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Correlation between pathogenesis of dampness syndrome and Interleukin-2,Interleukin-8 in rats 被引量:2
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作者 Xiaolin Chen Youwu Lin +4 位作者 Shijun Zhang Zexiong Chen Carlini Fan Hardi Ting Xiang Baoguo Sun 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2013年第1期114-118,共5页
OBJECTIVE: To explore the pathogenesis of dampness syndrome by detecting the changes of inter- leukin-2 (IL-2) and interleukin-8 (IL-8) levels. METHODS: Female Sprague Dawley rats were divided randomly into five... OBJECTIVE: To explore the pathogenesis of dampness syndrome by detecting the changes of inter- leukin-2 (IL-2) and interleukin-8 (IL-8) levels. METHODS: Female Sprague Dawley rats were divided randomly into five groups according to the random number table: a normal group (Group Ⅰ ), an external dampness group (Group Ⅱ ), an internal dampness group (Group Ⅲ), and an external and internal dampness group (Group Ⅳ). Twenty days after the model made, IL-2 and IL-8 levels were detected by radioimmunoassay method. RESULTS: The IL-2 and IL-8 levels among groups were significant (F=3.102, P〈0.05; F=2.657, P〈0.05, respectively). The level of IL-2 in Group Ⅱ and Group Ⅲ were higher than that in Group Ⅰ (P〈0.05, P〈0.01, respectively), especially higher in the Group Ⅲ compared with Group Ⅱ (P〈0.05). The level of IL-8 in Group Ⅲ were higher than those in Group Ⅰ, Group Ⅱ and GroupⅣ (P〈0.05, P〈0.01, P〈 0.05, respectively). In the Group Ⅲ, the 24-hour water and body weight were higher than that in the Group Ⅱ (all P〈0.05), and spontaneous movement frequency was higher than those in Group Ⅱ and GroupⅣ (P〈0.05). CONCLUSION: Immune activation and inflammatory reaction might be easily caused by external danpness other than internal dampness. 展开更多
关键词 Interior dampness syndrome excessivedampness syndrome INTERLEUKIN-2 INTERLEUKIN-8
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