Based on my teaching and working experience in Europe, I have made a comparison between the Chinese and European patients in acupuncture treatment, and hope it is of some significance in acupuncture clinical practice.
The Cambrian-lower Ordovician volcanic units of the South Armorican and Occitan domains are ana- lysed in a tectonostratigraphic survey of the French Variscan Belt. The South Armorican lavas consist of continental tho...The Cambrian-lower Ordovician volcanic units of the South Armorican and Occitan domains are ana- lysed in a tectonostratigraphic survey of the French Variscan Belt. The South Armorican lavas consist of continental tholeiites in middle Camhrian-Furongian sequences related to continental break-up. A significant volcanic activity occurred in the Tremadocian, dominated by crustal melted rhyolitic lavas and initial rifting tholeiites. The Occitan lavas are distributed into five volcanic phases： （I） basal Cambrian rhyolites, （2） upper lower Cambrian Mg-rich tholeiites close to N-MORBs but crustal contaminated, （3） upper lower-middle Cambrian continental tholeiites, （4） Tremadocian rhyolites, and （5） upper lower Ordovician initial rift tholeiites. A rifting event linked to asthenosphere upwelling took place in the late early Cambrian but did not evolve. It renewed in the Tremadocian with abundant crustal melting due to underplating of mixed asthenospheric and lithospheric magmas. This main tectono-magmatic conti- nental rift is termed the ＂Tremadocian Tectonic Belt＂ underlined by a chain of rhyolitic volcanoes from Occitan and South Armorican domains to Central Iberia. It evolved with the setting of syn-rift coarse siliciclastic deposits overlain by post-rift deep water shales in a suite of sedimentary basins that fore- casted the South Armorican-Medio-European Ocean as a part of the Palaeotethys Ocean.展开更多
AIM: To compare the racial differences of anatomical distribution of colorectal cancer (CRC) and determine the association of age, gender and time with anatomical distribution between patients from America (white) and...AIM: To compare the racial differences of anatomical distribution of colorectal cancer (CRC) and determine the association of age, gender and time with anatomical distribution between patients from America (white) and China (oriental).METHODS: Data was collected from 690 consecutive patients in Cleveland Clinic Florida, U.S.A. and 870consecutive patients in Nan Fang Hospital affiliated to the First Military Medical University, China over the past 11years from 1990 to 2000. All patients had colorectal adenocarcinoma diagnosed by histology and underwent surgery.RESULTS: The anatomical subsite distribution of tumor,age and gender were significantly different between white and oriental patients. Lesions in the proximal colon (P＜0.001) were found in 36.3 % of white vs 26.0 % of oriental patients and cancers located in the distal colon and rectum in 63.7 % of white and 74 % of oriental patients (P＜0.001). There was a trend towards the redistribution from distal colon and rectum to proximal colon in white males over time, especially in older patients (＞80 years).No significant change of anatomical distribution occurred in white women and Oriental patients. The mean age at diagnosis was 69.0 years in white patients and 48.3 years in Oriental patients (P＜0.001).CONCLUSION: This is the first study comparing the anatomical distribution of colorectal cancers in whites and Chinese patients. White Americans have a higher risk of proximal CRC and this risk increased with time. The proportion of white males with CRC also increased with time.Chinese patients were more likely to have distal CRC and developed the disease at a significantly earlier age than white patients. These findings have enhanced our understanding of the disease process of colorectal cancer in these two races.展开更多
目的评估解耦联蛋白2（UCP2）基因中45I／D和A55v多态性与高加索人肥胖的关联性。方法检索PubMed、Science Direct Online、Springer Link、EBSCO and Google Scholar databases中的相关研究。应用Stata10．0统计学软件对相关研究结果...目的评估解耦联蛋白2（UCP2）基因中45I／D和A55v多态性与高加索人肥胖的关联性。方法检索PubMed、Science Direct Online、Springer Link、EBSCO and Google Scholar databases中的相关研究。应用Stata10．0统计学软件对相关研究结果进行统计分析。采用异质性检验和发表偏倚的评估来验证研究的可信性。用Meta分析探讨研究间潜在的异质性来源。结果共有11篇文献符合纳入标准，包括3936例肥胖者和4156例对照。敏感性分析后，Meta分析结果显示，45I／D多态性与肥胖关系的共显性模型合并OR为1．025（95％CI=0．879～1．195）、显性模型为0．998（95％CI=0．845～1．179）、隐性模型为1．169（95％CI=0．867～1．578），A55V则分别为0．976（95％CI=0．871～1．093）、0．964（95％CI=0．807～1．151）、0．972（95％CI=0．799～1．183）。结论UCP2基因45I／D和A55V多态性与高加索人肥胖可能不存在关联。展开更多
BACKGROUND The Black/African Ancestry(AA)population has a higher prevalence of type 2 diabetes mellitus(T2DM)and a higher incidence and mortality rate for colorectal cancer(CRC)than all other races in the United State...BACKGROUND The Black/African Ancestry(AA)population has a higher prevalence of type 2 diabetes mellitus(T2DM)and a higher incidence and mortality rate for colorectal cancer(CRC)than all other races in the United States.T2DM has been shown to increase adenoma risk in predominantly white/European ancestry(EA)populations,but the effect of T2DM on adenoma risk in Black/AA individuals is less clear.We hypothesize that T2DM has a significant effect on adenoma risk in a predominantly Black/AA population.AIM To investigate the effect of T2DM and race on the adenoma detection rate(ADR)in screening colonoscopies in two disparate populations.METHODS A retrospective cohort study was conducted on ADR during index screening colonoscopies(age 45-75)performed at an urban public hospital serving a predominantly Black/AA population(92%)(2017-2018,n=1606).Clinical metadata collected included basic demographics,insurance,body mass index(BMI),family history of CRC,smoking,diabetes diagnosis,and aspirin use.This dataset was combined with a recently reported parallel retrospective cohort data set collected at a suburban university hospital serving a predominantly White/EA population(87%)(2012-2015,n=2882).RESULTS The ADR was higher in T2DM patients than in patients without T2DM or prediabetes(35.2%vs 27.9%,P=0.0166,n=981)at the urban public hospital.Multivariable analysis of the combined datasets showed that T2DM[odds ratio(OR)=1.29,95%confidence interval(CI):1.08-1.55,P=0.0049],smoking(current vs never OR=1.47,95%CI:1.18-1.82,current vs past OR=1.32,95%CI:1.02-1.70,P=0.0026),older age(OR=1.05 per year,95%CI:1.04-1.06,P<0.0001),higher BMI(OR=1.02 per unit,95%CI:1.01-1.03,P=0.0003),and male sex(OR=1.87,95%CI:1.62-2.15,P<0.0001)were associated with increased ADR in the combined datasets,but race,aspirin use and insurance were not.CONCLUSION T2DM,but not race,is significantly associated with increased ADR on index screening colonoscopy while controlling for other factors.展开更多
文摘Based on my teaching and working experience in Europe, I have made a comparison between the Chinese and European patients in acupuncture treatment, and hope it is of some significance in acupuncture clinical practice.
基金funded by project CGL2013-48877-P from Spanish MINECO
文摘The Cambrian-lower Ordovician volcanic units of the South Armorican and Occitan domains are ana- lysed in a tectonostratigraphic survey of the French Variscan Belt. The South Armorican lavas consist of continental tholeiites in middle Camhrian-Furongian sequences related to continental break-up. A significant volcanic activity occurred in the Tremadocian, dominated by crustal melted rhyolitic lavas and initial rifting tholeiites. The Occitan lavas are distributed into five volcanic phases： （I） basal Cambrian rhyolites, （2） upper lower Cambrian Mg-rich tholeiites close to N-MORBs but crustal contaminated, （3） upper lower-middle Cambrian continental tholeiites, （4） Tremadocian rhyolites, and （5） upper lower Ordovician initial rift tholeiites. A rifting event linked to asthenosphere upwelling took place in the late early Cambrian but did not evolve. It renewed in the Tremadocian with abundant crustal melting due to underplating of mixed asthenospheric and lithospheric magmas. This main tectono-magmatic conti- nental rift is termed the ＂Tremadocian Tectonic Belt＂ underlined by a chain of rhyolitic volcanoes from Occitan and South Armorican domains to Central Iberia. It evolved with the setting of syn-rift coarse siliciclastic deposits overlain by post-rift deep water shales in a suite of sedimentary basins that fore- casted the South Armorican-Medio-European Ocean as a part of the Palaeotethys Ocean.
文摘AIM: To compare the racial differences of anatomical distribution of colorectal cancer (CRC) and determine the association of age, gender and time with anatomical distribution between patients from America (white) and China (oriental).METHODS: Data was collected from 690 consecutive patients in Cleveland Clinic Florida, U.S.A. and 870consecutive patients in Nan Fang Hospital affiliated to the First Military Medical University, China over the past 11years from 1990 to 2000. All patients had colorectal adenocarcinoma diagnosed by histology and underwent surgery.RESULTS: The anatomical subsite distribution of tumor,age and gender were significantly different between white and oriental patients. Lesions in the proximal colon (P＜0.001) were found in 36.3 % of white vs 26.0 % of oriental patients and cancers located in the distal colon and rectum in 63.7 % of white and 74 % of oriental patients (P＜0.001). There was a trend towards the redistribution from distal colon and rectum to proximal colon in white males over time, especially in older patients (＞80 years).No significant change of anatomical distribution occurred in white women and Oriental patients. The mean age at diagnosis was 69.0 years in white patients and 48.3 years in Oriental patients (P＜0.001).CONCLUSION: This is the first study comparing the anatomical distribution of colorectal cancers in whites and Chinese patients. White Americans have a higher risk of proximal CRC and this risk increased with time. The proportion of white males with CRC also increased with time.Chinese patients were more likely to have distal CRC and developed the disease at a significantly earlier age than white patients. These findings have enhanced our understanding of the disease process of colorectal cancer in these two races.
文摘目的评估解耦联蛋白2（UCP2）基因中45I／D和A55v多态性与高加索人肥胖的关联性。方法检索PubMed、Science Direct Online、Springer Link、EBSCO and Google Scholar databases中的相关研究。应用Stata10．0统计学软件对相关研究结果进行统计分析。采用异质性检验和发表偏倚的评估来验证研究的可信性。用Meta分析探讨研究间潜在的异质性来源。结果共有11篇文献符合纳入标准，包括3936例肥胖者和4156例对照。敏感性分析后，Meta分析结果显示，45I／D多态性与肥胖关系的共显性模型合并OR为1．025（95％CI=0．879～1．195）、显性模型为0．998（95％CI=0．845～1．179）、隐性模型为1．169（95％CI=0．867～1．578），A55V则分别为0．976（95％CI=0．871～1．093）、0．964（95％CI=0．807～1．151）、0．972（95％CI=0．799～1．183）。结论UCP2基因45I／D和A55V多态性与高加索人肥胖可能不存在关联。
基金Stony Brook University Targeted Research Opportunity Seed Fusion Grant,No.1135373-3-37298National Cancer Institute,No.P20 CA192994Simons Foundation,No.415604.
文摘BACKGROUND The Black/African Ancestry(AA)population has a higher prevalence of type 2 diabetes mellitus(T2DM)and a higher incidence and mortality rate for colorectal cancer(CRC)than all other races in the United States.T2DM has been shown to increase adenoma risk in predominantly white/European ancestry(EA)populations,but the effect of T2DM on adenoma risk in Black/AA individuals is less clear.We hypothesize that T2DM has a significant effect on adenoma risk in a predominantly Black/AA population.AIM To investigate the effect of T2DM and race on the adenoma detection rate(ADR)in screening colonoscopies in two disparate populations.METHODS A retrospective cohort study was conducted on ADR during index screening colonoscopies(age 45-75)performed at an urban public hospital serving a predominantly Black/AA population(92%)(2017-2018,n=1606).Clinical metadata collected included basic demographics,insurance,body mass index(BMI),family history of CRC,smoking,diabetes diagnosis,and aspirin use.This dataset was combined with a recently reported parallel retrospective cohort data set collected at a suburban university hospital serving a predominantly White/EA population(87%)(2012-2015,n=2882).RESULTS The ADR was higher in T2DM patients than in patients without T2DM or prediabetes(35.2%vs 27.9%,P=0.0166,n=981)at the urban public hospital.Multivariable analysis of the combined datasets showed that T2DM[odds ratio(OR)=1.29,95%confidence interval(CI):1.08-1.55,P=0.0049],smoking(current vs never OR=1.47,95%CI:1.18-1.82,current vs past OR=1.32,95%CI:1.02-1.70,P=0.0026),older age(OR=1.05 per year,95%CI:1.04-1.06,P<0.0001),higher BMI(OR=1.02 per unit,95%CI:1.01-1.03,P=0.0003),and male sex(OR=1.87,95%CI:1.62-2.15,P<0.0001)were associated with increased ADR in the combined datasets,but race,aspirin use and insurance were not.CONCLUSION T2DM,but not race,is significantly associated with increased ADR on index screening colonoscopy while controlling for other factors.
