Recently,tissue engineering (TE)is one of the fast growing research fields due the accessibility of extra-molecular matrix (ECM)at cellular and molecular level with valuable potential prospective of hydrogels.The enha...Recently,tissue engineering (TE)is one of the fast growing research fields due the accessibility of extra-molecular matrix (ECM)at cellular and molecular level with valuable potential prospective of hydrogels.The enhancement in the production of hydrogel-based cellular scaffolds with the structural composition of ECM has been accelerated with involvement of rapid prototyping techniques.Basically,the recreation of ECM has been derived from naturally existed or synthetic hydrogelbased polymers.The rapid utilization of hydrogels in TE puts forward the scope of bioprinfing for the fabrication of the functional biological tissues,cartilage,skin and artificial organs.The main focus of the researchers is on biofabrication of the biomaterials with maintaining the biocompatibility,biodegradability and increasing growth efficiency.In this review, biological development in the structure and cross-linking connections of natural or synthetic hydrogels are discussed.The methods and design criteria that influence the chemical and mechanical properties and interaction of seeding cells before and after the implantations are also demonstrated.The methodology of bioprinting techniques along with recent development has also been reviewed.In the end,some capabilities and shortcomings are pointed out for further development of hydrogels-based scaffolds and selection of bioprinting technology depending on their application.展开更多
Experiments on NO2 reveal a substructure underlying the optically excited isolated hyperfine structure (hfs) levels of the molecule. This substructure is seen in a change of the symmetry of the excited molecule and is...Experiments on NO2 reveal a substructure underlying the optically excited isolated hyperfine structure (hfs) levels of the molecule. This substructure is seen in a change of the symmetry of the excited molecule and is represented by the two “states” and of a hfs-level. Optical excitation induces a transition from the ground state of the molecule to the excited state . However, the molecule evolves from to in a time τ0 ≈ 3 μs. Both and have the radiative lifetime τR ≈ 40 μs, but and differ in the degree of polarization of the fluorescence light. Zeeman coherence in the magnetic sublevels is conserved in the transition →, and optical coherence of and is able to affect (inversion effect) the transition →. This substructure, which is not caused by collisions with baryonic matter or by intramolecular dynamics in the molecule, contradicts our knowledge on an isolated hfs-level. We describe the experimental results using the assumption of extra dimensions with a compactification space of the size of the molecule, in which dark matter affects the nuclei by gravity. In , all nuclei of NO2 are confined in a single compactification space, and in , the two O nuclei of NO2 are in two different compactification spaces. Whereas and represent stable configurations of the nuclei,represents an unstable configuration because the vibrational motion in shifts one of the two O nuclei periodically off the common compactification space, enabling dark matter interaction to stimulate the transition →with the rate (τ0)−1. We revisit experimental results, which were not understood before, and we give a consistent description of these results based on the above assumption.展开更多
文摘Recently,tissue engineering (TE)is one of the fast growing research fields due the accessibility of extra-molecular matrix (ECM)at cellular and molecular level with valuable potential prospective of hydrogels.The enhancement in the production of hydrogel-based cellular scaffolds with the structural composition of ECM has been accelerated with involvement of rapid prototyping techniques.Basically,the recreation of ECM has been derived from naturally existed or synthetic hydrogelbased polymers.The rapid utilization of hydrogels in TE puts forward the scope of bioprinfing for the fabrication of the functional biological tissues,cartilage,skin and artificial organs.The main focus of the researchers is on biofabrication of the biomaterials with maintaining the biocompatibility,biodegradability and increasing growth efficiency.In this review, biological development in the structure and cross-linking connections of natural or synthetic hydrogels are discussed.The methods and design criteria that influence the chemical and mechanical properties and interaction of seeding cells before and after the implantations are also demonstrated.The methodology of bioprinting techniques along with recent development has also been reviewed.In the end,some capabilities and shortcomings are pointed out for further development of hydrogels-based scaffolds and selection of bioprinting technology depending on their application.
文摘Experiments on NO2 reveal a substructure underlying the optically excited isolated hyperfine structure (hfs) levels of the molecule. This substructure is seen in a change of the symmetry of the excited molecule and is represented by the two “states” and of a hfs-level. Optical excitation induces a transition from the ground state of the molecule to the excited state . However, the molecule evolves from to in a time τ0 ≈ 3 μs. Both and have the radiative lifetime τR ≈ 40 μs, but and differ in the degree of polarization of the fluorescence light. Zeeman coherence in the magnetic sublevels is conserved in the transition →, and optical coherence of and is able to affect (inversion effect) the transition →. This substructure, which is not caused by collisions with baryonic matter or by intramolecular dynamics in the molecule, contradicts our knowledge on an isolated hfs-level. We describe the experimental results using the assumption of extra dimensions with a compactification space of the size of the molecule, in which dark matter affects the nuclei by gravity. In , all nuclei of NO2 are confined in a single compactification space, and in , the two O nuclei of NO2 are in two different compactification spaces. Whereas and represent stable configurations of the nuclei,represents an unstable configuration because the vibrational motion in shifts one of the two O nuclei periodically off the common compactification space, enabling dark matter interaction to stimulate the transition →with the rate (τ0)−1. We revisit experimental results, which were not understood before, and we give a consistent description of these results based on the above assumption.
