Comparison of postoperative corneal changes between dry eye and non-dry eye in a murine cataract surgery model

AIM： To compare the effects of the surgical insult of cataract surgery on corneal inflammatory infiltration, neovascularization （NV） and lymphangiogenesis （LY） between the dry eye and non-dry eye in murine cataract surgery models.METHODS： We established two groups of animals, one with normal eyes （non-dry eye） and the second with induced dry eyes. In both groups, we used surgical insults to mimic human cataract surgery, which consisted of lens extraction, corneal incision and suture. After harvesting of corneas on the 9th postoperative day and immunohistochemical staining, we compared NV, LY and CD11b＋ cell infiltration in the corneas.RESULTS： Dry eye group had significantly more inflammatory infiltration （21.75%±7.17% r/s 3.65%±1.49%; P=0.049）. The dry eye group showed significantly more NV （48.21% ±4.02% ys 26.24% ±6.01% ; P =0.016） and greater levels of LY （9.27%±0.48% ys 4.84%±1.15%; P= 0.007）. In corneas on which no surgery was performed, there was no induction of NV in both the dry and non- dry group, but dry eye group demonstrated more CD11b＋ cells infiltration than the non-dry eye group （0.360%± 0.160% vs 0.023%±0.006%; P=0.068）. Dry eye group showed more NV than non-dry eye group in both topical PBS application and subconjunctival PBS injection （P= 0.020 and 0.000, respectively）.

Case Collection of Acupuncture Treatment for the Refractory Eye Diseases by Professor Zhang Ren

Zhang Ren, a master of medicine, professor, chief physician, and State Council expert for Special Allowances. He is the current vice president of Chinese Acupuncture Society, the honorary chairman of Shanghai Acupuncture Society, a member of Shanghai Intangible Cultural Heritage Assessment Committee. He used to be the director of Shanghai Municipal Literature Museum of Traditional Chinese Medicine and the director of the Shanghai Information Institute of Traditional Chinese Medicine. He has been engaged in acupuncture clinical and literature research for more than 40 years. He has been to Europe to give lectures and treat patients in clinic for 3 times, and received a favorable evaluation. And he has independently written and edited more than 60 books on acupuncture and traditional Chinese medicine as a chief editor （including English and Japanese versions）, which were published in Beijing, Shanghai, Chongqing, Taipei and Tokyo. He has published nearly 100 papers in both English and Chinese. He has also chaired Shanghai Municipal Public Health Bureau research projects, and participated in a number of projects such as Shanghai Municipal Science and Technology Commission project, the National 973 project. He has accumulated a wealth of clinical experience on acupuncture treamlent tor multiple modem intractable diseases, especially has unique experience on the acupuncture treammnt for stubborn eye diseases.