目的观察中医情志疗法对三阴性乳腺癌患者术后恢复期的生存质量的影响。方法选择90例三阴性乳腺癌患者术后恢复期患者为研究对象,采用随机数字表法分为观察组和对照组,各45例。所有患者均参照NCCN指南进行乳腺癌基础治疗及常规护理干预...目的观察中医情志疗法对三阴性乳腺癌患者术后恢复期的生存质量的影响。方法选择90例三阴性乳腺癌患者术后恢复期患者为研究对象,采用随机数字表法分为观察组和对照组,各45例。所有患者均参照NCCN指南进行乳腺癌基础治疗及常规护理干预,观察组联合应用中医情志疗法。观察治疗前后抑郁评分变化,采用乳腺癌患者生命质量测定量表(Functional Assessment of Cancer Therapy-Breast,FACT-B)评估两组生存质量,并通过T细胞亚群检测CD4+百分比、CD8+百分比、CD4+/CD8+的数值。结果治疗后观察组CES-D评分、HAMD-17评分明显低于对照组(P<0.05);情感状况、功能状况、附加关注、总量表等生活质量评分均明显低于对照组(P<0.05);观察组CD4+百分比、CD4+/CD8+明显高于对照组,CD8+百分比明显低于对照(P<0.05)。结论中医情志疗法能有效缓解三阴性乳腺癌术后抑郁症状,改善免疫功能,提高患者整体生活质量。展开更多
Objective： Chemotherapy with paclitaxel is associated with significant neurotoxicity that may offset patients＇ quality of life and therapeutic benefits. This prospective, non-randomized control study evaluated the e...Objective： Chemotherapy with paclitaxel is associated with significant neurotoxicity that may offset patients＇ quality of life and therapeutic benefits. This prospective, non-randomized control study evaluated the efficacy and safety of an antidepressant drug, duloxetine, at 30 or 60 mg/d, in the treatment of paclitaxel-induced peripheral neuropathy（PIPN） in Chinese breast cancer patients.Methods：A total of 102 patients with a median age of 50（range,25–60）years,treated in the Department of Medical Oncology,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,between November 2014 and January 2017 were finally enrolled.Stratified by baseline characteristics,the patients were classified into two groups,receiving either duloxetine or alternative antineurotoxicity drugs.During the course of the paclitaxel regimen,the eligibility criteria included sensory neuropathy,as evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse Events.The treatment consisted of receiving 30 mg duloxetine（for the first 4 weeks）and 60 mg duloxetine for an additional 8 weeks,or any other anti-neurotoxicity drug daily during the same crossover period.The improvement associated with PIPN from the patient’s perspective were assessed by the Functional Assessment of Cancer Therapy-Taxane（FACT-Tax）Scales,which contained questions scored from 0 to 4（0,not at all;4,very much;total score range,0–44）.Results：Duloxetine was more effective in decreasing PIPN（odds ratio=5.426;95%confidence interval,1.898–15.514;P=0.002）.Between duloxetine group and control group,the median（25th–75th percentiles）decreasing difference in the FACT-Tax pain score was 4（2–6）vs.1（0–4）（P=0.005）.Conclusions：Duloxetine is a promising and safe option with tolerable toxicity at a dose of 60 mg/d for Chinese breast cancer patients with PIPN.Non-neuropathy adverse events were mild and similar in both groups.The major toxicities of duloxetine included nausea,constipation,somnolence,dizziness and distention of the eyes.Further examination of the benefits of duloxetine in the prevention of PIPN is required.展开更多
Using Hall and Reginatto’s condition for a Wheeler De Witt Equation for a Friedman-Walker metric coupled to a (Inflaton) scalar field Φ, we delineate the outer boundary of the value of a scale factor a (t) for quant...Using Hall and Reginatto’s condition for a Wheeler De Witt Equation for a Friedman-Walker metric coupled to a (Inflaton) scalar field Φ, we delineate the outer boundary of the value of a scale factor a (t) for quantum effects, in an expanding universe. The inflaton field is from Padmanabhan’s reference, “An Invitation to Astrophysics” which yields a nonstandard Potential U (a, Φ) which will lead to an algebraic expression for a (t) for the value of the outer boundary of quantum effects in the universe. Afterwards, using the scale factor a (t)=ainitial·tα, with alpha given different values, we give an estimation as to a time, t (time) which is roughly the boundary of the range of quantum effects. How this is unusual? We use the Wheeler De Witt Equation, as a coupling to a given inflaton field Φ and find a different way as to delineate a time regime for the range of quantum effects in an expanding universe.展开更多
文摘目的观察中医情志疗法对三阴性乳腺癌患者术后恢复期的生存质量的影响。方法选择90例三阴性乳腺癌患者术后恢复期患者为研究对象,采用随机数字表法分为观察组和对照组,各45例。所有患者均参照NCCN指南进行乳腺癌基础治疗及常规护理干预,观察组联合应用中医情志疗法。观察治疗前后抑郁评分变化,采用乳腺癌患者生命质量测定量表(Functional Assessment of Cancer Therapy-Breast,FACT-B)评估两组生存质量,并通过T细胞亚群检测CD4+百分比、CD8+百分比、CD4+/CD8+的数值。结果治疗后观察组CES-D评分、HAMD-17评分明显低于对照组(P<0.05);情感状况、功能状况、附加关注、总量表等生活质量评分均明显低于对照组(P<0.05);观察组CD4+百分比、CD4+/CD8+明显高于对照组,CD8+百分比明显低于对照(P<0.05)。结论中医情志疗法能有效缓解三阴性乳腺癌术后抑郁症状,改善免疫功能,提高患者整体生活质量。
文摘Objective： Chemotherapy with paclitaxel is associated with significant neurotoxicity that may offset patients＇ quality of life and therapeutic benefits. This prospective, non-randomized control study evaluated the efficacy and safety of an antidepressant drug, duloxetine, at 30 or 60 mg/d, in the treatment of paclitaxel-induced peripheral neuropathy（PIPN） in Chinese breast cancer patients.Methods：A total of 102 patients with a median age of 50（range,25–60）years,treated in the Department of Medical Oncology,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,between November 2014 and January 2017 were finally enrolled.Stratified by baseline characteristics,the patients were classified into two groups,receiving either duloxetine or alternative antineurotoxicity drugs.During the course of the paclitaxel regimen,the eligibility criteria included sensory neuropathy,as evaluated by the National Cancer Institute-Common Toxicity Criteria for Adverse Events.The treatment consisted of receiving 30 mg duloxetine（for the first 4 weeks）and 60 mg duloxetine for an additional 8 weeks,or any other anti-neurotoxicity drug daily during the same crossover period.The improvement associated with PIPN from the patient’s perspective were assessed by the Functional Assessment of Cancer Therapy-Taxane（FACT-Tax）Scales,which contained questions scored from 0 to 4（0,not at all;4,very much;total score range,0–44）.Results：Duloxetine was more effective in decreasing PIPN（odds ratio=5.426;95%confidence interval,1.898–15.514;P=0.002）.Between duloxetine group and control group,the median（25th–75th percentiles）decreasing difference in the FACT-Tax pain score was 4（2–6）vs.1（0–4）（P=0.005）.Conclusions：Duloxetine is a promising and safe option with tolerable toxicity at a dose of 60 mg/d for Chinese breast cancer patients with PIPN.Non-neuropathy adverse events were mild and similar in both groups.The major toxicities of duloxetine included nausea,constipation,somnolence,dizziness and distention of the eyes.Further examination of the benefits of duloxetine in the prevention of PIPN is required.
文摘Using Hall and Reginatto’s condition for a Wheeler De Witt Equation for a Friedman-Walker metric coupled to a (Inflaton) scalar field Φ, we delineate the outer boundary of the value of a scale factor a (t) for quantum effects, in an expanding universe. The inflaton field is from Padmanabhan’s reference, “An Invitation to Astrophysics” which yields a nonstandard Potential U (a, Φ) which will lead to an algebraic expression for a (t) for the value of the outer boundary of quantum effects in the universe. Afterwards, using the scale factor a (t)=ainitial·tα, with alpha given different values, we give an estimation as to a time, t (time) which is roughly the boundary of the range of quantum effects. How this is unusual? We use the Wheeler De Witt Equation, as a coupling to a given inflaton field Φ and find a different way as to delineate a time regime for the range of quantum effects in an expanding universe.
