The auditory steady state response （ASSR） may reflect activity from different regions of the brain, depending on the modulation frequency used. In general, responses induced by low rates （_〈40 Hz） emanate mostly ...The auditory steady state response （ASSR） may reflect activity from different regions of the brain, depending on the modulation frequency used. In general, responses induced by low rates （_〈40 Hz） emanate mostly from central structures of the brain, and responses from high rates （〉80 Hz） emanate mostly from the peripheral auditory nerve or brainstem structures. Besides, it was reported that the gamma band ASSR （30-90 Hz） played an important role in working memory, speech understanding and recognition. This paper investigated the 40 Hz ASSR evoked by modulated speech and reversed speech. The speech was Chinese phrase voice, and the noise-like reversed speech was obtained by temporally reversing the speech. Both auditory stimuli were modulated with a frequency of 40 Hz. Ten healthy subjects and 5 patients with hallucination symptom participated in the experiment. Results showed re- duction in left auditory cortex response when healthy subjects listened to the reversed speech compared with the speech. In contrast, when the patients who experienced auditory hallucinations listened to the reversed speech, the auditory cortex of left hemispheric responded more actively. The ASSR results were consistent with the behavior results of patients. Therefore, the gamma band ASSR is expected to be helpful for rapid and objective diagnosis of hallucination in clinic.展开更多
BACKGROUND: Auditory steady-state evoked response (ASSR) is one of the new objective electrophysiological methods to test hearing in infants. It can provide a reliable and complete audiogram with specific frequency to...BACKGROUND: Auditory steady-state evoked response (ASSR) is one of the new objective electrophysiological methods to test hearing in infants. It can provide a reliable and complete audiogram with specific frequency to help the hearing diagnosis and rehabilitation of hearing and languaging following auditory screening. OBJECTIVE: To compare the response threshold of ASSR with auditory threshold of visual reinforcement audiometry (VRA) in infants failed in the hearing screening for investigating their hearing loss. DESIGN: A comparative observation. SETTINGS: Maternal and child health care hospitals of Guangdong province, Shunde city, Nanhai city and Huadu district. PARTICIPANTS: Totally 321 infants of 0-3 years undergoing ASSR test were selected from the Hearing Center of Guangdong Maternal and Child Health Care Hospital from January 2002 to December 2004. Informed consents were obtained from their guardians. There were 193 cases (60.2%) of 0-6 months, 31 cases (9.7%) of 7-12 months, 17 cases (5.3%) of 13-18 months, 14 cases (4.4%) of 19-24 months, 33 cases of 25-30 months, and 33 cases (10.2%) of 31-36 months. METHODS: ① The 321 infants failed in the hearing screening were tested under sleeping status, the ranges of response threshold distribution in ASSR of different frequencies were analyzed in each age group. ② The infants above 2 years old were also tested with VRA, and their response thresholds were compared between VRA and ASSR. ③ Evaluative standards: The response threshold was < 30 dB for normal hearing, 31-50 dB for mild hearing loss, 51-70 dB for moderate hearing loss, 71-90 dB for severe hearing loss, and > 91 dB for extremely severe hearing loss. MAIN OUTCOME MEASURES: ① ASSR results of the infants failed in the screening; ② Proportion of cases of each response threshold in each age group; ③ Comparison of ASSR response thresholds and VRA auditory thresholds in the infants of 2-3 years old. RESULTS: ①The response threshold was < 30 dB in 47.4% of the 321 infants failed in the initial hearing screening and secondary screening after 42 days. ② Severe to extremely severe hearing loss was detected in only 16 cases (8.3%) of the 193 infants of 0-6 months, in 9 cases (27.3%) of the 33 infants of 25-30 months, and 13 cases (39.4%) of the 33 infants of 31-36 months. Of the 193 infants of 0-6 months old who failed in the initial screening and the second screening after 42 days, the ASSR auditory threshold was < 30 dB in 97 cases (50.26%), 31-50 dB in 63 cases (32.6%), 51-70 dB in 17 cases (8.8%), 71-90 dB in 7 cases (3.6%), and > 91 dB in 9 cases (4.7%). ③ Among the 321 infants failed in the screening, the auditory threshold in the 6 age groups was < 30 dB in 47.4%, 31-50 dB in 27.1%, 51-70 dB in 8.4%, 71-90 dB in 6.2%, and > 91 dB in 10.9%. ④ The difference between ASSR response threshold and VRA auditory thresholds was 6-18 dB in the normal hearing group, mild and moderate hearing loss groups, and there was high correlation between them. The difference of ASSR and VRA thresholds was less than 5 dB between extremely severe and severe hearing loss groups, 5-13 dB between extremely severe and moderate-to-severe hearing loss groups (P < 0.05), and there was no significant differences between severe and moderate-to-severe hearing loss groups (P > 0.05). CONCLUSION: ① The hearing was normal in about half of the infants, although they failed in the primary screening and secondary screening. ② The proportion of the severity of hearing loss was increased along with aging. ③ Mild and moderate hearing losses are dominant in infants. ④ ASSR is reliable to evaluate the hearing of infants.展开更多
目的分析3岁听障儿童与同龄健听儿童语言细节句子测试结果,为提高康复教学效果提供参考依据。方法在康复机构和普通幼儿园选取听障儿童与健听儿童各30例,采用言语听觉反应评估(evaluation of auditory resporse to speech,EARS)中的语...目的分析3岁听障儿童与同龄健听儿童语言细节句子测试结果,为提高康复教学效果提供参考依据。方法在康复机构和普通幼儿园选取听障儿童与健听儿童各30例,采用言语听觉反应评估(evaluation of auditory resporse to speech,EARS)中的语言细节句子测试表进行测试,比较两组儿童的句子和词汇水平得分。结果儿童的听力状况对语言细节句子测试得分影响显著(T句子(1,58)=3.36,P<0.01;T词语(1,58)=2.89,P<0.01),健听儿童句子和词汇水平得分(M句子=8.47,M词语=58.23)均显著高于听障儿童(M句子=7.03,M词语=56.63)(P<0.05)。结论与健听儿童相比,语言年龄达到3岁水平的听障儿童句法语法能力滞后,这可能与听障儿童输入性语言信息不足及输入环境有关。康复训练中应加强相应训练,拓展应用到生活场景中。展开更多
目的比较3岁听障儿童与同龄健听儿童开放式单音节测试结果,为提高康复教学效果提供依据。方法选取3岁听障儿童与同龄健听儿童各30例,采用言语听觉反应评估(evaluation of auditory response to speech,EARS)中的开放式单音节分别对两组...目的比较3岁听障儿童与同龄健听儿童开放式单音节测试结果,为提高康复教学效果提供依据。方法选取3岁听障儿童与同龄健听儿童各30例,采用言语听觉反应评估(evaluation of auditory response to speech,EARS)中的开放式单音节分别对两组儿童进行测试,比较其结果。结果两组儿童各测试项得分高低排序均为声调得分>韵母得分>声母得分>字得分,且两两之间的差异均有统计学意义(P<0.01);3岁听障儿童的声母、韵母和字得分均显著低于同龄健听儿童(P<0.001)。错误分析表明两组儿童中舌尖后音、边音的正确率均最低;健听儿童的双唇音、唇齿音、鼻音、塞音正确率最高,而听障儿童的舌根音正确率最高。听障儿童各发音部位及发音方法的声母、鼻韵母的正确率均显著低于健听儿童(P<0.05)。结论 3岁听障儿童在开放式单音节测试中的声母、韵母和字得分差于同龄健听儿童,且以舌尖后音、边音最为突出,这可能与听障儿童听力状况带来的输入性语言信息不足和听觉干预起始年龄有关。展开更多
基金supported by the National Natural Science Foundation of China(No.90820304,61105123,and 31100714)National Basic Research Program of China(No.2011CB933204)
文摘The auditory steady state response （ASSR） may reflect activity from different regions of the brain, depending on the modulation frequency used. In general, responses induced by low rates （_〈40 Hz） emanate mostly from central structures of the brain, and responses from high rates （〉80 Hz） emanate mostly from the peripheral auditory nerve or brainstem structures. Besides, it was reported that the gamma band ASSR （30-90 Hz） played an important role in working memory, speech understanding and recognition. This paper investigated the 40 Hz ASSR evoked by modulated speech and reversed speech. The speech was Chinese phrase voice, and the noise-like reversed speech was obtained by temporally reversing the speech. Both auditory stimuli were modulated with a frequency of 40 Hz. Ten healthy subjects and 5 patients with hallucination symptom participated in the experiment. Results showed re- duction in left auditory cortex response when healthy subjects listened to the reversed speech compared with the speech. In contrast, when the patients who experienced auditory hallucinations listened to the reversed speech, the auditory cortex of left hemispheric responded more actively. The ASSR results were consistent with the behavior results of patients. Therefore, the gamma band ASSR is expected to be helpful for rapid and objective diagnosis of hallucination in clinic.
基金a grant from Medical Scientific Research Foundation of G uangdong Bureau of Hygiene,No.W STJJ2001111044082219581224001
文摘BACKGROUND: Auditory steady-state evoked response (ASSR) is one of the new objective electrophysiological methods to test hearing in infants. It can provide a reliable and complete audiogram with specific frequency to help the hearing diagnosis and rehabilitation of hearing and languaging following auditory screening. OBJECTIVE: To compare the response threshold of ASSR with auditory threshold of visual reinforcement audiometry (VRA) in infants failed in the hearing screening for investigating their hearing loss. DESIGN: A comparative observation. SETTINGS: Maternal and child health care hospitals of Guangdong province, Shunde city, Nanhai city and Huadu district. PARTICIPANTS: Totally 321 infants of 0-3 years undergoing ASSR test were selected from the Hearing Center of Guangdong Maternal and Child Health Care Hospital from January 2002 to December 2004. Informed consents were obtained from their guardians. There were 193 cases (60.2%) of 0-6 months, 31 cases (9.7%) of 7-12 months, 17 cases (5.3%) of 13-18 months, 14 cases (4.4%) of 19-24 months, 33 cases of 25-30 months, and 33 cases (10.2%) of 31-36 months. METHODS: ① The 321 infants failed in the hearing screening were tested under sleeping status, the ranges of response threshold distribution in ASSR of different frequencies were analyzed in each age group. ② The infants above 2 years old were also tested with VRA, and their response thresholds were compared between VRA and ASSR. ③ Evaluative standards: The response threshold was < 30 dB for normal hearing, 31-50 dB for mild hearing loss, 51-70 dB for moderate hearing loss, 71-90 dB for severe hearing loss, and > 91 dB for extremely severe hearing loss. MAIN OUTCOME MEASURES: ① ASSR results of the infants failed in the screening; ② Proportion of cases of each response threshold in each age group; ③ Comparison of ASSR response thresholds and VRA auditory thresholds in the infants of 2-3 years old. RESULTS: ①The response threshold was < 30 dB in 47.4% of the 321 infants failed in the initial hearing screening and secondary screening after 42 days. ② Severe to extremely severe hearing loss was detected in only 16 cases (8.3%) of the 193 infants of 0-6 months, in 9 cases (27.3%) of the 33 infants of 25-30 months, and 13 cases (39.4%) of the 33 infants of 31-36 months. Of the 193 infants of 0-6 months old who failed in the initial screening and the second screening after 42 days, the ASSR auditory threshold was < 30 dB in 97 cases (50.26%), 31-50 dB in 63 cases (32.6%), 51-70 dB in 17 cases (8.8%), 71-90 dB in 7 cases (3.6%), and > 91 dB in 9 cases (4.7%). ③ Among the 321 infants failed in the screening, the auditory threshold in the 6 age groups was < 30 dB in 47.4%, 31-50 dB in 27.1%, 51-70 dB in 8.4%, 71-90 dB in 6.2%, and > 91 dB in 10.9%. ④ The difference between ASSR response threshold and VRA auditory thresholds was 6-18 dB in the normal hearing group, mild and moderate hearing loss groups, and there was high correlation between them. The difference of ASSR and VRA thresholds was less than 5 dB between extremely severe and severe hearing loss groups, 5-13 dB between extremely severe and moderate-to-severe hearing loss groups (P < 0.05), and there was no significant differences between severe and moderate-to-severe hearing loss groups (P > 0.05). CONCLUSION: ① The hearing was normal in about half of the infants, although they failed in the primary screening and secondary screening. ② The proportion of the severity of hearing loss was increased along with aging. ③ Mild and moderate hearing losses are dominant in infants. ④ ASSR is reliable to evaluate the hearing of infants.
文摘目的分析3岁听障儿童与同龄健听儿童语言细节句子测试结果,为提高康复教学效果提供参考依据。方法在康复机构和普通幼儿园选取听障儿童与健听儿童各30例,采用言语听觉反应评估(evaluation of auditory resporse to speech,EARS)中的语言细节句子测试表进行测试,比较两组儿童的句子和词汇水平得分。结果儿童的听力状况对语言细节句子测试得分影响显著(T句子(1,58)=3.36,P<0.01;T词语(1,58)=2.89,P<0.01),健听儿童句子和词汇水平得分(M句子=8.47,M词语=58.23)均显著高于听障儿童(M句子=7.03,M词语=56.63)(P<0.05)。结论与健听儿童相比,语言年龄达到3岁水平的听障儿童句法语法能力滞后,这可能与听障儿童输入性语言信息不足及输入环境有关。康复训练中应加强相应训练,拓展应用到生活场景中。
文摘目的比较3岁听障儿童与同龄健听儿童开放式单音节测试结果,为提高康复教学效果提供依据。方法选取3岁听障儿童与同龄健听儿童各30例,采用言语听觉反应评估(evaluation of auditory response to speech,EARS)中的开放式单音节分别对两组儿童进行测试,比较其结果。结果两组儿童各测试项得分高低排序均为声调得分>韵母得分>声母得分>字得分,且两两之间的差异均有统计学意义(P<0.01);3岁听障儿童的声母、韵母和字得分均显著低于同龄健听儿童(P<0.001)。错误分析表明两组儿童中舌尖后音、边音的正确率均最低;健听儿童的双唇音、唇齿音、鼻音、塞音正确率最高,而听障儿童的舌根音正确率最高。听障儿童各发音部位及发音方法的声母、鼻韵母的正确率均显著低于健听儿童(P<0.05)。结论 3岁听障儿童在开放式单音节测试中的声母、韵母和字得分差于同龄健听儿童,且以舌尖后音、边音最为突出,这可能与听障儿童听力状况带来的输入性语言信息不足和听觉干预起始年龄有关。
