In this study, organic solar cells (OSCs) with an active layer, a blend of polymer of non-fullerene (NFA) Y6 as an acceptor, and donor PBDB-T-2F as donor were simulated through the one-dimensional solar capacitance si...In this study, organic solar cells (OSCs) with an active layer, a blend of polymer of non-fullerene (NFA) Y6 as an acceptor, and donor PBDB-T-2F as donor were simulated through the one-dimensional solar capacitance simulator (SCAPS-1D) software to examine the performance of this type of organic polymer thin-film solar cell by varying the thickness of the active layer. PFN-Br interfacial layer entrenched in OPV devices gives overall enhanced open-circuit voltage, short-circuit current density and fill factor thus improving device performance. PEDOT: PSS is an electro-conductive polymer solution that has been extensively utilized in solar cell devices as a hole transport layer (HTL) due to its strong hole affinity, good thermal and mechanical stability, high work function, and high transparency in the visible range. The structure of the organic solar cell is ITO/PEDOT: PSS/BTP-4F: PBDB-T-2F/PFN-Br/Ag. Firstly, the active layer thickness was optimized to 100 nm;after that, the active-layer thickness was varied up to 900 nm. The results of these simulations demonstrated that the active layer thickness improves efficiency significantly up to 500 nm, then it decreased with increasing the thickness of the active layer from 600 nm, also notice that the short circuit current and the fill factor decrease with increasing the active layer from 600 nm, while the open voltage circuit increased with increasing the thickness of the active layer. The optimum thickness is 500 nm.展开更多
Prosthesis implantation and fat transplantation are common breast reconstructionmethods.In general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficul...Prosthesis implantation and fat transplantation are common breast reconstructionmethods.In general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficult to achieve in the correct capacity.To date,no reports have focused on methods of combining fat with implanted prostheses for breast reconstruction.Using a newly designed bionic ink(i.e.,polyether F127 diacrylate(F127DA)&poly(ethylene glycol)diacrylate(PEGDA))and projection-based three-dimensional bioprinting(PBP),we report the development of a new method for printing porous prostheses.PEGDA was used to improve the printing precision of the prosthesis by increasing the gel point of F127DA and reducing the impact of external temperature.The compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural breasts.Finally,stromal vascular fraction gel(SVF-gel),a human fat extract,was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose tissue.These were implanted subcutaneously in nude mice to observe their biological performance.After 14 and 28 days of observation,the prosthesis showed good biocompatibility,and adipose tissues grew well in and around the prosthesis.This result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.展开更多
目的:探讨维生素D受体基因FokⅠ酶切位点多态性与胃癌的相关性.方法:随机选取2013-03/2015-05新疆肿瘤医院就诊的维吾尔族胃癌患者147例(A组)及维吾尔族健康对照者151例(B组),采用多聚酶链反应-限制性酶切片段长度多态性方法测定维生素...目的:探讨维生素D受体基因FokⅠ酶切位点多态性与胃癌的相关性.方法:随机选取2013-03/2015-05新疆肿瘤医院就诊的维吾尔族胃癌患者147例(A组)及维吾尔族健康对照者151例(B组),采用多聚酶链反应-限制性酶切片段长度多态性方法测定维生素D受体基因FokⅠ酶切位点多态性,进行两组间比较;将本研究全部胃癌患者经PCR-RFLP测定后按是否带有f基因分为FF组(a组)与Ff+ff组(b组),进行组间D-二聚体测定水平比较.结果:胃癌患者的f等位基因表达频率高于对照组(57.8%vs 47.4%,P<0.05).多因素分析显示:含f等位基因(Ff+ff)的研究对象患胃癌的风险高于不含f等位基因(FF)的研究对象(OR=2.85);含f等位基因组中D-二聚体测定水平较不含f等位基因组明显升高(2.79±1.21 vs 1.09±0.65,P<0.05);随胃癌患者分化严重程度的逐步加重,单纯含F基因(FF)的患者的比例逐步下降(P<0.05).结论:维生素D受体基因FokⅠ酶切位点多态性与维吾尔族胃癌易感性相关联,f等位基因可能是维吾尔族胃癌发生的危险因素之一,而F位点可能是维吾尔族胃癌发生的保护因素.f等位基因可能是调节D-二聚体水平的因素之一,从而影响了维吾尔族胃癌患者的发生或预后.展开更多
文摘In this study, organic solar cells (OSCs) with an active layer, a blend of polymer of non-fullerene (NFA) Y6 as an acceptor, and donor PBDB-T-2F as donor were simulated through the one-dimensional solar capacitance simulator (SCAPS-1D) software to examine the performance of this type of organic polymer thin-film solar cell by varying the thickness of the active layer. PFN-Br interfacial layer entrenched in OPV devices gives overall enhanced open-circuit voltage, short-circuit current density and fill factor thus improving device performance. PEDOT: PSS is an electro-conductive polymer solution that has been extensively utilized in solar cell devices as a hole transport layer (HTL) due to its strong hole affinity, good thermal and mechanical stability, high work function, and high transparency in the visible range. The structure of the organic solar cell is ITO/PEDOT: PSS/BTP-4F: PBDB-T-2F/PFN-Br/Ag. Firstly, the active layer thickness was optimized to 100 nm;after that, the active-layer thickness was varied up to 900 nm. The results of these simulations demonstrated that the active layer thickness improves efficiency significantly up to 500 nm, then it decreased with increasing the thickness of the active layer from 600 nm, also notice that the short circuit current and the fill factor decrease with increasing the active layer from 600 nm, while the open voltage circuit increased with increasing the thickness of the active layer. The optimum thickness is 500 nm.
基金This work was supported by the National Key Research andDevelopment Program of China(No.2018YFA0703000)the National Natural Science Foundation of China(Nos.T2121004,52235007,and 82203602)+2 种基金Zhejiang Provincial Natural Science Foundation of China under Grant No.LQ22H160020 to JWThis work was also supported by Start-up Funding of Zhejiang Provincial People’s Hospital(No.ZRY2021A001 to JW)Basic Scientific Research Funds of Department of Education of Zhejiang Province(No.KYQN202109 to JW).
文摘Prosthesis implantation and fat transplantation are common breast reconstructionmethods.In general,prosthesis implantation alone does not achieve a realistic enough appearance,and fat transplantation alone is difficult to achieve in the correct capacity.To date,no reports have focused on methods of combining fat with implanted prostheses for breast reconstruction.Using a newly designed bionic ink(i.e.,polyether F127 diacrylate(F127DA)&poly(ethylene glycol)diacrylate(PEGDA))and projection-based three-dimensional bioprinting(PBP),we report the development of a new method for printing porous prostheses.PEGDA was used to improve the printing precision of the prosthesis by increasing the gel point of F127DA and reducing the impact of external temperature.The compression modulus of the printed prosthesis was very close to that of prostheses currently used in clinical practice and to that of natural breasts.Finally,stromal vascular fraction gel(SVF-gel),a human fat extract,was injected into the pores of the synthesized prostheses to prepare a prosthesis mixed with adipose tissue.These were implanted subcutaneously in nude mice to observe their biological performance.After 14 and 28 days of observation,the prosthesis showed good biocompatibility,and adipose tissues grew well in and around the prosthesis.This result shows that a porous prosthesis containing pre-placed adipose tissues is a promising breast reconstruction material.
文摘目的:探讨维生素D受体基因FokⅠ酶切位点多态性与胃癌的相关性.方法:随机选取2013-03/2015-05新疆肿瘤医院就诊的维吾尔族胃癌患者147例(A组)及维吾尔族健康对照者151例(B组),采用多聚酶链反应-限制性酶切片段长度多态性方法测定维生素D受体基因FokⅠ酶切位点多态性,进行两组间比较;将本研究全部胃癌患者经PCR-RFLP测定后按是否带有f基因分为FF组(a组)与Ff+ff组(b组),进行组间D-二聚体测定水平比较.结果:胃癌患者的f等位基因表达频率高于对照组(57.8%vs 47.4%,P<0.05).多因素分析显示:含f等位基因(Ff+ff)的研究对象患胃癌的风险高于不含f等位基因(FF)的研究对象(OR=2.85);含f等位基因组中D-二聚体测定水平较不含f等位基因组明显升高(2.79±1.21 vs 1.09±0.65,P<0.05);随胃癌患者分化严重程度的逐步加重,单纯含F基因(FF)的患者的比例逐步下降(P<0.05).结论:维生素D受体基因FokⅠ酶切位点多态性与维吾尔族胃癌易感性相关联,f等位基因可能是维吾尔族胃癌发生的危险因素之一,而F位点可能是维吾尔族胃癌发生的保护因素.f等位基因可能是调节D-二聚体水平的因素之一,从而影响了维吾尔族胃癌患者的发生或预后.
