Background:The target definition of consolidation radiotherapy(RT)for extensive stage small-cell lung cancer(ES-SCLC)has not been standardized.This study aimed to demonstrate the feasibility of post-chemotherapy based...Background:The target definition of consolidation radiotherapy(RT)for extensive stage small-cell lung cancer(ES-SCLC)has not been standardized.This study aimed to demonstrate the feasibility of post-chemotherapy based consolidation RT in ES-SCLC.Methods:All ES-SCLC patients without initial brain metastases who completed≥4 cycles of systemic therapy at Department of Radiation and Medical Oncology,Zhongnan Hospital of Wuhan University from 2012 to 2021 were included in this retrospective study.We correlated the site of first recurrence to the post-chemotherapy-based radiation volume(small-field).Relapse pattern,progression-free survival(PFS)and overall survival(OS)were compared between those received and did not receive consolidation RT.Results:A total of 152 patients were followed up for a median of 31.7 months(interquartile range[IQR],23.9-39.6 months).The median PFS and OS of the cohort were 8.3 months(IQR,6.1-11.2 months)and 16.2 months(IQR,9.9-24.9 months),respectively.Thoracic consolidation RT served not only as an independent prognostic factor for improved PFS in the entire cohort,but also significantly prolonged OS in the subgroup without syn-chronous liver metastases.Small-field consolidation RT markedly reduced in-field recurrences(hazard ratio[HR],0.28[95%CI,0.12-0.38];P<0.001)without increasing out-of-field recurrences(HR,0.40[95%CI,0.13-1.16];P=0.080).No relapse was observed at the margin of the targets.Treatment-related toxicities were moderate,with grade 3 acute radiation pneumonia,radiation esophagitis,and bone marrow suppression rates of 8.3%,3.1%,and 12.5%,respectively.No grade 5 toxicity occurred.Conclusion:Small-field consolidation RT based on post-chemotherapy volume is safe and can significantly im-prove local control in ES-SCLC.展开更多
The Louzidian metamorphic core complex (LMCC) in southern Chifeng is located on the northern margin of the North China craton. Structural analyses of the LMCC and its extensional detachment system indicate that the LM...The Louzidian metamorphic core complex (LMCC) in southern Chifeng is located on the northern margin of the North China craton. Structural analyses of the LMCC and its extensional detachment system indicate that the LMCC experienced two-stage extension. The ductile regime experienced top-to-northeast shearing extension and the brittle detachment fault underwent top-down-outwards slipping. Between these two stages, a semi-ductile regime recorded the transition from ductile to brittle. The hanging wall of the detachment fault is similar to those classic supradetachment basins in western North America. Analyses of provenance and paleocurrent directions in the basins show that there were two filling stages. In the early stage, materials came from the southwest margin of the basin and the hanging wall of the detachment system and were transported from southwest to northeast; while in the late stage, deposits were derived from the footwall of the detachment fault and transported outwards to the two sides of the core complex. Since the filling period of the basins is from the late Jurassic to the late Cretaceous and it is coeval with the extension, the two filling stages reflect the two-stage history of the detachment fault. The large-scale late Jurassic underplating in the deep crust of the Chifeng area led to thickening and heating of the middle-upper crust and trigged the extension at depths and volcanism on the surface. In the early Cretaceous the upper plate of the detachment fault moved northeastwards and sediments were transported from southwest to northeast, while in the late Cretaceous the core complex was uplifted rapidly, the original basin was separated by the uplifted core, and lower-plate-derived debris was deposited in the adjacent upper-plate basins of the detachment fault. Evidentially, the development of the supradetachment basins were controlled by the extension and in turn the fillings in the basins recorded information of the extension, which has provided new evidence for kinematic interpretation of the Louzidian core complex.展开更多
Abstract: The great majority of the Palaeozoic orogenic belts of Central Asia are of the intercontinental type, whose evolution always follows a five-stage model, i.e. the basal continental crust-extensional transitio...Abstract: The great majority of the Palaeozoic orogenic belts of Central Asia are of the intercontinental type, whose evolution always follows a five-stage model, i.e. the basal continental crust-extensional transitional crust-oceanic crust-convergent transitional crust-new continental crust model. The stage for the extensional transitional crust is a pretty long, independent and inevitable phase. The dismembering mechanism of the basal continental crust becoming an extensional continental crust is delineated by the simple shear model put forward by Wernike (1981). The continental margins on the sides of a gently dipping detachment zone and moving along it are asymmetric: one side is of the nonmagmatic type and the other of the magmatic type with a typical bimodal volcanic formation. In the latter case, however, they were often confused with island arcs. This paper discusses the five-stage process of the crustal evolution of some typical orogenic belts in Xinjiang.展开更多
To stop excessive plasma loss,alleviate noxious effcets of devitalized tissues on the body and shorten the hospitalization time,we performed extensive escharectomy during the shock period in extensively burned patie...To stop excessive plasma loss,alleviate noxious effcets of devitalized tissues on the body and shorten the hospitalization time,we performed extensive escharectomy during the shock period in extensively burned patients.展开更多
Background:This study evaluated the efficacy and safety of low‐dose anlotinib combined with immune checkpoint inhibitors as second‐line or later treatment for extensive‐stage small cell lung cancer(ES‐SCLC).Method...Background:This study evaluated the efficacy and safety of low‐dose anlotinib combined with immune checkpoint inhibitors as second‐line or later treatment for extensive‐stage small cell lung cancer(ES‐SCLC).Methods:The study included 42 patients with ES‐SCLC who were treated with low‐dose anlotinib combined with programmed cell death protein 1/programmed cell death‐ligand 1 inhibitors at Henan Cancer Hospital between March 2019 and August 2022.We retrospectively analyzed the efficacy and safety data for these patients.Indicators assessed included progression‐free survival(PFS),overall survival(OS),the overall response rate(ORR),the disease control rate(DCR),and adverse events(AEs).Prognostic factors were identified in univariate and multivariate analyses.Results:Median PFS was 11.0 months(95%CI:7.868–14.132)and median OS was 17.3 months(95%CI:11.517–23.083).The ORR was 28.5%and the DCR was 95.2%.Treatment‐related AEs were noted in 27 patients(64.3%),the most common of which was thyroid dysfunction(26.2%).Grade 3/4 treatmentrelated AEs were observed in two patients(4.8%).Conclusions:A combination of low‐dose anlotinib and immune checkpoint inhibitors as second‐line or later treatment for ES‐SCLC may achieve longer PFS and OS and have manageable AEs.展开更多
基金supported by the Health Commission of Hubei Province Scientific Research Project(grant number:WJ2021F108)。
文摘Background:The target definition of consolidation radiotherapy(RT)for extensive stage small-cell lung cancer(ES-SCLC)has not been standardized.This study aimed to demonstrate the feasibility of post-chemotherapy based consolidation RT in ES-SCLC.Methods:All ES-SCLC patients without initial brain metastases who completed≥4 cycles of systemic therapy at Department of Radiation and Medical Oncology,Zhongnan Hospital of Wuhan University from 2012 to 2021 were included in this retrospective study.We correlated the site of first recurrence to the post-chemotherapy-based radiation volume(small-field).Relapse pattern,progression-free survival(PFS)and overall survival(OS)were compared between those received and did not receive consolidation RT.Results:A total of 152 patients were followed up for a median of 31.7 months(interquartile range[IQR],23.9-39.6 months).The median PFS and OS of the cohort were 8.3 months(IQR,6.1-11.2 months)and 16.2 months(IQR,9.9-24.9 months),respectively.Thoracic consolidation RT served not only as an independent prognostic factor for improved PFS in the entire cohort,but also significantly prolonged OS in the subgroup without syn-chronous liver metastases.Small-field consolidation RT markedly reduced in-field recurrences(hazard ratio[HR],0.28[95%CI,0.12-0.38];P<0.001)without increasing out-of-field recurrences(HR,0.40[95%CI,0.13-1.16];P=0.080).No relapse was observed at the margin of the targets.Treatment-related toxicities were moderate,with grade 3 acute radiation pneumonia,radiation esophagitis,and bone marrow suppression rates of 8.3%,3.1%,and 12.5%,respectively.No grade 5 toxicity occurred.Conclusion:Small-field consolidation RT based on post-chemotherapy volume is safe and can significantly im-prove local control in ES-SCLC.
基金supported by the National Natural Science Foundation of China(grant 40102017)the Doctoral Program of Higher Education(grant 2000000128).
文摘The Louzidian metamorphic core complex (LMCC) in southern Chifeng is located on the northern margin of the North China craton. Structural analyses of the LMCC and its extensional detachment system indicate that the LMCC experienced two-stage extension. The ductile regime experienced top-to-northeast shearing extension and the brittle detachment fault underwent top-down-outwards slipping. Between these two stages, a semi-ductile regime recorded the transition from ductile to brittle. The hanging wall of the detachment fault is similar to those classic supradetachment basins in western North America. Analyses of provenance and paleocurrent directions in the basins show that there were two filling stages. In the early stage, materials came from the southwest margin of the basin and the hanging wall of the detachment system and were transported from southwest to northeast; while in the late stage, deposits were derived from the footwall of the detachment fault and transported outwards to the two sides of the core complex. Since the filling period of the basins is from the late Jurassic to the late Cretaceous and it is coeval with the extension, the two filling stages reflect the two-stage history of the detachment fault. The large-scale late Jurassic underplating in the deep crust of the Chifeng area led to thickening and heating of the middle-upper crust and trigged the extension at depths and volcanism on the surface. In the early Cretaceous the upper plate of the detachment fault moved northeastwards and sediments were transported from southwest to northeast, while in the late Cretaceous the core complex was uplifted rapidly, the original basin was separated by the uplifted core, and lower-plate-derived debris was deposited in the adjacent upper-plate basins of the detachment fault. Evidentially, the development of the supradetachment basins were controlled by the extension and in turn the fillings in the basins recorded information of the extension, which has provided new evidence for kinematic interpretation of the Louzidian core complex.
文摘Abstract: The great majority of the Palaeozoic orogenic belts of Central Asia are of the intercontinental type, whose evolution always follows a five-stage model, i.e. the basal continental crust-extensional transitional crust-oceanic crust-convergent transitional crust-new continental crust model. The stage for the extensional transitional crust is a pretty long, independent and inevitable phase. The dismembering mechanism of the basal continental crust becoming an extensional continental crust is delineated by the simple shear model put forward by Wernike (1981). The continental margins on the sides of a gently dipping detachment zone and moving along it are asymmetric: one side is of the nonmagmatic type and the other of the magmatic type with a typical bimodal volcanic formation. In the latter case, however, they were often confused with island arcs. This paper discusses the five-stage process of the crustal evolution of some typical orogenic belts in Xinjiang.
文摘To stop excessive plasma loss,alleviate noxious effcets of devitalized tissues on the body and shorten the hospitalization time,we performed extensive escharectomy during the shock period in extensively burned patients.
基金National Natural Science Foundation of China,Grant/Award Number:81972690Medical Science and Technology Research Project of Health Commission of Henan Province,Grant/Award Number:YXKC2021007。
文摘Background:This study evaluated the efficacy and safety of low‐dose anlotinib combined with immune checkpoint inhibitors as second‐line or later treatment for extensive‐stage small cell lung cancer(ES‐SCLC).Methods:The study included 42 patients with ES‐SCLC who were treated with low‐dose anlotinib combined with programmed cell death protein 1/programmed cell death‐ligand 1 inhibitors at Henan Cancer Hospital between March 2019 and August 2022.We retrospectively analyzed the efficacy and safety data for these patients.Indicators assessed included progression‐free survival(PFS),overall survival(OS),the overall response rate(ORR),the disease control rate(DCR),and adverse events(AEs).Prognostic factors were identified in univariate and multivariate analyses.Results:Median PFS was 11.0 months(95%CI:7.868–14.132)and median OS was 17.3 months(95%CI:11.517–23.083).The ORR was 28.5%and the DCR was 95.2%.Treatment‐related AEs were noted in 27 patients(64.3%),the most common of which was thyroid dysfunction(26.2%).Grade 3/4 treatmentrelated AEs were observed in two patients(4.8%).Conclusions:A combination of low‐dose anlotinib and immune checkpoint inhibitors as second‐line or later treatment for ES‐SCLC may achieve longer PFS and OS and have manageable AEs.
