Objective:To investigate the clinic significance of the combined detection of peripheral fibrinogen(Fbg)and neutrophils-to-lymphocyte ratio(NLR)(F-NLR)on the prognosis of postoperative gastric cancer patients.Methods:...Objective:To investigate the clinic significance of the combined detection of peripheral fibrinogen(Fbg)and neutrophils-to-lymphocyte ratio(NLR)(F-NLR)on the prognosis of postoperative gastric cancer patients.Methods:The clinical and pathological characteristics of 70 gastric cancer patients who were diagnosed by gastroscopy and surgically resected were collected,and the relationship between Fbg,NLR and F-NLR scores and pathological characteristics and prognosis of gastric cancer patients was retrospectively analyzed.Results:There were statistically significant differences in the levels of NLR in gastric cancer patients of different genders(P<0.05),while there were no significant differences in the levels of NLR and Fbg in other pathological factors such as age,T stage,lymph node metastasis and TNM stage(P>0.05).The f-NLR score of gastric cancer patients with different gender,T stage and TNM stage had statistical significance(P<0.05),but there was no statistical significance in the F-NLR score of gastric cancer patients with different age and whether lymph node metastasis(P>0.05).Univariate analysis showed that Fbg,NLR,F-NLR score,and TNM stage had an effect on recurrence and survival of patients with gastric cancer after surgery(P<0.05);multivariate COX regression analysis showed that only F-NLR score and TNM stage were independent risk factors for relapse and survival of patients with gastric cancer(P<0.05).Conclusion:The F-NLR scores about the combined detection of Fbg and NLR may guide clinical prediction of the prognosis of gastric cancer patients.展开更多
目的探讨腹水/血清CEA比值(F/S CEA)、中性粒细胞与淋巴细胞比值(ratio of neutrophils to lymphocytes,NLR)、血小板与淋巴细胞比值(ratio of platelet to lymphocytes,PLR)在良恶性腹水鉴别诊断中的临床意义。方法回顾性分析2014年1月...目的探讨腹水/血清CEA比值(F/S CEA)、中性粒细胞与淋巴细胞比值(ratio of neutrophils to lymphocytes,NLR)、血小板与淋巴细胞比值(ratio of platelet to lymphocytes,PLR)在良恶性腹水鉴别诊断中的临床意义。方法回顾性分析2014年1月至2018年12月因腹水原因待查就诊于武汉大学人民医院共317例(良性腹水94例,恶性腹水223例)患者的病例资料。并用受试者工作特征曲线(ROC)评价F/S CEA、NLR、PLR、联合检测对良恶性腹水的诊断价值。结果恶性腹水组的F/S CEA、NLR、PLR均高于良性腹水组,差异均有统计学意义(P<0.05)。F/S CEA、NLR、PLR的ROC曲线下面积分别为0.712、0.643、0.689。F/S CEA、NLR、PLR联合诊断恶性腹水的灵敏度和特异度分别为82.96%、84.04%,优于单个或两两检测,差异有统计学意义(P<0.05)。F/S CEA、NLR、PLR联合诊断在肿瘤细胞学阴性的恶性腹水中灵敏度、特异度分别为84.75%、85.10%。结论F/S CEA、NLR、PLR是鉴别良恶性腹水有价值的生物学指标,三项指标联合检测可提高恶性腹水的诊断效能。展开更多
基金General Project of National Natural Science Foundation of China(No.81872275)Highlevel Health Talent Project of Jiangsu Provincial Health Commission(No.LGY2018017)Wujin District Science and Technology PlanDevelopment Project(No.WS201702)。
文摘Objective:To investigate the clinic significance of the combined detection of peripheral fibrinogen(Fbg)and neutrophils-to-lymphocyte ratio(NLR)(F-NLR)on the prognosis of postoperative gastric cancer patients.Methods:The clinical and pathological characteristics of 70 gastric cancer patients who were diagnosed by gastroscopy and surgically resected were collected,and the relationship between Fbg,NLR and F-NLR scores and pathological characteristics and prognosis of gastric cancer patients was retrospectively analyzed.Results:There were statistically significant differences in the levels of NLR in gastric cancer patients of different genders(P<0.05),while there were no significant differences in the levels of NLR and Fbg in other pathological factors such as age,T stage,lymph node metastasis and TNM stage(P>0.05).The f-NLR score of gastric cancer patients with different gender,T stage and TNM stage had statistical significance(P<0.05),but there was no statistical significance in the F-NLR score of gastric cancer patients with different age and whether lymph node metastasis(P>0.05).Univariate analysis showed that Fbg,NLR,F-NLR score,and TNM stage had an effect on recurrence and survival of patients with gastric cancer after surgery(P<0.05);multivariate COX regression analysis showed that only F-NLR score and TNM stage were independent risk factors for relapse and survival of patients with gastric cancer(P<0.05).Conclusion:The F-NLR scores about the combined detection of Fbg and NLR may guide clinical prediction of the prognosis of gastric cancer patients.
文摘目的探讨腹水/血清CEA比值(F/S CEA)、中性粒细胞与淋巴细胞比值(ratio of neutrophils to lymphocytes,NLR)、血小板与淋巴细胞比值(ratio of platelet to lymphocytes,PLR)在良恶性腹水鉴别诊断中的临床意义。方法回顾性分析2014年1月至2018年12月因腹水原因待查就诊于武汉大学人民医院共317例(良性腹水94例,恶性腹水223例)患者的病例资料。并用受试者工作特征曲线(ROC)评价F/S CEA、NLR、PLR、联合检测对良恶性腹水的诊断价值。结果恶性腹水组的F/S CEA、NLR、PLR均高于良性腹水组,差异均有统计学意义(P<0.05)。F/S CEA、NLR、PLR的ROC曲线下面积分别为0.712、0.643、0.689。F/S CEA、NLR、PLR联合诊断恶性腹水的灵敏度和特异度分别为82.96%、84.04%,优于单个或两两检测,差异有统计学意义(P<0.05)。F/S CEA、NLR、PLR联合诊断在肿瘤细胞学阴性的恶性腹水中灵敏度、特异度分别为84.75%、85.10%。结论F/S CEA、NLR、PLR是鉴别良恶性腹水有价值的生物学指标,三项指标联合检测可提高恶性腹水的诊断效能。