We performed long-term wind-wave hindcast in the Yellow Sea and the Bohai Sea from the year 1988 to 2002, and then analyzed the regional wave climate. Comparisons between model results and satellite data are generally...We performed long-term wind-wave hindcast in the Yellow Sea and the Bohai Sea from the year 1988 to 2002, and then analyzed the regional wave climate. Comparisons between model results and satellite data are generally consistent on monthly mean significant wave height. Then we discuss the temporal and spatial characteristics of the climatological monthly mean significant wave heights and mean wave periods. The climatologically spatial patterns are observed as increasing from northwest to southeast and from offshore to deep-water area for both significant wave height and mean wave period, and the patterns are highly related to the wind forcing and local topography. Seasonal variations of wave parameters are also significant. Furthermore, we compute the extreme values of wind and significant wave height using statistical methods. Results reveal the spatial patterns of N-year return significant wave height in the Yellow Sea and the Bohai Sea, and we discuss the relationship between extreme values of significant wave height and wind forcing.展开更多
Adiponectin plays an important role in the development of hypertension, atherosclerosis, and cardio- myocyte hypertrophy, but very little was known about the influence of serum adiponectin or the adiponectin gene poly...Adiponectin plays an important role in the development of hypertension, atherosclerosis, and cardio- myocyte hypertrophy, but very little was known about the influence of serum adiponectin or the adiponectin gene polymorphism on myocardial fibrosis. Our study investigates the influence of the SNP ＋45 polymorphism of the adi- ponectin gene and serum levels of adiponectin on myocardial fibrosis in patients with essential hypertension. A case-control study was conducted on 165 hypertensive patients and 126 normotensive healthy controls. The geno- types of adiponectin gene polymorphisms were detected by the polymerase chain reaction （PCR） method. Serum concentrations of procollagen were measured by a double antibody sandwich enzyme-linked immunosorbent assay （ELISA） in all subjects. The integrated backscatter score （IBS） was measured in the left ventricular myocardium using echocardiography. The serum levels of adiponectin in hypertensive patients were significantly lower than those in the normal control group （（2.69±1.0） μg/ml vs. （4.21±2.89） μg/ml, respectively, P〈0.001）. The serum levels of type-Ⅰ procoilagen carboxyl end peptide （PiCP） and type-Ⅲprocollagen ammonia cardinal extremity peptide （PIIINP） in the hypertension group were significantly higher than those in the control group. In the hypertension group, serum levels of adiponectin were significantly and negatively related to the average acoustic intensity and corrected acoustic intensity of the myocardium （t=0.46 and 0.61, respectively, P〈0.05 for both）. The serum levels of PICP and PIIINP were sig- nificantly different among the three genotypes of SNP ＋45 （P〈0.01）. Logistic regression analyses showed that sex and genotype （GG＋GT） were the major risk factors of myocardial fibrosis in hypertensive patients （OR=5.343 and 3.278, respectively, P〈0.05）. These data suggest that lower levels of adiponectin and SNP ＋45 polymorphism of the adi- ponectin gene are likely to play an important role in myocardial fibrosis in hypertensive patients.展开更多
基金The National Natural Science Foundation of China under contract Nos 41476021 and 41321004the Strategic Priority Research Program of the Chinese Academy of Sciences under contract No.XDA11010104the project of Indo-Pacific Ocean Environment Variation and Air-sea Interaction under contract No.GASI-IPOVAI-04
文摘We performed long-term wind-wave hindcast in the Yellow Sea and the Bohai Sea from the year 1988 to 2002, and then analyzed the regional wave climate. Comparisons between model results and satellite data are generally consistent on monthly mean significant wave height. Then we discuss the temporal and spatial characteristics of the climatological monthly mean significant wave heights and mean wave periods. The climatologically spatial patterns are observed as increasing from northwest to southeast and from offshore to deep-water area for both significant wave height and mean wave period, and the patterns are highly related to the wind forcing and local topography. Seasonal variations of wave parameters are also significant. Furthermore, we compute the extreme values of wind and significant wave height using statistical methods. Results reveal the spatial patterns of N-year return significant wave height in the Yellow Sea and the Bohai Sea, and we discuss the relationship between extreme values of significant wave height and wind forcing.
基金Project supported by the Natural Science Foundation of Shandong Province, China (No. ZR2012HL19)the Science and Technology Development Plan of Tai’an City, China (No. 20113096)
文摘Adiponectin plays an important role in the development of hypertension, atherosclerosis, and cardio- myocyte hypertrophy, but very little was known about the influence of serum adiponectin or the adiponectin gene polymorphism on myocardial fibrosis. Our study investigates the influence of the SNP ＋45 polymorphism of the adi- ponectin gene and serum levels of adiponectin on myocardial fibrosis in patients with essential hypertension. A case-control study was conducted on 165 hypertensive patients and 126 normotensive healthy controls. The geno- types of adiponectin gene polymorphisms were detected by the polymerase chain reaction （PCR） method. Serum concentrations of procollagen were measured by a double antibody sandwich enzyme-linked immunosorbent assay （ELISA） in all subjects. The integrated backscatter score （IBS） was measured in the left ventricular myocardium using echocardiography. The serum levels of adiponectin in hypertensive patients were significantly lower than those in the normal control group （（2.69±1.0） μg/ml vs. （4.21±2.89） μg/ml, respectively, P〈0.001）. The serum levels of type-Ⅰ procoilagen carboxyl end peptide （PiCP） and type-Ⅲprocollagen ammonia cardinal extremity peptide （PIIINP） in the hypertension group were significantly higher than those in the control group. In the hypertension group, serum levels of adiponectin were significantly and negatively related to the average acoustic intensity and corrected acoustic intensity of the myocardium （t=0.46 and 0.61, respectively, P〈0.05 for both）. The serum levels of PICP and PIIINP were sig- nificantly different among the three genotypes of SNP ＋45 （P〈0.01）. Logistic regression analyses showed that sex and genotype （GG＋GT） were the major risk factors of myocardial fibrosis in hypertensive patients （OR=5.343 and 3.278, respectively, P〈0.05）. These data suggest that lower levels of adiponectin and SNP ＋45 polymorphism of the adi- ponectin gene are likely to play an important role in myocardial fibrosis in hypertensive patients.
