Objective:To investigate the neural electrophysiologieal activity underlying Chinese and Eng- lish Stroop tasks for Chinese English bilinguals.Methods:Event-related potentials(ERPs)were recorded in 14 Chinese bilingua...Objective:To investigate the neural electrophysiologieal activity underlying Chinese and Eng- lish Stroop tasks for Chinese English bilinguals.Methods:Event-related potentials(ERPs)were recorded in 14 Chinese bilinguals with a moderate command of English when they performed the Stroop task pre- sented in English words and Chinese characters,respectively.Results:In Chinese task version,it was found an increased positivity over bilateral front-polar regions on incongruent trials compared with congru- ent trials,followed by an increased negativity over fronto-central region and an increased positivity over occipital region.While in English task version,only the increased negativity was observed over fronto-cen- tral region,but with reduced amplitude and anterior distribution.Conclusion:This increased negativity was proposed as an index of the resolution processes of conflicting information in the incongruent situa- tion.The increased positivity over occipital region on Chinese incongruent trials may indicate visually rechecking effect for Chinese character.展开更多
Objective:To explore the difference and its clinical significance of event-related potential N400 in patients with bipolar depression,unipolar depression and schizophrenia Methods:It was N400 detection for 24 cases of...Objective:To explore the difference and its clinical significance of event-related potential N400 in patients with bipolar depression,unipolar depression and schizophrenia Methods:It was N400 detection for 24 cases of bipolar depression,25 cases of unipolar depression,26 cases of schizophrenia and 28 healthy adults.All were tested with China Runjie WJ-1 ERP Instrument,congruent ending words of Chinese idioms(matching)and incongruent ending words of Chinese idioms(mismatching)mode.Results:(1)Compared with healthy adults in the control group,N400 latencies were prolonged in Cz brain regions and amplitudes were decreased period of three groups of patients before taking the medicine.(2)The delay in latencies and the decrease in amplitude of schizophrenia N400 were negatively correlated with the PANSS total score of the neuropsychological scale.(3)The abnormal degree of N400 in bipolar depression group was between unipolar depression group and schizophrenia group.Conclusions:We initially believe that(1)the bipolar depression group may be an intermediate state between unipolar depression and schizophrenia.(2)Bipolar depression with psychotic symptoms may have specific language barriers and N400 abnormalities.(3)After the next ERP follow-up,N400 can be used as a laboratory aid for identifying unipolar depression,bipolar depression and schizophrenia.展开更多
The dopamine transporter (DAT) is responsible for dopamine reuptake from the synaptic cleft. A variable number of tandem repeats polymorphism in the DAT gene is related to DAT availability and has been associated wi...The dopamine transporter (DAT) is responsible for dopamine reuptake from the synaptic cleft. A variable number of tandem repeats polymorphism in the DAT gene is related to DAT availability and has been associated with cognition. With the advantage of high-time resolution, event-related potential is an important method to study the time course of human information processing. Previous results have suggested that dopamine exhibits a close relationship with conflicting information processing. Therefore, the present study assumed that conflicting information processing could be influenced by DAT variable number of tandem repeats polymorphism. To confirm this, the present study analyzed the influence of DAT genotypes on N270, which is presumed to reflect neural activity of conflict information processing in young healthy adults. A S1-S2 matching task was performed in healthy adults with 10/10 genotype (n = 14) and 10/9 genotypes (n = 14), respectively, when event-related potentials were recorded. Results demonstrated that subjects with the 10/10 genotype exhibited shorter N270 latency and quicker reaction times compared with subjects with the 10/9 genotype. There were no differences in N270 amplitude between the two genotypes. These results suggested that 10/10 genotype subjects more efficiently processed conflict information.展开更多
This study investigated behavioral inhibition in female college students with psychometrically defined schizotypal traits using a Go/NoGo task and event-related potentials (ERPs). The schizotypal-trait (n = 15) and no...This study investigated behavioral inhibition in female college students with psychometrically defined schizotypal traits using a Go/NoGo task and event-related potentials (ERPs). The schizotypal-trait (n = 15) and normal control (n = 15) groups were selected based on scores of the Schizotypal Personality Questionnaire (SPQ). The Go/NoGo task consisted of Go (requires response) and NoGo (requires no response) conditions. In terms of response time and accuracy rate for the Go/NoGo task, the two groups did not differ significantly. In terms of ERPs, the control group showed greater N2 amplitudes in response to NoGo (NoGo-N2) than to Go stimuli (Go-N2), whereas the schizotypal-trait group showed no significant difference in NoGo-N2 and Go-N2 amplitudes. In addition, the schizotypal-trait group showed reduced NoGo-N2 amplitudes at the frontal site compared to controls, and an association between SPQ scores and NoGo-N2 amplitudes measured at the frontal site. The two groups did not differ in P3 amplitudes. Since the N2 reflects the detection of response conflict and behavioral inhibition, the present results indicate that nonclinical individuals with schizotypal traits have difficulties in detecting response conflict and behavioral inhibition.展开更多
The entity and symbolic fraction comparison tasks separating identification and semantic access stages based on event-related potential technology were used to investigate neural differences between fraction and decim...The entity and symbolic fraction comparison tasks separating identification and semantic access stages based on event-related potential technology were used to investigate neural differences between fraction and decimal strategies in magnitude processing of nonsymbolic entities and symbolic numbers.The experimental results show that continuous entities elicit stronger left-lateralized anterior N2 in decimals,while discretized ones elicit more significant right-lateralized posterior N2 in fractions during the identification stage.On the other hand,decimals elicit stronger N2 over the left-lateralized fronto-central sites while fractions elicit the more profound P2 over the right-lateralized fronto-central sites and N2 at biparietal regions during the semantic access stage.Hence,for nonsymbolic entity processing,alignments of decimals and continuous entities activate the phonological network,while alignments of fractions and discretized entities trigger the visuospatial regions.For symbolic numbers processing,exact strategies with rote arithmetic retrieval in verbal format are used in decimal processing,while approximate strategies with complex magnitude processing in a visuospatial format are used in fraction processing.展开更多
Language difficulties vary widely among people with autism spectrum disorder(ASD).However,the semantic processing of autistic person and its underlying electrophysiological mechanism are still unclear.This meta-analys...Language difficulties vary widely among people with autism spectrum disorder(ASD).However,the semantic processing of autistic person and its underlying electrophysiological mechanism are still unclear.This meta-analysis aimed to explore the disturbance of semantic processing in patients with ASD.PubMed,Web of Science,and Embase were searched for eventrelated potential(ERP)studies on semantic processing in autistic people published in English before September 01,2022.Pooled estimates were calculated by fixed-effects or random-effects models according to the heterogeneity using Comprehensive Meta-Analysis 2.0.The potential moderators were explored by meta-regression and subgroup analysis.This meta-analysis has been registered at the Prospero International Prospective Register of Systematic Reviews(no.CRD 42021265852).A total of 14 articles and 18 studies,including 254 autistic people and 262 neurodevelopmental people were included in this meta-analysis.Compared to the comparison group,autistic people showed an overall reduced N400 amplitude(Hedges’g=0.350,p<0.001)in response to linguistic stimuli instead of non-linguistic stimuli.The N400 amplitude was affected by verbal intelligence and gender.The reduced overall N400 amplitude in autistic people under linguistic stimuli suggests a linguistic-specific deficit in semantic processing in individuals of autism.The decrease of N400 amplitude might be a promising indication of the pool language capacity of autism.展开更多
The perception of complex auditory information such as complete speech sequences develops during human ontogeny. In order to explore age differences in the auditory perception of predictable speech sequences we compar...The perception of complex auditory information such as complete speech sequences develops during human ontogeny. In order to explore age differences in the auditory perception of predictable speech sequences we compared event-related potentials (ERPs) recorded in 5- to 6-year-old children (N = 15) and adults (N = 15) in response to anticipated speech sequences as successive and reverse digital series with randomly omitted digits. The ERPs obtained from the omitted digits significantly differed in the amplitude and latency of the N200 and P300 components between adults and children, the N400 and LPC components were more pronounced in children in the right frontal area for the digits presentation. These findings indicate that the perception of a successive speech structure is less automated in children and requires a detailed analysis of the successive structure and error detection. These differences in auditory ERPs reflect developmental changes in the auditory perception of speech sequences and can serve as indicators of the maturity of cognitive functions in children.展开更多
Background:Risperidone and paliperidone have been the mainstay treatment for schizophrenia and their potential role in neuroprotection could be associated with brain-derived neurotrophic factor (BDNF) and N400 (an...Background:Risperidone and paliperidone have been the mainstay treatment for schizophrenia and their potential role in neuroprotection could be associated with brain-derived neurotrophic factor (BDNF) and N400 (an event-related brain potential component).So far,different effects on both BDNF and N400 were reported in relation to various antipsychotic treatments.However,few studies have been conducted on the mechanism ofrisperidone and paliperidone on BDNF and N400.This study aimed to compare the effects ofrisperidone and paliperidone on BDNF and the N400 component of the event-related brain potential in patients with first-episode schizophrenia.Methods:Ninety-eight patients with first-episode schizophrenia were randomly divided into the risperidone and paliperidone groups and treated with risperidone and paliperidone,respectively,for 12 weeks.Serum BDNF level,the latency,and amplitude of the N400 event-related potential before and after the treatment and Positive and Negative Syndrome Scale (PANSS) scores were compared between the two groups.Results:A total of 94 patients were included in the final analysis (47 patients in each group).After the treatment,the serum BDNF levels in both groups increased (all P 〈 0.01),while no significant difference in serum BDNF level was found between the groups before and after the treatment (all P 〉 0.05).After the treatment,N400 amplitudes were increased (from 4.73 ± 2.86 μv and 4.51 ± 4.63 μv to 5.35 ± 4.18 μv and 5.52 ± 3.08 μv,respectively) under congruent condition in both risperidone and paliperidone groups (all P 〈 0.01).Under incongruent conditions,the N400 latencies were shortened in the paliperidone group (from 424.13 ± 110.42 ms to 4.7.41 ± 154.59 ms,P 〈 0.05),and the N400 amplitudes were increased in the risperidone group (from 5.80 ± 3.50 μv to 7.17 ± 5.51 μv,P 〈 0.01).After treatment,the total PANSS score in both groups decreased significantly (all P 〈 0.01),but the difference between the groups was not significant (P 〉 0.05).A negative correlation between the reduction rate of the PANSS score and the increase in serum BDNF level after the treatment was found in the paliperidone group but not in the risperidone group.Conclusions:Both risperidone and paliperidone could increase the serum BDNF levels in patients with first-episode schizophrenia and improve their cognitive function (N400 latency and amplitude),but their antipsychotic mechanisms might differ.展开更多
Background:The N400 component of event-related potentials (ERP) has recently drawn widespread attention at home and abroad.This study was to explore the relationship between N400 changes and risperidone treatment a...Background:The N400 component of event-related potentials (ERP) has recently drawn widespread attention at home and abroad.This study was to explore the relationship between N400 changes and risperidone treatment and rehabilitation in first-episode schizophrenia (FES).Methods:ERP component N400 was recorded by Guangzhou Runjie W J-l ERP instruments,in 58 FES before and 6 months,15 months after risperidone treatment,and in 62 normal controls.The patients' syndromes were assessed by Positive and Negative Syndrome Scale (PANSS).And the stimuli are Chinese sentences with matching (congruent) or mismatching (incongruent) ending words.Results:N400 latencies were prolonged,and amplitudes were decreased in Cz,Pz,Fz,C3,C4,in FES compared with in NC,before treatment.The prolonged N400 latencies and decreased amplitudes were negatively correlated with the patients' positive scale and total scale of PANSS.There are significant differences of N400 amplitudes and latencies in 6 months and 15 months follow-up after treatment.Before treatment,6 months and 15 months after treatment,N400 latencies are 446 ± 35 ms,440 ± 37 ms,414 ± 31 ms (F =9.72,P 〈 0.01) in incongruent situation;N400 amplitudes are 5.2 ± 4.6 μtⅤ,5.7 ± 4.8 μⅤ,7.3 ± 5.0 μⅤ (F =2.06,P 〉 0.05) in congruent situation,and 8.5 ± 5.9 μⅤ,10.1 ± 5.0 μⅤ,11.9 ± 7.0 μⅤ (F =3.697,P 〈 0.05) in incongruent situation.Conclusions:N400 could be used to predict the effects of treatment of schizophrenia to some degree.The linguistic and cognitive impairment in schizophrenia can be improved by antipsychotic drugs.展开更多
Closure or the presence of a "hole" is an emergent perceptual feature that can be extracted by the visual system early on. This feature has been shown to have perceptual advantages over openness or "no-hole". in t...Closure or the presence of a "hole" is an emergent perceptual feature that can be extracted by the visual system early on. This feature has been shown to have perceptual advantages over openness or "no-hole". in this study, we investigated when and how the human brain differentiates between "hole" and "no-hole" figures. Event-related potentials (ERPs) were recorded during a passive observation paradigm. Two pairs of simple figures (Experiment 1) and two sets of Greek letters (Experiment 2) were used as stimuli. The ERPs of "hole" and "no-hole" figures differed ~90 ms after stimulus onset: "hole" figures elicited smaller P1 and N1 amplitudes than "no-hole" figures. These suggest that both P1 and N1 components are sensitive to the difference between "hole" and "no-hole" figures; perception of "hole" and "no-hole" figures might be differentiated early during visual processing.展开更多
文摘Objective:To investigate the neural electrophysiologieal activity underlying Chinese and Eng- lish Stroop tasks for Chinese English bilinguals.Methods:Event-related potentials(ERPs)were recorded in 14 Chinese bilinguals with a moderate command of English when they performed the Stroop task pre- sented in English words and Chinese characters,respectively.Results:In Chinese task version,it was found an increased positivity over bilateral front-polar regions on incongruent trials compared with congru- ent trials,followed by an increased negativity over fronto-central region and an increased positivity over occipital region.While in English task version,only the increased negativity was observed over fronto-cen- tral region,but with reduced amplitude and anterior distribution.Conclusion:This increased negativity was proposed as an index of the resolution processes of conflicting information in the incongruent situa- tion.The increased positivity over occipital region on Chinese incongruent trials may indicate visually rechecking effect for Chinese character.
文摘Objective:To explore the difference and its clinical significance of event-related potential N400 in patients with bipolar depression,unipolar depression and schizophrenia Methods:It was N400 detection for 24 cases of bipolar depression,25 cases of unipolar depression,26 cases of schizophrenia and 28 healthy adults.All were tested with China Runjie WJ-1 ERP Instrument,congruent ending words of Chinese idioms(matching)and incongruent ending words of Chinese idioms(mismatching)mode.Results:(1)Compared with healthy adults in the control group,N400 latencies were prolonged in Cz brain regions and amplitudes were decreased period of three groups of patients before taking the medicine.(2)The delay in latencies and the decrease in amplitude of schizophrenia N400 were negatively correlated with the PANSS total score of the neuropsychological scale.(3)The abnormal degree of N400 in bipolar depression group was between unipolar depression group and schizophrenia group.Conclusions:We initially believe that(1)the bipolar depression group may be an intermediate state between unipolar depression and schizophrenia.(2)Bipolar depression with psychotic symptoms may have specific language barriers and N400 abnormalities.(3)After the next ERP follow-up,N400 can be used as a laboratory aid for identifying unipolar depression,bipolar depression and schizophrenia.
文摘The dopamine transporter (DAT) is responsible for dopamine reuptake from the synaptic cleft. A variable number of tandem repeats polymorphism in the DAT gene is related to DAT availability and has been associated with cognition. With the advantage of high-time resolution, event-related potential is an important method to study the time course of human information processing. Previous results have suggested that dopamine exhibits a close relationship with conflicting information processing. Therefore, the present study assumed that conflicting information processing could be influenced by DAT variable number of tandem repeats polymorphism. To confirm this, the present study analyzed the influence of DAT genotypes on N270, which is presumed to reflect neural activity of conflict information processing in young healthy adults. A S1-S2 matching task was performed in healthy adults with 10/10 genotype (n = 14) and 10/9 genotypes (n = 14), respectively, when event-related potentials were recorded. Results demonstrated that subjects with the 10/10 genotype exhibited shorter N270 latency and quicker reaction times compared with subjects with the 10/9 genotype. There were no differences in N270 amplitude between the two genotypes. These results suggested that 10/10 genotype subjects more efficiently processed conflict information.
文摘This study investigated behavioral inhibition in female college students with psychometrically defined schizotypal traits using a Go/NoGo task and event-related potentials (ERPs). The schizotypal-trait (n = 15) and normal control (n = 15) groups were selected based on scores of the Schizotypal Personality Questionnaire (SPQ). The Go/NoGo task consisted of Go (requires response) and NoGo (requires no response) conditions. In terms of response time and accuracy rate for the Go/NoGo task, the two groups did not differ significantly. In terms of ERPs, the control group showed greater N2 amplitudes in response to NoGo (NoGo-N2) than to Go stimuli (Go-N2), whereas the schizotypal-trait group showed no significant difference in NoGo-N2 and Go-N2 amplitudes. In addition, the schizotypal-trait group showed reduced NoGo-N2 amplitudes at the frontal site compared to controls, and an association between SPQ scores and NoGo-N2 amplitudes measured at the frontal site. The two groups did not differ in P3 amplitudes. Since the N2 reflects the detection of response conflict and behavioral inhibition, the present results indicate that nonclinical individuals with schizotypal traits have difficulties in detecting response conflict and behavioral inhibition.
基金The National Natural Science Foundation of China(No.62077013,61773114)the Jiangsu Provincial Innovation Project for Scientific Research of Graduate Students in Universities(No.KYCX17_0160).
文摘The entity and symbolic fraction comparison tasks separating identification and semantic access stages based on event-related potential technology were used to investigate neural differences between fraction and decimal strategies in magnitude processing of nonsymbolic entities and symbolic numbers.The experimental results show that continuous entities elicit stronger left-lateralized anterior N2 in decimals,while discretized ones elicit more significant right-lateralized posterior N2 in fractions during the identification stage.On the other hand,decimals elicit stronger N2 over the left-lateralized fronto-central sites while fractions elicit the more profound P2 over the right-lateralized fronto-central sites and N2 at biparietal regions during the semantic access stage.Hence,for nonsymbolic entity processing,alignments of decimals and continuous entities activate the phonological network,while alignments of fractions and discretized entities trigger the visuospatial regions.For symbolic numbers processing,exact strategies with rote arithmetic retrieval in verbal format are used in decimal processing,while approximate strategies with complex magnitude processing in a visuospatial format are used in fraction processing.
基金The National Key Research and Development Program of China(Grant Number 2021ZD0202004).
文摘Language difficulties vary widely among people with autism spectrum disorder(ASD).However,the semantic processing of autistic person and its underlying electrophysiological mechanism are still unclear.This meta-analysis aimed to explore the disturbance of semantic processing in patients with ASD.PubMed,Web of Science,and Embase were searched for eventrelated potential(ERP)studies on semantic processing in autistic people published in English before September 01,2022.Pooled estimates were calculated by fixed-effects or random-effects models according to the heterogeneity using Comprehensive Meta-Analysis 2.0.The potential moderators were explored by meta-regression and subgroup analysis.This meta-analysis has been registered at the Prospero International Prospective Register of Systematic Reviews(no.CRD 42021265852).A total of 14 articles and 18 studies,including 254 autistic people and 262 neurodevelopmental people were included in this meta-analysis.Compared to the comparison group,autistic people showed an overall reduced N400 amplitude(Hedges’g=0.350,p<0.001)in response to linguistic stimuli instead of non-linguistic stimuli.The N400 amplitude was affected by verbal intelligence and gender.The reduced overall N400 amplitude in autistic people under linguistic stimuli suggests a linguistic-specific deficit in semantic processing in individuals of autism.The decrease of N400 amplitude might be a promising indication of the pool language capacity of autism.
文摘The perception of complex auditory information such as complete speech sequences develops during human ontogeny. In order to explore age differences in the auditory perception of predictable speech sequences we compared event-related potentials (ERPs) recorded in 5- to 6-year-old children (N = 15) and adults (N = 15) in response to anticipated speech sequences as successive and reverse digital series with randomly omitted digits. The ERPs obtained from the omitted digits significantly differed in the amplitude and latency of the N200 and P300 components between adults and children, the N400 and LPC components were more pronounced in children in the right frontal area for the digits presentation. These findings indicate that the perception of a successive speech structure is less automated in children and requires a detailed analysis of the successive structure and error detection. These differences in auditory ERPs reflect developmental changes in the auditory perception of speech sequences and can serve as indicators of the maturity of cognitive functions in children.
基金This study was supported by grants from the National Natural Science Foundation of China (No. 81471357) and Shanghai Natural Science Foundation (No. 13ZR1439300).
文摘Background:Risperidone and paliperidone have been the mainstay treatment for schizophrenia and their potential role in neuroprotection could be associated with brain-derived neurotrophic factor (BDNF) and N400 (an event-related brain potential component).So far,different effects on both BDNF and N400 were reported in relation to various antipsychotic treatments.However,few studies have been conducted on the mechanism ofrisperidone and paliperidone on BDNF and N400.This study aimed to compare the effects ofrisperidone and paliperidone on BDNF and the N400 component of the event-related brain potential in patients with first-episode schizophrenia.Methods:Ninety-eight patients with first-episode schizophrenia were randomly divided into the risperidone and paliperidone groups and treated with risperidone and paliperidone,respectively,for 12 weeks.Serum BDNF level,the latency,and amplitude of the N400 event-related potential before and after the treatment and Positive and Negative Syndrome Scale (PANSS) scores were compared between the two groups.Results:A total of 94 patients were included in the final analysis (47 patients in each group).After the treatment,the serum BDNF levels in both groups increased (all P 〈 0.01),while no significant difference in serum BDNF level was found between the groups before and after the treatment (all P 〉 0.05).After the treatment,N400 amplitudes were increased (from 4.73 ± 2.86 μv and 4.51 ± 4.63 μv to 5.35 ± 4.18 μv and 5.52 ± 3.08 μv,respectively) under congruent condition in both risperidone and paliperidone groups (all P 〈 0.01).Under incongruent conditions,the N400 latencies were shortened in the paliperidone group (from 424.13 ± 110.42 ms to 4.7.41 ± 154.59 ms,P 〈 0.05),and the N400 amplitudes were increased in the risperidone group (from 5.80 ± 3.50 μv to 7.17 ± 5.51 μv,P 〈 0.01).After treatment,the total PANSS score in both groups decreased significantly (all P 〈 0.01),but the difference between the groups was not significant (P 〉 0.05).A negative correlation between the reduction rate of the PANSS score and the increase in serum BDNF level after the treatment was found in the paliperidone group but not in the risperidone group.Conclusions:Both risperidone and paliperidone could increase the serum BDNF levels in patients with first-episode schizophrenia and improve their cognitive function (N400 latency and amplitude),but their antipsychotic mechanisms might differ.
文摘Background:The N400 component of event-related potentials (ERP) has recently drawn widespread attention at home and abroad.This study was to explore the relationship between N400 changes and risperidone treatment and rehabilitation in first-episode schizophrenia (FES).Methods:ERP component N400 was recorded by Guangzhou Runjie W J-l ERP instruments,in 58 FES before and 6 months,15 months after risperidone treatment,and in 62 normal controls.The patients' syndromes were assessed by Positive and Negative Syndrome Scale (PANSS).And the stimuli are Chinese sentences with matching (congruent) or mismatching (incongruent) ending words.Results:N400 latencies were prolonged,and amplitudes were decreased in Cz,Pz,Fz,C3,C4,in FES compared with in NC,before treatment.The prolonged N400 latencies and decreased amplitudes were negatively correlated with the patients' positive scale and total scale of PANSS.There are significant differences of N400 amplitudes and latencies in 6 months and 15 months follow-up after treatment.Before treatment,6 months and 15 months after treatment,N400 latencies are 446 ± 35 ms,440 ± 37 ms,414 ± 31 ms (F =9.72,P 〈 0.01) in incongruent situation;N400 amplitudes are 5.2 ± 4.6 μtⅤ,5.7 ± 4.8 μⅤ,7.3 ± 5.0 μⅤ (F =2.06,P 〉 0.05) in congruent situation,and 8.5 ± 5.9 μⅤ,10.1 ± 5.0 μⅤ,11.9 ± 7.0 μⅤ (F =3.697,P 〈 0.05) in incongruent situation.Conclusions:N400 could be used to predict the effects of treatment of schizophrenia to some degree.The linguistic and cognitive impairment in schizophrenia can be improved by antipsychotic drugs.
基金supported by the National Natural Science Foundation of China(61005087,61263042)Science and Technology Project of Yunnan Province,China(2009CD018)+2 种基金Key Science and Technology Project of Department of Education,Yunnan Province,China(2010Z067)Science and Technology Basic Research Fund of Yunnan University,China(KL080012,030-WX069051)the Major Program of National Social Science Foundation of China(11 & ZD187)
文摘Closure or the presence of a "hole" is an emergent perceptual feature that can be extracted by the visual system early on. This feature has been shown to have perceptual advantages over openness or "no-hole". in this study, we investigated when and how the human brain differentiates between "hole" and "no-hole" figures. Event-related potentials (ERPs) were recorded during a passive observation paradigm. Two pairs of simple figures (Experiment 1) and two sets of Greek letters (Experiment 2) were used as stimuli. The ERPs of "hole" and "no-hole" figures differed ~90 ms after stimulus onset: "hole" figures elicited smaller P1 and N1 amplitudes than "no-hole" figures. These suggest that both P1 and N1 components are sensitive to the difference between "hole" and "no-hole" figures; perception of "hole" and "no-hole" figures might be differentiated early during visual processing.