multiple-input-multipleoutput(MIMO) has been recently proposed as a promising technique for underwater wireless sensor networks(UWSNs).For the more,the energy utilization of energy-constrained sensor nodes is one of the key issues in UWSNs,and it relates to the network lifetime.In this paper,we present an energy-efficient data collection for underwater MI-assisted acoustic cooperative MIMO wireless sensor networks(WSNs),including the formation of cooperative MIMO and relay link establishment.Firstly,the cooperative MIMO is formed by considering its expected transmission range and the energy balance of nodes with it.Particularly,from the perspective of the node’s energy consumption,the expected cooperative MIMO size and the selection of master node(MN) are proposed.Sequentially,to improve the coverage of the networks and prolong the network lifetime,relay links are established by relay selection algorithm that using matching theory.Finally,the simulation results show that the proposed data collection improves its efficiency,reduces the energy consumption of the master node,improves the networks’ coverage,and extends the network lifetime.