Comparison of microendoscopic discectomy and open discectomy for single-segment lumbar disc herniation

BACKGROUND Lumbar disc herniation is a common disease.Endoscopic treatment may have more advantages than traditional surgery.AIM To compare the clinical efficacy and safety of microendoscopic discectomy(MED)and open discectomy with lamina nucleus enucleation in the treatment of singlesegment lumbar intervertebral disc herniation.METHODS Ninety-six patients who were operated at our hospital were selected for this study.Patients with single-segment lumbar disc herniation were admitted to the hospital from March 2018 to March 2019 and were randomly divided into the observation group and the control group with 48 cases in each group.The former group underwent lumbar discectomy and the latter underwent laparotomy and nucleus pulpectomy.Surgical effects were compared between the two groups.RESULTS In terms of surgical indicators,the observation group had a longer operation time,shorter postoperative bedtime and hospital stay,less intraoperative blood loss,and smaller incision length than the control group(P<0.05).The excellent recovery rate did not differ significantly between the observation group(93.75%)and the control group(91.67%).Visual analogue scale pain scores were significantly lower in the observation group than in the control group at 1 d,3 d,1 mo,and 6 mo after surgery(P<0.05).The incidence of complications was significantly lower in the observation group than in the control group(6.25%vs 22.92%,P<0.05).CONCLUSION Both MED and open discectomy can effectively improve single-segment lumbar disc herniation,but MED is associated with less trauma,less bleeding,and a lower incidence of complications.

Technique of Percutaneous Transforaminal Endoscopic Discectomy for the Treatment of Lumbar Disc Herniation

Percutaneous Transforaminal Endoscopic Discectomy is a minimally invasive surgery with little pain, less blood loss, less hospital stay and the surgery can be done in local anesthesia, which was started during late 20th century. Kambin and Gellmann in 1973 in the United States and Hijikata in Japanin 1977 individually preformed posterolateral percutaneous nucleotomy for the resection of the nucleus pulposus and release of compressed exiting nerve root, which is now spreading through the world and many surgeons are developing their skill but it needs experience and patience for successful outcomes. Along with advanced instruments now the surgery can be performed only giving a small skin incision of 8 - 10 mm and is as effective as the conventional method of surgery and open microdiscectomy surgery for the treatment of symptomatic lumbar disc herniation. In this review, we are explaining the technique of minimally invasive Percutaneous Transforaminal Endoscopic Discectomy surgery along its advantages and complications which can be encountered while performing this technique.

Early efficacy of endoscopic translaminar and intervertebral foraminal approaches in the treatment of lumbar disc herniation

Objective:To investigate the early efficacy of two approaches for lumbar disc herniation under spinal endoscopy.Methods:45 cases of lumbar disc herniation were divided into interlaminar approach(27 cases)and intervertebral foramen approach(18 cases)according to different surgical approaches.Postoperative pain visual analogue scale(VAS)was used.Japanese Orthopaedic Association(JOA)lumbar spine score(JOA)and modified Macnab criteria were used to evaluate the postoperative outcome.Results:(1)VAS score.There is no interaction effect between the access mode and the time factor(F=0.620,P=0.603).There were statistically significant differences in pain VAS scores between preoperative and postoperative time points,that is,there was a time effect(F=2157.488,P=0.000).The overall VAS scores of the two groups were compared,and the difference was not statistically significant,that is,there was no grouping effect(F=2.610,P=0.114).The VAS score of pain in both groups decreased with time,and the differences between the two groups were not statistically significant before surgery,at discharge,1 month after surgery and 3 months after surgery(t=0.067,P=0.947;t=1.415,P=0.164;t=0.564,P=0.575;t=0.442,P=0.660);JOA score.There is no interaction effect between the access mode and the time factor(F=1.296,P=0.280).The difference of JOA score between preoperative and postoperative time points was statistically significant,that is,there was a time effect(F=1464.830,P=0.000).JOA scores of the two groups showed an increasing trend with time,and the differences between the two groups were not statistically significant before surgery,at discharge,1 month after surgery and 3 months after surgery(t=0.067,P=0.947;t=1.415,P=0.164;t=0.564,P=0.575;t=0.442,P=0.660);(2)The improved Macnab standard was used to evaluate the excellent and good rate at 3 months after surgery.In the interlaminar group,12 cases were excellent,13 cases were good and 2 cases were fair.The excellent and good rate was 92.6%.In the intervertebral foramen group,7 cases were excellent,10 cases were good and 1 case was fair.The excellent and good rate was 94.4%.The overall excellent and good rate of the two groups was 93.3%.Conclusion:Both approaches can achieve satisfactory efficacy in the treatment of lumbar intervertebral disc herniation,which is worthy of clinical application.However,for beginners,l5-s1 lumbar disc herniation is more suitable for intervertebral disc approach,so as to achieve satisfactory efficacy.

Anti-inflammatory Effect of Wumen Zhike Gancao Decoction on Rats with Lumbar Disc Herniation Associated with Lipid Metabolic Disorder

[Objectives] To study the anti-inflammatory effect of Wumen Zhike Gancao Decoction (ZKGC) on rats with lumbar disc herniation (LDH) associated with lipid metabolic disorder.[Methods] A rat model of LDH was established by implantation of the autologous nucleus pulposus from the coccygeal vertebra of each rat tail, and histopathology, immunohistochemistry and biochemistry assays were employed to evaluate the treatment effects of ZKGC. In addition, the metabolic characteristics of LDH and ZKGC treatment were investigated with a liquid-chromatography with time-of-flight mass spectrometer (LC/Q-TOF-MS)-based metabolomics study. Nucleus pulpous tissues from rat models were collected and analyzed by metabolomics.[Results] By metabolism network analysis, lipid metabolism was up-regulated in LDH rat models and the treatment with ZKGC significantly reversed the abnormal up-regulated lipid metabolism. Meanwhile, the treatment of ZKGC also regulated the markers of neuron autophagy and inflammatory response in serum.[Conclusions] These results indicated that a complex mechanism, including abnormal lipid metabolism, associates with the progress of LDH, and multiple pathways might be involved in ZKGC s therapeutic effects on LDH.

Autologous nucleus pulposus transplantation to lumbar 5 dorsal root ganglion after epineurium discission in rats： a modified model of non-compressive lumbar herniated intervertebral disc

Background Nucleus pulposus of intervertebral discs has proinflammatory characteristics that play a key role in neuropathic pain in lumbar herniated intervertebral disc. One of the most commonly used animal models （the traditional model） of non-compressive lumbar herniated intervertebral disc is created by L4-L5 hemilaminectomy and the application of autologous nucleus pulposus to cover the left L4 and L5 nerve roots in rats. However, such procedures have the disadvantages of excessive trauma and low success rate. We proposed a modified model of non-compressive lumbar herniated intervertebral disc in which only the left L5 dorsal root ganglion is exposed and transplanted with autologous nucleus pulposus following incision of epineurium. We aimed to compare the modified model with the traditional one with regard to trauma and success rate. Methods Thirty Sprague-Dawley male rats were randomized into three groups： sham operation group （n=6）, traditional group （n=12）, and modified group （n=12）. The amount of blood loss and operative time for each group were analyzed. The paw withdrawal threshold of the left hind limb to mechanical stimuli and paw withdrawal latency to heat stimuli were examined from the day before surgery to day 35 after surgery. Results Compared with the traditional group, the modified group had shorter operative time, smaller amount of blood loss, and higher success rate （91.7% versus 58.3%, P 〈0.05）. There was no decrease in paw withdrawal latency in any group. The sham operation group had no decrease in postoperative paw withdrawal threshold, whereas the modified and traditional groups had significant reduction in paw withdrawal threshold after surgery （mechanical hyperalgesia）. Conclusions Transplantation of nucleus pulposus onto the L5 dorsal root ganglion following incision of epineurium in rats established an improved animal model of non-compressive lumbar herniated intervertebral disc with less trauma and more stable pain ethology.

Gua Sha attenuates thermal hyperalgesia and decreases proinflammatory cytokine expression in serum in rats with lumbar disc herniation induced by autologous nucleus pulposus

OBJECTIVE: To investigate the analgesic effect of Gua Sha and its underlying mechanism in rats with noncompressive lumbar disk herniation induced by autologous nucleus pulposus.METHODS: A rat model of noncompressive lumbar disk herniation was established and rats were randomly divided into model group, sham group, and Gua Sha group(24 in each group). Gua Sha was performed from the 5 th day after the surgery, once every other day, 3 times for a course of treatment,and totally 3 courses. The thermal withdrawal latency was evaluated using the intelligent hot plate one day before the surgery, and on days 4(the day before the treatment), 10(the end of the firstcourse), 16(the end of the second course) and 22(the end of the third course). On days 4, 10, 16 and22, six rats in each group were picked randomly and their blood samples were drawn to assess the expression of interleukin-1β(IL-1β), interleukin-6(IL-6) and tumor necrosis factor-alpha(TNF-α).RESULTS: Compared to rats in the sham group, the application of nucleus pulposus to right L5 dorsal root ganglion induced prolonged thermal hyperalgesia, and up-regulated the expression of IL-1β,IL-6 and TNF-α in serum(P < 0.01). The therapy of Gua Sha attenuated thermal hyperalgesia potently,inhibited the expression of IL-1β, IL-6 and TNF-α in a time-dependent manner(P < 0.01). There were no significant differences in the thermal withdrawal latency and the expression of inflammatory cytokines between the sham and Gua Sha groups at the end of the treatment(P > 0.01).CONCLUSION: The current study showed that Gua Sha might alleviate thermal hyperalgesia in rats with lumbar disc herniation induced by autologous nucleus pulposus via inhibiting the expression of proinflammatory cytokins.

单侧双通道脊柱内镜技术治疗腰椎间盘突出症的效果观察及护理研究

目的探讨LDH的治疗及护理方法。方法回顾性收集80例LDH患者的临床资料,根据治疗方法的不同分为两组,各40例。对照组:采用椎间盘后路摘除术,观察组采用单侧双通道脊柱内镜下髓核摘除术,两组均予以常规护理与术后康复锻炼。观察两组临床效果。结果观察组手术时间长于对照组,但手术出血量、术后下床活动时间、住院时间低于对照组(t=3.01~20.87,P<0.01);观察组术后疼痛及ODI改善程度均优于对照组(t=7.45,10.14;P<0.01);观察组并发症发生率低于对照组(χ^(2)=4.49,P=0.034)。结论单侧双通道脊柱内镜下髓核摘除术治疗LDH效果更优。

中药单体促髓核细胞自噬缓解椎间盘退变的研究进展

椎间盘退变是临床常见疾病,髓核与髓核细胞是椎间盘中主要的病变组织与细胞类型。髓核细胞受病理因素影响而加速衰老或出现代谢障碍时,髓核稳态被破坏,这导致了椎间盘退变的发生发展。自噬是细胞在病理环境下降解受损细胞器与异常蛋白质以维持正常生理功能的途径之一,能促进细胞自我调节以抵御致病因素影响。椎间盘退变时,髓核细胞处于应力失衡与代谢障碍的异常环境中,促进髓核细胞自噬可清除有害代谢产物累积、延缓细胞老化,这有助于维持髓核与椎间盘的健康生理状态。随着中医药治疗椎间盘退变疾病相关研究的不断深入,大量提取自传统中草药的单体成分被发现可以促进髓核细胞自噬以缓解椎间盘退变。根据最新的研究进展,讨论了髓核细胞的自噬与椎间盘退变的关联,共获取了14种在促进髓核细胞自噬以缓解椎间盘退变领域展现出潜力的中药单体,并将其作用机制归纳为以下4种:促自噬抑制髓核细胞凋亡、促自噬拮抗髓核细胞氧化应激、促自噬抑制髓核细胞外基质降解和促自噬促进髓核细胞外基质大分子合成,以期为中药单体调节髓核细胞自噬从而缓解椎间盘退变的研究提供新的思路与参考。

侧后路椎间孔镜与后侧椎板间入路脊柱内镜在腰椎间盘突出症髓核摘除术中的应用对比

目的:分析侧后路椎间孔镜与后侧椎板间入路脊柱内镜在腰椎间盘突出症髓核摘除术中的应用效果。方法:选择2020年1月—2022年12月龙岩市第二医院收治的80例腰椎间盘突出症患者作为研究对象,将2020年1月—2021年6月收治的40例设为A组,采取侧后路椎间孔镜下腰椎间盘突出症髓核摘除术;将2021年7月—2022年12月收治的40例设为B组,采取后侧椎板间入路脊柱内镜下腰椎间盘突出症髓核摘除术。记录并比较两组手术相关指标与并发症发生率,并于术后评价两组疼痛程度与功能恢复情况。结果:A组手术时间长于B组,术中出血量少于B组,手术切口长度短于B组,差异有统计学意义(P<0.05);但两组住院时间比较,差异无统计学意义(P>0.05)。术后48 h、1周,两组视觉模拟评分法(VAS)评分均低于术后24 h,且A组低于B组,差异有统计学意义(P<0.05)。术后4周、3个月,两组Oswestry功能障碍指数(ODI)评分均低于术前,且B组低于A组,差异有统计学意义(P<0.05)。A组术后并发症总发生率为15.00%,高于B组的10.00%,但两组间比较差异无统计学意义(P>0.05)。结论:侧后路椎间孔镜与后侧椎板间入路脊柱内镜两种手术方案各有优劣,前者术后疼痛程度更轻,出血量更少,后者手术时间更短、腰椎功能恢复更快,两者并发症风险相当。

椎间孔镜下腰椎间盘髓核摘除联合纤维环缝合修复对腰椎间盘突出症的效果

目的:本文主要探究经赣南医学院第二附属医院相关检查明确为腰椎间盘突出症的患者,临床给予椎间孔镜下腰椎间盘髓核摘除联合纤维环缝合修复治疗的可行性。方法:选取2020年11月—2022年11月赣南医学院第二附属医院医治的腰椎间盘突出症患者68例作为研究对象,根据电脑随机法将其分成对照组和观察组,各34例。对照组采取腰椎小开窗手术治疗,观察组采取椎间孔镜下腰椎间盘髓核摘除联合纤维环缝合修复治疗。比较两组术前术后疼痛因子水平、腰部活动度、脊柱稳定性的差异。结果:两组术前疼痛因子水平比较,差异均无统计学意义(P>0.05)。两组术后3个月β-内啡肽、前列腺素E2、5-羟色胺水平等疼痛因子水平均低于本组术前,差异均有统计学意义(P<0.05);观察组术后3个月β-内啡肽、前列腺素E2、5-羟色胺水平等疼痛因子水平均低于对照组,差异均有统计学意义(P<0.05)。两组术前腰部活动度比较,差异均无统计学意义(P>0.05)。两组术后3个月腰椎后伸、腰椎前屈、腰椎左侧屈、腰椎右侧屈等腰部活动度均高于本组术前,差异均有统计学意义(P<0.05);观察组术后3个月腰椎后伸、腰椎前屈、腰椎左侧屈、腰椎右侧屈等腰部活动度均高于对照组,差异均有统计学意义(P<0.05)。两组术前脊柱稳定性比较,差异均无统计学意义(P>0.50)。两组术后3个月胸椎后凸角均高于本组术前,腰椎前凸角、矢状面平衡、颌眉角均低于本组术前,差异均有统计学意义(P<0.05);观察组术后3个月胸椎后凸角高于对照组,腰椎前凸角、矢状面平衡、颌眉角均低于对照组,差异均有统计学意义(P<0.05)。结论:对于存在腰椎间盘突出症的患者,临床给予椎间孔镜下腰椎间盘髓核摘除联合纤维环缝合修复效果显著,该方案不仅能够改善腰椎间盘突出症患者疼痛情况及腰部活动度,还有助于恢复脊柱的稳定性,为广大腰椎间盘突出症患者提供了更加精准、高效的治疗新选择。

腰椎间盘突出症行UBE内镜下髓核摘除术后连续臭氧椎管内注射的疗效观察

目的 观察腰椎间盘突出症(LDH)患者行单侧双通道内镜技术(UBE)内镜下髓核摘除术后连续臭氧椎管内注射治疗的疗效。方法 选取60例腰椎间盘突出症患者,随机分为观察组和对照组,各30例。所有患者均行UBE内镜下髓核摘除术,观察组术后连续臭氧椎管内注射治疗,对照组常规切口缝合、覆盖无菌辅料。比较两组手术前后腰腿痛评分及术后切口肿胀和渗出评分。结果 对照组术前1 d及术后1、5、12 d的视觉模拟评分法(VAS)评分分别为(6.65±1.59)、(5.13±1.18)、(3.92±1.15)、(2.28±1.18)分,观察组分别为(6.62±1.15)、(3.87±1.27)、(2.31±1.10)、(1.11±0.92)分;两组术前1 d VAS评分比较差异无统计学意义(P>0.05);术后1、5、12 d,两组VAS评分均低于术前1 d,且观察组均低于对照组,差异有统计学意义(P<0.05)。对照组术后1、5、12 d的肿胀评分和渗出评分分别为(2.16±0.58)、(1.33±0.79)、(0.42±0.12)分和(2.31±0.63)、(1.60±0.27)、(0.91±0.29)分,观察组分别为(1.82±0.47)、(0.89±0.83)、(0.15±0.16)分和(1.95±0.58)、(1.32±0.21)、(0.43±0.21)分;术后5、12 d,两组肿胀评分和渗出评分均低于术后1 d,差异有统计学意义(P<0.05);术后12 d,两组肿胀评分和渗出评分均低于术后5 d,差异有统计学意义(P<0.05);观察组术后1、5、12 d肿胀评分和渗出评分均低于对照组,差异有统计学意义(P<0.05)。结论 腰椎间盘突出症行UBE内镜下髓核摘除术后连续臭氧椎管内注射,可有效改善患者腰腿痛症状,且切口肿胀和渗出情况较轻,值得在临床上推广应用。

中药熏蒸疼痛干预结合路径式康复措施对微创治疗腰椎间盘突出症术后患者VAS评分与康复效果的影响

目的分析中药熏蒸疼痛干预结合路径式康复措施对微创治疗腰椎间盘突出症术后患者视觉模拟评分法(VAS)评分与康复效果的影响。方法选取2022年6月至2023年9月接受脊柱内镜下髓核摘除术的腰椎间盘突出症126例,随机分为对照组(n=63)、观察组(n=63),在常规干预基础上,对照组采用中药熏蒸疼痛干预,观察组采用中药熏蒸疼痛干预结合路径式康复措施。比较2组腰痛VAS评分、腰椎功能、健康状况调查简表(SF-36)评分及不良反应发生率。结果干预后,观察组腰痛VAS评分、Oswestry功能障碍指数评分低于对照组,日本骨科协会评分及不同维度SF-36评分高于对照组(P<0.05,P<0.01)。观察组不良反应发生率低于对照组(P<0.05)。结论微创治疗腰椎间盘突出症术后患者应用中药熏蒸疼痛干预结合路径式康复措施,可行性良好,能有效减轻腰痛症状,提升腰椎功能及生活质量。

经皮椎间孔镜髓核摘除术在腰椎间盘突出症患者中的临床效果

目的探讨经皮椎间孔镜髓核摘除术(Percutaneous Endoscopic Lumbar Discectomy,PELD)在腰椎间盘突出症(Lumbar Disc Herniation,LDH)患者中的临床效果。方法选取2021年1月—2023年6月靖西市人民医院收治的80例LDH患者为研究对象,按手术方式分为对照组(n=40,椎板开窗髓核摘除术)和研究组(n=40,PELD治疗),随访6个月,比较两组治疗前(T0)、后(T1)的临床效果。结果研究组患者术中失血量、手术时间以及住院时间均优于对照组,差异有统计学意义(P均<0.05)。两组患者T1时的腰椎功能评分均较T0时低,且研究组显著低于对照组,差异有统计学意义(P<0.05)。两组患者T1时的生活质量各维度评分均较T0时高,且研究组高于对照组,差异有统计学意义(P均<0.05)。研究组并发症总发生率(2.50%)和复发率(2.50%)均低于对照组,差异有统计学意义(χ^(2)=4.507、4.507,P均<0.05)。结论采用PELD治疗LDH效果显著,且并发症发生率、复发率均较低。

经皮内镜椎板间手术入路髓核摘除术联合核心肌群训练对腰椎间盘突出症术后患者疗效的临床研究

目的 探究经皮内镜椎板间手术入路髓核摘除术联合核心肌群训练对腰椎间盘突出症术后患者疗效。方法 非随机选取2021年3月—2023年5月天水四零七医院收治的86例腰椎间盘突出症患者为研究对象,按治疗方法分为观察组与对照组,每组43例。观察组实施经皮内镜椎板间手术入路髓核摘除术联合核心肌群训练,对照组实施传统手术联合常规康复训练。对比两组手术相关指标、临床疗效、腰椎功能、生活质量评分以及并发症发生率。结果 观察组住院时间短于对照组,差异有统计学意义(P<0.05);观察组优良率(97.67%)高于对照组(79.07%),差异有统计学意义(χ^(2)=7.242,P<0.05);治疗前,两组功能障碍指数、日本骨科协会评估治疗分数及生活质量评分对比,差异无统计学意义(P均>0.05),治疗后,两组均较治疗前改善,且观察组优于对照组,差异有统计学意义(P均<0.05)。两组并发症相比,差异无统计学意义(P>0.05)。结论将手术和核心肌群训练结合,可促进患者腰椎功能的恢复,减轻其疼痛程度,值得临床借鉴。

侧后路经皮椎间孔镜髓核摘除术治疗腰椎间盘突出症的效果

目的探讨侧后路经皮椎间孔镜髓核摘除术在腰椎间盘突出症治疗中的应用效果。方法选取2017年1月—2019年12月福建医科大学附属闽东医院91例腰椎间盘突出症患者为对照组,采取后路椎板间开窗髓核摘除术治疗;并选取2020年1月—2022年12月福建医科大学附属闽东医院91例腰椎间盘突出症患者为观察组,采取侧后路经皮椎间孔镜髓核摘除术治疗。对比治疗效果,包括术中出血量、手术时间、住院时间、颈脊髓功能评分法(Japanese Orthopaedic Association scores,JOA)、视觉模拟评分法(visual analogue scale,VAS)评分和并发症发生情况。结果观察组术中出血量少于对照组,手术时间长于对照组,但术后住院时间短于对照组,差异有统计学意义(P<0.05);术后,观察组JOA评分高于对照组,差异有统计学意义(P<0.05)。观察组术后1、3 d VAS评分低于对照组(P<0.05)。观察组并发症总发生率为5.49%,低于对照组的15.39%(P<0.05)。结论侧后路经皮椎间孔镜髓核摘除术在腰椎间盘突出症治疗中应用价值较高,不仅可以减少整体治疗时间及术中出血量,且能够提高腰椎功能,减轻疼痛。此外,该方法有助于降低术后并发症发生率。

PE-TLIF对单节段腰椎间盘突出症伴节段性不稳患者腰椎功能和远期退变的影响

目的探讨经皮内镜下经椎间孔腰椎椎间融合术(PE-TLIF)对单节段腰椎间盘突出症伴节段性不稳患者腰椎功能和远期退变的影响。方法选取2020年1月至2022年5月在许昌市人民医院收治的120例单节段腰椎间盘突出症伴节段性不稳患者,随机将患者分为PE-TLIF组和对照组,每组各60例。对照组患者采用髓核摘除术治疗,PETLIF组采用PE-TLIF治疗。分别于术前和术后1个月,比较两组患者的疼痛评分和腰椎功能恢复情况,术后半年对患者进行随访,记录比较两组患者的腰椎远期退变情况。结果术后1个月,PE-TLIF组患者的各项视觉模拟疼痛(VAS)评分均低于对照组患者,差异均有统计学意义(P<0.05)。术后1个月,PE-TLIF组患者的Oswestry功能障碍指数低于对照组,关节活动度小于对照组,差异有统计学意义(P<0.05)。术后1个月,PE-TLIF组患者治疗疗效为76.67%,对照组为63.33%,差异无统计学意义(P>0.05)。术后3个月,PE-TLIF组患者治疗有效率85.00%,对照组为65.00%,差异有统计学意义(P<0.05)。术后6个月,PE-TLIF组患者治疗有效率95.00%,对照组为85.00%,差异无统计学意义(P>0.05)。结论PE-TLIF治疗术可以更快地减轻患者疼痛,使患者的腰椎功能可以更快地康复。

经皮椎间孔镜髓核摘除术在腰椎间盘突出症患者中的应用效果

目的 探讨经皮椎间孔镜髓核摘除术治疗腰椎间盘突出症的效果。方法 选取2020年5月至2022年5月解放军联勤保障部队第九七○医院收治的70例腰椎间盘突出症患者为研究对象,采用随机数表法分为对照组和观察组,每组各35例。对照组行小切口椎板间开窗髓核摘除术治疗,观察组行经皮椎间孔镜髓核摘除术治疗。比较两组应激指标、炎症状况、日本骨科协会(JOA)评分、Oswsetry功能障碍指数(ODI)及影像学指标。结果 术后,观察组血清谷胱甘肽过氧化物酶、超氧化物歧化酶水平高于对照组,丙二醛水平低于对照组,差异有统计学意义(P <0.05);观察组白细胞介素-10水平高于对照组,肿瘤坏死因子-α、白细胞介素-6水平低于对照组,差异有统计学意义(P <0.05);观察组JOA评分高于对照组,ODI评分低于对照组,差异有统计学意义(P <0.05);两组影像学指标比较,差异无统计学意义(P> 0.05)。结论 腰椎间盘突出症采用经皮椎间孔镜髓核摘除术治疗效果较好,可有效改善患者应激指标水平,减轻机体炎症指标水平,促进腰椎功能恢复,利于患者病情预后,临床上可借鉴及推广。

地佐辛复合咪达唑仑辅助局部麻醉在椎间孔镜腰椎髓核摘除术中的应用效果

目的:探讨地佐辛复合咪达唑仑辅助局部麻醉在椎间孔镜下髓核摘除术(PELD)中的应用效果.方法:选取2022年1月—2023年6月于玉林市中西医结合骨科医院实施PELD的腰椎间盘突出症(LDH)患者120例作为研究对象,按照随机数字表法分为局部麻醉组、局部麻醉+地佐辛组、局部麻醉+地佐辛复合咪达唑仑组,各40例.比较三组在体位摆好5 min时(T_(0))、局部浸润麻醉时(T_(1))、刺入穿刺针时(T_(2))、置入工作套管时(T_(3))、打磨关节突时(T_(4))、取髓核时(T_(5))的平均动脉压(MAP)、心率(HR)、氧饱和度(SpO_(2))和视觉模拟评分法(VAS)、警觉/镇静(OAA/S)评分.结果:T_(1)~T_(5),局部麻醉+地佐辛复合咪达唑仑组MAP、HR和VAS、OAA/S评分低于局部麻醉+地佐辛组,局部麻醉+地佐辛组MAP、HR和VAS、OAA/S评分低于局部麻醉组,差异有统计学意义(P<0.05).结论:地佐辛复合咪达唑仑辅助局部麻醉在PELD中应用效果较好,可维持LDH患者血流动力学稳定,减轻围术期的焦虑与疼痛.

集束化护理干预在椎间孔镜下腰椎间盘突出髓核摘除术中的作用探究

目的分析集束化护理干预在椎间孔镜下腰椎间盘突出髓核摘除术中的临床疗效。方法选取南华大学附属第二医院2022年3月—2023年3月收治的80例行椎间孔镜下腰椎间盘突出髓核摘除术的患者为研究对象,采取随机数字表法将患者分为对照组(n=40)与观察组(n=40),对照组实施常规护理,观察组实施集束化护理,比较患者临床指标、腰痛疾患疗效评分、腰椎功能情况。结果观察组卧床时间、住院时间、康复训练时间均短于对照组(P<0.05)。干预后,观察组日本骨科协会推荐的颈脊髓功能(JOA)评分高于对照组,腰椎功能障碍(ODI)评分低于对照组(P<0.05)。结论集束化护理效果显著,能缩短椎间孔镜下腰椎间盘突出髓核摘除术患者的卧床时间、住院时长及康复训练时间,并明显改善了患者的腰椎功能,为患者康复提供了有力支持。

Coflex系统在腰4/5椎间盘突出治疗中的应用效果

目的探讨Coflex系统在腰4/5椎间盘突出治疗中的应用效果。方法收集2009年1月至2011年6月郑州大学第一附属医院收治的67例腰4/5椎间盘突出患者,按治疗方式分为A组(35例)和B组(32例)。A组患者接受单纯腰椎间盘髓核摘除术治疗,B组患者接受腰椎间盘髓核摘除术联合Coflex系统治疗。术后定期随访,分别采用日本矫形外科协会评分(JOA)和Oswestry功能障碍指数(ODI)比较手术前后患者的疼痛和功能改善程度。比较两组患者手术前后椎间隙前后缘高度。结果 A组和B组随访时间分别为(93.1±6.4)、(86.3±2.5)个月,无失访患者,两组患者随访时间比较,差异无统计学意义(P<0.05)。两组患者的JOA评分随术后时间延长而升高,ODI随术后时间延长而下降,并且两相邻时间点比较,差异有统计学意义(均P<0.05)。B组患者术前、术后2 a、末次随访的JOA评分分别与A组比较,差异无统计学意义(P>0.05)。B组患者术前、术后2 a的ODI分别与A组比较,差异无统计学意义(P>0.05)。B组患者末次随访的ODI高于A组,差异有统计学意义(P<0.05)。两组患者手术节段椎间隙前缘及后缘高度均随术后时间延长而下降,并且两相邻时间点比较,差异有统计学意义(均P<0.05)。B组患者术前手术节段椎间隙前缘及后缘高度分别与A组比较,差异无统计学意义(P>0.05)。术后2 a、末次随访,B组患者手术节段椎间隙前缘及后缘高度均高于A组,差异有统计学意义(P<0.05)。结论单独采用腰椎间盘髓核摘除术或联合Coflex系统治疗腰4/5椎间盘突出症的效果均较好,但Coflex系统能更好地维持手术节段椎间隙高度。