目的探讨高频畸变产物耳声发射（high frequency DPOAE，HFDPOAE）在新生儿听力筛查中的特点及应用价值。方法对261例（522耳）新生儿（正常对照组93例186耳及疾病组168例336耳）同时进行常频畸变产物耳声发射（conventional frequency ...目的探讨高频畸变产物耳声发射（high frequency DPOAE，HFDPOAE）在新生儿听力筛查中的特点及应用价值。方法对261例（522耳）新生儿（正常对照组93例186耳及疾病组168例336耳）同时进行常频畸变产物耳声发射（conventional frequency DPOAE，CFDPOAE）和HFDPOAE听力筛查测试，分别比较采用CFDPOAE和HFDPOAE的初筛阳性率以及不同组新生儿各频率DPOAE的平均幅值，并进行统计学分析。结果对照组CFDPOAE的阳性率显著高于HFDPOAE（P=0．000），疾病组采用CFDPOAE和HFDPOAE的阳性率无显著性差异（P〉0．05）；采用CFDPOAE时，对照组与疾病组的筛查阳性率无显著性差异（P〉0．05）；采用HFDPOAE时，疾病组的筛查阳性率显著高于对照组（P=0．007）。DPOAE的幅值在2、8、12和16kHz频率时各组间有统计学差异；各组DPOAE平均幅值：对照组最高，早产儿和非听损伤危险因素相关疾病组仅次于对照组，其次为新生儿窒息组和黄疸组，具有二种及以上听损伤危险因素相关疾病组最小；各组新生儿频率幅值函数曲线呈双峰型，在4kHz为峰值低谷，在2和8～12kHz分别为二个峰值。结论HFDPOAE能较敏感地反映听觉的受损情况，并能降低CFDPOAE听力筛查的假阳性率，对高频听力障碍的早期发现可能具有一定的应用价值。展开更多
BACKGROUND Noise-induced hearing loss(NIHL)is the second most common acquired hearing loss following presbycusis.Exposure to recreational noise and minimal use of hearing protection increase the prevalence of NIHL in ...BACKGROUND Noise-induced hearing loss(NIHL)is the second most common acquired hearing loss following presbycusis.Exposure to recreational noise and minimal use of hearing protection increase the prevalence of NIHL in young females.NIHL is irreversible.Identifying minor hearing pathologies before they progress to hearing problems that affect daily life is crucial.AIM To compare the advantages and disadvantages of extended high frequency(EHF)and otoacoustic emission and determine an indicator of hearing pathologies at the early sub-clinical stage.METHODS This cross-sectional study was implemented in West China Hospital of Sichuan University from May to September 2019.A total of 86 participants,aged 18-22 years,were recruited to establish normative thresholds for EHF.Another 159 adults,aged 18-25 years with normal hearing(0.25-8 kHz≤25 dBHL),were allocated to low noise and noise exposure groups.Distortion otoacoustic emission(DPOAE),transient evoked otoacoustic emissions(TEOAE),and EHF were assessed in the two groups to determine the superior technique for detecting early-stage noise-induced pathologies.The chi-square test was used to assess the noise and low noise exposure groups with respect to extended high-frequency audiometry(EHFA),DPOAE,and TEOAE.P≤0.05 was considered statistically significant.RESULTS A total of 86 participants(66 females and 20 males)aged between 18 and 22(average:20.58±1.13)years were recruited to establish normative thresholds for EHF.The normative thresholds for 9,10,11.2,12.5,14,16,18,and 20 kHz were 15,10,20,15,15,20,28,and 0 dBHL,respectively.A total of 201 participants were recruited and examined for eligibility.Among them,159 adults aged between 18 and 25 years were eligible in this study.No statistical difference was detected between the noise exposure and the low noise exposure groups using EHFA,DPOAE,and TEOAE(P>0.05)except in the right ear at 4 kHz using TEOAE(abnormal rate 20.4%vs 5.2%,respectively;P=0.05).CONCLUSION These results showed TEOAE as the earliest indicator of minor pathology compared to DPOAE and EHFA.However,a multicenter controlled study or prospective study is essential to verify these results.展开更多
目的研究在高危新生儿听力筛查中测试听性脑干反应和畸变产物耳声发射的价值。方法方便选择2016年1月—2017年12月该院高危新生儿150例,全部新生儿均接受听性脑干反应和畸变产物耳声发射检查,对照两项检查结果。结果听力脑干反应测试正...目的研究在高危新生儿听力筛查中测试听性脑干反应和畸变产物耳声发射的价值。方法方便选择2016年1月—2017年12月该院高危新生儿150例,全部新生儿均接受听性脑干反应和畸变产物耳声发射检查,对照两项检查结果。结果听力脑干反应测试正常率为85.33%,异常率为14.67%,畸变产物耳声发射测试正常率64.67%、异常率35.33%(χ2=5.628 2,P=0.001 3);两种方法在吸入综合征、早产低体重中的异常率差异有统计学意义(χ2=4.269 2、3.963 4,P=0.007 0、0.017 4);22例听性脑干反应测试结果显示异常的患儿阈值处于40~79 d B n HL之间占72.73%,80 d B n HL及以上占27.27%(χ2=7.551 8,P=0.001 7)。结论在高危新生儿听力筛查中进行听性脑干反应和畸变产物耳声发射检查都能够较准确判断新生儿听力。展开更多
文摘目的探讨高频畸变产物耳声发射（high frequency DPOAE，HFDPOAE）在新生儿听力筛查中的特点及应用价值。方法对261例（522耳）新生儿（正常对照组93例186耳及疾病组168例336耳）同时进行常频畸变产物耳声发射（conventional frequency DPOAE，CFDPOAE）和HFDPOAE听力筛查测试，分别比较采用CFDPOAE和HFDPOAE的初筛阳性率以及不同组新生儿各频率DPOAE的平均幅值，并进行统计学分析。结果对照组CFDPOAE的阳性率显著高于HFDPOAE（P=0．000），疾病组采用CFDPOAE和HFDPOAE的阳性率无显著性差异（P〉0．05）；采用CFDPOAE时，对照组与疾病组的筛查阳性率无显著性差异（P〉0．05）；采用HFDPOAE时，疾病组的筛查阳性率显著高于对照组（P=0．007）。DPOAE的幅值在2、8、12和16kHz频率时各组间有统计学差异；各组DPOAE平均幅值：对照组最高，早产儿和非听损伤危险因素相关疾病组仅次于对照组，其次为新生儿窒息组和黄疸组，具有二种及以上听损伤危险因素相关疾病组最小；各组新生儿频率幅值函数曲线呈双峰型，在4kHz为峰值低谷，在2和8～12kHz分别为二个峰值。结论HFDPOAE能较敏感地反映听觉的受损情况，并能降低CFDPOAE听力筛查的假阳性率，对高频听力障碍的早期发现可能具有一定的应用价值。
文摘BACKGROUND Noise-induced hearing loss(NIHL)is the second most common acquired hearing loss following presbycusis.Exposure to recreational noise and minimal use of hearing protection increase the prevalence of NIHL in young females.NIHL is irreversible.Identifying minor hearing pathologies before they progress to hearing problems that affect daily life is crucial.AIM To compare the advantages and disadvantages of extended high frequency(EHF)and otoacoustic emission and determine an indicator of hearing pathologies at the early sub-clinical stage.METHODS This cross-sectional study was implemented in West China Hospital of Sichuan University from May to September 2019.A total of 86 participants,aged 18-22 years,were recruited to establish normative thresholds for EHF.Another 159 adults,aged 18-25 years with normal hearing(0.25-8 kHz≤25 dBHL),were allocated to low noise and noise exposure groups.Distortion otoacoustic emission(DPOAE),transient evoked otoacoustic emissions(TEOAE),and EHF were assessed in the two groups to determine the superior technique for detecting early-stage noise-induced pathologies.The chi-square test was used to assess the noise and low noise exposure groups with respect to extended high-frequency audiometry(EHFA),DPOAE,and TEOAE.P≤0.05 was considered statistically significant.RESULTS A total of 86 participants(66 females and 20 males)aged between 18 and 22(average:20.58±1.13)years were recruited to establish normative thresholds for EHF.The normative thresholds for 9,10,11.2,12.5,14,16,18,and 20 kHz were 15,10,20,15,15,20,28,and 0 dBHL,respectively.A total of 201 participants were recruited and examined for eligibility.Among them,159 adults aged between 18 and 25 years were eligible in this study.No statistical difference was detected between the noise exposure and the low noise exposure groups using EHFA,DPOAE,and TEOAE(P>0.05)except in the right ear at 4 kHz using TEOAE(abnormal rate 20.4%vs 5.2%,respectively;P=0.05).CONCLUSION These results showed TEOAE as the earliest indicator of minor pathology compared to DPOAE and EHFA.However,a multicenter controlled study or prospective study is essential to verify these results.
文摘目的研究在高危新生儿听力筛查中测试听性脑干反应和畸变产物耳声发射的价值。方法方便选择2016年1月—2017年12月该院高危新生儿150例,全部新生儿均接受听性脑干反应和畸变产物耳声发射检查,对照两项检查结果。结果听力脑干反应测试正常率为85.33%,异常率为14.67%,畸变产物耳声发射测试正常率64.67%、异常率35.33%(χ2=5.628 2,P=0.001 3);两种方法在吸入综合征、早产低体重中的异常率差异有统计学意义(χ2=4.269 2、3.963 4,P=0.007 0、0.017 4);22例听性脑干反应测试结果显示异常的患儿阈值处于40~79 d B n HL之间占72.73%,80 d B n HL及以上占27.27%(χ2=7.551 8,P=0.001 7)。结论在高危新生儿听力筛查中进行听性脑干反应和畸变产物耳声发射检查都能够较准确判断新生儿听力。
