According to Claude Bernard,each of the sciences investigates different natural phenomena using experimental methods unique to that science,especially experimental medicine.However,Bernard also argued that these scien...According to Claude Bernard,each of the sciences investigates different natural phenomena using experimental methods unique to that science,especially experimental medicine.However,Bernard also argued that these sciences share a“common”experimental method that depends on both the“head”and the“hand”.What he accomplished with his common method is to combine both rationalism and empiricism-head and hand,respectively-to undergird the unity of the experimental sciences while maintaining their plurality.Bernard’s experimental method as articulated in terms of the rational head and the empirical hand metaphor is relevant today to the unity of science vs.pluralism debate,as well as to the rationalism vs.empiricism debate and to the hypothesis-driven vs.data-driven science debate-each of which is explored in turn after briefly reconstructing Bernard’s philosophy of experimental medicine.And his metaphor of head and hand provides a means for examining the natural and biomedical sciences as they evolve with regard to specialization.展开更多
According to the problems such as low level and depth of experimental teaching research of Mongolian medicine in higher vocational colleges, lack of applicable teaching model mold, lack of students practical operation...According to the problems such as low level and depth of experimental teaching research of Mongolian medicine in higher vocational colleges, lack of applicable teaching model mold, lack of students practical operation in time, and single teaching, the development direction and ideas of bloodletting model mold in Mongolian medicine in vocational Mongolian medicine teaching were proposed to provide valuable reference for the experimental teaching reform of traditional therapy of Mongolian medicine and the teaching reform and development ideas of Mongolian medicine and other traditional medicine.展开更多
Neurologic impairments are usually irreversible as a result of limited regeneration in the central nervous system.Therefore,based on the regenerative capacity of stem cells,transplantation therapies of various stem ce...Neurologic impairments are usually irreversible as a result of limited regeneration in the central nervous system.Therefore,based on the regenerative capacity of stem cells,transplantation therapies of various stem cells have been tested in basic research and preclinical trials,and some have shown great prospects.This manuscript overviews the cellular and molecular characteristics of embryonic stem cells,induced pluripotent stem cells,neural stem cells,retinal stem/progenitor cells,mesenchymal stem/stromal cells,and their derivatives in vivo and in vitro as sources for regenerative therapy.These cells have all been considered as candidates to treat several major neurological disorders and diseases,owing to their self-renewal capacity,multi-directional differentiation,neurotrophic properties,and immune modulation effects.We also review representative basic research and recent clinical trials using stem cells for neurodegenerative diseases,including Parkinson＇s disease,Alzheimer＇s disease,and age-related macular degeneration,as well as traumatic brain injury and glioblastoma.In spite of a few unsuccessful cases,risks of tumorigenicity,and ethical concerns,most results of animal experiments and clinical trials demonstrate efficacious therapeutic effects of stem cells in the treatment of nervous system disease.In summary,these emerging findings in regenerative medicine are likely to contribute to breakthroughs in the treatment of neurological disorders.Thus,stem cells are a promising candidate for the treatment of nervous system diseases.展开更多
Owing to its unique superiority in improving quality of life and prolonging survival time among advanced lung cancer patients, Chinese medicine（CM） has, in recent years, received increased attentions worldwide. We u...Owing to its unique superiority in improving quality of life and prolonging survival time among advanced lung cancer patients, Chinese medicine（CM） has, in recent years, received increased attentions worldwide. We utilized a bibliometric statistical method based on MEDLINE/Go Pub Med to conduct a comprehensive analysis of the current application status of CM in lung cancer, by including annual and accumulated publications, origin distribution of countries and journals, and keywords with a higher frequency score. Then the relevant clinical trials and mechanistic studies were systematically summarized within the field according to research types. We have raised potential problems and provided potentially useful reference information that could guide similar studies in the future. The basic experimental results are highly consistent with clinical trials, leading us to conclude that CM can offer better overall therapeutic benefits when used in combination with routine Western medicine for patients with advanced lung cancer.展开更多
文摘According to Claude Bernard,each of the sciences investigates different natural phenomena using experimental methods unique to that science,especially experimental medicine.However,Bernard also argued that these sciences share a“common”experimental method that depends on both the“head”and the“hand”.What he accomplished with his common method is to combine both rationalism and empiricism-head and hand,respectively-to undergird the unity of the experimental sciences while maintaining their plurality.Bernard’s experimental method as articulated in terms of the rational head and the empirical hand metaphor is relevant today to the unity of science vs.pluralism debate,as well as to the rationalism vs.empiricism debate and to the hypothesis-driven vs.data-driven science debate-each of which is explored in turn after briefly reconstructing Bernard’s philosophy of experimental medicine.And his metaphor of head and hand provides a means for examining the natural and biomedical sciences as they evolve with regard to specialization.
基金Supported by the Project of Research on Medical Simulation Education and Teaching of Higher Vocational Colleges in Guangdong Province(2022MYLX060).
文摘According to the problems such as low level and depth of experimental teaching research of Mongolian medicine in higher vocational colleges, lack of applicable teaching model mold, lack of students practical operation in time, and single teaching, the development direction and ideas of bloodletting model mold in Mongolian medicine in vocational Mongolian medicine teaching were proposed to provide valuable reference for the experimental teaching reform of traditional therapy of Mongolian medicine and the teaching reform and development ideas of Mongolian medicine and other traditional medicine.
基金supported by the National Natural Science Foundation of China,No.31471044a grant from the Ministry of Science and Technology of China,No.2015AA020918
文摘Neurologic impairments are usually irreversible as a result of limited regeneration in the central nervous system.Therefore,based on the regenerative capacity of stem cells,transplantation therapies of various stem cells have been tested in basic research and preclinical trials,and some have shown great prospects.This manuscript overviews the cellular and molecular characteristics of embryonic stem cells,induced pluripotent stem cells,neural stem cells,retinal stem/progenitor cells,mesenchymal stem/stromal cells,and their derivatives in vivo and in vitro as sources for regenerative therapy.These cells have all been considered as candidates to treat several major neurological disorders and diseases,owing to their self-renewal capacity,multi-directional differentiation,neurotrophic properties,and immune modulation effects.We also review representative basic research and recent clinical trials using stem cells for neurodegenerative diseases,including Parkinson＇s disease,Alzheimer＇s disease,and age-related macular degeneration,as well as traumatic brain injury and glioblastoma.In spite of a few unsuccessful cases,risks of tumorigenicity,and ethical concerns,most results of animal experiments and clinical trials demonstrate efficacious therapeutic effects of stem cells in the treatment of nervous system disease.In summary,these emerging findings in regenerative medicine are likely to contribute to breakthroughs in the treatment of neurological disorders.Thus,stem cells are a promising candidate for the treatment of nervous system diseases.
文摘Owing to its unique superiority in improving quality of life and prolonging survival time among advanced lung cancer patients, Chinese medicine（CM） has, in recent years, received increased attentions worldwide. We utilized a bibliometric statistical method based on MEDLINE/Go Pub Med to conduct a comprehensive analysis of the current application status of CM in lung cancer, by including annual and accumulated publications, origin distribution of countries and journals, and keywords with a higher frequency score. Then the relevant clinical trials and mechanistic studies were systematically summarized within the field according to research types. We have raised potential problems and provided potentially useful reference information that could guide similar studies in the future. The basic experimental results are highly consistent with clinical trials, leading us to conclude that CM can offer better overall therapeutic benefits when used in combination with routine Western medicine for patients with advanced lung cancer.
