Objective To investigate HLA-A,-B and -DRB1 allele and HLA-A-B-DRB1 haplotype frequencies in Mongolia ethnic group. Methods HLA-A, -B, -DRB1 allele and haplotype in the Mongolia ethnic group were investigated based on...Objective To investigate HLA-A,-B and -DRB1 allele and HLA-A-B-DRB1 haplotype frequencies in Mongolia ethnic group. Methods HLA-A, -B, -DRB1 allele and haplotype in the Mongolia ethnic group were investigated based on 93 individuals by PCR- sequence-based typing (SBT) method. Results Twenty-one alleles were detected for HLA-A, 44 for HLA-B, and 26 for HLA-DRB1. The most frequent alleles were HLA-A*2402(0.2097), HLA-B*1302(0.0699), and HLA-DRB1*0701(0.1237). The most common HLA-A-B-DRB1 haplotype were A*3001-B*1302-DRB1*0701, A*0101-B*3701-DRB1*1001, followed by the A*0201-B*4601-DRB1*0901, A*2402-B*4801-DRB1*1101, A*2402-B*5201-DRB1*1501, A*3201-B*3503-DRB1*1301, and A*3303-B*5801-DRB1*0301, which were also presented in Chinese populations. Conclusion The data can be used in forensic and paternity tests to estimate the frequency of a DNA profile or anthropologic research. The characteristics of the distribution of HLA alleles revealed that Mongolia ethnic group is characterized by northern Mongolian Chinese.展开更多
According to the current situation of Fubaoshan Reservoir, we put forward the planning methods of rational development of the tourism resources. In addition to protecting the natural resources, we should try to develo...According to the current situation of Fubaoshan Reservoir, we put forward the planning methods of rational development of the tourism resources. In addition to protecting the natural resources, we should try to develop the tourism products marked by national characteristics and local features, in order to obtain the economic benefits and protect the ecological environment, in which way it can realize the virtuous circle and sustainable development of the protection and development of eco-tourism resources.展开更多
目的回顾性分析宁夏地区回、汉族三种上消化道肿瘤患者的流行特征,为更好地开展肿瘤防治工作提供参考依据.方法收集整理2003-01-01/2012-12-31十年间在宁夏医科大学总医院住院治疗的5616例回、汉族上消化道肿瘤(食管癌、贲门癌、胃癌)...目的回顾性分析宁夏地区回、汉族三种上消化道肿瘤患者的流行特征,为更好地开展肿瘤防治工作提供参考依据.方法收集整理2003-01-01/2012-12-31十年间在宁夏医科大学总医院住院治疗的5616例回、汉族上消化道肿瘤(食管癌、贲门癌、胃癌)患者临床资料.以患者确诊日期作为观察起点,以因上消化道肿瘤死亡的日期作为观察终点,对上消化道肿瘤手术患者(3634例)进行电话随访,随访成功1454例患者,生存时间的计算截止到2016-01-26.建立数据库,采用描述性统计方法分析患者年龄、性别、民族、入院时间、结局变量、生存时间等指标的分布特征,用寿命表法分时期和民族求出1年、3年和5年的生存率.用KaplanM e i e r法计算中位生存时间,生存率比较用Log-rank检验.结果共有5616例患者资料纳入分析,其中汉族患者4695例(83.5%),回族921例(16.5%),汉族vs回族比例为5.10 vs 1;男性患者共计4325例(77.0%),女性患者1291例(23.0%),男性vs女性比例为3.35 vs 1;食管癌患者1563例(27.8%),贲门癌患者1478例(26.3%),胃癌患者2575例(45.9%);食管癌与贲门癌均以≥60岁组(67.7%vs 63.9%)患者为主,胃癌以40-60岁组(45.9%)及≥60岁组(45.1%)患者为主.上消化道肿瘤手术患者3634例,其中食管癌手术患者794例,回、汉族中位生存时间分别为29 mo vs 38 mo,回、汉族1、3、5年生存率分别为72.3%vs 74.7%、46.8%vs50.9%、23.4%v s 30.9%.贲门癌手术患者734例,回、汉族中位生存时间分别为62 mo vs 33 mo,回、汉族1、3、5年生存率分别为73.9%vs 76.3%、58.7%vs 48.0%、54.3%vs39.9%.胃癌手术患者2106例,回、汉族中位生存时间分别为98 mo vs 81 mo,回、汉族1、3、5年生存率分别为77.3%vs 77.0%、50.7%vs 48.1%、24.7%vs 22.7%,食管癌、贲门癌、胃癌患者回、汉族间1、3、5年生存率差异均无统计学意义(P>0.05).结论宁夏地区三种上消化道肿瘤患者在性别与年龄的分布与我国其他区域相同病种患者的分布近似;宁夏地区胃癌与贲门癌患者数量呈现逐年递增趋势;包括宁夏在内的几个北方地区的胃癌人群5年生存率低于南方地区人群.展开更多
基金This work was supported by the National Natural Science Foundation of China (No.39970401)
文摘Objective To investigate HLA-A,-B and -DRB1 allele and HLA-A-B-DRB1 haplotype frequencies in Mongolia ethnic group. Methods HLA-A, -B, -DRB1 allele and haplotype in the Mongolia ethnic group were investigated based on 93 individuals by PCR- sequence-based typing (SBT) method. Results Twenty-one alleles were detected for HLA-A, 44 for HLA-B, and 26 for HLA-DRB1. The most frequent alleles were HLA-A*2402(0.2097), HLA-B*1302(0.0699), and HLA-DRB1*0701(0.1237). The most common HLA-A-B-DRB1 haplotype were A*3001-B*1302-DRB1*0701, A*0101-B*3701-DRB1*1001, followed by the A*0201-B*4601-DRB1*0901, A*2402-B*4801-DRB1*1101, A*2402-B*5201-DRB1*1501, A*3201-B*3503-DRB1*1301, and A*3303-B*5801-DRB1*0301, which were also presented in Chinese populations. Conclusion The data can be used in forensic and paternity tests to estimate the frequency of a DNA profile or anthropologic research. The characteristics of the distribution of HLA alleles revealed that Mongolia ethnic group is characterized by northern Mongolian Chinese.
文摘According to the current situation of Fubaoshan Reservoir, we put forward the planning methods of rational development of the tourism resources. In addition to protecting the natural resources, we should try to develop the tourism products marked by national characteristics and local features, in order to obtain the economic benefits and protect the ecological environment, in which way it can realize the virtuous circle and sustainable development of the protection and development of eco-tourism resources.
文摘目的回顾性分析宁夏地区回、汉族三种上消化道肿瘤患者的流行特征,为更好地开展肿瘤防治工作提供参考依据.方法收集整理2003-01-01/2012-12-31十年间在宁夏医科大学总医院住院治疗的5616例回、汉族上消化道肿瘤(食管癌、贲门癌、胃癌)患者临床资料.以患者确诊日期作为观察起点,以因上消化道肿瘤死亡的日期作为观察终点,对上消化道肿瘤手术患者(3634例)进行电话随访,随访成功1454例患者,生存时间的计算截止到2016-01-26.建立数据库,采用描述性统计方法分析患者年龄、性别、民族、入院时间、结局变量、生存时间等指标的分布特征,用寿命表法分时期和民族求出1年、3年和5年的生存率.用KaplanM e i e r法计算中位生存时间,生存率比较用Log-rank检验.结果共有5616例患者资料纳入分析,其中汉族患者4695例(83.5%),回族921例(16.5%),汉族vs回族比例为5.10 vs 1;男性患者共计4325例(77.0%),女性患者1291例(23.0%),男性vs女性比例为3.35 vs 1;食管癌患者1563例(27.8%),贲门癌患者1478例(26.3%),胃癌患者2575例(45.9%);食管癌与贲门癌均以≥60岁组(67.7%vs 63.9%)患者为主,胃癌以40-60岁组(45.9%)及≥60岁组(45.1%)患者为主.上消化道肿瘤手术患者3634例,其中食管癌手术患者794例,回、汉族中位生存时间分别为29 mo vs 38 mo,回、汉族1、3、5年生存率分别为72.3%vs 74.7%、46.8%vs50.9%、23.4%v s 30.9%.贲门癌手术患者734例,回、汉族中位生存时间分别为62 mo vs 33 mo,回、汉族1、3、5年生存率分别为73.9%vs 76.3%、58.7%vs 48.0%、54.3%vs39.9%.胃癌手术患者2106例,回、汉族中位生存时间分别为98 mo vs 81 mo,回、汉族1、3、5年生存率分别为77.3%vs 77.0%、50.7%vs 48.1%、24.7%vs 22.7%,食管癌、贲门癌、胃癌患者回、汉族间1、3、5年生存率差异均无统计学意义(P>0.05).结论宁夏地区三种上消化道肿瘤患者在性别与年龄的分布与我国其他区域相同病种患者的分布近似;宁夏地区胃癌与贲门癌患者数量呈现逐年递增趋势;包括宁夏在内的几个北方地区的胃癌人群5年生存率低于南方地区人群.
