Metabonomic analysis of hepatitis B virus-induced liver failure:identification of potential diagnostic biomarkers by fuzzy support vector machine

Hepatitis B virus （HBV）-induced liver failure is an emergent liver disease leading to high mortality. The severity of liver failure may be reflected by the profile of some metabolites. This study assessed the potential of using metabolites as biomarkers for liver failure by identifying metabolites with good discriminative performance for its phenotype. The serum samples from 24 HBV-indueed liver failure patients and 23 healthy volunteers were collected and analyzed by gas chromatography-mass spectrometry （GC-MS） to generate metabolite profiles. The 24 patients were further grouped into two classes according to the severity of liver failure. Twenty-five eommensal peaks in all metabolite profiles were extracted, and the relative area values of these peaks were used as features for each sample. Three algorithms, F-test, k-nearest neighbor （KNN） and fuzzy support vector machine （FSVM） combined with exhaustive search （ES）, were employed to identify a subset of metabolites （biomarkers） that best predict liver failure. Based on the achieved experimental dataset, 93.62% predictive accuracy by 6 features was selected with FSVM-ES and three key metabolites, glyeerie acid, cis-aeonitie acid and citric acid, are identified as potential diagnostic biomarkers.

Retrieval of Vertical Distribution of Tropospheric Refractivity through Ground-Based GPS Observation

In the present reported study, the vertical distributions of local atmospheric refractivity were retrieved from ground- based GPS observations at low elevation angles. An improved optimization method was implemented at altitudes of 0-10 km to search for a best-fit refractivity profile that resulted in atmospheric delays most similar to the delays calculated from the observations. A ray-tracing model was used to simulate neutral atmospheric delays corresponding to a given refractivity profile. We initially performed a ＂theoretical retrieval＂, in which no observation data were involved, to verify the optimization method. A statistical relative error of this ＂theoretical retrieval＂ （-2% to 2%） indicated that such a retrieval is effective. In a practical retrieval, observations were obtained using a dual-frequency GPS receiver, and its initial value was provided by CIRA86aQ_UoG data. The statistical relative errors of the practical retrieval range from -3% to 5% were compared with co-located radiosonde measurements, Results clearly revealed diurnal variations in local refractivity prc,files, The results also suggest that the general vertical distribution of refractivity can be derived with a high temporal resolution. However, further study is needed to describe the vertical refractivity gradient clearly.

A New Method to Generate the Complete Set of Unique Signals for Application in High Consequence System

This paper proposed a new method to generate the complete sets of unique signals.It contains sequences comparing,improved exhaustive searches and ranking method.Characters of this new method are complete set;higher effective;independent of certain mathematical constraints.And also some 24 bi-valued events sets generated by this method were discussed and these set are now used in our high consequence system.

Relay Selection Strategy in the Secure Cooperative Communications System

With the low cost and low hardware complex considerations,cooperative systems are a tendency in the future communications.This work considers the secure cooperative communications systems.For a practical situation in the system,the scenario includes multiple source stations,multiple relay stations,multiple destination stations,and eavesdroppers.To analyze the optimal relay selection in the system,we begin with the performance analysis for a single source station and a single destination station.By applying two cooperative models,the amplify-andforward（AF） mode and decode-and-forward（DF）mode,the secrecy capacity is derived.Then,we apply the derived results to the considered environment to find the optimal relay assignment.By the way,the relay selection can be obtained by the exhaustive search algorithm.However,there are a lot of steps needed if the number of source stations is large.Hence,applying the characters of the cooperative modes in the relay selection,the pre-selection step is proposed with a mathematical derivation.It could be used for the practical situation without a long-time calculation.

Greedy Algorithm Applied to Relay Selection for Cooperative Communication Systems in Amplify-and-Forward Mode

Using a relaying system to provide spatial diversity and improve the system performance is a tendency in the wireless cooperative communications. Amplify-and-forward （AF） mode with a low complexity is easy to be implemented. Under the consideration of cooperative communication systems, the scenario includes one information source, M relay stations and N destinations. This work proposes a relay selection algorithm in the Raleigh fading channel. Based on the exhaustive search method, easily to realize, the optimal selection scheme can be found with a highly complicated calculation. In order to reduce the computational complexity, an approximate optimal solution with a greedy algorithm applied for the relay station selection is proposed. With different situations of the communication systems, the performance evaluation obtained by both the proposed algorithm and the exhaustive search algorithm are given for comparison. It shows the proposed algorithm could provide a solution approach to the optimal one.