Objective: To observe the effects of compound cyproterone acetate (Daine-35) in combination with metformin on the endocrinologic, metabolic changes and the outcomes of ovulation induction in the infertility women with...Objective: To observe the effects of compound cyproterone acetate (Daine-35) in combination with metformin on the endocrinologic, metabolic changes and the outcomes of ovulation induction in the infertility women with polycystic ovarian syndrome (PCOS). Methods: A prospective study recruited 65 PCOS patients and 30 non-PCOS infertility women. The body mass index (BMI), waist: hip ratio (WHR), Ferriman-Gallwey score, gonadotrophin, testosterone (T), fasting glucose, fasting insulin, triglyceride, total cholesterol, apoA, apoB and HDL-cholesterol were determined in all patients before the treatment and served as the baseline. At the end of 12-week therapy, these parameters were re-measured. 50 PCOS infertile patients as study group were treated with combination of Daine-35 with metformin for three months. Clomiphene citrate (CC) and human menopause gonadotrophin (hMG) were added for three cycles to induce ovulation. Other 15 PCOS cases as control group directly underwent ovulation induction with CC and hMG for three cycles. Results: The PCOS patients had higher levels of LH, T, E2, fasting insulin, FG/FI, total cholesterol and triglyceride, and lower levels of HDL-cholesterol when compared with the non-PCOS women (P<0.001-P<0.05). After treatment, the levels of LH, T, E2 were significantly decreased (58.9%, 38% and 30.1%, respectively) and the levels of apoB and HDL-C were significantly increased (17.2% and 20%, respectively) in the study group (P<0.001-P<0.05). FI and FG/FI showed a slight change in the study group, but no significant difference was found. The rates of ovulation and pregnancy were higher than those in control group (71% vs 60.5% and 38% vs 13.3%, respectively).Conclusions: Metformin in combination with compound cyproterone acetate (Daine-35) therapy may normalize the endocrine and metabolic abnormalities, and improve the ovarian response to ovulation induction drugs and increase the pregnancy rate of infertility patients with PCOS.展开更多
目的研究复方玄驹胶囊对肥胖型多囊卵巢综合征患者的临床效果。方法采用随机数字表法将172例受试对象分为研究组和对照组,各86例。对照组予以二甲双胍进行治疗,研究组在对照组的基础上联合复方玄驹胶囊进行治疗。对比患者临床疗效、血...目的研究复方玄驹胶囊对肥胖型多囊卵巢综合征患者的临床效果。方法采用随机数字表法将172例受试对象分为研究组和对照组,各86例。对照组予以二甲双胍进行治疗,研究组在对照组的基础上联合复方玄驹胶囊进行治疗。对比患者临床疗效、血脂水平、性激素水平、促排卵效果、不良反应。结果在接受治疗后,研究组的总有效率高于对照组(91.86%vs 72.09%,P<0.05)。研究组高密度脂蛋白胆固醇、总胆固醇、三酰甘油、低密度脂蛋白胆固醇较对照组改善更明显[(2.29±0.32、3.36±0.51、1.17±0.37、1.57±0.47)vs(2.04±0.28、4.57±0.66、1.56±0.33、2.61±0.58)mmol·L^(-1),均P<0.05];较对照组而言,研究组黄体生成素、睾酮水平下降[(6.16±1.23 vs 9.23±1.38)IU·L^(-1),(1.27±0.35 vs 1.86±0.43)nmol·L^(-1),均P<0.05],雌二醇、促卵泡激素水平上升[(95.32±13.56 vs 82.70±11.15)pg·mL^(-1),(9.11±1.09 vs 7.48±1.22)IU·L^(-1),P<0.05]。研究组的子宫内膜厚度及成熟卵泡数[(1.02±0.21)cm,(2.18±0.22)个]高于对照组[(0.76±0.25)cm,(1.53±0.26)个](均P<0.05),研究组促排卵天数少于对照组(9.47±0.54 vs 13.39±1.38)d(P<0.05)。两组不良反应差异无统计学意义(11.63%vs 13.95%,P>0.05)。结论复方玄驹胶囊治疗肥胖型多囊卵巢综合征效果显著,能有效促进排卵、调节性激素水平、改善血脂代谢。展开更多
文摘Objective: To observe the effects of compound cyproterone acetate (Daine-35) in combination with metformin on the endocrinologic, metabolic changes and the outcomes of ovulation induction in the infertility women with polycystic ovarian syndrome (PCOS). Methods: A prospective study recruited 65 PCOS patients and 30 non-PCOS infertility women. The body mass index (BMI), waist: hip ratio (WHR), Ferriman-Gallwey score, gonadotrophin, testosterone (T), fasting glucose, fasting insulin, triglyceride, total cholesterol, apoA, apoB and HDL-cholesterol were determined in all patients before the treatment and served as the baseline. At the end of 12-week therapy, these parameters were re-measured. 50 PCOS infertile patients as study group were treated with combination of Daine-35 with metformin for three months. Clomiphene citrate (CC) and human menopause gonadotrophin (hMG) were added for three cycles to induce ovulation. Other 15 PCOS cases as control group directly underwent ovulation induction with CC and hMG for three cycles. Results: The PCOS patients had higher levels of LH, T, E2, fasting insulin, FG/FI, total cholesterol and triglyceride, and lower levels of HDL-cholesterol when compared with the non-PCOS women (P<0.001-P<0.05). After treatment, the levels of LH, T, E2 were significantly decreased (58.9%, 38% and 30.1%, respectively) and the levels of apoB and HDL-C were significantly increased (17.2% and 20%, respectively) in the study group (P<0.001-P<0.05). FI and FG/FI showed a slight change in the study group, but no significant difference was found. The rates of ovulation and pregnancy were higher than those in control group (71% vs 60.5% and 38% vs 13.3%, respectively).Conclusions: Metformin in combination with compound cyproterone acetate (Daine-35) therapy may normalize the endocrine and metabolic abnormalities, and improve the ovarian response to ovulation induction drugs and increase the pregnancy rate of infertility patients with PCOS.
文摘目的研究复方玄驹胶囊对肥胖型多囊卵巢综合征患者的临床效果。方法采用随机数字表法将172例受试对象分为研究组和对照组,各86例。对照组予以二甲双胍进行治疗,研究组在对照组的基础上联合复方玄驹胶囊进行治疗。对比患者临床疗效、血脂水平、性激素水平、促排卵效果、不良反应。结果在接受治疗后,研究组的总有效率高于对照组(91.86%vs 72.09%,P<0.05)。研究组高密度脂蛋白胆固醇、总胆固醇、三酰甘油、低密度脂蛋白胆固醇较对照组改善更明显[(2.29±0.32、3.36±0.51、1.17±0.37、1.57±0.47)vs(2.04±0.28、4.57±0.66、1.56±0.33、2.61±0.58)mmol·L^(-1),均P<0.05];较对照组而言,研究组黄体生成素、睾酮水平下降[(6.16±1.23 vs 9.23±1.38)IU·L^(-1),(1.27±0.35 vs 1.86±0.43)nmol·L^(-1),均P<0.05],雌二醇、促卵泡激素水平上升[(95.32±13.56 vs 82.70±11.15)pg·mL^(-1),(9.11±1.09 vs 7.48±1.22)IU·L^(-1),P<0.05]。研究组的子宫内膜厚度及成熟卵泡数[(1.02±0.21)cm,(2.18±0.22)个]高于对照组[(0.76±0.25)cm,(1.53±0.26)个](均P<0.05),研究组促排卵天数少于对照组(9.47±0.54 vs 13.39±1.38)d(P<0.05)。两组不良反应差异无统计学意义(11.63%vs 13.95%,P>0.05)。结论复方玄驹胶囊治疗肥胖型多囊卵巢综合征效果显著,能有效促进排卵、调节性激素水平、改善血脂代谢。
