Recent developments in Unmanned Aerial Vehicles(UAVs)and their applications in various subjects are of interest to polar communities.Due to the harsh climate and dangerous environment,these regions pose challenges for...Recent developments in Unmanned Aerial Vehicles(UAVs)and their applications in various subjects are of interest to polar communities.Due to the harsh climate and dangerous environment,these regions pose challenges for the expedition teams.Several countries have tested the UAV technology to support Antarctic research and logistics.In this trend paper,we provide insightful reviews and discussions on such a prospective topic.Based on a comprehensive literature survey,we firstly summarize the key research progress of UAV in Antarctic studies.Then the examples of risk scenarios during the field exploration are given,after which several promising applications of the UAVs in safety guarantee are illustrated.In particular,we present a case of site-selection for the Chinese first ice sheet airfield,using the data collected in the 34th Chinese National Antarctic Research Expedition(CHINARE).In the end,we highlight the unique value of the UAVs in the popularization of polar science before concluding the advantages and limitations.Considering their excellent performance,we expect more innovations for UAV’s applications in the following Antarctic expeditions.展开更多
This paper aims to discuss the real intention behind Caesar’s two British expeditions and the evidence against the conquest theory.In Commentarii de Bello Gallico,Caesar claimed that he invaded Britain because he wou...This paper aims to discuss the real intention behind Caesar’s two British expeditions and the evidence against the conquest theory.In Commentarii de Bello Gallico,Caesar claimed that he invaded Britain because he would like to teach the Britons a lesson for aiding the Gauls.Most modern scholars disagree that Caesar’s true intention is what Caesar has said,so they come up with their own theories.Ranzani says Caesar’s expedition is for glory,while Deutsch argues that Caesar’s expeditions are for pearls.Mitchell suggests that Caesar went to Britain for tin,while Ranzani,Schadee,Raaflaub,and Riggsby all come up with the theory of Caesar’s military and political gains.Brady is one of the few scholars who believe in what Caesar has said-to punish the Gauls.Moreover,Brady also considers Caesar’s expeditions a success since he does not think Caesar’s true goal is to conquer Britain.展开更多
Pore pressure(PP)information plays an important role in analysing the geomechanical properties of the reservoir and hydrocarbon field development.PP prediction is an essential requirement to ensure safe drilling opera...Pore pressure(PP)information plays an important role in analysing the geomechanical properties of the reservoir and hydrocarbon field development.PP prediction is an essential requirement to ensure safe drilling operations and it is a fundamental input for well design,and mud weight estimation for wellbore stability.However,the pore pressure trend prediction in complex geological provinces is challenging particularly at oceanic slope setting,where sedimentation rate is relatively high and PP can be driven by various complex geo-processes.To overcome these difficulties,an advanced machine learning(ML)tool is implemented in combination with empirical methods.The empirical method for PP prediction is comprised of data pre-processing and model establishment stage.Eaton's method and Porosity method have been used for PP calculation of the well U1517A located at Tuaheni Landslide Complex of Hikurangi Subduction zone of IODP expedition 372.Gamma-ray,sonic travel time,bulk density and sonic derived porosity are extracted from well log data for the theoretical framework construction.The normal compaction trend(NCT)curve analysis is used to check the optimum fitting of the low permeable zone data.The statistical analysis is done using the histogram analysis and Pearson correlation coefficient matrix with PP data series to identify potential input combinations for ML-based predictive model development.The dataset is prepared and divided into two parts:Training and Testing.The PP data and well log of borehole U1517A is pre-processed to scale in between[-1,+1]to fit into the input range of the non-linear activation/transfer function of the decision tree regression model.The Decision Tree Regression(DTR)algorithm is built and compared to the model performance to predict the PP and identify the overpressure zone in Hikurangi Tuaheni Zone of IODP Expedition 372.展开更多
During the 10th Chinese Arctic scientific expedition carried out in the summer of 2019,the surface current in the high-latitude areas of the Arctic Ocean was observed using a self-developed surface drifting buoy,which...During the 10th Chinese Arctic scientific expedition carried out in the summer of 2019,the surface current in the high-latitude areas of the Arctic Ocean was observed using a self-developed surface drifting buoy,which was initially deployed in the Chukchi Sea.The buoy traversed the Chukchi Sea,Chukchi Abyssal Plain,Mendeleev Ridge,Makarov Basin,and Canada Basin over a period of 632 d.After returning to the Mendeleev Ridge,it continued to drift toward the pole.Overall,the track of the buoy reflected the characteristics of the transpolar drift and Chukchi Slope Current,as well as the inertial flow,cross-ridge surface flow,and even the surface disorganized flow for some time intervals.The results showed that:(1)the transpolar drift mainly occurs in the Chukchi Abyssal Plain,Mendeleev Ridge,and western Canada Basin to the east of the ridge where sea ice concentration is high,and the average northward flow velocity in the region between 79.41°N and 86.32°N was 5.1 cm/s;(2)the average surface velocity of the Chukchi Slope Current was 13.5 cm/s,and while this current moves westward along the continental slope,it also extends northwestward across the continental slope and flows to the deep sea;and(3)when sea ice concentration was less than 50%,the inertial flow was more significant(the maximum observed inertial flow was 26 cm/s,and the radius of the inertia circle was 3.6 km).展开更多
Objective To analyze the characteristics of breakthrough therapy designation(BTD)and its implementation in China,and to provide reference for the optimization of BTD system.Methods A comparative research method was us...Objective To analyze the characteristics of breakthrough therapy designation(BTD)and its implementation in China,and to provide reference for the optimization of BTD system.Methods A comparative research method was used to study the content and implementation effect of BTD system in China and the relevant policies and implementation of the same procedures of drug regulatory authorities in the United States,Japan and the European Union.Then,the differences in policies and implementation results among these countries were analyzed to provide suggestions for the implementation and optimization of this system in China.Results and Conclusion China’s BTD system is implemented late and a small number of drugs has been approved.At the same time,there are problems such as insufficient guidance and communication from the agency to applicants,a broad application condition,single review mode,and lack of full-time personnel.Both the agencies and the applicants have limited experience due to the short implementation time of BTD system in China.There are still some problems despite we have learned a lot from the experience of other drug regulatory agencies.Therefore,based on our national conditions,we should strengthen the guidance of evaluation agency to applicants,optimize the eligibility criteria of BTD system,introduce the rolling review,and increase the number of professional liaisons,which can accelerate the development and marketing process of drugs with obvious clinical value,and finally to address unmet medical need.展开更多
This article aims to study the history of scientific investigations in China in the nineteenth century,made by Russian scientists who ranged in status and position including official agents,the directors of the Russia...This article aims to study the history of scientific investigations in China in the nineteenth century,made by Russian scientists who ranged in status and position including official agents,the directors of the Russian Magneto-Meteorological Observatory in Beijing,the members of the Russian Orthodox Mission(ROM),and others.The article gives a detailed analysis of the unique expeditions of H.Fritsche(1839–1913),director of the Russian Magneto-Meteorological Observatory in Beijing,and Archimandrite Palladius(1817–1878),head of the ROM to the northeast part of China.During those expeditions,existing maps were corrected and new maps were made.The article also covers the history of natural science investigations,made by other members of missions,doctors,and attached persons.This article employs sources from Russian archives(Saint Petersburg Branch of the Archive of the Russian Academy of Sciences,Russian State Historical Archive,Archive of the Foreign Policy of the Russian Empire),which were rarely used by the scientific community,and adopts an empirical approach based on objectivity and historicism to the sources and research.展开更多
In recent years, the Arctic climate has changed dramatically. This paper sums up the remarkable performance of climate change in the Arctic Circle by going deep into the Arctic Circle, collecting climate data and comp...In recent years, the Arctic climate has changed dramatically. This paper sums up the remarkable performance of climate change in the Arctic Circle by going deep into the Arctic Circle, collecting climate data and comparing it with previous years’ data and literature. The factors affecting climate change in the Arctic Circle are discussed from three aspects: artificial factors, natural factors and potential factors. The study finds out that the main factors that affect the Arctic climate are the large amount of greenhouse gases emitted by human activities, the warming of tropical ocean currents, and the potential eruption of solar flares.展开更多
Our recent archaeological expeditions in the Siuyu and Ughaugha wards of Singida eastern province have recuperated the very compelling rock engravings (petroglyphs) that weren’t reported in Tanzania before. Archaeolo...Our recent archaeological expeditions in the Siuyu and Ughaugha wards of Singida eastern province have recuperated the very compelling rock engravings (petroglyphs) that weren’t reported in Tanzania before. Archaeologically, Singida’s fame emanated from her endowments of rock paintings. However;during this research, we did discover rock cupules, gongs, and grinding hollows art together with rock paintings (pictographs) that have opened up a new avenue for rock art studies in Tanzania. We carried out intensive site surveys around four sites namely Siuyu, Ngaghe, Misimbwa and Ughaugha B with the aims of solely examining, recording, and documenting archaeological artifacts on the surface in order to research the cultural and behavioural patterns of early humans in the Singida region. Surveys also enabled us to locate suitable areas where future excavations would be established. In some cases, ethnographic enquiries were employed to get supplementary information on the present-day use of rock art sites. Besides, we interviewed local people to assess their general understanding of the presence of more sites or helping in locating, and discovering new sites. Through ethnographic inquiries, we discovered several sites with substantial number of rock engravings that were never document by any researcher. On top of that, this study reports other archaeological potentials of the region by describing in detail their significances for future research undertakings. Additionally, this paper article reports on the occurrence of Middle Stone Age (MSA) archaeological assemblages from the open-air site and the presence of grinding hollows and rock cupules (Siuyu complexes) in central Tanzania for the first time.展开更多
Chinese radioglaciological studies on the Antarctic ice sheet(AIS) began in 2004/05 when the 21 st Chinese National Antarctic Research Expedition(CHINARE 21) team arrived at Dome A for the first time and radio echo so...Chinese radioglaciological studies on the Antarctic ice sheet(AIS) began in 2004/05 when the 21 st Chinese National Antarctic Research Expedition(CHINARE 21) team arrived at Dome A for the first time and radio echo sounding(RES) was conducted along the inland traverse and in the Dome A region. Subsequently, more field surveys were conducted along the traverse and in the Dome A region using different radar systems targeting different scientific purposes, such as revealing the landscape of the Gamburtsev Subglacial Mountains by detailed grid RES, or locating a deep ice core drilling site by mapping and studying internal structures, bedrock topography and subglacial conditions in the Dome A region. Furthermore, the evolution of the AIS was inferred from the typical mountain glaciation topography beneath Dome A, and the age of the deep ice core at Kunlun Station was estimated through numerical modeling. Recently, the Snow Eagle 601 airplane was acquired and an airborne geophysical system was constructed to survey the AIS in Princess Elizabeth Land during CHINARE 32(2015/16) and CHINARE 33(2016/17) in order to fill the large data gap there. In this paper, we review both the recent progress of Chinese radioglaciological science in Antarctica and future proposed work.展开更多
The 9th Chinese National Arctic Research Expedition was carried out from 20 July to 26 September 2018. The expedition was successful in undertaking multidisciplinary comprehensive surveys in the fields of physical oce...The 9th Chinese National Arctic Research Expedition was carried out from 20 July to 26 September 2018. The expedition was successful in undertaking multidisciplinary comprehensive surveys in the fields of physical oceanography, marine meteorology, sea ice, marine chemistry,marine biology, marine ecology, geology, and geophysics in the Bering Sea, Chukchi Sea, Chukchi Plateau, Mendeleev Ridge, and Canada Basin. This paper gives an overview of the main achievements of this expedition and highlights the scientific achievements.展开更多
The spatial distribution of snow cover on the central Arctic sea ice is investigated here based on the observations made during the Third Chinese Arctic Expedition. Six types of snow were observed during the expeditio...The spatial distribution of snow cover on the central Arctic sea ice is investigated here based on the observations made during the Third Chinese Arctic Expedition. Six types of snow were observed during the expedition: new/recent snow, melt-fi'eeze crust, icy layer, depth hoar, coarse-grained, and chains of depth hoar. Across most measurement areas, the snow surface was covered by a melt-freeze crust 2-3 cm thick, which was produced by alternate strong solar radiation and the sharp temperature decrease over the summer Arctic Ocean. There was an intermittent layer of snow and ice at the base of the snow pack. The mean bulk density of the snow was 304.01~29.00 kg/m3 along the expedition line, and the surface values were generally smaller than those of the sub- surface, confirming the principle of snow densification. In addition, the thicknesses and water equivalents of the new/recent and total-layer snow showed a decreasing trend with latitude, suggesting that the amount of snow cover and its spatial variations were mainly determined by precipitation. Snow temperature also presented significant variations in the vertical profile, and ablation and evaporation were not the primary factors in the snow assessment in late summer. The mean temperature of the surface snow was -2.01±0.96℃, which was much higher than that observed in the interface of snow and sea ice.展开更多
The traverse route from Zhongshan Station to Dome A is one of the most important expedition routes of ITASE Project. China carried out 3 inland traverses during the 1996/1997, 1997/1998, 1998/1999 austral summer fie...The traverse route from Zhongshan Station to Dome A is one of the most important expedition routes of ITASE Project. China carried out 3 inland traverses during the 1996/1997, 1997/1998, 1998/1999 austral summer field seasons. The field team reached inland 300 km, 500 km and 1100 km away from Zhongshan Station respectively. Some ice motion stakes were set up, occupied and reoccupied along the route by GPS technology. It showed that the ice along the traverse route flowed with an 8 25 ma -1 velocity to the northwest, the direction of the bottom of Lambert Glacier Basin. They coincide with the results along the eastern section from LGB59 70 of the LGB route deduced by Australia in both values and directions. Furthermore, the directions of the horizontal flow are perpendicular to the surface topography contour. The much larger velocity at the point of LT980 with an approximate value of 100 ma -1 was probed. It was caused by a 15 km wide trough on the bed beneath this point.展开更多
On the basis of the CTD data obtained within the Bering Sea shelf by the Second to Sixth Chinese National Arctic Research Expedition in the summers of 2003, 2008, 2010, 2012 and 2014, the classification and interannua...On the basis of the CTD data obtained within the Bering Sea shelf by the Second to Sixth Chinese National Arctic Research Expedition in the summers of 2003, 2008, 2010, 2012 and 2014, the classification and interannual variation of water masses on the central Bering Sea shelf and the northern Bering Sea shelf are analyzed. The results indicate that there are both connection and difference between two regions in hydrological features. On the central Bering Sea shelf, there are mainly four types of water masses distribute orderly from the slope to the coast of Alaska: Bering Slope Current Water(BSCW), MW(Mixed Water), Bering Shelf Water(BSW) and Alaska Coastal Water(ACW). In summer, BSW can be divided into Bering Shelf Surface Water(BSW_S) and Bering Shelf Cold Water(BSW_C). On the northern Bering Sea shelf near the Bering Strait,it contains Anadyr Water(AW), BSW and ACW from west to east. But the spatial-temporal features are also remarkable in each region. On the central shelf, the BSCW is saltiest and occupies the west of 177°W, which has the highest salinity in 2014. The BSW_C is the coldest water mass and warmest in 2014; the ACW is freshest and mainly occupies the east of 170°W, which has the highest temperature and salinity in 2012. On the northern Bering Sea shelf near the Bering Strait, the AW is saltiest with temperature decreasing sharply compared with BSCW on the central shelf. In the process of moving northward to the Bering Strait, the AW demonstrates a trend of eastward expansion. The ACW is freshest but saltier than the ACW on the central shelf,which is usually located above the BSW and is saltiest in 2014. The BSW distributes between the AW and the ACW and coldest in 2012, but the cold water of the BSW_C on the central shelf, whose temperature less than 0°C, does not exist on the northern shelf. Although there are so many changes, the respond to a climate change is synchronized in the both regions, which can be divided into the warm years(2003 and 2014) and cold years(2008, 2010 and 2012). The year of 2014 may be a new beginning of warm period.展开更多
By 2018, China had conducted 34 scientific explorations in Antarctica spearheaded by the Chinese National Antarctic Research Expedition(CHINARE). Since the first CHINARE over 30 years ago, considerable work has been u...By 2018, China had conducted 34 scientific explorations in Antarctica spearheaded by the Chinese National Antarctic Research Expedition(CHINARE). Since the first CHINARE over 30 years ago, considerable work has been undertaken to promote the development of techniques for the observation of surface and upper-air meteorological elements, and satellite image and data reception systems at Chinese Antarctic stations and onboard Chinese icebreakers have played critical roles in this endeavor. The upgrade of in situ and remote sensing measurement methods and the improvement of weather forecasting skill have enabled forecasters to achieve reliable on-site weather forecasting for the CHINARE. Nowadays, the routing of icebreakers, navigation of aircraft, and activities at Chinese Antarctic stations all benefit from the accurate weather forecasting service. In this paper, a review of the conventional meteorological measurement and operational weather forecasting services of the CHINARE is presented.展开更多
The serum thyroid hormone and plasma catecholamine were examined in 18 male and 2 female members of the Chinese Antarctic Expedition (who spent the 2000 or 2001 austral winter at the Great Wall Station) . The changes ...The serum thyroid hormone and plasma catecholamine were examined in 18 male and 2 female members of the Chinese Antarctic Expedition (who spent the 2000 or 2001 austral winter at the Great Wall Station) . The changes of serum thyroid hormone i. e. total thyroxine (TT4) and free T4 (FT4) , total triodothyronine (TT3) and freeT3 ( FT3 ) , thyroid stimulating hormone ( TSH ) and plasma catecholamine, including norepinephrine (NE) , epinephrine ( E) and dopamine ( DA ) , were investigated by Chemoluminescence Immunoassay (CLIA) and High Performance Liquid Chromatography with electrochemical detection (HPLC-ECD) . Samples were taken at different time; (1)1 day before departure to Antarctica (16th expedition 1999/12/ 09; 17th expedition 2000/12/06). (2) 1 day after returned to China after living 54 weeks in Antarctica ( 16th expedition 2000/12/25 ; 17th expedition 2001/12/25 ). Comparing the data of before departure and returned, results showed that there was a significant decrease in the contents of TT4 (P <0. 01) with no significant change in the content of TT3 , FT3 and FT4. It was also found that the content of TSH increased significantly (P <0. 001) ; No significant changes of plasma NE and DA were found but the content of E decreased significantly ( P < 0. 001) . The results indicated that the special Antarctic environment led to a restrain effect on the thyroid function and the level of plasma E in Antarctic expedition members. Both the thyroid and adrenal medulla system were associated in response to the Antarctic systemic stress.展开更多
In order to clarify the possible relationship between the changes of behavior/personality and metabolic changes of 5 hydroxytryptamine (5 HT) in Antarctic expedition members, plasma tryptophan (Trp) and urinary 5 ...In order to clarify the possible relationship between the changes of behavior/personality and metabolic changes of 5 hydroxytryptamine (5 HT) in Antarctic expedition members, plasma tryptophan (Trp) and urinary 5 hydroxy 3 indoleacetic acid (5 HIAA) were studied for 24 winter over and 19 summer over members of the 8th and 11th CHINARE respectively. Results showed that plasma Trp decreased significantly after residing 1 ̄3 months at Great Wall Station and did not recover on returning back to Beijing from Antarctica by two weeks travelling. Urinary 5 HIAA increased significantly after residing 6 months at Great Wall Station, and recovered on returning back to Beijing from Antarctica in the winter over members. The decrease of plasma Trp may be related to the decline of brain 5 HT which might play a role in the changes of behavior/personality . Increase of urinary 5 HIAA might reflect metabolic changes of 5 HT as a whole, but cold weather involving in the release response of platelet should be considered. Therefore, supplement of related food rich in Trp or intervention of L Trp might be valuable.展开更多
基金the National Natural Science Foundation of China(Grant nos.41830536,41676176 and 41676182)the Chinese Polar Environment Comprehensive Investigation and Assessment ProgramTeng Li is also funded by the UK-China Joint Research and Innovation Partnership Fund PhD Placement Program.
文摘Recent developments in Unmanned Aerial Vehicles(UAVs)and their applications in various subjects are of interest to polar communities.Due to the harsh climate and dangerous environment,these regions pose challenges for the expedition teams.Several countries have tested the UAV technology to support Antarctic research and logistics.In this trend paper,we provide insightful reviews and discussions on such a prospective topic.Based on a comprehensive literature survey,we firstly summarize the key research progress of UAV in Antarctic studies.Then the examples of risk scenarios during the field exploration are given,after which several promising applications of the UAVs in safety guarantee are illustrated.In particular,we present a case of site-selection for the Chinese first ice sheet airfield,using the data collected in the 34th Chinese National Antarctic Research Expedition(CHINARE).In the end,we highlight the unique value of the UAVs in the popularization of polar science before concluding the advantages and limitations.Considering their excellent performance,we expect more innovations for UAV’s applications in the following Antarctic expeditions.
文摘This paper aims to discuss the real intention behind Caesar’s two British expeditions and the evidence against the conquest theory.In Commentarii de Bello Gallico,Caesar claimed that he invaded Britain because he would like to teach the Britons a lesson for aiding the Gauls.Most modern scholars disagree that Caesar’s true intention is what Caesar has said,so they come up with their own theories.Ranzani says Caesar’s expedition is for glory,while Deutsch argues that Caesar’s expeditions are for pearls.Mitchell suggests that Caesar went to Britain for tin,while Ranzani,Schadee,Raaflaub,and Riggsby all come up with the theory of Caesar’s military and political gains.Brady is one of the few scholars who believe in what Caesar has said-to punish the Gauls.Moreover,Brady also considers Caesar’s expeditions a success since he does not think Caesar’s true goal is to conquer Britain.
文摘Pore pressure(PP)information plays an important role in analysing the geomechanical properties of the reservoir and hydrocarbon field development.PP prediction is an essential requirement to ensure safe drilling operations and it is a fundamental input for well design,and mud weight estimation for wellbore stability.However,the pore pressure trend prediction in complex geological provinces is challenging particularly at oceanic slope setting,where sedimentation rate is relatively high and PP can be driven by various complex geo-processes.To overcome these difficulties,an advanced machine learning(ML)tool is implemented in combination with empirical methods.The empirical method for PP prediction is comprised of data pre-processing and model establishment stage.Eaton's method and Porosity method have been used for PP calculation of the well U1517A located at Tuaheni Landslide Complex of Hikurangi Subduction zone of IODP expedition 372.Gamma-ray,sonic travel time,bulk density and sonic derived porosity are extracted from well log data for the theoretical framework construction.The normal compaction trend(NCT)curve analysis is used to check the optimum fitting of the low permeable zone data.The statistical analysis is done using the histogram analysis and Pearson correlation coefficient matrix with PP data series to identify potential input combinations for ML-based predictive model development.The dataset is prepared and divided into two parts:Training and Testing.The PP data and well log of borehole U1517A is pre-processed to scale in between[-1,+1]to fit into the input range of the non-linear activation/transfer function of the decision tree regression model.The Decision Tree Regression(DTR)algorithm is built and compared to the model performance to predict the PP and identify the overpressure zone in Hikurangi Tuaheni Zone of IODP Expedition 372.
基金The Fundamental Research Fund Project of the First Institute of OceanographyMinistry of Natural Resources+1 种基金under contract No.GY022Y07the National Natural Science Foundation of China under contract No.42106232。
文摘During the 10th Chinese Arctic scientific expedition carried out in the summer of 2019,the surface current in the high-latitude areas of the Arctic Ocean was observed using a self-developed surface drifting buoy,which was initially deployed in the Chukchi Sea.The buoy traversed the Chukchi Sea,Chukchi Abyssal Plain,Mendeleev Ridge,Makarov Basin,and Canada Basin over a period of 632 d.After returning to the Mendeleev Ridge,it continued to drift toward the pole.Overall,the track of the buoy reflected the characteristics of the transpolar drift and Chukchi Slope Current,as well as the inertial flow,cross-ridge surface flow,and even the surface disorganized flow for some time intervals.The results showed that:(1)the transpolar drift mainly occurs in the Chukchi Abyssal Plain,Mendeleev Ridge,and western Canada Basin to the east of the ridge where sea ice concentration is high,and the average northward flow velocity in the region between 79.41°N and 86.32°N was 5.1 cm/s;(2)the average surface velocity of the Chukchi Slope Current was 13.5 cm/s,and while this current moves westward along the continental slope,it also extends northwestward across the continental slope and flows to the deep sea;and(3)when sea ice concentration was less than 50%,the inertial flow was more significant(the maximum observed inertial flow was 26 cm/s,and the radius of the inertia circle was 3.6 km).
基金Special Fund for Academy of Pharmaceutical Regulatory Sciences of Research Base for Drug Regulatory Science of National Medical Products Administration-Shenyang Pharmaceutical University(2021jgkx004).
文摘Objective To analyze the characteristics of breakthrough therapy designation(BTD)and its implementation in China,and to provide reference for the optimization of BTD system.Methods A comparative research method was used to study the content and implementation effect of BTD system in China and the relevant policies and implementation of the same procedures of drug regulatory authorities in the United States,Japan and the European Union.Then,the differences in policies and implementation results among these countries were analyzed to provide suggestions for the implementation and optimization of this system in China.Results and Conclusion China’s BTD system is implemented late and a small number of drugs has been approved.At the same time,there are problems such as insufficient guidance and communication from the agency to applicants,a broad application condition,single review mode,and lack of full-time personnel.Both the agencies and the applicants have limited experience due to the short implementation time of BTD system in China.There are still some problems despite we have learned a lot from the experience of other drug regulatory agencies.Therefore,based on our national conditions,we should strengthen the guidance of evaluation agency to applicants,optimize the eligibility criteria of BTD system,introduce the rolling review,and increase the number of professional liaisons,which can accelerate the development and marketing process of drugs with obvious clinical value,and finally to address unmet medical need.
文摘This article aims to study the history of scientific investigations in China in the nineteenth century,made by Russian scientists who ranged in status and position including official agents,the directors of the Russian Magneto-Meteorological Observatory in Beijing,the members of the Russian Orthodox Mission(ROM),and others.The article gives a detailed analysis of the unique expeditions of H.Fritsche(1839–1913),director of the Russian Magneto-Meteorological Observatory in Beijing,and Archimandrite Palladius(1817–1878),head of the ROM to the northeast part of China.During those expeditions,existing maps were corrected and new maps were made.The article also covers the history of natural science investigations,made by other members of missions,doctors,and attached persons.This article employs sources from Russian archives(Saint Petersburg Branch of the Archive of the Russian Academy of Sciences,Russian State Historical Archive,Archive of the Foreign Policy of the Russian Empire),which were rarely used by the scientific community,and adopts an empirical approach based on objectivity and historicism to the sources and research.
文摘In recent years, the Arctic climate has changed dramatically. This paper sums up the remarkable performance of climate change in the Arctic Circle by going deep into the Arctic Circle, collecting climate data and comparing it with previous years’ data and literature. The factors affecting climate change in the Arctic Circle are discussed from three aspects: artificial factors, natural factors and potential factors. The study finds out that the main factors that affect the Arctic climate are the large amount of greenhouse gases emitted by human activities, the warming of tropical ocean currents, and the potential eruption of solar flares.
文摘Our recent archaeological expeditions in the Siuyu and Ughaugha wards of Singida eastern province have recuperated the very compelling rock engravings (petroglyphs) that weren’t reported in Tanzania before. Archaeologically, Singida’s fame emanated from her endowments of rock paintings. However;during this research, we did discover rock cupules, gongs, and grinding hollows art together with rock paintings (pictographs) that have opened up a new avenue for rock art studies in Tanzania. We carried out intensive site surveys around four sites namely Siuyu, Ngaghe, Misimbwa and Ughaugha B with the aims of solely examining, recording, and documenting archaeological artifacts on the surface in order to research the cultural and behavioural patterns of early humans in the Singida region. Surveys also enabled us to locate suitable areas where future excavations would be established. In some cases, ethnographic enquiries were employed to get supplementary information on the present-day use of rock art sites. Besides, we interviewed local people to assess their general understanding of the presence of more sites or helping in locating, and discovering new sites. Through ethnographic inquiries, we discovered several sites with substantial number of rock engravings that were never document by any researcher. On top of that, this study reports other archaeological potentials of the region by describing in detail their significances for future research undertakings. Additionally, this paper article reports on the occurrence of Middle Stone Age (MSA) archaeological assemblages from the open-air site and the presence of grinding hollows and rock cupules (Siuyu complexes) in central Tanzania for the first time.
基金financially supported by the National Natural Science Foundation of China (Grant nos. 41776186, 41730102 and 41571407)the Chinese Polar Environmental Comprehensive Investigation and Assessment Programs (Grant no. CHINARE-02-02)
文摘Chinese radioglaciological studies on the Antarctic ice sheet(AIS) began in 2004/05 when the 21 st Chinese National Antarctic Research Expedition(CHINARE 21) team arrived at Dome A for the first time and radio echo sounding(RES) was conducted along the inland traverse and in the Dome A region. Subsequently, more field surveys were conducted along the traverse and in the Dome A region using different radar systems targeting different scientific purposes, such as revealing the landscape of the Gamburtsev Subglacial Mountains by detailed grid RES, or locating a deep ice core drilling site by mapping and studying internal structures, bedrock topography and subglacial conditions in the Dome A region. Furthermore, the evolution of the AIS was inferred from the typical mountain glaciation topography beneath Dome A, and the age of the deep ice core at Kunlun Station was estimated through numerical modeling. Recently, the Snow Eagle 601 airplane was acquired and an airborne geophysical system was constructed to survey the AIS in Princess Elizabeth Land during CHINARE 32(2015/16) and CHINARE 33(2016/17) in order to fill the large data gap there. In this paper, we review both the recent progress of Chinese radioglaciological science in Antarctica and future proposed work.
文摘The 9th Chinese National Arctic Research Expedition was carried out from 20 July to 26 September 2018. The expedition was successful in undertaking multidisciplinary comprehensive surveys in the fields of physical oceanography, marine meteorology, sea ice, marine chemistry,marine biology, marine ecology, geology, and geophysics in the Bering Sea, Chukchi Sea, Chukchi Plateau, Mendeleev Ridge, and Canada Basin. This paper gives an overview of the main achievements of this expedition and highlights the scientific achievements.
基金funded by the Opening Founding of the State Key Laboratory of Cryospheric Sciences (SKLCS 09-07)the Special Polar Program of the Ministry of Finance (CHINARE2012-02-02)the National Natural Science Foundation of China (NSFC) (41121001)
文摘The spatial distribution of snow cover on the central Arctic sea ice is investigated here based on the observations made during the Third Chinese Arctic Expedition. Six types of snow were observed during the expedition: new/recent snow, melt-fi'eeze crust, icy layer, depth hoar, coarse-grained, and chains of depth hoar. Across most measurement areas, the snow surface was covered by a melt-freeze crust 2-3 cm thick, which was produced by alternate strong solar radiation and the sharp temperature decrease over the summer Arctic Ocean. There was an intermittent layer of snow and ice at the base of the snow pack. The mean bulk density of the snow was 304.01~29.00 kg/m3 along the expedition line, and the surface values were generally smaller than those of the sub- surface, confirming the principle of snow densification. In addition, the thicknesses and water equivalents of the new/recent and total-layer snow showed a decreasing trend with latitude, suggesting that the amount of snow cover and its spatial variations were mainly determined by precipitation. Snow temperature also presented significant variations in the vertical profile, and ablation and evaporation were not the primary factors in the snow assessment in late summer. The mean temperature of the surface snow was -2.01±0.96℃, which was much higher than that observed in the interface of snow and sea ice.
文摘The traverse route from Zhongshan Station to Dome A is one of the most important expedition routes of ITASE Project. China carried out 3 inland traverses during the 1996/1997, 1997/1998, 1998/1999 austral summer field seasons. The field team reached inland 300 km, 500 km and 1100 km away from Zhongshan Station respectively. Some ice motion stakes were set up, occupied and reoccupied along the route by GPS technology. It showed that the ice along the traverse route flowed with an 8 25 ma -1 velocity to the northwest, the direction of the bottom of Lambert Glacier Basin. They coincide with the results along the eastern section from LGB59 70 of the LGB route deduced by Australia in both values and directions. Furthermore, the directions of the horizontal flow are perpendicular to the surface topography contour. The much larger velocity at the point of LT980 with an approximate value of 100 ma -1 was probed. It was caused by a 15 km wide trough on the bed beneath this point.
基金The Basic Research Operating Funds of The First Institute of Oceanography,State Oceanic Administration of China under contact Nos 2014T02 and 2014G02the Chinese Polar Environment Comprehensive Investigation and Assessment Programmes,State Oceanic Administration of China under contact Nos CHINARE2016-03-01 and CHINARE2016-04-03the Public Science and Technology Research Fund Project of Ocean under contact No.201205007
文摘On the basis of the CTD data obtained within the Bering Sea shelf by the Second to Sixth Chinese National Arctic Research Expedition in the summers of 2003, 2008, 2010, 2012 and 2014, the classification and interannual variation of water masses on the central Bering Sea shelf and the northern Bering Sea shelf are analyzed. The results indicate that there are both connection and difference between two regions in hydrological features. On the central Bering Sea shelf, there are mainly four types of water masses distribute orderly from the slope to the coast of Alaska: Bering Slope Current Water(BSCW), MW(Mixed Water), Bering Shelf Water(BSW) and Alaska Coastal Water(ACW). In summer, BSW can be divided into Bering Shelf Surface Water(BSW_S) and Bering Shelf Cold Water(BSW_C). On the northern Bering Sea shelf near the Bering Strait,it contains Anadyr Water(AW), BSW and ACW from west to east. But the spatial-temporal features are also remarkable in each region. On the central shelf, the BSCW is saltiest and occupies the west of 177°W, which has the highest salinity in 2014. The BSW_C is the coldest water mass and warmest in 2014; the ACW is freshest and mainly occupies the east of 170°W, which has the highest temperature and salinity in 2012. On the northern Bering Sea shelf near the Bering Strait, the AW is saltiest with temperature decreasing sharply compared with BSCW on the central shelf. In the process of moving northward to the Bering Strait, the AW demonstrates a trend of eastward expansion. The ACW is freshest but saltier than the ACW on the central shelf,which is usually located above the BSW and is saltiest in 2014. The BSW distributes between the AW and the ACW and coldest in 2012, but the cold water of the BSW_C on the central shelf, whose temperature less than 0°C, does not exist on the northern shelf. Although there are so many changes, the respond to a climate change is synchronized in the both regions, which can be divided into the warm years(2003 and 2014) and cold years(2008, 2010 and 2012). The year of 2014 may be a new beginning of warm period.
基金supported by the project of National Key R&D Program of China(Grant no.2016YFC1402705)
文摘By 2018, China had conducted 34 scientific explorations in Antarctica spearheaded by the Chinese National Antarctic Research Expedition(CHINARE). Since the first CHINARE over 30 years ago, considerable work has been undertaken to promote the development of techniques for the observation of surface and upper-air meteorological elements, and satellite image and data reception systems at Chinese Antarctic stations and onboard Chinese icebreakers have played critical roles in this endeavor. The upgrade of in situ and remote sensing measurement methods and the improvement of weather forecasting skill have enabled forecasters to achieve reliable on-site weather forecasting for the CHINARE. Nowadays, the routing of icebreakers, navigation of aircraft, and activities at Chinese Antarctic stations all benefit from the accurate weather forecasting service. In this paper, a review of the conventional meteorological measurement and operational weather forecasting services of the CHINARE is presented.
基金support by Chinese National Science Foundation(No.3997801)
文摘The serum thyroid hormone and plasma catecholamine were examined in 18 male and 2 female members of the Chinese Antarctic Expedition (who spent the 2000 or 2001 austral winter at the Great Wall Station) . The changes of serum thyroid hormone i. e. total thyroxine (TT4) and free T4 (FT4) , total triodothyronine (TT3) and freeT3 ( FT3 ) , thyroid stimulating hormone ( TSH ) and plasma catecholamine, including norepinephrine (NE) , epinephrine ( E) and dopamine ( DA ) , were investigated by Chemoluminescence Immunoassay (CLIA) and High Performance Liquid Chromatography with electrochemical detection (HPLC-ECD) . Samples were taken at different time; (1)1 day before departure to Antarctica (16th expedition 1999/12/ 09; 17th expedition 2000/12/06). (2) 1 day after returned to China after living 54 weeks in Antarctica ( 16th expedition 2000/12/25 ; 17th expedition 2001/12/25 ). Comparing the data of before departure and returned, results showed that there was a significant decrease in the contents of TT4 (P <0. 01) with no significant change in the content of TT3 , FT3 and FT4. It was also found that the content of TSH increased significantly (P <0. 001) ; No significant changes of plasma NE and DA were found but the content of E decreased significantly ( P < 0. 001) . The results indicated that the special Antarctic environment led to a restrain effect on the thyroid function and the level of plasma E in Antarctic expedition members. Both the thyroid and adrenal medulla system were associated in response to the Antarctic systemic stress.
文摘In order to clarify the possible relationship between the changes of behavior/personality and metabolic changes of 5 hydroxytryptamine (5 HT) in Antarctic expedition members, plasma tryptophan (Trp) and urinary 5 hydroxy 3 indoleacetic acid (5 HIAA) were studied for 24 winter over and 19 summer over members of the 8th and 11th CHINARE respectively. Results showed that plasma Trp decreased significantly after residing 1 ̄3 months at Great Wall Station and did not recover on returning back to Beijing from Antarctica by two weeks travelling. Urinary 5 HIAA increased significantly after residing 6 months at Great Wall Station, and recovered on returning back to Beijing from Antarctica in the winter over members. The decrease of plasma Trp may be related to the decline of brain 5 HT which might play a role in the changes of behavior/personality . Increase of urinary 5 HIAA might reflect metabolic changes of 5 HT as a whole, but cold weather involving in the release response of platelet should be considered. Therefore, supplement of related food rich in Trp or intervention of L Trp might be valuable.