[Objectives]To study the anti-inflammatory effects of water extract and ethanol extract from Excoecaria cochinchinensis Lour.[Methods]The acute and chronic inflammation models of mouse paw edema induced by cotton ball...[Objectives]To study the anti-inflammatory effects of water extract and ethanol extract from Excoecaria cochinchinensis Lour.[Methods]The acute and chronic inflammation models of mouse paw edema induced by cotton ball granuloma and carrageenan were established respectively,and the anti-inflammatory effects of water and ethanol extract from E.cochinchinensis Lour.on acute and chronic inflammation in mice were evaluated.The experimental mice were equally divided into three groups of high,medium and low dose of E.cochinchinensis Lour.(60,40 and 20 g/kg),dexamethasone(0.006 g/kg)group and blank group(distilled water).In the cotton ball granuloma test in mice,the mice were given intragastric administration continuously for 7 d after cotton ball implantation.In the experiment of inflammation induced by carrageenan,the mice in each group were given intragastric administration once a day for 7 d,and the inflammatory model was made after the last administration.[Results]The granuloma inhibition rates of mice in the high,medium and low dose groups of water extract and ethanol extract from E.cochinchinensis Lour were significantly lower than those in the blank group(P<0.05).The degree of paw edema in each dose group of water and ethanol extract from E.cochinchinensis Lour.was significantly lower than that in the blank group(P<0.05).[Conclusions]The water and ethanol extracts from E.cochinchinensis Lour.had significant anti-inflammatory effects.展开更多
A new flavanone was isolated from the roots of Desmos cochinchinensis Lour Its chemical structure was elucidated by spectral analysis as 7 hydroxy 5 methoxy 8 formyl 6 methylflavanone, named desmosflavanone Ⅱ
Two new furostanol oligoglycosides named as aspacochioside A (1) and B (2) were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Their structures were elucidated to be 3-O-[{a-L-rhamnopyranosyl-(14)...Two new furostanol oligoglycosides named as aspacochioside A (1) and B (2) were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Their structures were elucidated to be 3-O-[{a-L-rhamnopyranosyl-(14)}{b-D-glucopyranosyl}]-26-O-[b-D-glucopy- ranosyl]-(25S)-5b-furostane-3b,22a,26-triol 1 and 3-O-[{a-L-rhamnopyranosyl-(14)}{b-D-glu- copyranosyl}]-26-O-[b-D-glucopyranosyl]-22a-methoxy-(25S)-5b-furostane-3b,26-diol 2 on the basis of spectroscopic techniques and chemical methods.展开更多
A new furost-20(22)-ene oligoglycoside named as aspacochioside C was isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Its structure was elucidated to be 26-O-b- D-glucopyranosyl-(25S)-5b-furost-20(...A new furost-20(22)-ene oligoglycoside named as aspacochioside C was isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Its structure was elucidated to be 26-O-b- D-glucopyranosyl-(25S)-5b-furost-20(22)-en-3b,26-diol-3-O-a-L-rhamnopyranosyl-(14)-b-D- glucopyranoside on the basis of spectroscopic techniques including 1D and 2D NMR experiments.展开更多
基金Supported by National Natural Science Foundation(81360524)First Scientific Research Project of High-level Talents in the Affiliated Hospital of Youjiang Medical University for Nationalities in 2019(Y20196311)+3 种基金2019 Project of Improving the Basic Scientific Research Ability of Young Teachers in Guangxi Colleges and Universities(2019KY0341)2019 Youth Fund Project of Guangxi University of Chinese Medicine(2019QN036)School-level Scientific Research Project of Youjiang Medical University for Nationalities(YY2018KY018)Laboratory for Chemical and Quality Analysis of Traditional Chinese(Zhuang)Medicine,Third-level Scientific Research Laboratory of the State Administration of Traditional Chinese Medicine(Guo Zhong Yi Yao Fa200921).
文摘[Objectives]To study the anti-inflammatory effects of water extract and ethanol extract from Excoecaria cochinchinensis Lour.[Methods]The acute and chronic inflammation models of mouse paw edema induced by cotton ball granuloma and carrageenan were established respectively,and the anti-inflammatory effects of water and ethanol extract from E.cochinchinensis Lour.on acute and chronic inflammation in mice were evaluated.The experimental mice were equally divided into three groups of high,medium and low dose of E.cochinchinensis Lour.(60,40 and 20 g/kg),dexamethasone(0.006 g/kg)group and blank group(distilled water).In the cotton ball granuloma test in mice,the mice were given intragastric administration continuously for 7 d after cotton ball implantation.In the experiment of inflammation induced by carrageenan,the mice in each group were given intragastric administration once a day for 7 d,and the inflammatory model was made after the last administration.[Results]The granuloma inhibition rates of mice in the high,medium and low dose groups of water extract and ethanol extract from E.cochinchinensis Lour were significantly lower than those in the blank group(P<0.05).The degree of paw edema in each dose group of water and ethanol extract from E.cochinchinensis Lour.was significantly lower than that in the blank group(P<0.05).[Conclusions]The water and ethanol extracts from E.cochinchinensis Lour.had significant anti-inflammatory effects.
文摘A new flavanone was isolated from the roots of Desmos cochinchinensis Lour Its chemical structure was elucidated by spectral analysis as 7 hydroxy 5 methoxy 8 formyl 6 methylflavanone, named desmosflavanone Ⅱ
文摘Two new furostanol oligoglycosides named as aspacochioside A (1) and B (2) were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Their structures were elucidated to be 3-O-[{a-L-rhamnopyranosyl-(14)}{b-D-glucopyranosyl}]-26-O-[b-D-glucopy- ranosyl]-(25S)-5b-furostane-3b,22a,26-triol 1 and 3-O-[{a-L-rhamnopyranosyl-(14)}{b-D-glu- copyranosyl}]-26-O-[b-D-glucopyranosyl]-22a-methoxy-(25S)-5b-furostane-3b,26-diol 2 on the basis of spectroscopic techniques and chemical methods.
文摘A new furost-20(22)-ene oligoglycoside named as aspacochioside C was isolated from the roots of Asparagus cochinchinensis (Lour.) Merr.. Its structure was elucidated to be 26-O-b- D-glucopyranosyl-(25S)-5b-furost-20(22)-en-3b,26-diol-3-O-a-L-rhamnopyranosyl-(14)-b-D- glucopyranoside on the basis of spectroscopic techniques including 1D and 2D NMR experiments.
